DK1005488T4 - Receptor som binder TRAIL - Google Patents
Receptor som binder TRAILInfo
- Publication number
- DK1005488T4 DK1005488T4 DK98908474.4T DK98908474T DK1005488T4 DK 1005488 T4 DK1005488 T4 DK 1005488T4 DK 98908474 T DK98908474 T DK 98908474T DK 1005488 T4 DK1005488 T4 DK 1005488T4
- Authority
- DK
- Denmark
- Prior art keywords
- trail
- receptor
- expression vectors
- dna sequences
- binds trail
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79986197A | 1997-02-13 | 1997-02-13 | |
US81525597A | 1997-03-12 | 1997-03-12 | |
US82953697A | 1997-03-28 | 1997-03-28 | |
US86985297A | 1997-06-04 | 1997-06-04 | |
US08/883,036 US6072047A (en) | 1997-02-13 | 1997-06-26 | Receptor that binds trail |
PCT/US1998/002239 WO1998035986A1 (en) | 1997-02-13 | 1998-02-11 | Receptor that binds trail |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1005488T3 DK1005488T3 (da) | 2006-03-06 |
DK1005488T4 true DK1005488T4 (da) | 2012-01-16 |
Family
ID=27542220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98908474.4T DK1005488T4 (da) | 1997-02-13 | 1998-02-11 | Receptor som binder TRAIL |
Country Status (13)
Country | Link |
---|---|
US (3) | US6072047A (da) |
EP (2) | EP1005488B9 (da) |
JP (1) | JP5031132B2 (da) |
AT (1) | ATE308561T1 (da) |
AU (1) | AU735686B2 (da) |
CA (1) | CA2279838A1 (da) |
DE (1) | DE69832178T3 (da) |
DK (1) | DK1005488T4 (da) |
ES (1) | ES2251767T5 (da) |
HK (1) | HK1029796A1 (da) |
IL (2) | IL131030A0 (da) |
NZ (1) | NZ336929A (da) |
WO (1) | WO1998035986A1 (da) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020160446A1 (en) * | 2000-11-14 | 2002-10-31 | Holtzman Douglas A. | Novel genes encoding proteins having prognostic diagnostic preventive therapeutic and other uses |
US6313269B1 (en) * | 1997-03-14 | 2001-11-06 | Smithkline Beecham Corporation | Tumor necrosis factor related receptor, TR6 |
US20040136951A1 (en) * | 1997-03-17 | 2004-07-15 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
US20050233958A1 (en) * | 1997-03-17 | 2005-10-20 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
US20080248046A1 (en) * | 1997-03-17 | 2008-10-09 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
CA2644454A1 (en) | 1997-03-17 | 1998-09-24 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
US20100152426A1 (en) * | 1997-05-15 | 2010-06-17 | Ashkenazi Avi J | Apo-2 receptor fusion proteins |
US6342369B1 (en) * | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
EP0981618B2 (en) * | 1997-05-15 | 2011-08-24 | Genentech, Inc. | Anti-apo-2 antibody |
JP2001514888A (ja) * | 1997-08-15 | 2001-09-18 | アイドゥン ファーマシューティカルズ, インコーポレイテッド | Trailレセプター、これをコードする核酸、およびその使用方法 |
EP1012179A2 (en) * | 1997-09-12 | 2000-06-28 | Apotech R&D S.A. | Cysteine rich receptors: trail |
US6252050B1 (en) * | 1998-06-12 | 2001-06-26 | Genentech, Inc. | Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
AU4561199A (en) * | 1998-06-12 | 1999-12-30 | Genentech Inc. | Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
US20050281821A1 (en) * | 1999-01-06 | 2005-12-22 | Flavia Pernasetti | Method and composition for angiogenesis inhibition |
US6627199B1 (en) | 1999-07-09 | 2003-09-30 | Amgen Inc | Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family |
US6951738B2 (en) | 1999-07-16 | 2005-10-04 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptors TR13 and TR14 |
EP1203024A4 (en) * | 1999-07-16 | 2003-02-26 | Human Genome Sciences Inc | HUMAN TUMOR NECROSIS FACTOR RECEPTORS TR13 AND TR14 |
WO2001010908A1 (en) | 1999-08-04 | 2001-02-15 | Amgen Inc. | Ntr3, a member of the tnf-receptor supergene family |
MXPA02001264A (es) | 1999-08-04 | 2002-07-22 | Amgen Inc | Fhm, nuevo miembro de la familia de supergenes de ligando de factor de necrosis tumoral. |
US20030134788A1 (en) * | 1999-08-12 | 2003-07-17 | Baker Kevin P. | Human tumor necrosis factor receptor TR16 |
WO2001012671A1 (en) * | 1999-08-12 | 2001-02-22 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor tr16 |
ATE313634T1 (de) | 1999-09-27 | 2006-01-15 | Genentech Inc | Verfahren zur herstellung von rekombinanten proteinen mittels inhibitoren von apoptose |
AU2006201322A1 (en) * | 1999-09-27 | 2006-04-27 | Genentech, Inc. | Methods for making recombinant proteins using apoptosis inhibitors |
ES2267593T3 (es) | 2000-02-16 | 2007-03-16 | Genentech, Inc. | Anticuerpos anti-april y celulas hibridomas. |
ES2637801T3 (es) | 2000-04-11 | 2017-10-17 | Genentech, Inc. | Anticuerpos multivalentes y usos de los mismos |
TWI318983B (en) * | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
US7476383B2 (en) * | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
US7279160B2 (en) * | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
KR100436089B1 (ko) * | 2000-07-06 | 2004-06-14 | 설대우 | 분비성 재조합 트라이머형의 트레일 단백질 생산을 위한 디엔에이 카세트, 테트라사이클린/독시사이클린-유도성아데노-관련 바이러스 벡터, 이 둘의 조합, 및 이들을이용한 유전자 치료 |
EP1303293B1 (en) | 2000-07-27 | 2008-12-03 | Genentech, Inc. | Sequential administration of cpt-11 and apo-2l polypeptide |
US20040005314A1 (en) * | 2001-07-27 | 2004-01-08 | Enrique Escandon | Apo-2l receptor agonist and cpt-11 synergism |
US20060062786A1 (en) * | 2000-11-08 | 2006-03-23 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
US20030228309A1 (en) * | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
CA2426710A1 (en) * | 2000-11-08 | 2002-10-10 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
US20030139963A1 (en) * | 2000-12-08 | 2003-07-24 | Chickering D. Maxwell | Decision theoretic approach to targeted solicitation by maximizing expected profit increases |
US20020155109A1 (en) * | 2001-04-20 | 2002-10-24 | Lynch David H. | Bispecific antibodies that bind TRAIL-R1 and TRAIL-R2 |
KR100932577B1 (ko) * | 2001-05-18 | 2009-12-17 | 기린 홀딩스 가부시키가이샤 | 항 trail-r 항체 |
US20090226429A1 (en) * | 2001-05-25 | 2009-09-10 | Human Genome Sciences, Inc. | Antibodies That Immunospecifically Bind to TRAIL Receptors |
US20050214209A1 (en) * | 2001-05-25 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
US7361341B2 (en) * | 2001-05-25 | 2008-04-22 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to trail receptors |
MXPA03010747A (es) * | 2001-05-25 | 2004-03-02 | Human Genome Sciences Inc | Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral. |
US20050129616A1 (en) * | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
EP2192130A1 (en) | 2001-07-03 | 2010-06-02 | Genentech, Inc. | Human DR4 antibodies and uses thereof |
WO2003013555A1 (en) * | 2001-08-08 | 2003-02-20 | Board Of Regents, The University Of Texas System | Method for amplifying expression from a cell specific promoter |
IL161051A0 (en) | 2001-10-02 | 2004-08-31 | Genentech Inc | Apo-2 ligand variants and uses thereof |
US7741285B2 (en) | 2001-11-13 | 2010-06-22 | Genentech, Inc. | APO-2 ligand/trail formulations |
DK1450847T3 (da) | 2001-11-13 | 2010-12-13 | Genentech Inc | Apo2-ligand/TRAIL-formuleringer og anvendelser deraf |
US7842668B1 (en) | 2001-11-13 | 2010-11-30 | Genentech, Inc. | Apo-2 ligand/trail formulations |
WO2003054216A2 (en) * | 2001-12-20 | 2003-07-03 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
EP2500032A1 (en) | 2002-06-24 | 2012-09-19 | Genentech, Inc. | APO-2 ligand/trail variants and uses thereof |
ES2327409T3 (es) * | 2003-03-26 | 2009-10-29 | Apogenix Gmbh | Proteinas de fusion fc mejoradas. |
KR20060132006A (ko) * | 2004-03-23 | 2006-12-20 | 비오겐 아이덱 엠에이 아이엔씨. | 수용체 커플링제 및 이의 치료적 용도 |
DK1774037T3 (da) * | 2004-08-06 | 2011-08-15 | Genentech Inc | Analyser og fremgangsmåder, der anvender biomarkører |
ZA200701614B (en) * | 2004-08-06 | 2008-10-29 | Genentech Inc | Assays and methods using biomarkers |
KR20070050950A (ko) * | 2004-09-08 | 2007-05-16 | 제넨테크, 인크. | 사멸 수용체 리간드 및 cd20 항체의 사용 방법 |
BRPI0515604A (pt) * | 2004-09-08 | 2008-07-29 | Genentech Inc | método para o tratamento de células de cáncer e método de tratamento de uma doença imune relacionada |
JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
AU2006210838B2 (en) | 2005-02-02 | 2011-10-20 | The Uab Research Foundation | Agents and methods related to reducing resistance to apoptosis-inducing death receptor agonists |
US8029783B2 (en) | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
US20060188498A1 (en) * | 2005-02-18 | 2006-08-24 | Genentech, Inc. | Methods of using death receptor agonists and EGFR inhibitors |
US20090155247A1 (en) * | 2005-02-18 | 2009-06-18 | Ashkenazi Avi J | Methods of Using Death Receptor Agonists and EGFR Inhibitors |
US7629315B2 (en) * | 2005-03-09 | 2009-12-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions for blocking the inhibitory effect of human CRP on human leptin |
WO2007094842A2 (en) | 2005-12-02 | 2007-08-23 | Genentech, Inc. | Binding polypeptides and uses thereof |
WO2007022157A2 (en) | 2005-08-16 | 2007-02-22 | Genentech, Inc. | Apoptosis sensitivity to ap02l/trail by testing for 'galnac-t14 expression in cells/tissues |
WO2007024921A2 (en) * | 2005-08-24 | 2007-03-01 | Cell Matrix | Combination therapies for inhibiting integrin-extracellular matrix interactions |
JP6088723B2 (ja) | 2005-11-23 | 2017-03-01 | ジェネンテック, インコーポレイテッド | B細胞アッセイに関する組成物及び方法。 |
US20070218504A1 (en) * | 2006-03-09 | 2007-09-20 | University Of Pittsburgh | Human leptin-derived polypeptides and uses thereof |
EP2379585A2 (en) | 2008-10-10 | 2011-10-26 | Anaphore, Inc. | Polypeptides that bind trail-ri and trail-r2 |
CA2777162A1 (en) * | 2009-10-09 | 2011-04-14 | Anaphore, Inc. | Polypeptides that bind il-23r |
KR20120101050A (ko) | 2009-11-05 | 2012-09-12 | 더 유에이비 리서치 파운데이션 | 기저형 유전자형 암의 치료 방법 |
WO2011116344A2 (en) | 2010-03-18 | 2011-09-22 | The Uab Research Foundation | Targeting cancer stem cells |
RS54846B1 (sr) | 2010-10-29 | 2016-10-31 | Daiichi Sankyo Co Ltd | Novo anti-dr5 antitelo |
CA2828405A1 (en) | 2011-02-28 | 2012-09-07 | Istituto Di Ricovero E Cura A Carattere Scientifico Materno-Infantile Bu Rlo Garofolo - Ospedale Di Alta Specializzazione E Di Rilievo Nazionale | Apoptosis-inducing molecules and uses therefor |
WO2012151317A1 (en) | 2011-05-03 | 2012-11-08 | Genentech, Inc. | Vascular disruption agents and uses thereof |
CN102898526A (zh) * | 2011-07-28 | 2013-01-30 | 山东先声麦得津生物制药有限公司 | 一种肿瘤坏死因子相关凋亡诱导配体融合蛋白及其制备和应用 |
DK2970473T3 (da) | 2013-03-14 | 2017-11-27 | Bristol Myers Squibb Co | Kombination af dr5-agonist og anti-pd-1-antagonist og fremgangsmåder til anvendelse heraf |
GB201312155D0 (en) | 2013-07-05 | 2013-08-21 | Ucl Business Plc | Therapeutic invention |
WO2015138638A1 (en) | 2014-03-11 | 2015-09-17 | Theraly Pharmaceuticals, Inc. | Long acting trail receptor agonists for treatment of autoimmune diseases |
US11007251B2 (en) | 2015-12-17 | 2021-05-18 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
EP3439687A1 (en) | 2016-04-07 | 2019-02-13 | The Johns Hopkins University | Compositions and methods for treating pancreatitis and pain with death receptor agonists |
EP3323428A1 (en) | 2016-11-17 | 2018-05-23 | CNRS Centre National de la Recherche Scientifique | Selective c-flip inhibitors as anticancer agents |
EP3910331A1 (en) | 2020-05-15 | 2021-11-17 | iOmx Therapeutics AG | Intracellular kinase associated with resistance against t-cell mediated cytotoxicity, and uses thereof |
GB202016058D0 (en) | 2020-10-09 | 2020-11-25 | Ucl Business Ltd | Therapeautic treatment |
EP4257132A1 (en) | 2022-04-08 | 2023-10-11 | iOmx Therapeutics AG | Sik3 inhibitors for treating diseases resistant to death receptor signalling |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL122408A0 (en) | 1995-06-29 | 1998-06-15 | Immunex Corp | Dna encoding a trail polypeptide and its preparation |
EP1862548A1 (en) | 1997-01-28 | 2007-12-05 | Human Genome Sciences, Inc. | Death domain containing receptor 4 (DR4 : death receptor 4), member of the TNF-receptor superfamily and binding to trail (APO2-L) |
US20010010924A1 (en) * | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
US6313269B1 (en) * | 1997-03-14 | 2001-11-06 | Smithkline Beecham Corporation | Tumor necrosis factor related receptor, TR6 |
US6872568B1 (en) * | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
CA2644454A1 (en) * | 1997-03-17 | 1998-09-24 | Human Genome Sciences, Inc. | Death domain containing receptor 5 |
EP1007562A4 (en) * | 1997-04-16 | 2000-09-27 | Millennium Pharm Inc | TANGO-63d AND TANGO-63e PROTEINS RELATED TO THE TUMOR NECROSIS FACTOR RECEPTOR |
US6342369B1 (en) * | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
EP0981618B2 (en) * | 1997-05-15 | 2011-08-24 | Genentech, Inc. | Anti-apo-2 antibody |
AU8400398A (en) | 1997-07-11 | 1999-02-08 | Trustees Of The University Of Pennsylvania, The | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
JP2001514888A (ja) | 1997-08-15 | 2001-09-18 | アイドゥン ファーマシューティカルズ, インコーポレイテッド | Trailレセプター、これをコードする核酸、およびその使用方法 |
EP1012179A2 (en) | 1997-09-12 | 2000-06-28 | Apotech R&D S.A. | Cysteine rich receptors: trail |
-
1997
- 1997-06-26 US US08/883,036 patent/US6072047A/en not_active Expired - Lifetime
-
1998
- 1998-02-11 DE DE69832178T patent/DE69832178T3/de not_active Expired - Lifetime
- 1998-02-11 WO PCT/US1998/002239 patent/WO1998035986A1/en active Application Filing
- 1998-02-11 NZ NZ336929A patent/NZ336929A/xx not_active IP Right Cessation
- 1998-02-11 JP JP53582098A patent/JP5031132B2/ja not_active Expired - Lifetime
- 1998-02-11 DK DK98908474.4T patent/DK1005488T4/da active
- 1998-02-11 CA CA002279838A patent/CA2279838A1/en not_active Abandoned
- 1998-02-11 AT AT98908474T patent/ATE308561T1/de active
- 1998-02-11 EP EP98908474A patent/EP1005488B9/en not_active Expired - Lifetime
- 1998-02-11 EP EP05023483A patent/EP1676857A3/en not_active Withdrawn
- 1998-02-11 ES ES98908474T patent/ES2251767T5/es not_active Expired - Lifetime
- 1998-02-11 IL IL13103098A patent/IL131030A0/xx active IP Right Grant
- 1998-02-11 AU AU66505/98A patent/AU735686B2/en not_active Ceased
-
1999
- 1999-07-21 IL IL131030A patent/IL131030A/en not_active IP Right Cessation
-
2000
- 2000-03-27 US US09/536,201 patent/US6569642B1/en not_active Expired - Fee Related
- 2000-05-25 US US09/578,392 patent/US6642358B1/en not_active Expired - Fee Related
- 2000-12-05 HK HK00107806A patent/HK1029796A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69832178T2 (de) | 2006-07-20 |
EP1005488B9 (en) | 2012-04-18 |
EP1005488B2 (en) | 2011-12-14 |
CA2279838A1 (en) | 1998-08-20 |
DK1005488T3 (da) | 2006-03-06 |
US6072047A (en) | 2000-06-06 |
AU735686B2 (en) | 2001-07-12 |
ES2251767T5 (es) | 2012-03-07 |
EP1676857A3 (en) | 2007-04-04 |
IL131030A0 (en) | 2001-01-28 |
EP1005488A4 (en) | 2003-03-05 |
AU6650598A (en) | 1998-09-08 |
EP1676857A2 (en) | 2006-07-05 |
WO1998035986A1 (en) | 1998-08-20 |
EP1005488A1 (en) | 2000-06-07 |
JP5031132B2 (ja) | 2012-09-19 |
DE69832178T3 (de) | 2012-03-29 |
IL131030A (en) | 2011-02-28 |
NZ336929A (en) | 2000-11-24 |
DE69832178D1 (de) | 2005-12-08 |
ES2251767T9 (es) | 2012-10-17 |
EP1005488B1 (en) | 2005-11-02 |
JP2002514069A (ja) | 2002-05-14 |
HK1029796A1 (en) | 2001-04-12 |
ATE308561T1 (de) | 2005-11-15 |
ES2251767T3 (es) | 2006-05-01 |
US6569642B1 (en) | 2003-05-27 |
US6642358B1 (en) | 2003-11-04 |
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