DK0977560T3 - Ibuprofen-thioestere som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer (CoA-thioestere af arylpropionsyrer, aryleddikesyrer og salicylater som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer) - Google Patents

Ibuprofen-thioestere som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer (CoA-thioestere af arylpropionsyrer, aryleddikesyrer og salicylater som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer)

Info

Publication number
DK0977560T3
DK0977560T3 DK98921471T DK98921471T DK0977560T3 DK 0977560 T3 DK0977560 T3 DK 0977560T3 DK 98921471 T DK98921471 T DK 98921471T DK 98921471 T DK98921471 T DK 98921471T DK 0977560 T3 DK0977560 T3 DK 0977560T3
Authority
DK
Denmark
Prior art keywords
kappab
inflammation
inhibitors
thioesters
acids
Prior art date
Application number
DK98921471T
Other languages
Danish (da)
English (en)
Inventor
Holger Bang
Kay Brune
Gerd Geisslinger
Nicole Scheuren
Andreas Pahl
Werner Neupert
Original Assignee
Paz Arzneimittelentwicklung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paz Arzneimittelentwicklung filed Critical Paz Arzneimittelentwicklung
Application granted granted Critical
Publication of DK0977560T3 publication Critical patent/DK0977560T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK98921471T 1997-04-21 1998-04-20 Ibuprofen-thioestere som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer (CoA-thioestere af arylpropionsyrer, aryleddikesyrer og salicylater som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer) DK0977560T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19716713A DE19716713A1 (de) 1997-04-21 1997-04-21 Arzneimittel, enthaltend Ibuprofenthioester als Hemmer der Nf-kappaB abhängigen Bildung von Mediatoren von Entzündung und Schmerz
EP98921471A EP0977560B1 (de) 1997-04-21 1998-04-20 IBUPROFENTHIOESTER ALS HEMMER DER Nf-kappa B ABHÄNGIGEN BILDUNG VON MEDIATOREN VON ENTZÜNDUNG UND SCHMERZ
PCT/EP1998/002318 WO1998047502A1 (de) 1997-04-21 1998-04-20 IBUPROFENTHIOESTER ALS HEMMER DER Nf-λB ABHÄNGIGEN BILDUNG VON MEDIATOREN VON ENTZÜNDUNG UND SCHMERZ

Publications (1)

Publication Number Publication Date
DK0977560T3 true DK0977560T3 (da) 2004-11-01

Family

ID=7827221

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98921471T DK0977560T3 (da) 1997-04-21 1998-04-20 Ibuprofen-thioestere som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer (CoA-thioestere af arylpropionsyrer, aryleddikesyrer og salicylater som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer)

Country Status (10)

Country Link
EP (1) EP0977560B1 (pt)
JP (1) JP2001521539A (pt)
AT (1) ATE270100T1 (pt)
CA (1) CA2287501A1 (pt)
DE (2) DE19716713A1 (pt)
DK (1) DK0977560T3 (pt)
ES (1) ES2219889T3 (pt)
PT (1) PT977560E (pt)
RU (1) RU2204388C2 (pt)
WO (1) WO1998047502A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838436B1 (en) 1998-07-10 2005-01-04 Osteoscreen Inc. Inhibitors of proteasomal activity for stimulating bone growth
US6462019B1 (en) * 1998-07-10 2002-10-08 Osteoscreen, Inc. Inhibitors of proteasomal activity and production for stimulating bone growth
US6902721B1 (en) 1998-07-10 2005-06-07 Osteoscreen, Inc. Inhibitors of proteasomal activity for stimulating bone growth
US7544772B2 (en) 2001-06-26 2009-06-09 Biomarck Pharmaceuticals, Ltd. Methods for regulating inflammatory mediators and peptides useful therein
DE19907895A1 (de) * 1999-02-24 2000-11-16 Paz Arzneimittelentwicklung Verwendung von R-Arylpropionsäuren zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen bei Mensch und Tier, welche durch die Hemmung der Aktivierung von NF-kB therapeutisch beeinflußt werden können
DE10047319A1 (de) 2000-09-25 2002-04-18 Paz Arzneimittelentwicklung Verwendung von R-Arylpropionsäuren zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen, welche durch die Hemmung der Aktivierung des nukleären Transkriptionsfaktors AP-1 therapeutisch beeinflußt werden können
US20060253100A1 (en) 2004-10-22 2006-11-09 Medtronic, Inc. Systems and Methods to Treat Pain Locally
RU2423379C2 (ru) 2005-01-20 2011-07-10 Байомарк Фармасьютикалз, Лтд. Ингибиторы гиперсекреции муцина и способы их применения
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
EP3210964A1 (en) * 2006-07-18 2017-08-30 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate
EP2722052B1 (en) 2006-07-26 2019-03-20 Biomarck Pharmaceuticals, Ltd. Methods For Attenuating Release Of Inflammatory Mediators And Peptides Useful Therein
WO2008149181A1 (en) 2007-06-04 2008-12-11 Techfields Inc Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses
USRE48948E1 (en) 2008-04-18 2022-03-01 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable polymer
WO2010065936A1 (en) 2008-12-04 2010-06-10 Chongxi Yu High penetration compositions and their applications
US20100239632A1 (en) 2009-03-23 2010-09-23 Warsaw Orthopedic, Inc. Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue
EP2387391B1 (de) 2009-07-24 2017-01-11 MIKA Pharma Gesellschaft für die Entwicklung und Vermarktung pharmazeutischer Produkte mbH Verfahren zur entwicklung einer als schaum auf die haut zu applizierenden flüssigen zusammensetzung sowie eine topisch applizierbare zusammensetzung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213301B (it) * 1986-07-14 1989-12-20 Zambon Spa Composizioni per il trattamento del le sindromi da ischemia e riperfusione
GB8715476D0 (en) * 1987-07-01 1987-08-05 Shell Int Research Preparation of ibuprofen
DE4140179C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Ibuprofen enthaltendes Arzneimittel
DE59209706D1 (de) * 1992-12-01 1999-07-08 Spirig Ag S(+)-Ibuprofen enthaltende Arzneimittel
US5545669A (en) * 1994-06-02 1996-08-13 Adams; Jerry L. Anti-inflammatory compounds
WO1997048391A2 (en) * 1996-06-21 1997-12-24 Advanced Research And Technology Institute Methods and compositions comprising r-ibuprofen

Also Published As

Publication number Publication date
PT977560E (pt) 2004-10-29
DE19716713A1 (de) 1998-10-22
EP0977560B1 (de) 2004-06-30
CA2287501A1 (en) 1998-10-29
ES2219889T3 (es) 2004-12-01
EP0977560A1 (de) 2000-02-09
ATE270100T1 (de) 2004-07-15
RU2204388C2 (ru) 2003-05-20
DE59811642D1 (de) 2004-08-05
WO1998047502A1 (de) 1998-10-29
JP2001521539A (ja) 2001-11-06

Similar Documents

Publication Publication Date Title
DK0977560T3 (da) Ibuprofen-thioestere som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer (CoA-thioestere af arylpropionsyrer, aryleddikesyrer og salicylater som hæmmere af den Nf-kappaB-afhængige dannelse af betændelses og smertemediatorer)
BR0112073A (pt) Combinações terapêuticas de ácidos graxos
DE69805846D1 (de) Verwendung von 3-benzoylphenylessigsäuren, deren estern oder amiden zur behandlung von glc1a glaukom
ATE236627T1 (de) Pharmazeutische zubereitung enhaltend eicosapentaensäure und/oder stearidonsäure
ES2099022B1 (es) Composiciones farmaceuticas que contienen las sales de acido s(+)-2-(4-isobutilfenil) propionico con aminoacidos basicos.
IS2749B (is) Ný tegund af lyfjablöndu
AR064895A2 (es) Composicion farmaceutica anhidra para el tratamiento de desordenes inducidos por histamina
DE60000133D1 (de) Essentielle fettsäuren zur vorbeugung von kardiovaskulären anfällen
TR200001982T2 (tr) Farmasötik vurulu salınımlı oral dozaj şekli.
RU99124628A (ru) Ибупрофеновый триоэфир в качестве ингибитора, зависящего от nf-kb образования медиаторов воспаления и боли
FI863976A0 (fi) Terapeutisk komposition.
ES2194003T3 (es) Huperzina a racemica.
IT1187687B (it) Composizioni farmaceutiche contenenti come principi attivi flavanolignani e fosfolipidi
PT825857E (pt) Utilizacao de gabapentina e dos seus derivados no tratamento de estados maniacos e de perturbacoes bipolares
AU563831B2 (en) N-(2-amino-3,5-dibromobenzyl)- trans-4-amino-cyclohexanol derivatives
DK0498144T3 (da) Anvendelse af acetyl-L-carnitin ved terapeutisk behandling af coma
NO996468L (no) Anvendelse av gaba-analoger slik som gabapentin i fremstillingen av et medikament for behandling av betennelsessykdommer
DE60313998D1 (de) Schmerzfreie injektions-zubereitungen von 2-arylpropionsäuresalzen
IT1254314B (it) Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari.
NO932843D0 (no) Farmasoeytiske preparater
RS50139B (sr) Upotreba alfa-lipoinske kiseline ili njenih derivata
RS49520B (sr) Antimikrobno aktivne smeše
BR9811954A (pt) ácidos 3-aril-succinamido-hidroxâmicos, processos para sua produção e preparações farmacêuticas contendo estas substâncias
DE60112578D1 (de) Pharmazeutische diclofenac-verbindung basierend auf vitamin e, papain und hyaluronidase
AR022475A1 (es) Metodo para la prevencion o reduccion de eventos cardiovasculares asociados con intervencion coronaria.