DK0835325T3 - In vitro testmetode til påvisning afkemikalieinducerede embryotoksiske/teratogene virkninger - Google Patents
In vitro testmetode til påvisning afkemikalieinducerede embryotoksiske/teratogene virkningerInfo
- Publication number
- DK0835325T3 DK0835325T3 DK96922735T DK96922735T DK0835325T3 DK 0835325 T3 DK0835325 T3 DK 0835325T3 DK 96922735 T DK96922735 T DK 96922735T DK 96922735 T DK96922735 T DK 96922735T DK 0835325 T3 DK0835325 T3 DK 0835325T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- cells
- detection
- differentiation
- tissue
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5073—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19525285A DE19525285C2 (de) | 1995-06-28 | 1995-06-28 | In vitro Testverfahren zum Nachweis Chemikalien-induzierter embryotoxischer/teratogener Effekte |
PCT/DE1996/001183 WO1997001644A1 (de) | 1995-06-28 | 1996-06-27 | In vitro-testverfahren zum nachweis chemikalien-induzierter embryotoxischer/teratogener effekte |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0835325T3 true DK0835325T3 (da) | 2001-07-16 |
Family
ID=7766572
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96922735T DK0835325T3 (da) | 1995-06-28 | 1996-06-27 | In vitro testmetode til påvisning afkemikalieinducerede embryotoksiske/teratogene virkninger |
Country Status (7)
Country | Link |
---|---|
US (1) | US6007993A (da) |
EP (1) | EP0835325B1 (da) |
AT (1) | ATE199400T1 (da) |
DE (2) | DE19525285C2 (da) |
DK (1) | DK0835325T3 (da) |
ES (1) | ES2156283T3 (da) |
WO (1) | WO1997001644A1 (da) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01005745A (es) * | 1998-12-09 | 2003-07-14 | Vistagen Inc | Tipificacion de la toxicidad utilizando cuerpos embrioides. |
AU2001268449A1 (en) | 2000-06-14 | 2001-12-24 | Vistagen, Inc. | Toxicity typing using liver stem cells |
AU2002241758A1 (en) * | 2000-10-26 | 2002-06-18 | University Of Florida | Drug screening system |
IL160507A0 (en) * | 2001-08-24 | 2004-07-25 | Advanced Cell Tech Inc | Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy |
EP1641912B1 (en) | 2003-06-20 | 2016-04-27 | Axiogenesis Ag | Tissue modelling in embryonic stem (es) cell system |
ITMI20040467A1 (it) * | 2004-03-12 | 2004-06-12 | Istituto Sperimentale Italiano | Uso di gameti ed embrioni preimpianto per la determinazione della tossicita' di composti biologicamente attivi |
JP4814875B2 (ja) | 2004-05-11 | 2011-11-16 | アキシオジェネシス エージー | invitro分化細胞に基づく薬物発見のための検定 |
US8431397B2 (en) * | 2004-09-14 | 2013-04-30 | The Trustees Of Columbia University In The City Of New York | Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair |
WO2006032054A2 (en) * | 2004-09-14 | 2006-03-23 | The Trustees Of Columbia University In The City Of New York | Differentiation of human mesenchymal stem cells to cardiac progenitor cells that promote cardiac repair |
CA2613529A1 (en) * | 2005-06-22 | 2007-01-04 | Geron Corporation | Reporter hepatocytes and other cells for drug screening and toxicity testing |
US20060292694A1 (en) * | 2005-06-22 | 2006-12-28 | Roslin Institute | Reporter hepatocytes and other cells for drug screening and toxicity testing |
US20060292695A1 (en) * | 2005-06-22 | 2006-12-28 | Roslin Institute | Methods and kits for drug screening and toxicity testing using promoter-reporter cells derived from embryonic stem cells |
US9155762B2 (en) * | 2005-12-08 | 2015-10-13 | University Of Louisville Research Foundation, Inc. | Uses and isolation of stem cells from bone marrow |
PL2535403T3 (pl) * | 2005-12-08 | 2019-10-31 | Univ Louisville Res Found Inc | Bardzo małe komórki macierzyste typu embrionalnego (VSEL) oraz sposoby ich izolowania i zastosowania |
WO2007084585A2 (en) * | 2006-01-19 | 2007-07-26 | Magee-Womans Health Corporation | Non-human primate embryonic stem and germ cells: methods of use and methods of making same |
GB0911060D0 (en) | 2009-06-26 | 2009-08-12 | Ge Healthcare Uk Ltd | Methods for predicting the toxicity of a chemical |
WO2011115993A2 (en) * | 2010-03-15 | 2011-09-22 | The Johns Hopkins University | Method for determining substance non-toxicity |
JP5814337B2 (ja) * | 2010-03-22 | 2015-11-17 | ステミナ バイオマーカー ディスカバリー, インコーポレイテッド | ヒト幹細胞様細胞及びメタボロミクスを使用した医薬のヒト発生毒性の予測 |
RU2685914C1 (ru) | 2013-12-11 | 2019-04-23 | Регенерон Фармасьютикалс, Инк. | Способы и композиции для направленной модификации генома |
WO2021015611A1 (en) * | 2019-07-19 | 2021-01-28 | Toxys B.V. | Methods to determine the effect of an agent on mammalian embryonic development. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4744909A (en) * | 1987-02-02 | 1988-05-17 | Vertech Treatment Systems, Inc. | Method of effecting accelerated oxidation reaction |
EP0390857A4 (en) * | 1987-12-15 | 1991-04-17 | The Trustees Of Princeton University | Transgenic testing systems for mutagens and carcinogens |
EP0370813A3 (en) * | 1988-11-25 | 1991-06-19 | Exemplar Corporation | Rapid screening mutagenesis and teratogenesis assay |
US5346812A (en) * | 1989-09-07 | 1994-09-13 | The University Of Miami | Teratogen assay |
-
1995
- 1995-06-28 DE DE19525285A patent/DE19525285C2/de not_active Expired - Fee Related
-
1996
- 1996-06-27 DK DK96922735T patent/DK0835325T3/da active
- 1996-06-27 DE DE59606520T patent/DE59606520D1/de not_active Expired - Fee Related
- 1996-06-27 AT AT96922735T patent/ATE199400T1/de not_active IP Right Cessation
- 1996-06-27 WO PCT/DE1996/001183 patent/WO1997001644A1/de active IP Right Grant
- 1996-06-27 US US08/983,147 patent/US6007993A/en not_active Expired - Fee Related
- 1996-06-27 EP EP96922735A patent/EP0835325B1/de not_active Expired - Lifetime
- 1996-06-27 ES ES96922735T patent/ES2156283T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE59606520D1 (de) | 2001-04-05 |
EP0835325B1 (de) | 2001-02-28 |
DE19525285A1 (de) | 1997-01-02 |
WO1997001644A1 (de) | 1997-01-16 |
DE19525285C2 (de) | 1999-04-15 |
ES2156283T3 (es) | 2001-06-16 |
ATE199400T1 (de) | 2001-03-15 |
US6007993A (en) | 1999-12-28 |
EP0835325A1 (de) | 1998-04-15 |
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