DK0967207T3 - Nitron-derivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende derivaterne - Google Patents

Nitron-derivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende derivaterne

Info

Publication number
DK0967207T3
DK0967207T3 DK99401565T DK99401565T DK0967207T3 DK 0967207 T3 DK0967207 T3 DK 0967207T3 DK 99401565 T DK99401565 T DK 99401565T DK 99401565 T DK99401565 T DK 99401565T DK 0967207 T3 DK0967207 T3 DK 0967207T3
Authority
DK
Denmark
Prior art keywords
derivatives
preparation
processes
pharmaceutical compositions
compositions containing
Prior art date
Application number
DK99401565T
Other languages
Danish (da)
English (en)
Inventor
Solo Goldstein
Alain Dhainaut
Andre Tizot
Brian Lockhart
Pierre Lestage
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK0967207T3 publication Critical patent/DK0967207T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK99401565T 1998-06-26 1999-06-24 Nitron-derivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende derivaterne DK0967207T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9808116A FR2780404B1 (fr) 1998-06-26 1998-06-26 Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
DK0967207T3 true DK0967207T3 (da) 2003-01-20

Family

ID=9527896

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99401565T DK0967207T3 (da) 1998-06-26 1999-06-24 Nitron-derivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende derivaterne

Country Status (17)

Country Link
US (1) US6034250A (ja)
EP (1) EP0967207B1 (ja)
JP (1) JP2000026428A (ja)
CN (1) CN1153766C (ja)
AT (1) ATE223904T1 (ja)
AU (1) AU747203B2 (ja)
BR (1) BR9903282A (ja)
CA (1) CA2274621C (ja)
DE (1) DE69902851T2 (ja)
DK (1) DK0967207T3 (ja)
ES (1) ES2183492T3 (ja)
FR (1) FR2780404B1 (ja)
HU (1) HUP9902199A1 (ja)
NO (1) NO312722B1 (ja)
NZ (1) NZ336460A (ja)
PT (1) PT967207E (ja)
ZA (1) ZA994201B (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096899A (en) * 1998-04-14 2000-08-01 The Regents Of The University Of Michigan Cylic imidazole compounds having relatively low hydrogen content and relatively high nitrogen content and polymers formed therefrom
US20050026811A1 (en) * 2003-05-20 2005-02-03 Mjalli Adnan M. M. Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
WO2002064169A1 (fr) * 2001-02-16 2002-08-22 Daiichi Suntory Pharma Co., Ltd. Procedes de traitement de maladies en association avec la diminution de l'expression du gene aop-1 ou de aop-1 et remedes conçus pour ces maladies
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
ES2373875T3 (es) 2002-03-05 2012-02-09 Transtech Pharma, Inc. Derivados de azol mono y bicíclicos que inhiben la interacción de ligandos con rage.
AU2003230770A1 (en) * 2002-03-28 2003-10-13 Oxis International, Inc. Neuroprotectant methods, compositions, and screening methods thereof
CN101468970B (zh) 2008-04-25 2011-05-11 暨南大学 一种硝酮类化合物及其制备方法和在制药中的应用
WO2011041198A1 (en) 2009-09-30 2011-04-07 Transtech Pharma, Inc. Substituted imidazole derivatives for treatment of alzheimers disease
JP5885620B2 (ja) * 2012-08-22 2016-03-15 四国化成工業株式会社 ２−（２−フリル）イミダゾール化合物及び酸化防止剤
FR3012451B1 (fr) 2013-10-25 2016-11-11 Michelin & Cie Compose 1,3-dipolaire portant une fonction imidazole
FR3012458B1 (fr) 2013-10-25 2015-10-30 Michelin & Cie Composition de caoutchouc comprenant un additif compose 1,3-dipolaire portant une fonction imidazole
FR3012460B1 (fr) 2013-10-25 2015-12-11 Michelin & Cie Composition de caoutchouc comprenant un elastomere dienique portant des fonctions imidazole reparties de facon aleatoire le long de la chaine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0643403B2 (ja) * 1986-01-25 1994-06-08 四国化成工業株式会社 イミダゾール―アルドキシム化合物の合成方法
US4803282A (en) * 1986-08-27 1989-02-07 Pennwalt Corporation Alpha-substituted ketonitrone derivatives
EP0590072B1 (en) * 1991-06-18 2001-12-05 Oklahoma Medical Research Foundation Use of spin trapping for the treatment of diseases associated with oxidation of lipids and proteins
US5455272A (en) * 1993-10-22 1995-10-03 Oklahoma Medical Research Foundation Spin trap nitronyl hindered phenols
JP3887020B2 (ja) * 1995-11-17 2007-02-28 フロリダ インターナショナル ユニバーシティー アズレニルニトロンスピントラッピング剤、ならびにその製造方法および使用方法

Also Published As

Publication number Publication date
NO993122L (no) 1999-12-27
EP0967207B1 (fr) 2002-09-11
HU9902199D0 (en) 1999-08-30
CN1245169A (zh) 2000-02-23
AU747203B2 (en) 2002-05-09
DE69902851T2 (de) 2003-05-28
US6034250A (en) 2000-03-07
CN1153766C (zh) 2004-06-16
ES2183492T3 (es) 2003-03-16
CA2274621C (fr) 2004-01-20
EP0967207A1 (fr) 1999-12-29
NZ336460A (en) 2000-05-26
CA2274621A1 (fr) 1999-12-26
BR9903282A (pt) 2000-04-18
NO993122D0 (no) 1999-06-23
AU3680099A (en) 2000-01-13
FR2780404A1 (fr) 1999-12-31
ATE223904T1 (de) 2002-09-15
DE69902851D1 (de) 2002-10-17
JP2000026428A (ja) 2000-01-25
FR2780404B1 (fr) 2001-04-13
PT967207E (pt) 2002-12-31
HUP9902199A1 (hu) 2000-06-28
ZA994201B (en) 2000-01-11
NO312722B1 (no) 2002-06-24

Similar Documents

Publication Publication Date Title
MX9306831A (es) Nuevos compuestos heterociclicos.
BR9508375A (pt) Antagonista de receptor de taquicinina heterociclica
DK0528337T3 (da) Thiazolylbenzofuranderivater, fremgangsmåde til fremstilling deraf og farmaceutiske præparater, der indeholder disse forbin
DK0622361T3 (da) Heterocykliske forbindelser som bradykininantagonister
DK165370C (da) Benzoxazol-, benzothiazol- og thiazolopyridinaminderivater, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater indeholdende disse
DK0967207T3 (da) Nitron-derivater, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger indeholdende derivaterne
TW333527B (en) Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them
DK0903347T3 (da) Hidtil ukendte cyclodepsipeptid PF1022-derivater
NO20022232L (no) Imidazolforbindelser for anvendelse som inhibitorer for fosfodiesterase VII
MXPA04005837A (es) Nuevos derivados de benzotiazina y benzotiadiazina, metodo para su preparacion y composiciones farmaceuticas que los contienen.
HUT42268A (en) Pesticide compositions containing pyrazolin-5-one derivatives and process for producing the active agents
HUP0105111A1 (hu) 2,5-Helyettesített benzolszulfonilkarbamid- és tiokarbamidszármazékok, eljárás előállításukra, alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
DK434789D0 (da) 3-piperidinyl-indazolderivater, fremgangsmaade til fremstilling deraf samt praeparater indeholdende samme
TH22952A (th) " อนุพันธ์วิตามิน d การใช้และกระบวนการเตรียมสารนี้ "
TH22952B (th) " อนุพันธ์วิตามิน d การใช้และกระบวนการเตรียมสารนี้ "