DK0889875T3 - Cycloproylalkansyrederivater - Google Patents
CycloproylalkansyrederivaterInfo
- Publication number
- DK0889875T3 DK0889875T3 DK97915937T DK97915937T DK0889875T3 DK 0889875 T3 DK0889875 T3 DK 0889875T3 DK 97915937 T DK97915937 T DK 97915937T DK 97915937 T DK97915937 T DK 97915937T DK 0889875 T3 DK0889875 T3 DK 0889875T3
- Authority
- DK
- Denmark
- Prior art keywords
- cycloproylalkanoic
- acid derivatives
- formula
- compounds
- antagonizing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1441196P | 1996-03-29 | 1996-03-29 | |
| PCT/US1997/003987 WO1997036858A1 (en) | 1996-03-29 | 1997-03-20 | Cyclopropyl alkanoic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0889875T3 true DK0889875T3 (da) | 2001-09-03 |
Family
ID=21765323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97915937T DK0889875T3 (da) | 1996-03-29 | 1997-03-20 | Cycloproylalkansyrederivater |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5773644A (pt) |
| EP (1) | EP0889875B1 (pt) |
| JP (1) | JP2000507575A (pt) |
| AT (1) | ATE202337T1 (pt) |
| AU (1) | AU2323897A (pt) |
| CA (1) | CA2250695A1 (pt) |
| DE (1) | DE69705300T2 (pt) |
| DK (1) | DK0889875T3 (pt) |
| ES (1) | ES2158537T3 (pt) |
| GR (1) | GR3036253T3 (pt) |
| PT (1) | PT889875E (pt) |
| WO (1) | WO1997036858A1 (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
| US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| ATE542797T1 (de) | 1998-04-09 | 2012-02-15 | Meiji Seika Pharma Co Ltd | Aminopiperidinderivate als integrin alpha v beta 3 antagonisten |
| GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
| JP2002522504A (ja) * | 1998-08-13 | 2002-07-23 | ジー・ディー・サール・アンド・カンパニー | 多価ａｖｂ３および転移関連レセプター・リガンド |
| GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
| CA2356606A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Method of using a cyclooxygenase-2 inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6291503B1 (en) | 1999-01-15 | 2001-09-18 | Bayer Aktiengesellschaft | β-phenylalanine derivatives as integrin antagonists |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
| WO2001010844A1 (en) | 1999-08-05 | 2001-02-15 | Meiji Seika Kaisha, Ltd. | φ-AMINO-α-HYDROXYCARBOXYLIC ACID DERIVATIVES HAVING INTEGRIN αvβ3 ANTAGONISM |
| US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
| US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
| EP1250935A1 (en) * | 2000-01-25 | 2002-10-23 | Meiji Seika Kaisha Ltd. | REMEDIES FOR REPERFUSION INJURY CONTAINING INTEGRIN ALPHAvBETA3 ANTAGONIST |
| CA2399001C (en) * | 2000-02-03 | 2010-07-20 | Eisai Co., Ltd. | Integrin expression inhibitor |
| JP2003531141A (ja) | 2000-04-17 | 2003-10-21 | セルテック アール アンド ディ リミテッド | エナミン誘導体 |
| US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
| US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
| WO2001096307A2 (en) * | 2000-06-15 | 2001-12-20 | Pharmacia Corporation | Cycloalkyl alkanoic acids as integrin receptor antagonists |
| CA2414464A1 (en) * | 2000-06-29 | 2002-01-10 | Abbott Laboratories | Aryl phenycyclopropyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
| WO2002004426A1 (en) | 2000-07-07 | 2002-01-17 | Celltech R & D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
| EP1305291A1 (en) | 2000-08-02 | 2003-05-02 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
| US20040043988A1 (en) * | 2001-06-15 | 2004-03-04 | Khanna Ish Kurmar | Cycloalkyl alkanoic acids as intergrin receptor antagonists |
| CN100560131C (zh) | 2001-10-22 | 2009-11-18 | 斯克里普斯研究学院 | 抗体靶向化合物 |
| EP1487489A4 (en) * | 2002-03-04 | 2008-10-01 | Medimmune Inc | METHODS FOR PREVENTING OR TREATING DISORDERS BY ADMINISTERING AN INTEGRIN AVB3 ANTAGONIST ASSOCIATED WITH HMG-COA REDUCTASE INHIBITOR OR BISPHOSPHONATE |
| AU2003217930A1 (en) * | 2002-03-04 | 2003-09-22 | Medimmune, Llc | The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents |
| JP2006516635A (ja) * | 2003-01-30 | 2006-07-06 | メディミューン，インコーポレーテッド | インテグリンαｖβ３アンタゴニストの使用 |
| US7834013B2 (en) * | 2003-11-19 | 2010-11-16 | Glaxosmithkline Llc | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to GPR40 |
| UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
| WO2007048127A2 (en) * | 2005-10-20 | 2007-04-26 | The Scripps Research Institute | Fc labeling for immunostaining and immunotargeting |
| PT2222636E (pt) | 2007-12-21 | 2013-07-16 | Ligand Pharm Inc | Moduladores seletivos de recetores de andrógeno (sarms) e suas utilizações |
| US8518927B2 (en) | 2009-02-10 | 2013-08-27 | The Scripps Research Institute | Chemically programmed vaccination |
| SG173680A1 (en) | 2009-02-24 | 2011-09-29 | Alexion Pharma Inc | Antibodies containing therapeutic tpo/epo mimetic peptides |
| EA022459B1 (ru) * | 2010-04-20 | 2016-01-29 | Университа' Дельи Студи Ди Рома "Ла Сапиенца" | Производные транилципромина в качестве ингибиторов гистон деметилаз lsd1 и/или lsd2 |
| RU2016146826A (ru) | 2014-05-30 | 2018-07-04 | Пфайзер Инк. | Производные карбонитрилов как селективные модуляторы андрогенового рецептора |
| WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1905813A1 (de) * | 1968-07-04 | 1970-03-05 | Akad Wissenschaften Ddr | 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren |
| FR2456731A1 (fr) * | 1979-05-16 | 1980-12-12 | Choay Sa | Nouveaux derives substitues d'ary |
| EP0222608B1 (en) * | 1985-11-12 | 1991-09-11 | Ono Pharmaceutical Co., Ltd. | Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as active ingredient |
| IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
| NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
| WO1992008464A1 (en) * | 1990-11-15 | 1992-05-29 | Tanabe Seiyaku Co. Ltd. | Substituted urea and related cell adhesion modulation compounds |
| US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| US5741796A (en) * | 1994-05-27 | 1998-04-21 | Merck & Co., Inc. | Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption |
-
1997
- 1997-03-20 EP EP97915937A patent/EP0889875B1/en not_active Expired - Lifetime
- 1997-03-20 WO PCT/US1997/003987 patent/WO1997036858A1/en active IP Right Grant
- 1997-03-20 DE DE69705300T patent/DE69705300T2/de not_active Expired - Fee Related
- 1997-03-20 JP JP9535279A patent/JP2000507575A/ja not_active Ceased
- 1997-03-20 AU AU23238/97A patent/AU2323897A/en not_active Abandoned
- 1997-03-20 CA CA002250695A patent/CA2250695A1/en not_active Abandoned
- 1997-03-20 AT AT97915937T patent/ATE202337T1/de not_active IP Right Cessation
- 1997-03-20 DK DK97915937T patent/DK0889875T3/da active
- 1997-03-20 PT PT97915937T patent/PT889875E/pt unknown
- 1997-03-20 ES ES97915937T patent/ES2158537T3/es not_active Expired - Lifetime
- 1997-03-27 US US08/825,040 patent/US5773644A/en not_active Expired - Fee Related
-
2001
- 2001-07-24 GR GR20010401102T patent/GR3036253T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT889875E (pt) | 2001-10-30 |
| GR3036253T3 (en) | 2001-10-31 |
| AU2323897A (en) | 1997-10-22 |
| US5773644A (en) | 1998-06-30 |
| EP0889875A1 (en) | 1999-01-13 |
| ES2158537T3 (es) | 2001-09-01 |
| CA2250695A1 (en) | 1997-10-09 |
| JP2000507575A (ja) | 2000-06-20 |
| EP0889875B1 (en) | 2001-06-20 |
| WO1997036858A1 (en) | 1997-10-09 |
| DE69705300D1 (de) | 2001-07-26 |
| DE69705300T2 (de) | 2002-05-02 |
| ATE202337T1 (de) | 2001-07-15 |
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