DE60022879D1 - Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität - Google Patents

Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität

Info

Publication number
DE60022879D1
DE60022879D1 DE60022879T DE60022879T DE60022879D1 DE 60022879 D1 DE60022879 D1 DE 60022879D1 DE 60022879 T DE60022879 T DE 60022879T DE 60022879 T DE60022879 T DE 60022879T DE 60022879 D1 DE60022879 D1 DE 60022879D1
Authority
DE
Germany
Prior art keywords
methods
protease activity
highly specific
specific protease
obtaining highly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60022879T
Other languages
English (en)
Other versions
DE60022879T2 (de
Inventor
Acker Lodewijk Van
Inge Dierynck
Wilfried Pauwels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Infectious Diseases Diagnostics BVBA
Original Assignee
Tibotec BVBA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec BVBA filed Critical Tibotec BVBA
Publication of DE60022879D1 publication Critical patent/DE60022879D1/de
Application granted granted Critical
Publication of DE60022879T2 publication Critical patent/DE60022879T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5026—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on cell morphology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43595—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
DE60022879T 1999-05-26 2000-05-26 Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität Expired - Fee Related DE60022879T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99201659A EP1055929A1 (de) 1999-05-26 1999-05-26 Mittel und Verfahren für Medizinentdeckung und phenotypische Charakterisierung von Zellen
EP99201659 1999-05-26
PCT/EP2000/004923 WO2000073802A1 (en) 1999-05-26 2000-05-26 Reporter molecules and methods for assaying high specificity protease activity

Publications (2)

Publication Number Publication Date
DE60022879D1 true DE60022879D1 (de) 2006-02-09
DE60022879T2 DE60022879T2 (de) 2006-07-20

Family

ID=8240238

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60022879T Expired - Fee Related DE60022879T2 (de) 1999-05-26 2000-05-26 Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität
DE60034672T Expired - Lifetime DE60034672D1 (de) 1999-05-26 2000-05-26 Reporterverbindungen und verfahren zur bestimmung des lipidisierungsstatus einer zelle

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60034672T Expired - Lifetime DE60034672D1 (de) 1999-05-26 2000-05-26 Reporterverbindungen und verfahren zur bestimmung des lipidisierungsstatus einer zelle

Country Status (9)

Country Link
US (1) US7129036B1 (de)
EP (3) EP1055929A1 (de)
AT (2) ATE305612T1 (de)
AU (2) AU778272B2 (de)
CA (2) CA2374038A1 (de)
DE (2) DE60022879T2 (de)
DK (1) DK1185873T3 (de)
ES (1) ES2249273T3 (de)
WO (2) WO2000073802A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756207B1 (en) 1997-02-27 2004-06-29 Cellomics, Inc. System for cell-based screening
AU2002365119A1 (en) * 2001-07-30 2003-09-04 Meso Scale Technologies, Llc. Assay electrodes having immobilized lipid/protein layers and methods of making and using the same
AU2002330756B2 (en) 2001-08-10 2009-07-16 Ahram Biosystems Inc. System for detecting protease
WO2009015071A1 (en) * 2007-07-23 2009-01-29 Dharmacon, Inc. Screening of micro-rna cluster inhibitor pools
WO2009100760A1 (en) * 2008-02-13 2009-08-20 Novartis Ag Cellular screening assay for modulators of mevalonate pathway
WO2013134499A1 (en) * 2012-03-07 2013-09-12 The Johns Hopkins University Anastasis biosensor
EP3542162B1 (de) * 2016-11-16 2021-09-01 The Johns Hopkins University Anastasebiosensor
WO2019099769A1 (en) 2017-11-16 2019-05-23 The Johns Hopkins University Anastasis biosensor caspase tracker

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226065D0 (en) * 1992-12-14 1993-02-10 Ici Plc Peptides
AU4483096A (en) * 1995-01-31 1996-08-21 Novo Nordisk A/S A method of detecting biologically active substances
EP1295952A3 (de) 1996-01-23 2003-07-09 The Board of Trustees of The Leland Stanford Junior University Verfahren zum screenen für transdominate Effectorpeptiden und RNS molekülen
ATE354089T1 (de) * 1997-04-07 2007-03-15 Fisher Bioimage Aps Ein verfahren zum screenen von substanzen hinsichtlich ihres effekts auf camp spiegel basierend auf intrazellulärer translokation von pka
KR20010031056A (ko) * 1997-10-10 2001-04-16 시토비아 인크. 신규 형광 리포터 분자 및 카스파제에 대한 분석을 비롯한이의 용도

Also Published As

Publication number Publication date
EP1185873B1 (de) 2005-09-28
AU5676700A (en) 2000-12-18
CA2374038A1 (en) 2000-12-07
EP1185689B1 (de) 2007-05-02
AU778272B2 (en) 2004-11-25
EP1055929A1 (de) 2000-11-29
EP1185873A1 (de) 2002-03-13
EP1185689A1 (de) 2002-03-13
ATE361374T1 (de) 2007-05-15
EP1185873B8 (de) 2005-11-23
DE60034672D1 (de) 2007-06-14
WO2000073497A1 (en) 2000-12-07
DK1185873T3 (da) 2006-01-30
ES2249273T3 (es) 2006-04-01
WO2000073802A1 (en) 2000-12-07
US7129036B1 (en) 2006-10-31
DE60022879T2 (de) 2006-07-20
CA2374047A1 (en) 2000-12-07
AU777118B2 (en) 2004-09-30
AU5217700A (en) 2000-12-18
ATE305612T1 (de) 2005-10-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee