DK0835133T3 - Rekombinant koppevirus-rabies-præparater og kombinationspræparater samt anvendelser deraf - Google Patents

Rekombinant koppevirus-rabies-præparater og kombinationspræparater samt anvendelser deraf

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Publication number
DK0835133T3
DK0835133T3 DK96922173T DK96922173T DK0835133T3 DK 0835133 T3 DK0835133 T3 DK 0835133T3 DK 96922173 T DK96922173 T DK 96922173T DK 96922173 T DK96922173 T DK 96922173T DK 0835133 T3 DK0835133 T3 DK 0835133T3
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Prior art keywords
recombinant viruses
compositions
smallpox virus
combination preparations
virus rabies
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DK96922173T
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Danish (da)
English (en)
Inventor
Enzo Paoletti
Joanne Maki
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Connaught Technology Corp
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DK96922173T 1995-06-07 1996-06-03 Rekombinant koppevirus-rabies-præparater og kombinationspræparater samt anvendelser deraf DK0835133T3 (da)

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US08/486,969 US5843456A (en) 1991-03-07 1995-06-07 Alvac poxvirus-rabies compositions and combination compositions and uses
PCT/IB1996/000715 WO1996040241A1 (en) 1995-06-07 1996-06-03 Recombinant poxvirus-rabies compositions and combination compositions and uses

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Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767449B1 (en) 1981-12-24 2010-08-03 Health Research Incorporated Methods using modified vaccinia virus
US5505941A (en) * 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
US7374768B1 (en) 1990-09-25 2008-05-20 Xenova Research Limited Viral vaccines
US6309647B1 (en) * 1999-07-15 2001-10-30 Aventis Pasteur Poxvirus—canine dispemper virus (CDV) or measles virus recombinants and compositions and methods employing the recombinants
DE69229390T2 (de) * 1991-08-26 1999-11-11 Immuno Ag, Wien Direkt molekuläre Klonierung eines modifizierten Genoms eines Chordopocken-Virus
AU694519B2 (en) * 1994-04-29 1998-07-23 Immuno Aktiengesellschaft Recombinant poxviruses with foreign polynucleotides in essential regions
FR2750865B1 (fr) * 1996-06-27 1998-12-04 Rhone Merieux Vaccin vivant recombinant a base d'herpesvirus canin, notamment contre la maladie de carre, la rage ou le virus parainfluenza de type 2
US7294338B2 (en) * 1996-07-19 2007-11-13 Merial Polynucleotide vaccine formula against canine pathologies, in particular respiratory and digestive pathologies
US6368603B1 (en) * 1997-03-05 2002-04-09 Merial Limited Lyme combination compositions and uses
US6517843B1 (en) 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
FR2775601B1 (fr) * 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
JP4540033B2 (ja) 1999-10-22 2010-09-08 サノフィ パストゥール リミテッド 腫瘍抗原に対する免疫応答を誘発および／または増強する方法
DK1248646T3 (da) * 1999-12-21 2008-05-19 Merial Sas Præparater og vacciner indeholdende antigen(er) fra cryptosporidium parvum og fra andet enterisk patogen
US20030027246A1 (en) * 2000-03-31 2003-02-06 Artur Pedyczak Immunogenic peptides derived from prostate-specific membrane antigen (PSMA) and uses thereof
ATE513913T1 (de) 2000-05-10 2011-07-15 Sanofi Pasteur Ltd Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen
US7097842B2 (en) * 2000-11-23 2006-08-29 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
US7628980B2 (en) * 2000-11-23 2009-12-08 Bavarian Nordic A/S Modified vaccinia virus ankara for the vaccination of neonates
WO2002042480A2 (en) * 2000-11-23 2002-05-30 Bavarian Nordic A/S Modified vaccinia ankara virus variant
FR2823222B1 (fr) 2001-04-06 2004-02-06 Merial Sas Vaccin contre le virus de la fievre du nil
US20030228327A1 (en) * 2001-11-05 2003-12-11 Lasher Alfred W. DNA-based plasmid formulations and vaccines and prophylactics containing the same
US20070269456A1 (en) * 2001-11-05 2007-11-22 Lasher Alfred W DNA-based plasmid formulations and vaccines and prophylactics containing the same
NZ547776A (en) * 2002-04-19 2009-08-28 Bavarian Nordic As Modified vaccinia virus ankara for protecting an animal against an antigen or self-protein
US8088889B2 (en) 2002-05-02 2012-01-03 David Lovejoy Teneurin c-terminal associated peptides (TCAP) and uses thereof
PT1434858E (pt) * 2002-09-05 2008-07-28 Bavarian Nordic As Método de amplificação de um poxvírus em condições sem soro
CA2510229A1 (en) * 2002-12-13 2004-07-08 Aventis Pasteur, Inc. Production of alvac on avian embryonic stem cells
US8663622B2 (en) * 2002-12-16 2014-03-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Recombinant vaccine viruses expressing IL-15 and methods using the same
US7468273B2 (en) 2003-05-01 2008-12-23 Meial Limited Canine GHRH gene, polypeptides and methods of use
WO2004110482A1 (en) * 2003-06-13 2004-12-23 Isis Innovation Limited Improved vaccines
WO2005012526A1 (en) 2003-08-04 2005-02-10 The Hospital For Sick Children Lafora's disease gene
US20050214316A1 (en) 2003-11-13 2005-09-29 Brown Thomas P Methods of characterizing infectious bursal disease virus
CA2580305A1 (en) * 2004-06-02 2005-12-15 The Governors Of The University Of Alberta Polymer based nano-carriers for the solubilization and delivery of hydrophobic drugs
US7998733B2 (en) 2004-10-05 2011-08-16 Merial Limited Chimeric vectors
ES2343270T3 (es) * 2005-04-25 2010-07-27 Merial Ltd. Vacunas contra el virus nipah.
US20080241184A1 (en) 2005-08-25 2008-10-02 Jules Maarten Minke Canine influenza vaccines
US7771995B2 (en) 2005-11-14 2010-08-10 Merial Limited Plasmid encoding human BMP-7
CA2629522A1 (en) 2005-11-14 2007-05-18 Merial Limited Gene therapy for renal failure
CA2647566C (en) 2006-03-29 2017-01-03 Merial Limited Vaccine against streptococci
US7682619B2 (en) 2006-04-06 2010-03-23 Cornell Research Foundation, Inc. Canine influenza virus
US7862821B2 (en) 2006-06-01 2011-01-04 Merial Limited Recombinant vaccine against bluetongue virus
KR20100014290A (ko) 2006-11-30 2010-02-10 더 유니버시티 오브 브리티쉬 콜럼비아 분자 아주반트로서 ｔａｐ―１ 및/또는 ｔａｐ―２를 포함하는 폭스비리대 치료
JP2010525812A (ja) 2007-05-02 2010-07-29 メリアル リミテッド 発現及び安定性が改善されたｄｎａプラスミド
MX2010012069A (es) 2008-05-08 2010-12-14 Merial Ltd Vacuna de la leishmaniasis con el uso del inmunogeno salival de la mosca de la arena.
CA2765298A1 (en) 2008-06-27 2009-12-30 University Of Guelph Probiotic bacterial molecules and their use in methods to treat/prevent infection by harmful bacteria and to provide nutritional health
US8168200B2 (en) 2008-10-24 2012-05-01 Merial Limited Vaccine against african horse sickness virus
WO2012129295A1 (en) 2011-03-21 2012-09-27 Vaxin Inc. Rapid and prolonged immunologic-therapeutic
WO2012145577A1 (en) 2011-04-20 2012-10-26 Merial Limited Adjuvanted rabies vaccine with improved viscosity profile
ES2674439T3 (es) 2011-06-01 2018-06-29 Merial, Inc. Administración sin aguja de vacunas contra el VSRRP
AU2012284558B2 (en) 2011-07-20 2017-06-29 Centre National De La Recherche Scientifique Recombinant feline leukemia virus vaccine containing optimized feline leukemia virus envelope gene
LT2741740T (lt) 2011-08-12 2017-08-10 Merial, Inc. Biologinių produktų, ypatingai vakcinų, vakuuminis konservavimas
US9402894B2 (en) 2011-10-27 2016-08-02 International Aids Vaccine Initiative Viral particles derived from an enveloped virus
CN104203271B (zh) 2012-02-14 2017-08-25 梅里亚股份有限公司 表达狂犬病病毒和ox40蛋白的重组痘病毒载体及从其制造的疫苗
SG11201405847SA (en) 2012-03-20 2014-10-30 Merial Inc Recombinant equine herpesvirus-1 vaccine containing mutated glycoprotein c and uses thereof
CN105026422B (zh) 2012-03-27 2019-09-27 西安大略大学 Sh2结构域变体
US9347065B2 (en) 2012-03-29 2016-05-24 International Aids Vaccine Initiative Methods to improve vector expression and genetic stability
WO2014141244A1 (en) 2013-03-12 2014-09-18 Tel Hashomer Medical Research Infrastructure And Services Ltd. Synthetic peptides for the treatment of autoimmune diseases
AU2015343369B2 (en) 2014-11-03 2018-11-22 Georgia Tech Research Corporation Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus
EP3042666A1 (en) 2015-01-06 2016-07-13 Rheinisch-Westfälische Technische Hochschule Aachen ITIH5 fragments for the treatment of cancer
EP3288546B1 (en) 2015-04-28 2021-12-15 Avivagen Inc. Oxidized carotenoids and components thereof for preventing necrotic enteritis
US20210299245A1 (en) * 2020-03-31 2021-09-30 Sementis Limited Attenuated poxvirus vector based vaccine for protection against covid-19
CN116656730B (zh) * 2023-05-25 2024-03-19 军事科学院军事医学研究院军事兽医研究所 一种表达狂犬病病毒g、m蛋白的重组金丝雀痘病毒及其构建方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU672359B2 (en) * 1991-03-07 1996-10-03 Virogenetics Corporation Genetically engineered vaccine strain
US5349741A (en) * 1992-06-24 1994-09-27 L.H. Carbide Corporation Method of making an interlocked core spaced for anneal penetration

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WO1996040241A1 (en) 1996-12-19
EP0835133B1 (en) 2008-08-13
CA2223416A1 (en) 1996-12-19
ES2314980T3 (es) 2009-03-16
EP0835133A1 (en) 1998-04-15
DE69637642D1 (de) 2008-09-25
AU711472B2 (en) 1999-10-14
JP4140862B2 (ja) 2008-08-27
PT835133E (pt) 2008-11-19
US5843456A (en) 1998-12-01
JP2000500115A (ja) 2000-01-11
EP0835133A4 (en) 2003-01-02
AU6314996A (en) 1996-12-30
ATE404220T1 (de) 2008-08-15

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