RU99124628A - Ибупрофеновый триоэфир в качестве ингибитора, зависящего от nf-kb образования медиаторов воспаления и боли - Google Patents
Ибупрофеновый триоэфир в качестве ингибитора, зависящего от nf-kb образования медиаторов воспаления и болиInfo
- Publication number
- RU99124628A RU99124628A RU99124628/14A RU99124628A RU99124628A RU 99124628 A RU99124628 A RU 99124628A RU 99124628/14 A RU99124628/14 A RU 99124628/14A RU 99124628 A RU99124628 A RU 99124628A RU 99124628 A RU99124628 A RU 99124628A
- Authority
- RU
- Russia
- Prior art keywords
- ibuprofen
- thioesters
- inflammation
- coa
- pain
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title claims 5
- 230000004054 inflammatory process Effects 0.000 title claims 5
- 206010061218 Inflammation Diseases 0.000 title claims 3
- 230000002401 inhibitory effect Effects 0.000 title claims 2
- 239000003112 inhibitor Substances 0.000 title 1
- 239000003814 drug Substances 0.000 claims 5
- 229940079593 drugs Drugs 0.000 claims 4
- 125000005273 2-acetoxybenzoic acid group Chemical class 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 235000011054 acetic acid Nutrition 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 150000007513 acids Chemical class 0.000 claims 3
- -1 aryl acetic acids Chemical class 0.000 claims 3
- 208000005298 Acute Pain Diseases 0.000 claims 2
- 206010003816 Autoimmune disease Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical class CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- HEFNNWSXXWATRW-SNVBAGLBSA-N levibuprofen Chemical compound CC(C)CC1=CC=C([C@@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-SNVBAGLBSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000035633 Metabolized Effects 0.000 claims 1
- 230000001419 dependent Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Claims (5)
1. Лекарственное средство, содержащее СоА-тиоэфиры арилпропионовых кислот, арилуксусных кислот или ацетилсалицилатов или R- или/и S-ибупрофен-СоА-тиоэфиры.
2. Применение лекарственного средства по п.1 для показании острой или/и хронической боли, воспалений любого происхождения и для противодействия всем другим симптомам воспалительных процессов.
3. Применение СоА-тиоэфиров арилпропионовых кислот, арилуксусных кислот или ацетилсалицилатов или R- или/и S-ибупрофен-тиоэфиров для изготовления лекарственного средства для показаний острой или/и хронической боли, воспалений любого происхождения и для противодействия всем другим симптомам воспалительных процессов.
4. Применение лекарственных средств по п.1 или R-ибупрофена или рацематов ибупрофена, содержащих до 49% S-ибупрофена, или производных указанных соединений, которые метаболизируются в организме аналогичным образом, для торможения зависящих от Nf-kB процессов при возникновении или росте опухолей, при аутоиммунных заболеваниях или аллергических реакциях.
5. Применение СоА-тиоэфиров арилпропионовых кислот, арилуксусных кислот или ацетилсалицилатов, R-ибупрофена или рацематов ибупрофена, содержащих до 49% S-ибупрофена, или производных указанных соединений, содержащих до 49% S-ибупрофена, для получения лекарственного средства для торможения зависящих от Nf-kB процессов при возникновении или росте опухолей, при аутоиммунных заболеваниях или аллергических реакциях.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19716713.6 | 1997-04-21 | ||
| DE19716713A DE19716713A1 (de) | 1997-04-21 | 1997-04-21 | Arzneimittel, enthaltend Ibuprofenthioester als Hemmer der Nf-kappaB abhängigen Bildung von Mediatoren von Entzündung und Schmerz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU99124628A true RU99124628A (ru) | 2001-08-27 |
| RU2204388C2 RU2204388C2 (ru) | 2003-05-20 |
Family
ID=7827221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU99124628/14A RU2204388C2 (ru) | 1997-04-21 | 1998-04-20 | ИБУПРОФЕНОВЫЙ ТИОЭФИР В КАЧЕСТВЕ ИНГИБИТОРА, ЗАВИСЯЩЕГО ОТ Nf-kB ОБРАЗОВАНИЯ МЕДИАТОРОВ ВОСПАЛЕНИЯ И БОЛИ |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0977560B1 (ru) |
| JP (1) | JP2001521539A (ru) |
| AT (1) | ATE270100T1 (ru) |
| CA (1) | CA2287501A1 (ru) |
| DE (2) | DE19716713A1 (ru) |
| DK (1) | DK0977560T3 (ru) |
| ES (1) | ES2219889T3 (ru) |
| PT (1) | PT977560E (ru) |
| RU (1) | RU2204388C2 (ru) |
| WO (1) | WO1998047502A1 (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6838436B1 (en) | 1998-07-10 | 2005-01-04 | Osteoscreen Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
| US6462019B1 (en) * | 1998-07-10 | 2002-10-08 | Osteoscreen, Inc. | Inhibitors of proteasomal activity and production for stimulating bone growth |
| US6902721B1 (en) | 1998-07-10 | 2005-06-07 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
| US7544772B2 (en) | 2001-06-26 | 2009-06-09 | Biomarck Pharmaceuticals, Ltd. | Methods for regulating inflammatory mediators and peptides useful therein |
| DE19907895A1 (de) * | 1999-02-24 | 2000-11-16 | Paz Arzneimittelentwicklung | Verwendung von R-Arylpropionsäuren zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen bei Mensch und Tier, welche durch die Hemmung der Aktivierung von NF-kB therapeutisch beeinflußt werden können |
| DE10047319A1 (de) | 2000-09-25 | 2002-04-18 | Paz Arzneimittelentwicklung | Verwendung von R-Arylpropionsäuren zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen, welche durch die Hemmung der Aktivierung des nukleären Transkriptionsfaktors AP-1 therapeutisch beeinflußt werden können |
| US20060253100A1 (en) | 2004-10-22 | 2006-11-09 | Medtronic, Inc. | Systems and Methods to Treat Pain Locally |
| RU2423379C2 (ru) | 2005-01-20 | 2011-07-10 | Байомарк Фармасьютикалз, Лтд. | Ингибиторы гиперсекреции муцина и способы их применения |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| EP3210964A1 (en) * | 2006-07-18 | 2017-08-30 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of ibuprofen with very fast skin penetration rate |
| EP2722052B1 (en) | 2006-07-26 | 2019-03-20 | Biomarck Pharmaceuticals, Ltd. | Methods For Attenuating Release Of Inflammatory Mediators And Peptides Useful Therein |
| WO2008149181A1 (en) | 2007-06-04 | 2008-12-11 | Techfields Inc | Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses |
| USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
| WO2010065936A1 (en) | 2008-12-04 | 2010-06-10 | Chongxi Yu | High penetration compositions and their applications |
| US20100239632A1 (en) | 2009-03-23 | 2010-09-23 | Warsaw Orthopedic, Inc. | Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue |
| EP2387391B1 (de) | 2009-07-24 | 2017-01-11 | MIKA Pharma Gesellschaft für die Entwicklung und Vermarktung pharmazeutischer Produkte mbH | Verfahren zur entwicklung einer als schaum auf die haut zu applizierenden flüssigen zusammensetzung sowie eine topisch applizierbare zusammensetzung |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213301B (it) * | 1986-07-14 | 1989-12-20 | Zambon Spa | Composizioni per il trattamento del le sindromi da ischemia e riperfusione |
| GB8715476D0 (en) * | 1987-07-01 | 1987-08-05 | Shell Int Research | Preparation of ibuprofen |
| DE4140179C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Ibuprofen enthaltendes Arzneimittel |
| DE59209706D1 (de) * | 1992-12-01 | 1999-07-08 | Spirig Ag | S(+)-Ibuprofen enthaltende Arzneimittel |
| US5545669A (en) * | 1994-06-02 | 1996-08-13 | Adams; Jerry L. | Anti-inflammatory compounds |
| WO1997048391A2 (en) * | 1996-06-21 | 1997-12-24 | Advanced Research And Technology Institute | Methods and compositions comprising r-ibuprofen |
-
1997
- 1997-04-21 DE DE19716713A patent/DE19716713A1/de not_active Withdrawn
-
1998
- 1998-04-20 DE DE59811642T patent/DE59811642D1/de not_active Expired - Fee Related
- 1998-04-20 JP JP54501198A patent/JP2001521539A/ja active Pending
- 1998-04-20 PT PT98921471T patent/PT977560E/pt unknown
- 1998-04-20 ES ES98921471T patent/ES2219889T3/es not_active Expired - Lifetime
- 1998-04-20 RU RU99124628/14A patent/RU2204388C2/ru not_active IP Right Cessation
- 1998-04-20 EP EP98921471A patent/EP0977560B1/de not_active Expired - Lifetime
- 1998-04-20 DK DK98921471T patent/DK0977560T3/da active
- 1998-04-20 AT AT98921471T patent/ATE270100T1/de not_active IP Right Cessation
- 1998-04-20 WO PCT/EP1998/002318 patent/WO1998047502A1/de active IP Right Grant
- 1998-04-20 CA CA002287501A patent/CA2287501A1/en not_active Abandoned
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