DK0888323T3 - Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler - Google Patents
Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midlerInfo
- Publication number
- DK0888323T3 DK0888323T3 DK97904019T DK97904019T DK0888323T3 DK 0888323 T3 DK0888323 T3 DK 0888323T3 DK 97904019 T DK97904019 T DK 97904019T DK 97904019 T DK97904019 T DK 97904019T DK 0888323 T3 DK0888323 T3 DK 0888323T3
- Authority
- DK
- Denmark
- Prior art keywords
- dihydrobenzofuran
- inflammatory agents
- compounds useful
- related compounds
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/595,337 US5618835A (en) | 1996-02-01 | 1996-02-01 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0888323T3 true DK0888323T3 (da) | 2004-08-09 |
Family
ID=24382842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97904019T DK0888323T3 (da) | 1996-02-01 | 1997-01-30 | Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5618835A (de) |
| EP (1) | EP0888323B1 (de) |
| JP (1) | JP3095424B2 (de) |
| KR (1) | KR100322402B1 (de) |
| CN (1) | CN1125062C (de) |
| AT (1) | ATE267187T1 (de) |
| AU (1) | AU730262B2 (de) |
| BR (1) | BR9707247A (de) |
| CA (1) | CA2244203A1 (de) |
| DE (1) | DE69729183T2 (de) |
| DK (1) | DK0888323T3 (de) |
| ES (1) | ES2221950T3 (de) |
| MX (1) | MX9806250A (de) |
| NO (1) | NO983530L (de) |
| WO (1) | WO1997028147A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1006794B1 (de) * | 1997-03-12 | 2007-11-28 | Robert W. Esmond | Verfahren zur behandlung oder prävention der alzheimerischen krankheit |
| DE69831950T2 (de) * | 1997-06-27 | 2006-07-20 | Kaneka Corp. | Inhibitoren des hitzeschock-faktors |
| CN1127492C (zh) | 1997-10-24 | 2003-11-12 | 盐野义制药株式会社 | 抗风湿剂 |
| US20040058873A1 (en) * | 1998-03-12 | 2004-03-25 | Esmond Robert W. | Method for treating or preventing Alzheimer's disease |
| US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
| RS52139B (en) | 2001-06-13 | 2012-08-31 | Magnachem International Laboratories Inc. | LACTON FORMULATIONS AND PROCEDURE FOR THEIR USE |
| DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
| CN102579427A (zh) | 2002-11-05 | 2012-07-18 | 马格纳化学国际实验室公司 | 合成的内酯制剂及其使用方法 |
| AU2003298693B2 (en) * | 2002-11-22 | 2010-09-30 | Smithkline Beecham Corporation | Novel chemical compounds |
| WO2005102315A1 (en) | 2004-04-23 | 2005-11-03 | Magnachem International Laboratories, Inc. | Synthetic lactone formulations for pain control |
| EP1889198B1 (de) | 2005-04-28 | 2014-11-26 | Proteus Digital Health, Inc. | Pharma-informatiksystem |
| PE20070083A1 (es) * | 2005-06-08 | 2007-01-27 | Smithkline Beecham Corp | (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona |
| WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| US20100286041A1 (en) * | 2007-03-22 | 2010-11-11 | Smithkline Beecham Corporation | (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one |
| US8501431B2 (en) | 2008-10-24 | 2013-08-06 | Magnachem International Laboratories, Inc. | Method for screening for compounds selectively interacting with RAD9 |
| JP5483601B2 (ja) | 2009-01-27 | 2014-05-07 | 国立大学法人名古屋大学 | 膜張力測定装置 |
| DK3395372T3 (da) | 2009-02-20 | 2022-04-19 | Enhanx Biopharm Inc | System til afgivelse af glutathion-baseret medikament |
| EP2427178B1 (de) | 2009-05-06 | 2023-01-04 | Laboratory Skin Care, Inc. | Dermale freisetzungszusammensetzung mit wirkstoff-calciumphosphat-partikelkomplexen und anwendungsverfahren |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019305B2 (ja) * | 1976-07-02 | 1985-05-15 | ウェルファイド株式会社 | ジヒドロベンゾフラン誘導体 |
| IT1093805B (it) * | 1978-01-31 | 1985-07-26 | Erba Carlo Spa | Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione |
| US4470440A (en) * | 1982-09-30 | 1984-09-11 | Thor Harry A | Impact producing tool |
| DE3777366D1 (de) * | 1986-12-27 | 1992-04-16 | Takeda Chemical Industries Ltd | 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung. |
| US4849428A (en) * | 1987-11-23 | 1989-07-18 | The Procter & Gamble Company | Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use |
| JP2855341B2 (ja) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | 新規２―置換クマラン誘導体 |
| US4966907A (en) * | 1988-08-12 | 1990-10-30 | Merck & Co., Inc. | 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis |
| FR2645537B1 (fr) * | 1989-04-05 | 1994-03-04 | Fabre Medicament Pierre | Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique |
| US4975457A (en) * | 1989-09-25 | 1990-12-04 | Merck & Co., Inc. | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis |
| KR920701190A (ko) * | 1989-11-17 | 1992-08-11 | 나까야마 히사시 | 벤조푸란유도체, 그의 제조법 및 이를 유효성분으로 하는 의약 |
| US5091533A (en) * | 1990-03-12 | 1992-02-25 | Merck Frosst Canada, Inc. | 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors |
| NZ237566A (en) * | 1990-03-27 | 1994-03-25 | Smithkline Beecham Corp | Substituted amide and hydroxyamine derivatives and pharmaceutical compositions |
| NZ290080A (en) * | 1994-07-27 | 1999-04-29 | Procter & Gamble | Dihydrobenzo(thio)furan derivatives and pharmaceutical compositions |
| US5684002A (en) * | 1994-09-07 | 1997-11-04 | The Procter & Gamble Company | Dihydorbenzofuran and related compounds useful as anti-inflammatory agents |
-
1996
- 1996-02-01 US US08/595,337 patent/US5618835A/en not_active Expired - Fee Related
-
1997
- 1997-01-30 JP JP09527762A patent/JP3095424B2/ja not_active Expired - Fee Related
- 1997-01-30 DK DK97904019T patent/DK0888323T3/da active
- 1997-01-30 CN CN97192018A patent/CN1125062C/zh not_active Expired - Fee Related
- 1997-01-30 ES ES97904019T patent/ES2221950T3/es not_active Expired - Lifetime
- 1997-01-30 AU AU18433/97A patent/AU730262B2/en not_active Ceased
- 1997-01-30 DE DE69729183T patent/DE69729183T2/de not_active Expired - Fee Related
- 1997-01-30 AT AT97904019T patent/ATE267187T1/de not_active IP Right Cessation
- 1997-01-30 WO PCT/US1997/001314 patent/WO1997028147A1/en active IP Right Grant
- 1997-01-30 CA CA002244203A patent/CA2244203A1/en not_active Abandoned
- 1997-01-30 KR KR1019980705950A patent/KR100322402B1/ko not_active IP Right Cessation
- 1997-01-30 EP EP97904019A patent/EP0888323B1/de not_active Expired - Lifetime
- 1997-01-30 BR BR9707247A patent/BR9707247A/pt not_active Application Discontinuation
-
1998
- 1998-07-31 NO NO983530A patent/NO983530L/no not_active Application Discontinuation
- 1998-08-03 MX MX9806250A patent/MX9806250A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO983530D0 (no) | 1998-07-31 |
| EP0888323A1 (de) | 1999-01-07 |
| DE69729183T2 (de) | 2004-10-07 |
| JPH11506121A (ja) | 1999-06-02 |
| AU1843397A (en) | 1997-08-22 |
| AU730262B2 (en) | 2001-03-01 |
| DE69729183D1 (de) | 2004-06-24 |
| NO983530L (no) | 1998-09-30 |
| BR9707247A (pt) | 1999-07-20 |
| CN1210530A (zh) | 1999-03-10 |
| CN1125062C (zh) | 2003-10-22 |
| KR100322402B1 (ko) | 2002-05-09 |
| MX9806250A (es) | 1998-11-30 |
| EP0888323B1 (de) | 2004-05-19 |
| JP3095424B2 (ja) | 2000-10-03 |
| KR19990082222A (ko) | 1999-11-25 |
| CA2244203A1 (en) | 1997-08-07 |
| ES2221950T3 (es) | 2005-01-16 |
| WO1997028147A1 (en) | 1997-08-07 |
| ATE267187T1 (de) | 2004-06-15 |
| US5618835A (en) | 1997-04-08 |
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