DK0854711T3 - RAR-gamma-agonist ligand eller alfa-antagonist ligand som apoptose-inhibitor - Google Patents
RAR-gamma-agonist ligand eller alfa-antagonist ligand som apoptose-inhibitorInfo
- Publication number
- DK0854711T3 DK0854711T3 DK96933503T DK96933503T DK0854711T3 DK 0854711 T3 DK0854711 T3 DK 0854711T3 DK 96933503 T DK96933503 T DK 96933503T DK 96933503 T DK96933503 T DK 96933503T DK 0854711 T3 DK0854711 T3 DK 0854711T3
- Authority
- DK
- Denmark
- Prior art keywords
- ligand
- pct
- apoptosis inhibitor
- gamma agonist
- alpha antagonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- AIDS & HIV (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Nutrition Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9511946A FR2739777B1 (fr) | 1995-10-11 | 1995-10-11 | Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose |
PCT/FR1996/001569 WO1997013506A1 (fr) | 1995-10-11 | 1996-10-08 | LIGANT ANTAGONISTE RAR-η OU AGONISTE RAR-α EN TANT QU'INHIBITEUR D'APOPTOSE |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0854711T3 true DK0854711T3 (da) | 2002-03-25 |
Family
ID=9483437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96933503T DK0854711T3 (da) | 1995-10-11 | 1996-10-08 | RAR-gamma-agonist ligand eller alfa-antagonist ligand som apoptose-inhibitor |
Country Status (21)
Country | Link |
---|---|
US (1) | US6063797A (pl) |
EP (1) | EP0854711B1 (pl) |
JP (1) | JP3135267B2 (pl) |
KR (1) | KR100300214B1 (pl) |
CN (1) | CN1104896C (pl) |
AT (1) | ATE212226T1 (pl) |
AU (1) | AU695311B2 (pl) |
BR (1) | BR9611035A (pl) |
CA (1) | CA2231558C (pl) |
DE (1) | DE69618802T2 (pl) |
DK (1) | DK0854711T3 (pl) |
ES (1) | ES2172680T3 (pl) |
FR (1) | FR2739777B1 (pl) |
HU (1) | HUP9900037A3 (pl) |
NO (1) | NO981652L (pl) |
NZ (1) | NZ319647A (pl) |
PL (1) | PL186821B1 (pl) |
PT (1) | PT854711E (pl) |
RU (1) | RU2191008C2 (pl) |
TR (1) | TR199800644T2 (pl) |
WO (1) | WO1997013506A1 (pl) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10158192A (ja) | 1996-10-03 | 1998-06-16 | Eisai Co Ltd | 移植片対宿主疾患(gvhd)の治療および臓器移植時の移植片拒絶反応抑制のための医薬組成物 |
FR2776511B1 (fr) * | 1998-03-31 | 2001-05-11 | Galderma Rech Dermatologique | Utilisation dans ou pour la preparation d'une composition d'au moins un inhibiteur de l'activite de l'acide retinoique |
CA2344653A1 (en) * | 1998-09-29 | 2000-04-06 | Gamida Cell Ltd. | Methods of controlling proliferation and differentiation of stem and progenitor cells |
US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
AU2001290816A1 (en) * | 2000-09-13 | 2002-03-26 | Bristol-Myers Squibb Company | Retinoic acid receptor antagonists as promoters of angiogenesis |
IL152904A0 (en) * | 2002-01-24 | 2003-06-24 | Gamida Cell Ltd | Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations |
EP1465982A4 (en) * | 2002-01-25 | 2006-06-07 | Gamida Cell Ltd | PROCESS FOR EXPANSION OF STEM AND PRESERVATIVE CELLS AND EXPANDED CELL POPULATIONS THEREWITH OBTAINED |
WO2006030442A2 (en) * | 2004-09-16 | 2006-03-23 | Gamida-Cell Ltd. | Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells |
BRPI0519111A2 (pt) * | 2004-12-17 | 2008-12-23 | Wyeth Corp | mÉtodos para tratar o mal de parkinson, para melhorar um sintoma do mal de parkinson e para melhorar um sintoma de uma doenÇa ou distérbio cognitivos, e, uso de um ligando seletivo de erbeta |
KR100798853B1 (ko) * | 2005-02-15 | 2008-01-28 | (주)한국스티펠 | 레티노이드를 유효성분으로 하는 백반증 예방 및 치료용 약학적 조성물 |
US8846393B2 (en) | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
US8082730B2 (en) * | 2008-05-20 | 2011-12-27 | Caterpillar Inc. | Engine system having particulate reduction device and method |
GB0915196D0 (en) | 2009-09-01 | 2009-10-07 | King S College London | Therapeutic compounds and their use |
MX361414B (es) * | 2010-09-01 | 2018-12-05 | Univ Jefferson | Composición y método para reparación y regeneración muscular. |
CN104204192A (zh) | 2012-02-13 | 2014-12-10 | 加米达细胞有限公司 | 间充质干细胞调理的基质及其产生和使用方法 |
US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
US9567569B2 (en) | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
US9861640B2 (en) | 2013-06-10 | 2018-01-09 | Kemphys Ltd. | Medicament for treatment of Alzheimer's disease |
JP2018512396A (ja) * | 2015-03-09 | 2018-05-17 | キングス・カレッジ・ロンドン | Th1応答を増強するためのrarアルファアゴニストを用いた併用療法 |
EP3967305A1 (en) | 2015-03-31 | 2022-03-16 | Syros Pharmaceuticals, Inc. | Methods of stratifying patients for treatment with retinoic acid receptor-alpha agonists |
EP3440046A1 (en) * | 2016-04-07 | 2019-02-13 | High Force Research Limited | Synthetic retinoids for use in rar mediated conditions |
US9868994B2 (en) | 2016-04-08 | 2018-01-16 | Syros Pharmaceuticals, Inc. | Methods of stratifying patients for treatment with retinoic acid receptor-α agonists |
WO2017177167A1 (en) | 2016-04-08 | 2017-10-12 | Syros Pharmaceuticals, Inc. | Rara agonists for the treatment of aml and mds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5780676A (en) * | 1992-04-22 | 1998-07-14 | Ligand Pharmaceuticals Incorporated | Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors |
US5399586A (en) * | 1993-03-11 | 1995-03-21 | Allergan, Inc. | Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity |
FR2713640B1 (fr) * | 1993-12-15 | 1996-01-05 | Cird Galderma | Nouveaux composés aromatiques polycycliques, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
FR2722985B1 (fr) * | 1994-07-27 | 1996-09-13 | Cird Galderma | Nouvelles compositions a base d'un melange synergetique entre au moins un ligand specifique des rxrs et au moins un ligand specifique de rar-x ou de vdr, et leurs utilisations |
-
1995
- 1995-10-11 FR FR9511946A patent/FR2739777B1/fr not_active Expired - Fee Related
-
1996
- 1996-10-08 ES ES96933503T patent/ES2172680T3/es not_active Expired - Lifetime
- 1996-10-08 KR KR1019980702690A patent/KR100300214B1/ko not_active IP Right Cessation
- 1996-10-08 PT PT96933503T patent/PT854711E/pt unknown
- 1996-10-08 CN CN96198770A patent/CN1104896C/zh not_active Expired - Fee Related
- 1996-10-08 PL PL96326162A patent/PL186821B1/pl not_active IP Right Cessation
- 1996-10-08 AU AU72210/96A patent/AU695311B2/en not_active Ceased
- 1996-10-08 US US09/051,397 patent/US6063797A/en not_active Expired - Fee Related
- 1996-10-08 DK DK96933503T patent/DK0854711T3/da active
- 1996-10-08 RU RU98108534/14A patent/RU2191008C2/ru not_active IP Right Cessation
- 1996-10-08 AT AT96933503T patent/ATE212226T1/de not_active IP Right Cessation
- 1996-10-08 WO PCT/FR1996/001569 patent/WO1997013506A1/fr active IP Right Grant
- 1996-10-08 JP JP09514768A patent/JP3135267B2/ja not_active Expired - Fee Related
- 1996-10-08 CA CA002231558A patent/CA2231558C/fr not_active Expired - Fee Related
- 1996-10-08 DE DE69618802T patent/DE69618802T2/de not_active Expired - Fee Related
- 1996-10-08 BR BR9611035A patent/BR9611035A/pt not_active Application Discontinuation
- 1996-10-08 HU HU9900037A patent/HUP9900037A3/hu unknown
- 1996-10-08 NZ NZ319647A patent/NZ319647A/en unknown
- 1996-10-08 TR TR1998/00644T patent/TR199800644T2/xx unknown
- 1996-10-08 EP EP96933503A patent/EP0854711B1/fr not_active Expired - Lifetime
-
1998
- 1998-04-08 NO NO981652A patent/NO981652L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU7221096A (en) | 1997-04-30 |
RU2191008C2 (ru) | 2002-10-20 |
EP0854711B1 (fr) | 2002-01-23 |
EP0854711A1 (fr) | 1998-07-29 |
AU695311B2 (en) | 1998-08-13 |
KR100300214B1 (ko) | 2001-11-22 |
HUP9900037A3 (en) | 1999-11-29 |
WO1997013506A1 (fr) | 1997-04-17 |
FR2739777B1 (fr) | 1997-11-14 |
NO981652L (no) | 1998-06-10 |
PT854711E (pt) | 2002-05-31 |
FR2739777A1 (fr) | 1997-04-18 |
PL186821B1 (pl) | 2004-03-31 |
CN1104896C (zh) | 2003-04-09 |
CA2231558C (fr) | 2003-05-27 |
ATE212226T1 (de) | 2002-02-15 |
ES2172680T3 (es) | 2002-10-01 |
JPH11500448A (ja) | 1999-01-12 |
DE69618802T2 (de) | 2002-11-14 |
HUP9900037A2 (hu) | 1999-04-28 |
KR19990064204A (ko) | 1999-07-26 |
BR9611035A (pt) | 1999-07-06 |
TR199800644T2 (xx) | 1998-07-21 |
PL326162A1 (en) | 1998-08-31 |
US6063797A (en) | 2000-05-16 |
CN1203529A (zh) | 1998-12-30 |
JP3135267B2 (ja) | 2001-02-13 |
NO981652D0 (no) | 1998-04-08 |
DE69618802D1 (de) | 2002-03-14 |
CA2231558A1 (fr) | 1997-04-17 |
NZ319647A (en) | 2000-06-23 |
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