DK1023263T3 - Nye vitamin D analoger - Google Patents
Nye vitamin D analogerInfo
- Publication number
- DK1023263T3 DK1023263T3 DK98947397T DK98947397T DK1023263T3 DK 1023263 T3 DK1023263 T3 DK 1023263T3 DK 98947397 T DK98947397 T DK 98947397T DK 98947397 T DK98947397 T DK 98947397T DK 1023263 T3 DK1023263 T3 DK 1023263T3
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atom
- hydroxy
- hydrogen
- groups
- hydrocarbylene
- Prior art date
Links
- 229930003316 Vitamin D Natural products 0.000 title 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title 1
- 235000019166 vitamin D Nutrition 0.000 title 1
- 239000011710 vitamin D Substances 0.000 title 1
- 150000003710 vitamin D derivatives Chemical class 0.000 title 1
- 229940046008 vitamin d Drugs 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000743 hydrocarbylene group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9721156.9A GB9721156D0 (en) | 1997-10-06 | 1997-10-06 | Novel vitamin d analogues |
| PCT/DK1998/000423 WO1999018070A1 (en) | 1997-10-06 | 1998-10-02 | Novel vitamin d analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1023263T3 true DK1023263T3 (da) | 2002-12-02 |
Family
ID=10820110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98947397T DK1023263T3 (da) | 1997-10-06 | 1998-10-02 | Nye vitamin D analoger |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6399797B1 (cs) |
| EP (1) | EP1023263B1 (cs) |
| JP (1) | JP2001519327A (cs) |
| KR (1) | KR20010030966A (cs) |
| CN (1) | CN1140509C (cs) |
| AT (1) | ATE219053T1 (cs) |
| AU (1) | AU740457B2 (cs) |
| CA (1) | CA2304152A1 (cs) |
| CZ (1) | CZ295955B6 (cs) |
| DE (1) | DE69806035T2 (cs) |
| DK (1) | DK1023263T3 (cs) |
| ES (1) | ES2175784T3 (cs) |
| GB (1) | GB9721156D0 (cs) |
| HU (1) | HUP0004226A3 (cs) |
| NZ (1) | NZ503344A (cs) |
| PL (1) | PL193060B1 (cs) |
| PT (1) | PT1023263E (cs) |
| RU (1) | RU2196132C2 (cs) |
| WO (1) | WO1999018070A1 (cs) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60117762T2 (de) * | 2000-03-27 | 2006-10-12 | Wisconsin Alumni Research Foundation, Madison | Vitamin d-verbindung zur behandlung von chronischer tranplantatnephropatie bei nieren transplantierten patienten |
| EP1458678A1 (en) * | 2002-11-18 | 2004-09-22 | Teva Pharmaceutical Industries Limited | A crystallization method for purification of calcipotriene |
| WO2006051106A1 (en) | 2004-11-12 | 2006-05-18 | Bioxell Spa | Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer |
| ES2346774T3 (es) * | 2004-11-22 | 2010-10-20 | Wisconsin Alumni Research Foundation | Analogos de 17,20(z)-deshidro vtamina d y sus usos. |
| US8193169B2 (en) * | 2006-04-06 | 2012-06-05 | Wisconsin Alumni Research Foundation | (20R)-2α-methyl-19,26,2-trinor-vitamin D analogs |
| RU2452488C2 (ru) * | 2006-08-29 | 2012-06-10 | Тева Фармасьютикал Индастриес Лтд. | Фармацевтические композиции, содержащие витамин группы d и кортикостероид |
| US8222236B2 (en) | 2008-07-10 | 2012-07-17 | Wisconsin Alumni Research Foundation | 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs |
| US8399439B2 (en) * | 2008-07-10 | 2013-03-19 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs |
| US7713953B2 (en) * | 2008-07-10 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-methylene-(22E)-25-(1-methylene-hexyl)-26,27-cyclo-22-dehydro-19-nor-vitamin D analogs |
| US7893043B2 (en) | 2008-07-10 | 2011-02-22 | Wisconsin Alumni Research Foundation | 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-vitamin D analogs |
| US7648974B1 (en) * | 2008-07-10 | 2010-01-19 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 3,2-dihydrofuran ring |
| US7879829B2 (en) * | 2008-07-10 | 2011-02-01 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2-dihydrofuran ring |
| US8193170B2 (en) * | 2008-07-10 | 2012-06-05 | Wisconsin Alumni Research Foundation | 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs |
| US7888339B2 (en) | 2008-07-10 | 2011-02-15 | Wisconsin Alumni Research Foundation | 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs |
| MX339746B (es) * | 2009-01-27 | 2016-06-08 | Berg Llc | Vitamina d3 y análogos de la misma para aliviar efectos secundarios asociados con la quimioterapia. |
| ES2742750T3 (es) | 2009-08-14 | 2020-02-17 | Berg Llc | Vitamina D3 y análogos de la misma para tratar la alopecia |
| US8217023B2 (en) | 2009-10-02 | 2012-07-10 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2- or 3,2-cyclopentene ring |
| EP2525799B1 (en) | 2009-10-02 | 2014-09-03 | Wisconsin Alumni Research Foundation | (20s,22e)-2-methylene-19-nor-22-ene-1alpha,25-dihydroxyvitamin d3 analogs |
| CA2837882C (en) | 2011-06-03 | 2019-03-26 | Wisconsin Alumni Research Foundation | (22e)-2-methylene-26,27-cyclo-22-dehydro-1.alpha.-hydroxy-19-norvitamin d3 derivatives |
| WO2013003307A1 (en) | 2011-06-28 | 2013-01-03 | Wisconsin Alumni Research Foundation | 2-methylene-(22e)-25-hexanoyl-24-oxo-26,27-cyclo-22-dehydro-19-nor-vitamin d analogs |
| WO2013012644A1 (en) | 2011-07-18 | 2013-01-24 | Wisconsin Alumni I Research Foundation | 2-methylene-20(21)-dehydro-19,24,25,26,27,-pentanor-vitamin d analogs |
| US9416102B2 (en) | 2013-01-23 | 2016-08-16 | Wisconsin Alumni Research Foundation | (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs |
| CN105492081A (zh) | 2013-05-29 | 2016-04-13 | 博格有限责任公司 | 使用维生素d预防或减轻化疗诱发的脱发 |
| CN114593917A (zh) * | 2022-03-08 | 2022-06-07 | 安徽理工大学 | 一种基于三元组模型的小样本轴承故障诊断方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0580968B1 (en) * | 1992-05-20 | 1996-08-28 | F. Hoffmann-La Roche Ag | Vitamin D3 fluorinated analogs |
| GB9214202D0 (en) * | 1992-07-03 | 1992-08-12 | Leo Pharm Prod Ltd | Chemical compounds |
| US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
| DK0717034T3 (da) * | 1994-12-14 | 1999-10-18 | Duphar Int Res | Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser |
-
1997
- 1997-10-06 GB GBGB9721156.9A patent/GB9721156D0/en not_active Ceased
-
1998
- 1998-10-02 HU HU0004226A patent/HUP0004226A3/hu unknown
- 1998-10-02 JP JP2000514882A patent/JP2001519327A/ja active Pending
- 1998-10-02 EP EP98947397A patent/EP1023263B1/en not_active Expired - Lifetime
- 1998-10-02 DK DK98947397T patent/DK1023263T3/da active
- 1998-10-02 PT PT98947397T patent/PT1023263E/pt unknown
- 1998-10-02 KR KR1020007003717A patent/KR20010030966A/ko not_active Ceased
- 1998-10-02 WO PCT/DK1998/000423 patent/WO1999018070A1/en not_active Ceased
- 1998-10-02 CN CNB988099330A patent/CN1140509C/zh not_active Expired - Fee Related
- 1998-10-02 DE DE69806035T patent/DE69806035T2/de not_active Expired - Fee Related
- 1998-10-02 US US09/543,418 patent/US6399797B1/en not_active Expired - Fee Related
- 1998-10-02 RU RU2000111255/04A patent/RU2196132C2/ru not_active IP Right Cessation
- 1998-10-02 PL PL339668A patent/PL193060B1/pl unknown
- 1998-10-02 CZ CZ20001178A patent/CZ295955B6/cs not_active IP Right Cessation
- 1998-10-02 AT AT98947397T patent/ATE219053T1/de not_active IP Right Cessation
- 1998-10-02 ES ES98947397T patent/ES2175784T3/es not_active Expired - Lifetime
- 1998-10-02 NZ NZ503344A patent/NZ503344A/en unknown
- 1998-10-02 AU AU94323/98A patent/AU740457B2/en not_active Ceased
- 1998-10-02 CA CA002304152A patent/CA2304152A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| GB9721156D0 (en) | 1997-12-03 |
| HUP0004226A3 (en) | 2001-10-29 |
| WO1999018070A1 (en) | 1999-04-15 |
| PT1023263E (pt) | 2002-10-31 |
| CN1140509C (zh) | 2004-03-03 |
| AU9432398A (en) | 1999-04-27 |
| EP1023263A1 (en) | 2000-08-02 |
| EP1023263B1 (en) | 2002-06-12 |
| CN1274344A (zh) | 2000-11-22 |
| HUP0004226A2 (hu) | 2001-04-28 |
| CZ295955B6 (cs) | 2005-12-14 |
| AU740457B2 (en) | 2001-11-01 |
| KR20010030966A (ko) | 2001-04-16 |
| DE69806035D1 (de) | 2002-07-18 |
| ATE219053T1 (de) | 2002-06-15 |
| RU2196132C2 (ru) | 2003-01-10 |
| CA2304152A1 (en) | 1999-04-15 |
| PL339668A1 (en) | 2001-01-02 |
| DE69806035T2 (de) | 2003-01-30 |
| PL193060B1 (pl) | 2007-01-31 |
| HK1031868A1 (zh) | 2001-06-29 |
| NZ503344A (en) | 2002-04-26 |
| CZ20001178A3 (cs) | 2000-09-13 |
| JP2001519327A (ja) | 2001-10-23 |
| ES2175784T3 (es) | 2002-11-16 |
| US6399797B1 (en) | 2002-06-04 |
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