DK1005488T4 - Receptor som binder TRAIL - Google Patents

Receptor som binder TRAIL

Info

Publication number
DK1005488T4
DK1005488T4 DK98908474.4T DK98908474T DK1005488T4 DK 1005488 T4 DK1005488 T4 DK 1005488T4 DK 98908474 T DK98908474 T DK 98908474T DK 1005488 T4 DK1005488 T4 DK 1005488T4
Authority
DK
Denmark
Prior art keywords
trail
receptor
expression vectors
dna sequences
binds trail
Prior art date
Application number
DK98908474.4T
Other languages
English (en)
Other versions
DK1005488T3 (da
Inventor
Charles Rauch
Henning Dr Walczak
Original Assignee
Immunex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27542220&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1005488(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunex Corp filed Critical Immunex Corp
Application granted granted Critical
Publication of DK1005488T3 publication Critical patent/DK1005488T3/da
Publication of DK1005488T4 publication Critical patent/DK1005488T4/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK98908474.4T 1997-02-13 1998-02-11 Receptor som binder TRAIL DK1005488T4 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US79986197A 1997-02-13 1997-02-13
US81525597A 1997-03-12 1997-03-12
US82953697A 1997-03-28 1997-03-28
US86985297A 1997-06-04 1997-06-04
US08/883,036 US6072047A (en) 1997-02-13 1997-06-26 Receptor that binds trail
PCT/US1998/002239 WO1998035986A1 (en) 1997-02-13 1998-02-11 Receptor that binds trail

Publications (2)

Publication Number Publication Date
DK1005488T3 DK1005488T3 (da) 2006-03-06
DK1005488T4 true DK1005488T4 (da) 2012-01-16

Family

ID=27542220

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98908474.4T DK1005488T4 (da) 1997-02-13 1998-02-11 Receptor som binder TRAIL

Country Status (13)

Country Link
US (3) US6072047A (da)
EP (2) EP1676857A3 (da)
JP (1) JP5031132B2 (da)
AT (1) ATE308561T1 (da)
AU (1) AU735686B2 (da)
CA (1) CA2279838A1 (da)
DE (1) DE69832178T3 (da)
DK (1) DK1005488T4 (da)
ES (1) ES2251767T5 (da)
HK (1) HK1029796A1 (da)
IL (2) IL131030A0 (da)
NZ (1) NZ336929A (da)
WO (1) WO1998035986A1 (da)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020160446A1 (en) * 2000-11-14 2002-10-31 Holtzman Douglas A. Novel genes encoding proteins having prognostic diagnostic preventive therapeutic and other uses
US6313269B1 (en) * 1997-03-14 2001-11-06 Smithkline Beecham Corporation Tumor necrosis factor related receptor, TR6
US6872568B1 (en) 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
NZ337795A (en) 1997-03-17 2001-06-29 Human Genome Sciences Inc Death domain containing receptor 5 and it's use in the treatment of DR5 related disease
US20040136951A1 (en) * 1997-03-17 2004-07-15 Human Genome Sciences, Inc. Death domain containing receptor 5
US20050233958A1 (en) * 1997-03-17 2005-10-20 Human Genome Sciences, Inc. Death domain containing receptor 5
US20080248046A1 (en) * 1997-03-17 2008-10-09 Human Genome Sciences, Inc. Death domain containing receptor 5
US20100152426A1 (en) * 1997-05-15 2010-06-17 Ashkenazi Avi J Apo-2 receptor fusion proteins
EP0981618B2 (en) * 1997-05-15 2011-08-24 Genentech, Inc. Anti-apo-2 antibody
US6342369B1 (en) * 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
AU8784498A (en) 1997-08-15 1999-03-08 Idun Pharmaceuticals, Inc. Trail receptors, nucleic acids encoding the same, and methods of use thereof
DE69837606T2 (de) * 1997-09-12 2008-02-14 Biogen Idec Ma Inc., Cambridge Cystein-reiche rezeptoren-train
ES2331901T3 (es) * 1998-06-12 2010-01-19 Genentech, Inc. Anticuerpos monoclonales, anticuerpos que reaccionan de forma cruzada y procedimiento para la produccion de los mismos.
US6252050B1 (en) * 1998-06-12 2001-06-26 Genentech, Inc. Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
US20050281821A1 (en) * 1999-01-06 2005-12-22 Flavia Pernasetti Method and composition for angiogenesis inhibition
US6627199B1 (en) 1999-07-09 2003-09-30 Amgen Inc Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
AU780060B2 (en) * 1999-07-16 2005-02-24 Human Genome Sciences, Inc. Human tumor necrosis factor receptors TR13 and TR14
US6951738B2 (en) 1999-07-16 2005-10-04 Human Genome Sciences, Inc. Human tumor necrosis factor receptors TR13 and TR14
WO2001011050A1 (en) 1999-08-04 2001-02-15 Amgen Inc. Fhm, A NOVEL MEMBER OF THE TNF LIGAND SUPERGENE FAMILY
AU6517800A (en) 1999-08-04 2001-03-05 Amgen, Inc. Ntr3, a member of the tnf-receptor supergene family
US20030134788A1 (en) * 1999-08-12 2003-07-17 Baker Kevin P. Human tumor necrosis factor receptor TR16
WO2001012671A1 (en) * 1999-08-12 2001-02-22 Human Genome Sciences, Inc. Human tumor necrosis factor receptor tr16
AU2006201322A1 (en) * 1999-09-27 2006-04-27 Genentech, Inc. Methods for making recombinant proteins using apoptosis inhibitors
EP1220934B1 (en) 1999-09-27 2005-12-21 Genentech, Inc. Methods for making recombinant proteins using apoptosis inhibitors
ATE329610T1 (de) 2000-02-16 2006-07-15 Genentech Inc Anti-april antikörper und hybridomazellen
JP2003531588A (ja) 2000-04-11 2003-10-28 ジェネンテック・インコーポレーテッド 多価抗体とその用途
TWI318983B (en) 2000-05-02 2010-01-01 Uab Research Foundation An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
US7476383B2 (en) * 2000-05-02 2009-01-13 The Uab Research Foundation Antibody selective for DR4 and uses thereof
US7279160B2 (en) * 2000-05-02 2007-10-09 The Uab Research Foundation Combinations of DR5 antibodies and other therapeutic agents
KR100436089B1 (ko) * 2000-07-06 2004-06-14 설대우 분비성 재조합 트라이머형의 트레일 단백질 생산을 위한 디엔에이 카세트, 테트라사이클린/독시사이클린-유도성아데노-관련 바이러스 벡터, 이 둘의 조합, 및 이들을이용한 유전자 치료
EP2014303A2 (en) 2000-07-27 2009-01-14 Genentech, Inc. APO-2L receptor agonist and CPT-11 synergism
US20040005314A1 (en) * 2001-07-27 2004-01-08 Enrique Escandon Apo-2l receptor agonist and cpt-11 synergism
US20060062786A1 (en) * 2000-11-08 2006-03-23 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
AU2001297702A1 (en) * 2000-11-08 2002-10-15 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US20030228309A1 (en) * 2000-11-08 2003-12-11 Theodora Salcedo Antibodies that immunospecifically bind to TRAIL receptors
US20030139963A1 (en) * 2000-12-08 2003-07-24 Chickering D. Maxwell Decision theoretic approach to targeted solicitation by maximizing expected profit increases
US20020155109A1 (en) * 2001-04-20 2002-10-24 Lynch David H. Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2
KR100932577B1 (ko) * 2001-05-18 2009-12-17 기린 홀딩스 가부시키가이샤 항 trail-r 항체
US7064189B2 (en) 2001-05-25 2006-06-20 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to trail receptors
US20050129616A1 (en) * 2001-05-25 2005-06-16 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US20050214209A1 (en) * 2001-05-25 2005-09-29 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to TRAIL receptors
US7348003B2 (en) 2001-05-25 2008-03-25 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors
US20090226429A1 (en) * 2001-05-25 2009-09-10 Human Genome Sciences, Inc. Antibodies That Immunospecifically Bind to TRAIL Receptors
US7361341B2 (en) * 2001-05-25 2008-04-22 Human Genome Sciences, Inc. Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
IL159527A0 (en) 2001-07-03 2004-06-01 Genentech Inc Human dr4 antibodies and uses thereof
JP2005502645A (ja) * 2001-08-08 2005-01-27 ザ ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 細胞特異的プロモーターからの発現を増幅するための方法
US20040186051A1 (en) 2001-10-02 2004-09-23 Kelley Robert F Apo-2 ligand variants and uses thereof
US7741285B2 (en) 2001-11-13 2010-06-22 Genentech, Inc. APO-2 ligand/trail formulations
WO2003042344A2 (en) 2001-11-13 2003-05-22 Genentech, Inc. Apo2 ligand/trail formulations
US7842668B1 (en) 2001-11-13 2010-11-30 Genentech, Inc. Apo-2 ligand/trail formulations
JP2005516958A (ja) * 2001-12-20 2005-06-09 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド Trailレセプターに免疫特異的に結合する抗体
JP4574350B2 (ja) 2002-06-24 2010-11-04 ジェネンテック, インコーポレイテッド Apo−2リガンド/trail変異体とその使用法
SI1606318T1 (sl) * 2003-03-26 2009-12-31 Apogenix Gmbh Izboljšani Fc fuzijski proteini
JP2007530588A (ja) * 2004-03-23 2007-11-01 バイオジェン・アイデック・エムエイ・インコーポレイテッド レセプターカップリング剤およびその治療用途
RU2431676C2 (ru) * 2004-08-06 2011-10-20 Дженентек, Инк. Анализы и способы с применением биомаркеров
AU2005271249A1 (en) * 2004-08-06 2006-02-16 Genentech, Inc. Assays and methods using biomarkers
CA2577828A1 (en) * 2004-09-08 2006-03-16 Genentech, Inc. Methods of using death receptor ligands and cd20 antibodies
EP1791864A2 (en) * 2004-09-08 2007-06-06 Genentech, Inc. Methods of using death receptor ligands and cd20 antibodies
JO3000B1 (ar) * 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US8129124B2 (en) * 2005-02-02 2012-03-06 The Uab Research Foundation Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists
US8029783B2 (en) * 2005-02-02 2011-10-04 Genentech, Inc. DR5 antibodies and articles of manufacture containing same
US20090155247A1 (en) * 2005-02-18 2009-06-18 Ashkenazi Avi J Methods of Using Death Receptor Agonists and EGFR Inhibitors
US20060188498A1 (en) * 2005-02-18 2006-08-24 Genentech, Inc. Methods of using death receptor agonists and EGFR inhibitors
US7629315B2 (en) * 2005-03-09 2009-12-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Compositions for blocking the inhibitory effect of human CRP on human leptin
DK1915626T3 (da) 2005-08-16 2012-02-13 Genentech Inc Apoptosesensitivitet mod Apo2L/TRAIL ved testning for GalNac-T14-ekspression i celler/væv
CA2619654A1 (en) * 2005-08-24 2007-03-01 Cell Matrix Combination therapies for inhibiting integrin-extracellular matrix interactions
ES2618543T3 (es) 2005-11-23 2017-06-21 Genentech, Inc. Métodos y composiciones relacionados con ensayos de linfocitos B
AU2006338198B2 (en) 2005-12-02 2012-04-26 Genentech, Inc. Binding polypeptides and uses thereof
US20070218504A1 (en) * 2006-03-09 2007-09-20 University Of Pittsburgh Human leptin-derived polypeptides and uses thereof
AU2009303304A1 (en) 2008-10-10 2010-04-15 Anaphore, Inc. Polypeptides that bind TRAIL-RI and TRAIL-R2
US20110086770A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Combinatorial Libraries Based on C-type Lectin-like Domain
BR112012010698A2 (pt) 2009-11-05 2016-11-29 Uab Research Foundation método para tratamento de um sujeito com câncer, método de triagem de uma célula de câncer de mama, e , anticorpo
US8703712B2 (en) 2010-03-18 2014-04-22 The Uab Research Foundation Targeting cancer stem cells with DR5 agonists
CN107188963A (zh) 2010-10-29 2017-09-22 第三共株式会社 新的抗dr5抗体
CA2828405A1 (en) 2011-02-28 2012-09-07 Istituto Di Ricovero E Cura A Carattere Scientifico Materno-Infantile Bu Rlo Garofolo - Ospedale Di Alta Specializzazione E Di Rilievo Nazionale Apoptosis-inducing molecules and uses therefor
WO2012151317A1 (en) 2011-05-03 2012-11-08 Genentech, Inc. Vascular disruption agents and uses thereof
CN102898526A (zh) * 2011-07-28 2013-01-30 山东先声麦得津生物制药有限公司 一种肿瘤坏死因子相关凋亡诱导配体融合蛋白及其制备和应用
PT2970473T (pt) 2013-03-14 2017-10-26 Bristol Myers Squibb Co Combinação de agonista de dr5 e antagonista anti-pd-1 e métodos de utilização
GB201312155D0 (en) * 2013-07-05 2013-08-21 Ucl Business Plc Therapeutic invention
US11299528B2 (en) 2014-03-11 2022-04-12 D&D Pharmatech Inc. Long acting TRAIL receptor agonists for treatment of autoimmune diseases
AU2016371021B2 (en) 2015-12-17 2020-04-09 The Johns Hopkins University Ameliorating systemic sclerosis with death receptor agonists
EA201892260A1 (ru) 2016-04-07 2019-03-29 Дзе Джонс Хопкинс Юниверсити Композиции и способы для лечения панкреатита и боли с применением агонистов рецептора смерти
EP3323428A1 (en) 2016-11-17 2018-05-23 CNRS Centre National de la Recherche Scientifique Selective c-flip inhibitors as anticancer agents
EP3910331A1 (en) 2020-05-15 2021-11-17 iOmx Therapeutics AG Intracellular kinase associated with resistance against t-cell mediated cytotoxicity, and uses thereof
GB202016058D0 (en) 2020-10-09 2020-11-25 Ucl Business Ltd Therapeautic treatment
EP4257132A1 (en) 2022-04-08 2023-10-11 iOmx Therapeutics AG Sik3 inhibitors for treating diseases resistant to death receptor signalling
WO2024175554A1 (en) 2023-02-21 2024-08-29 Institut Curie Trail agonists for use in the treatment of cancer in patients having an activating alteration of fgfr3

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1666591B1 (en) 1995-06-29 2011-03-23 Immunex Corporation Cytokine that induces apoptosis
EP1862548A1 (en) 1997-01-28 2007-12-05 Human Genome Sciences, Inc. Death domain containing receptor 4 (DR4 : death receptor 4), member of the TNF-receptor superfamily and binding to trail (APO2-L)
US20010010924A1 (en) * 1997-03-14 2001-08-02 Keith Charles Deen Tumor necrosis factor related receptor, tr6 polynecleotides
US6313269B1 (en) * 1997-03-14 2001-11-06 Smithkline Beecham Corporation Tumor necrosis factor related receptor, TR6
US6872568B1 (en) * 1997-03-17 2005-03-29 Human Genome Sciences, Inc. Death domain containing receptor 5 antibodies
NZ337795A (en) * 1997-03-17 2001-06-29 Human Genome Sciences Inc Death domain containing receptor 5 and it's use in the treatment of DR5 related disease
EP1007562A4 (en) * 1997-04-16 2000-09-27 Millennium Pharm Inc TANGO-63d AND TANGO-63e PROTEINS RELATED TO THE TUMOR NECROSIS FACTOR RECEPTOR
US6342369B1 (en) * 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
EP0981618B2 (en) * 1997-05-15 2011-08-24 Genentech, Inc. Anti-apo-2 antibody
AU8400398A (en) 1997-07-11 1999-02-08 Trustees Of The University Of Pennsylvania, The Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use
AU8784498A (en) * 1997-08-15 1999-03-08 Idun Pharmaceuticals, Inc. Trail receptors, nucleic acids encoding the same, and methods of use thereof
DE69837606T2 (de) 1997-09-12 2008-02-14 Biogen Idec Ma Inc., Cambridge Cystein-reiche rezeptoren-train

Also Published As

Publication number Publication date
ES2251767T5 (es) 2012-03-07
EP1005488B9 (en) 2012-04-18
DE69832178D1 (de) 2005-12-08
AU6650598A (en) 1998-09-08
EP1676857A2 (en) 2006-07-05
ES2251767T3 (es) 2006-05-01
WO1998035986A1 (en) 1998-08-20
IL131030A (en) 2011-02-28
IL131030A0 (en) 2001-01-28
JP5031132B2 (ja) 2012-09-19
EP1005488B1 (en) 2005-11-02
JP2002514069A (ja) 2002-05-14
EP1676857A3 (en) 2007-04-04
DE69832178T2 (de) 2006-07-20
EP1005488B2 (en) 2011-12-14
NZ336929A (en) 2000-11-24
ES2251767T9 (es) 2012-10-17
US6642358B1 (en) 2003-11-04
DE69832178T3 (de) 2012-03-29
ATE308561T1 (de) 2005-11-15
EP1005488A4 (en) 2003-03-05
US6569642B1 (en) 2003-05-27
CA2279838A1 (en) 1998-08-20
HK1029796A1 (en) 2001-04-12
US6072047A (en) 2000-06-06
DK1005488T3 (da) 2006-03-06
AU735686B2 (en) 2001-07-12
EP1005488A1 (en) 2000-06-07

Similar Documents

Publication Publication Date Title
DK1005488T3 (da) Receptor som binder TRAIL
ATE353906T1 (de) Cd27 ligand
EP0871702A4 (en) CYTOKINE DESIGNED BY LERK-7
NZ504548A (en) Polypeptides and nucleic acids encoding human chordin
NO960652D0 (no) Cytokiner som binder celleoverflatereseptoren hek
PT2241575E (pt) Polipéptidos de fusão que contêm o igf-1 e utilizações terapêuticas desses polipéptidos
HK1013847A1 (en) Gdf-1 and uog-1 proteins
DE69334100D1 (de) Elk ligand, ein cytokin
BR9912455A (pt) ácidos nucléicos codificadores de proteìnas envolvidas em transdução sensória
MXPA00003885A (es) Quimiocinas con modificiaciones de la terminacion amino.
WO2002005843A3 (en) Human rrp sequences and methods of use
DK0990703T3 (da) Nyt polypeptid, DNA, som koder herfor, samt anvendelse heraf
EP0692532A4 (en) NOVEL POLYPEPTIDE, DNA ENCODING SAID POLYPEPTIDE, RECOMBINATION VECTOR CONTAINING SAID DNA, RECOMBINATION VIRUS PREPARED BY SAID VECTOR, AND USE OF SAID VIRUS
WO2000058465A3 (en) Flint polypeptide analogs
EP0879879A3 (en) Polypeptide deformylase 1 (Def1)
WO1997036919A3 (en) Cytokine designated lerk-8
WO2001070808A3 (en) Angiogenesis - associated proteins, and nucleic acids encoding the same
DE69831584D1 (de) Polypeptide mit wasserkanalaktivität und dna sequenzen
EE200100234A (et) PRV-1-geen ja selle kasutamine
EP0893501A3 (en) Ferrichrome transport atp-binding protein
WO2001042295A3 (en) Clasp-7 transmembrane protein
AU5990100A (en) ICBP90 polypeptide and its fragments and polynucleotides coding for said polypeptides and applications for diagnosing and treating cancer
DK1019500T3 (da) IFN receptor 1-bindende proteiner, DNA, som koder for dem, og fremgangsmåder til modulering af cellulært respons på interferoner
EP0906957A3 (en) Lgt polypeptide
Black et al. Ferrichrome transport ATP-binding protein