DK0851874T3 - Hidtil ukendte varianter af grønt fluorescerende protein, GFP - Google Patents

Hidtil ukendte varianter af grønt fluorescerende protein, GFP

Info

Publication number
DK0851874T3
DK0851874T3 DK96900890T DK96900890T DK0851874T3 DK 0851874 T3 DK0851874 T3 DK 0851874T3 DK 96900890 T DK96900890 T DK 96900890T DK 96900890 T DK96900890 T DK 96900890T DK 0851874 T3 DK0851874 T3 DK 0851874T3
Authority
DK
Denmark
Prior art keywords
fluorescent protein
gfp
green fluorescent
novel variants
variants
Prior art date
Application number
DK96900890T
Other languages
Danish (da)
English (en)
Inventor
Ole Thastrup
Soren Tullin
Lars Kongsbak Poulsen
Sara Petersen Bjorn
Original Assignee
Bioimage A S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8100600&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0851874(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioimage A S filed Critical Bioimage A S
Application granted granted Critical
Publication of DK0851874T3 publication Critical patent/DK0851874T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43595—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from coelenteratae, e.g. medusae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds
    • Y10S530/857—Fish; fish eggs; shell fish; crustacea

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK96900890T 1995-09-22 1996-01-31 Hidtil ukendte varianter af grønt fluorescerende protein, GFP DK0851874T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK106595 1995-09-22
PCT/DK1996/000051 WO1997011094A1 (fr) 1995-09-22 1996-01-31 Nouveaux variants de la proteine verte fluorescente (gfp)

Publications (1)

Publication Number Publication Date
DK0851874T3 true DK0851874T3 (da) 2000-03-06

Family

ID=8100600

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96900890T DK0851874T3 (da) 1995-09-22 1996-01-31 Hidtil ukendte varianter af grønt fluorescerende protein, GFP

Country Status (10)

Country Link
US (3) US6172188B1 (fr)
EP (1) EP0851874B1 (fr)
JP (2) JP3535177B2 (fr)
AT (1) ATE184613T1 (fr)
AU (1) AU4482996A (fr)
CA (1) CA2232727C (fr)
DE (1) DE69604298T2 (fr)
DK (1) DK0851874T3 (fr)
ES (1) ES2139329T3 (fr)
WO (1) WO1997011094A1 (fr)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5777079A (en) * 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
JP3535177B2 (ja) 1995-09-22 2004-06-07 バイオイメージ・アクティーゼルスカブ 緑色蛍光性タンパクであるｇｆｐの新規な変種
US6900304B2 (en) 1996-01-31 2005-05-31 The Regents Of The University Of California Emission ratiometric indicators of phosphorylation
US6803188B1 (en) 1996-01-31 2004-10-12 The Regents Of The University Of California Tandem fluorescent protein constructs
US5804387A (en) * 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6027881A (en) 1996-05-08 2000-02-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence
US5925558A (en) * 1996-07-16 1999-07-20 The Regents Of The University Of California Assays for protein kinases using fluorescent protein substrates
US5912137A (en) 1996-07-16 1999-06-15 The Regents Of The University Of California Assays for protein kinases using fluorescent
US6593135B2 (en) 1996-08-16 2003-07-15 The State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Long wavelength engineered fluorescent proteins
US6124128A (en) * 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
WO1998021355A1 (fr) 1996-11-15 1998-05-22 Life Technologies, Inc. Mutants de la proteine fluorescente verte
US6090919A (en) * 1997-01-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6197928B1 (en) 1997-03-14 2001-03-06 The Regents Of The University Of California Fluorescent protein sensors for detection of analytes
US5998204A (en) * 1997-03-14 1999-12-07 The Regents Of The University Of California Fluorescent protein sensors for detection of analytes
EP2325308A3 (fr) 1997-04-04 2011-07-27 The Board of Regents of the University of Nebraska Procédés et matériaux pour la fabrication et l'utilisation d'organismes transgéniques dégradant le dicamba
DK0986753T4 (da) * 1997-04-07 2005-12-19 Bioimage As Fremgangsmåde til uddragning af kvantitativ information, hvad angår en påvirkning af et cellulært respons
US6046925A (en) * 1997-04-14 2000-04-04 The Regents Of The University Of California Photochromic fluorescent proteins and optical memory storage devices based on fluorescent proteins
US6407132B1 (en) 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
FR2766927B1 (fr) * 1997-07-31 1999-11-05 Centre Nat Rech Scient Methodes et kits pour le diagnostic de la maladie d'alzheimer
EP0928968A1 (fr) 1998-01-12 1999-07-14 Universität Basel Méthode pour le screening de l'apoptose, et de la nécrose
US6194548B1 (en) 1998-01-23 2001-02-27 Takashi Osumi Green fluorescent proteins and blue fluorescent proteins
CA2324648C (fr) * 1998-03-27 2013-02-26 Prolume, Ltd. Luciferases, proteines fluorescentes, acides nucleiques codant pour les luciferases et les proteines fluorescentes, et leur utilisation dans des diagnostics
US7090976B2 (en) 1999-11-10 2006-08-15 Rigel Pharmaceuticals, Inc. Methods and compositions comprising Renilla GFP
US6495664B1 (en) 1998-07-24 2002-12-17 Aurora Biosciences Corporation Fluorescent protein sensors of post-translational modifications
JP2002522040A (ja) * 1998-08-08 2002-07-23 インペリアル キャンサー リサーチ テクノロジー リミテッド 改変されたグリーン蛍光タンパク質
US6936421B2 (en) 1998-10-08 2005-08-30 Rigel Pharmaceuticals, Inc. Structurally biased random peptide libraries based on different scaffolds
US6180343B1 (en) 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
US7297482B2 (en) 1998-10-08 2007-11-20 Rigel Pharmaceuticals, Inc. Structurally biased random peptide libraries based on different scaffolds
EP1121593A2 (fr) * 1998-10-15 2001-08-08 BioImage A/S Procede ameliore destine a une extraction quantitative d'information se rapportant a une influence sur une reponse cellulaire
DE60014987T2 (de) * 1999-02-22 2005-11-10 Matsushita Electric Industrial Co., Ltd., Kadoma Verfahren zum Nachweis von Bakterien
DE19915137C2 (de) * 1999-03-26 2001-10-18 Michael Schaefer Verfahren zur Quantifizierung mehrerer Fluorochrome in einer mehrfach gefärbten Probe bei der Fluoreszenzmikroskopie und Verwendungen des Verfahrens
US6410255B1 (en) 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
US7151847B2 (en) 2001-02-20 2006-12-19 Cytokinetics, Inc. Image analysis of the golgi complex
JP4845073B2 (ja) * 1999-07-30 2011-12-28 全国農業協同組合連合会 再構築受精卵の作製方法及びそれを用いたトランスジェニック胚の作製方法
US6716614B1 (en) 1999-09-02 2004-04-06 Lexicon Genetics Incorporated Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
US6541252B1 (en) 2000-05-19 2003-04-01 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
ATE439373T1 (de) * 2000-06-19 2009-08-15 Fisher Bioimage Aps Fluoreszierende proteine
CA2427113A1 (fr) * 2000-10-27 2002-09-12 Lexicon Genetics Incorporated Proteines humaines 7tm et polynucleotides nouveaux codant lesdites proteines
US6956961B2 (en) 2001-02-20 2005-10-18 Cytokinetics, Inc. Extracting shape information contained in cell images
US7016787B2 (en) 2001-02-20 2006-03-21 Cytokinetics, Inc. Characterizing biological stimuli by response curves
JP3929250B2 (ja) * 2001-03-08 2007-06-13 株式会社ルネサステクノロジ 半導体装置
AU2002254173A1 (en) 2001-03-12 2002-10-08 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The Unive Oxidation-reduction sensitive green fluorescent protein variants
GB0109858D0 (en) * 2001-04-23 2001-06-13 Amersham Pharm Biotech Uk Ltd Fluorscent proteins
US7083941B2 (en) * 2001-04-23 2006-08-01 Lifesensors, Inc. Compositions and methods for gender sorting
JP3829252B2 (ja) 2001-06-08 2006-10-04 独立行政法人理化学研究所 蛍光蛋白質
US6894205B2 (en) * 2001-06-22 2005-05-17 Vanderbilt University Assay for toxin induced neuronal degeneration and viability in C. elegans
TWI332943B (en) * 2001-07-10 2010-11-11 Synta Pharmaceuticals Corp Taxol enhancer compounds
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
US6924312B2 (en) * 2001-07-10 2005-08-02 Synta Pharmaceuticals Corp. Taxol enhancer compounds
TWI297335B (en) * 2001-07-10 2008-06-01 Synta Pharmaceuticals Corp Taxol enhancer compounds
GB0123314D0 (en) * 2001-09-28 2001-11-21 Amersham Pharm Biotech Uk Ltd Fluorescent proteins
AU2002362537A1 (en) * 2001-10-01 2003-04-14 Bioimage A/S A method of detecting intracellular protein-protein interactions using three heterologous conjugates
WO2003067255A1 (fr) * 2002-02-04 2003-08-14 Hemolytics Ag Procede de criblage a debit eleve de composes ayant une activite non-, pro-, ou anti-apoptotique ou proliferative ou necrotique
WO2009095742A1 (fr) * 2008-01-31 2009-08-06 Cellectis Nouvelle méganucléase à chaîne unique dérivée de l'i-crei et ses utilisations
US7335488B2 (en) 2002-04-05 2008-02-26 The Chinese University Of Hong Kong Fluorescent proteins
US7271241B2 (en) * 2002-04-24 2007-09-18 Los Alamos National Security, Llc Directed evolution methods for improving polypeptide folding and solubility and superfolder fluorescent proteins generated thereby
WO2004028243A2 (fr) 2002-08-21 2004-04-08 Revivicor, Inc. Porcins ne presentant aucune expression de l'alpha 1,3-galactosyltransferase fonctionnelle
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
ATE509946T1 (de) * 2002-11-12 2011-06-15 Zakrytoe Aktsionernoe Obschestvo S Evrogens Fluoreszenzproteine und chromoproteine aus nicht- aequorea-hydrozoa-spezies sowie verfahren zur verwendung davon
US7413874B2 (en) 2002-12-09 2008-08-19 University Of Miami Nucleic acid encoding fluorescent proteins from aquatic species
TWI330079B (en) * 2003-01-15 2010-09-11 Synta Pharmaceuticals Corp Treatment for cancers
WO2004090115A2 (fr) * 2003-04-04 2004-10-21 Stratagene Mutants de proteines vertes fluorescentes derives de ranilla a intensite de fluorescence amelioree et mutants a remaniement special
WO2005010677A2 (fr) 2003-07-18 2005-02-03 Cytokinetics, Inc. Caracterisation de stimuli biologiques par courbes de reponse
AU2004315485A1 (en) 2003-10-24 2005-08-18 The Regents Of The University Of California Self-assembling split-fluorescent protein systems
GB0329353D0 (en) * 2003-12-19 2004-01-21 Amersham Biosciences Uk Ltd Cytochrome C protein and assay
EP1766095B1 (fr) 2004-05-18 2013-10-23 The Board of Trustees of the Leland Stanford Junior University Detection de translocation de proteine par complementation de fragment reporter de beta-galactosidase
US7385084B2 (en) * 2004-06-23 2008-06-10 Synta Pharmaceutical Corp. Bis(thio-hydrazide amide) salts for treatment of cancers
US7323318B2 (en) 2004-07-15 2008-01-29 Cytokinetics, Inc. Assay for distinguishing live and dead cells
CA2574953A1 (fr) 2004-07-26 2006-02-09 Dow Global Technolgies Inc. Procede permettant d'ameliorer l'expression d'une proteine par mise au point d'une souche par genie genetique
WO2006023231A2 (fr) * 2004-07-27 2006-03-02 Molecular Probes, Inc. Indicateurs d'ions metalliques fluorescents a decalage de stokes important
US20060031020A1 (en) * 2004-08-09 2006-02-09 Yang Jenny J Computational approach for constructing an analyte binding motif
EP1827410A2 (fr) * 2004-11-19 2007-09-05 Synta Pharmaceuticals Corporation Bis(thio-hydrazide amides) pour augmenter l'expression de hsp70
EP2482075A1 (fr) 2004-12-01 2012-08-01 Proteologics, Ltd Analyses de l'ubiquitine ligase et réactifs correspondants
US8017654B2 (en) * 2005-04-15 2011-09-13 Synta Pharmaceuticals Corp. Combination cancer therapy with bis(thiohydrazide) amide compounds
KR20080008399A (ko) 2005-05-16 2008-01-23 신타 파마슈티칼스 코프. 비스(티오-히드라지드 아미드) 염의 합성 방법
EP1888640B1 (fr) 2005-05-18 2012-03-14 Ablynx N.V. Nanocorps ameliores utilises contre le facteur-alpha de necrose tumorale
PL3415535T3 (pl) 2005-05-20 2021-06-14 Ablynx N.V. Ulepszone Nanociała TM do leczenia zaburzeń, w których pośredniczy agregacja
US8362250B2 (en) 2005-05-24 2013-01-29 Enzo Biochem, Inc. Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
AU2006292827B2 (en) 2005-08-09 2013-02-14 Revivicor, Inc. Transgenic ungulates expressing CTLA4-IG and uses thereof
RU2433822C2 (ru) * 2005-08-16 2011-11-20 Синта Фармасьютиклз Корп. Композиция бис(тио-гидразид амида)
WO2007052102A2 (fr) 2005-11-04 2007-05-10 Evrogen, Jsc Proteines fluorescentes vertes modifiees et procedes d'utilisation de celles-ci
EP1785434A1 (fr) 2005-11-11 2007-05-16 Ludwig-Maximilians-Universität München Ciblage et suivi d'antigènes dans des cellules vivantes
EP1984737A2 (fr) * 2006-01-17 2008-10-29 Cellumen, Inc. Procédé permettant de prédire les réponses des systèmes biologiques
GB0606430D0 (en) * 2006-03-31 2006-05-10 Ge Healthcare Uk Ltd Method for cell based assays
WO2007127428A2 (fr) * 2006-04-28 2007-11-08 University Of Florida Research Foundation, Inc. Vecteurs bicaténaires/autocomplémentaires avec promoteur de cba tronqué et méthodes d'administration de gènes
JP5406019B2 (ja) 2006-05-17 2014-02-05 セルーメン、インコーポレイテッド 自動化組織分析のための方法
US20080004410A1 (en) * 2006-06-30 2008-01-03 Yu-Chin Lai Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same
WO2008019123A2 (fr) 2006-08-04 2008-02-14 Georgia State University Research Foundation, Inc. Capteurs d'enzyme, procédés de préparation et utilisation de tels capteurs, et procédés de détection de l'activité protéase
JP2010501562A (ja) 2006-08-21 2010-01-21 シンタ ファーマシューティカルズ コーポレーション 増殖性障害を治療するための化合物
EP2076254A2 (fr) * 2006-08-31 2009-07-08 Synta Pharmaceuticals Corporation Combinaisons de bis(thio-hydrazide amides) traitant le cancer
TW200829543A (en) * 2006-09-15 2008-07-16 Synta Pharmaceuticals Corp Purification of bis(thiohydrazide amides)
EP2095119A2 (fr) * 2006-11-10 2009-09-02 Cellumen, Inc. Biocapteurs d'interaction proteine-proteine et leurs procedes d'utilisation
GB0624462D0 (en) * 2006-12-07 2007-01-17 Ge Healthcare Ltd Method for determining gentoxicity
EP2557090A3 (fr) 2006-12-19 2013-05-29 Ablynx N.V. Séquences d'acides aminés dirigées contre les GPCR et polypeptides les comprenant pour le traitement de maladies et de troubles liés au GPCR
WO2008074840A2 (fr) 2006-12-19 2008-06-26 Ablynx N.V. Séquences d'acides aminés dirigées contre une métalloprotéinase de la famille adam et polypeptides les comprenant à des fins de traitement de maladies et troubles liés à adam
CN101688213A (zh) 2007-04-27 2010-03-31 陶氏环球技术公司 用于快速筛选微生物宿主以鉴定某些在表达异源蛋白质方面具有改善的产量和/或质量的菌株的方法
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US8727554B2 (en) 2007-06-25 2014-05-20 Yorktown Technologies, L.P. Aquarium with adjustable lighting
US20090006219A1 (en) * 2007-06-29 2009-01-01 Alan Blake Method for distribution of an aquarium kit
WO2009020197A1 (fr) 2007-08-03 2009-02-12 National University Corporation Hokkaido University Protéine fluorescente avec couleur bleue nuit
ES2606706T3 (es) 2008-01-09 2017-03-27 Ludwig-Maximilians-Universitat München Un ensayo de doble híbrido fluorescente (F2H) para la visualización directa de interacciones de proteínas en células vivas
GB0800938D0 (en) * 2008-01-18 2008-02-27 Ge Healthcare Uk Ltd Multiplex cell signalling assay
WO2009124931A2 (fr) 2008-04-07 2009-10-15 Ablynx Nv Séquences d'acides aminés dirigées contre les voies notch et leurs utilisations
EP2128259A1 (fr) * 2008-05-27 2009-12-02 Koninklijke Philips Electronics N.V. Administration de thérapie et surveillance utilisant un gène de protéine de fusion de rapporteur-intérêt et imagerie optique
US9250249B2 (en) 2008-09-08 2016-02-02 Enzo Biochem, Inc. Autophagy and phospholipidosis pathway assays
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
US9260508B2 (en) 2008-12-19 2016-02-16 Ablynx N.V. Method for generation of immunoglobulin sequences
US8748581B2 (en) 2009-04-10 2014-06-10 Ablynx N.V. Anti-IL-6R polypeptides and pharmaceutical compositions thereof
SG176095A1 (en) 2009-06-05 2011-12-29 Ablynx Nv Monovalent, bivalent and trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections
EP2275442A1 (fr) 2009-07-06 2011-01-19 Ludwig-Maximilians-Universität München Détection et visualisation du cycle cellulaire dans des cellules vivantes
EP2507262A1 (fr) 2009-11-30 2012-10-10 Ablynx N.V. Séquences d'acides aminés améliorées dirigées contre le virus syncytial respiratoire humain (hrsv) et polypeptides comprenant celles-ci pour la prévention et/ou le traitement d'infections du tractus respiratoire
WO2011083140A1 (fr) 2010-01-08 2011-07-14 Ablynx Nv Domaines variables simples d'immunoglobuline dirigés contre le cxcr4 doués d'une meilleure activité thérapeutique et produits de recombinaison les comprenant
CN103415611B (zh) 2010-10-01 2016-08-10 国立大学法人九州大学 原生藻菌的转化方法
EP3553527A1 (fr) 2011-03-17 2019-10-16 Cernostics, Inc. Procédés et compositions pour le diagnostic de l' sophage de barrett et leurs procédés d'utilisation
EP2737070A1 (fr) 2011-07-27 2014-06-04 GBiotech SARL Production de protéine recombinante dans des cellules d'insectes à l'aide d'un système d'expression de baculovirus
EP2685260A1 (fr) 2012-07-09 2014-01-15 Ludwig-Maximilians-Universität München Détection quantitative et directe de cibles dans des cellules vivantes
TW201538518A (zh) 2014-02-28 2015-10-16 Dow Agrosciences Llc 藉由嵌合基因調控元件所賦予之根部特異性表現
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
WO2016007886A1 (fr) * 2014-07-11 2016-01-14 Northwestern University Biocapteur à base de levure
DE102014012130B3 (de) 2014-08-13 2015-03-05 Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung Nachweisverfahren unter Verwendung von rekombinanten lebenden Zellen zum Nachweis von xenobiotischen Stoffen sowie Anordnung und Testkit zur Durchführung des Nachweisverfahrens
WO2016186948A1 (fr) 2015-05-15 2016-11-24 Albert Einstein College Of Medicine, Inc. Étiquettes de fusion dérivées de gfp pour l'expression de protéines
CA3043515A1 (fr) 2016-11-16 2018-05-24 Ablynx Nv Polypeptides de recrutement de lymphocytes t capables de se lier a cd123 et tcr alpha/beta
EP3420811A1 (fr) 2017-06-29 2019-01-02 Paris Sciences et Lettres - Quartier Latin Modèle non-humain de la neurofibromatosis type 1
AR114269A1 (es) 2018-02-26 2020-08-12 Ablynx Nv Secuencias nucleotídicas mejoradas que codifican para péptidos de unión
EP3553080A1 (fr) 2018-04-12 2019-10-16 ETH Zürich Rapporteur fluorescent basé sur piezo1
US11834698B2 (en) 2018-05-02 2023-12-05 Indian Institute Of Science Education And Research Process for determining enzyme activity in a cell by activity-based reporter gene technology (ABRGT)
EP3810637A1 (fr) 2018-06-20 2021-04-28 DWI - Leibniz-Institut für Interaktive Materialien e.V. Peptides ou protéines de fusion, leur utilisation, et systèmes et kits basés sur ceux-ci, pour la séparation et/ou la détection de matières plastiques, en particulier de microplastiques
GB201904697D0 (en) 2019-04-03 2019-05-15 Vib Vzw Means and methods for single molecule peptide sequencing
CA3138861A1 (fr) 2019-05-02 2020-12-10 Board Of Regents, The University Of Texas System Systeme et procede d'augmentation de la stabilite de proteines synthetisees
CN116075725A (zh) 2020-04-17 2023-05-05 瑞泽恩制药公司 用于冠状病毒中和抗体的检测测定法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2169298A1 (fr) * 1993-09-10 1995-03-16 Martin Chalfie Utilisations d'une proteine fluorescente verte
US5491084A (en) * 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US5610031A (en) * 1993-10-27 1997-03-11 The General Hospital Corporation B1k chain of laminin and methods of use
WO1995021191A1 (fr) * 1994-02-04 1995-08-10 William Ward Indicateur bioluminescent fonde sur l'expression d'un gene codant pour une proteine modifiee a fluorescence verte
US5625048A (en) * 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
JP3535177B2 (ja) 1995-09-22 2004-06-07 バイオイメージ・アクティーゼルスカブ 緑色蛍光性タンパクであるｇｆｐの新規な変種
US5804387A (en) * 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US6124128A (en) * 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
US6090919A (en) * 1997-01-31 2000-07-18 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)

Also Published As

Publication number Publication date
WO1997011094A1 (fr) 1997-03-27
US6172188B1 (en) 2001-01-09
DE69604298D1 (de) 1999-10-21
ATE184613T1 (de) 1999-10-15
US20050054050A1 (en) 2005-03-10
DE69604298T2 (de) 2000-05-18
CA2232727C (fr) 2002-03-26
US7314915B2 (en) 2008-01-01
CA2232727A1 (fr) 1997-03-27
US6818443B2 (en) 2004-11-16
EP0851874A1 (fr) 1998-07-08
JP3535177B2 (ja) 2004-06-07
US20020107362A1 (en) 2002-08-08
AU4482996A (en) 1997-04-09
JP2004024258A (ja) 2004-01-29
JPH11512441A (ja) 1999-10-26
EP0851874B1 (fr) 1999-09-15
ES2139329T3 (es) 2000-02-01

Similar Documents

Publication Publication Date Title
DK0851874T3 (da) Hidtil ukendte varianter af grønt fluorescerende protein, GFP
BR9808491A (pt) Compostos calcilìticos
CY1112101T1 (el) Νευροτροφικοι παραγοντες
ATE411082T1 (de) Neue verwendung von kurzkettigen carbonsäuren
ID21235A (id) Produksi para-xylen terselektif oleh metilasi toluen
NO20012557L (no) Fluorescerende eller fosforescerende blanding
GEP20104997B (en) Composition comprising anther2 antibodies
EA200300464A1 (ru) ГУМАНИЗИРОВАННОЕ АНТИТЕЛО ПРОТИВ РЕЦЕПТОРА ЛИМФОТОКСИНА-β (ВАРИАНТЫ), КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ИЛИ СНИЖЕНИЯ РИСКА РАЗВИТИЯ, ТЯЖЕСТИ ИЛИ ПОСЛЕДСТВИЙ НЕОПЛАЗИИ У ЧЕЛОВЕКА, ВЫДЕЛЕННАЯ НУКЛЕИНОВАЯ КИСЛОТА (ВАРИАНТЫ), КЛЕТКА КЛЕТОЧНОЙ ЛИНИИ
DE60139267D1 (de) Etektion von licht
TR199701146T1 (xx) N�rotensin resept�rleri �zerinde etkili 1-Fenilpirazol-3-Karboksamidler.
CY1108567T1 (el) Αντιθρομβωτικες ενωσεις
DK1083903T3 (da) Brobundne indenopyrrolocarbazoler
TR200002921T2 (tr) Yarı-Sentetik ekteinasidinler
CY1111567T1 (el) Ενδιαμεσα διβενζο (b,f) αζεπινης
FI973571A0 (fi) Uusi kasvutekijä ja sitä koodaava geneettinen sekvenssi
DZ3357A1 (fr) Nouveaux médicaments composés de dibenzoazulène comme inhibiteurs de facteur onconécrosant
DK1285065T3 (da) Konstruerede proteiner, der fluorescerer ved lange bölgelængder
DE69806085D1 (de) Ringförmige Fluoreszenzlampe
BR9710919A (pt) Proteina purificada sr-p70
PT1206452E (pt) Processo de preparacao de compostos benzoper-hidroisoindole
DE59001722D1 (de) Leuchtstofflampe.
DK0942992T3 (da) O-fucosyltransferase
DE59803066D1 (de) Substituierte benzyloxyimino-verbindungen
TR200003203T2 (tr) Karboksaldehitin saflaştırılması
ATE238791T1 (de) Verwendung von 2-methyl-thiazolidin-2,4- dicarbonsäure als mukolytikum