DK0840893T3 - Fremgangsmåde og apparat til højeffektiv væskekromatografi - Google Patents
Fremgangsmåde og apparat til højeffektiv væskekromatografiInfo
- Publication number
- DK0840893T3 DK0840893T3 DK97904852T DK97904852T DK0840893T3 DK 0840893 T3 DK0840893 T3 DK 0840893T3 DK 97904852 T DK97904852 T DK 97904852T DK 97904852 T DK97904852 T DK 97904852T DK 0840893 T3 DK0840893 T3 DK 0840893T3
- Authority
- DK
- Denmark
- Prior art keywords
- column
- fluids
- eluant
- injections
- entrance
- Prior art date
Links
- 238000004811 liquid chromatography Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000012530 fluid Substances 0.000 abstract 7
- 239000007924 injection Substances 0.000 abstract 3
- 238000002347 injection Methods 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/163—Pressure or speed conditioning
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/203—Equilibration or regeneration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N2030/387—Turbulent flow of mobile phase
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58887496A | 1996-01-19 | 1996-01-19 | |
| US2721696P | 1996-09-30 | 1996-09-30 | |
| PCT/US1997/001096 WO1997026532A1 (en) | 1996-01-19 | 1997-01-21 | High performance liquid chromatography method and apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0840893T3 true DK0840893T3 (da) | 2000-04-03 |
Family
ID=26702215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97904852T DK0840893T3 (da) | 1996-01-19 | 1997-01-21 | Fremgangsmåde og apparat til højeffektiv væskekromatografi |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5795469A (da) |
| EP (1) | EP0840893B1 (da) |
| JP (1) | JP3452936B2 (da) |
| AT (1) | ATE184702T1 (da) |
| AU (1) | AU712735B2 (da) |
| CA (1) | CA2242885C (da) |
| DE (1) | DE69700523T2 (da) |
| DK (1) | DK0840893T3 (da) |
| ES (1) | ES2140209T3 (da) |
| NZ (1) | NZ330867A (da) |
| PL (1) | PL327920A1 (da) |
| WO (1) | WO1997026532A1 (da) |
Families Citing this family (84)
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|---|---|---|---|---|
| US6423233B1 (en) * | 2000-08-15 | 2002-07-23 | Biogal Gyogyszergyar Rt. | Purification process |
| US6110362A (en) * | 1997-11-19 | 2000-08-29 | Cohesive Technologies, Inc. | Chemical analysis |
| US6406632B1 (en) | 1998-04-03 | 2002-06-18 | Symyx Technologies, Inc. | Rapid characterization of polymers |
| US6866786B2 (en) * | 1998-04-03 | 2005-03-15 | Symyx Technologies, Inc. | Rapid characterization of polymers |
| US6416663B1 (en) | 1998-04-03 | 2002-07-09 | Symyx Technologies, Inc. | Chromatographic column for rapid characterizations of polymers |
| JP4067685B2 (ja) * | 1999-03-26 | 2008-03-26 | 山善株式会社 | インジェクション装置 |
| US6855258B2 (en) * | 1999-04-02 | 2005-02-15 | Symyx Technologies, Inc. | Methods for characterization of polymers using multi-dimensional liquid chromatography with parallel second-dimension sampling |
| US6190550B1 (en) * | 1999-09-30 | 2001-02-20 | Cohesive Technologies, Inc. | Monitoring high performance liquid chromatography |
| US6299767B1 (en) | 1999-10-29 | 2001-10-09 | Waters Investments Limited | High pressure capillary liquid chromatography solvent delivery system |
| US6460420B1 (en) * | 2000-04-13 | 2002-10-08 | Sandia National Laboratories | Flowmeter for pressure-driven chromatography systems |
| US20020117447A1 (en) * | 2000-11-21 | 2002-08-29 | Wheat Thomas E. | Mobile phase dilution scheme for enhanced chromatography |
| US6635173B2 (en) * | 2000-12-28 | 2003-10-21 | Cohesive Technologies, Inc. | Multi column chromatography system |
| WO2003021251A1 (en) * | 2001-08-28 | 2003-03-13 | Symyx Technologies, Inc. | Methods for characterization of polymers using multi-dimentional liquid chromatography |
| US6780315B2 (en) | 2002-12-09 | 2004-08-24 | Waters Investments Limited | Backflow prevention for high pressure gradient systems |
| JP3823092B2 (ja) * | 2003-03-11 | 2006-09-20 | 株式会社日立ハイテクノロジーズ | 分離分析装置 |
| US6977143B1 (en) * | 2003-09-08 | 2005-12-20 | Quest Diagnostics Investments Incorporated | Determination of testosterone by mass spectrometry |
| JP4377761B2 (ja) * | 2004-07-01 | 2009-12-02 | 株式会社日立ハイテクノロジーズ | 液体クロマトグラフ装置 |
| JP4399304B2 (ja) | 2004-03-29 | 2010-01-13 | 富士フイルム株式会社 | 自動核酸分離精製方法およびその装置 |
| US20060169640A1 (en) * | 2005-02-01 | 2006-08-03 | Hubert Quinn | High throughput screening, purification and recovery system for large and small molecules |
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| US8877051B2 (en) * | 2006-07-21 | 2014-11-04 | Waters Technologies Corporation | Time delay for sample collection in chromatography systems |
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| US8034627B2 (en) | 2009-12-03 | 2011-10-11 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
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| US8557593B2 (en) | 2010-09-16 | 2013-10-15 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of eicosapentaenoic acid and docosahexaenoic acid |
| US9063159B2 (en) | 2010-10-29 | 2015-06-23 | Cohesive Technologies Inc. | LC-MS separation and detection of vitamin D metabolites |
| US9625429B2 (en) | 2010-10-29 | 2017-04-18 | Cohesive Technologies Inc. | LC-MS configuration for purification and detection of analytes having a broad range of hydrophobicites |
| WO2012087438A1 (en) | 2010-11-08 | 2012-06-28 | Georgetown University | Methods for simultaneous quantification of thyroid hormones and metabolites thereof by mass spectrometry |
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| US9177766B2 (en) * | 2010-12-30 | 2015-11-03 | Quest Diagnostics Investments Incorporated | Mass spectrometric quantitation assay for metabolites of leflunomide |
| US8728824B2 (en) | 2011-06-22 | 2014-05-20 | Quest Diagnostics Investments Inc. | Mass spectrometric determination of fatty acids |
| WO2013078222A1 (en) | 2011-11-23 | 2013-05-30 | Quest Diagnostics Investments Incorporated | Kisspeptin-54 detection by tandem mass spectrometry |
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| US8779355B2 (en) | 2011-12-28 | 2014-07-15 | Quest Diagnostics Investments, Inc. | Methods for detecting lacosamide by mass spectrometry |
| EP2680005A1 (en) | 2012-06-28 | 2014-01-01 | Rheinische Friedrich-Wilhelms-Universität Bonn | Lipid analysis |
| CA2896539C (en) | 2012-12-26 | 2018-07-03 | Quest Diagnostics Investments Incorporated | C peptide detection by mass spectrometry |
| EP2951853B1 (en) | 2013-01-29 | 2022-03-30 | Georgetown University | Apparatus and methods for plasma-assisted reaction chemical ionization (parci) mass spectrometry |
| JP2016530482A (ja) | 2013-05-23 | 2016-09-29 | アイフィノタイプ エルエルシー | ウェルネスを維持するか、または向上するための方法およびシステム |
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| WO2015184430A1 (en) | 2014-05-30 | 2015-12-03 | Quantalytical Labs Inc. | Extraction, derivatization, and quantification of analytes |
| US10324082B2 (en) | 2015-03-03 | 2019-06-18 | Quest Diagnostics Investments Llc | Methods for quantitation of insulin levels by mass spectrometry |
| EP3118619A1 (en) * | 2015-07-14 | 2017-01-18 | Vrije Universiteit Brussel | High-performance liquid chromatography with a vortex flow inducer |
| US11360098B2 (en) | 2015-09-28 | 2022-06-14 | Quest Diagnostics Investments Llc | Amyloid beta detection by mass spectrometry |
| US10564062B2 (en) * | 2016-10-19 | 2020-02-18 | Honeywell International Inc. | Human-machine interface for gas valve |
| US10983108B2 (en) | 2017-03-31 | 2021-04-20 | Quest Diagnostics Investments Llc | Methods for quantitation of insulin and C-peptide |
| JP7146895B2 (ja) | 2017-07-31 | 2022-10-04 | クエスト ダイアグノスティックス インヴェストメンツ エルエルシー | マススペクトロメトリーによるアポリポタンパク質ｅアイソタイプの検出 |
| US11860141B2 (en) | 2017-08-14 | 2024-01-02 | Quest Diagnostics Investments Llc | Detection and quantitation of guanidinoacetate, creatine, and creatinine by mass spectrometry |
| GB201802123D0 (en) | 2018-02-09 | 2018-03-28 | Metabolomic Diagnostics Ltd | A method of processomg a biological sample |
| CA3094080A1 (en) | 2018-03-16 | 2019-09-19 | Quest Diagnostics Investments Llc | Methods for detecting chromogranin a by mass spectrometry |
| EP3791190A2 (en) | 2018-05-11 | 2021-03-17 | Laboratory Corporation of America Holdings | Compositions and methods to detect kidney fibrosis |
| WO2019232421A1 (en) | 2018-06-01 | 2019-12-05 | Laboratory Corporation Of America Holdings | Methods and systems for lc-ms/ms proteomic genotyping |
| JP7378469B2 (ja) | 2018-10-03 | 2023-11-13 | ラボラトリー コーポレイション オブ アメリカ ホールディングス | アスコルビン酸を測定するための方法およびシステム |
| CA3134234A1 (en) | 2019-04-16 | 2020-10-22 | Laboratory Corporation Of America Holdings | Methods and systems for the detection of 11-oxo androgens by lc-ms/ms |
| EP4211473A1 (en) | 2020-09-10 | 2023-07-19 | Laboratory Corporation of America Holdings | Methods and systems for detecting prostaglandins by lc-ms/ms |
| CA3213700A1 (en) | 2021-03-17 | 2022-09-22 | Nissui Corporation | Method of purification and purified products |
| CA3232283A1 (en) | 2021-10-27 | 2023-05-04 | Laboratory Corporation Of America Holdings | Methods and systems for measuring progesterone metabolites |
| CN115236217B (zh) * | 2022-06-17 | 2023-07-21 | 北京科技大学 | 一种三轴围压煤体氧化升温特性测定装置及方法 |
| WO2024196732A1 (en) | 2023-03-17 | 2024-09-26 | Quest Diagnostics Investments Llc | Improved quantitation of testosterone in multiplexed samples by mass spectrometry |
| AU2024247888A1 (en) | 2023-03-31 | 2025-10-09 | Quest Diagnostics Investments Llc | Methods for quantitation of adiponectin by mass spectrometry |
| US20250172548A1 (en) | 2023-11-16 | 2025-05-29 | Laboratory Corporation Of America Holdings | Methods and systems for using isotopically labeled analytes for calibration for quantification of analytes in dried samples |
| WO2025255166A2 (en) | 2024-06-04 | 2025-12-11 | Laboratory Corporation Of America Holdings | Methods and systems for detecting protein biomarkers of rheumatoid arthritis in a biological sample using lc-ms/ms |
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| GB1148661A (en) * | 1965-05-11 | 1969-04-16 | Victor Pretorius | Improvements relating to chromatography |
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-
1997
- 1997-01-21 DK DK97904852T patent/DK0840893T3/da active
- 1997-01-21 AU AU17537/97A patent/AU712735B2/en not_active Ceased
- 1997-01-21 DE DE69700523T patent/DE69700523T2/de not_active Expired - Lifetime
- 1997-01-21 US US08/785,324 patent/US5795469A/en not_active Expired - Lifetime
- 1997-01-21 NZ NZ330867A patent/NZ330867A/en unknown
- 1997-01-21 ES ES97904852T patent/ES2140209T3/es not_active Expired - Lifetime
- 1997-01-21 CA CA002242885A patent/CA2242885C/en not_active Expired - Lifetime
- 1997-01-21 PL PL97327920A patent/PL327920A1/xx unknown
- 1997-01-21 AT AT97904852T patent/ATE184702T1/de not_active IP Right Cessation
- 1997-01-21 WO PCT/US1997/001096 patent/WO1997026532A1/en not_active Ceased
- 1997-01-21 JP JP52630597A patent/JP3452936B2/ja not_active Expired - Lifetime
- 1997-01-21 EP EP97904852A patent/EP0840893B1/en not_active Expired - Lifetime
-
1998
- 1998-01-07 US US09/003,856 patent/US5968367A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2140209T3 (es) | 2000-02-16 |
| CA2242885A1 (en) | 1997-07-24 |
| JP3452936B2 (ja) | 2003-10-06 |
| AU712735B2 (en) | 1999-11-11 |
| NZ330867A (en) | 1998-11-25 |
| CA2242885C (en) | 2006-08-15 |
| PL327920A1 (en) | 1999-01-04 |
| US5968367A (en) | 1999-10-19 |
| JP2000504414A (ja) | 2000-04-11 |
| DE69700523T2 (de) | 2000-04-27 |
| US5795469A (en) | 1998-08-18 |
| WO1997026532A1 (en) | 1997-07-24 |
| ATE184702T1 (de) | 1999-10-15 |
| EP0840893B1 (en) | 1999-09-15 |
| AU1753797A (en) | 1997-08-11 |
| DE69700523D1 (de) | 1999-10-21 |
| EP0840893A1 (en) | 1998-05-13 |
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