DK0805156T3 - 8-alkoxyquinoloncarboxylsyrehydrat med fremragende stabilitet og fremgangsmåde til fremstilling af samme - Google Patents

8-alkoxyquinoloncarboxylsyrehydrat med fremragende stabilitet og fremgangsmåde til fremstilling af samme

Info

Publication number
DK0805156T3
DK0805156T3 DK95938644T DK95938644T DK0805156T3 DK 0805156 T3 DK0805156 T3 DK 0805156T3 DK 95938644 T DK95938644 T DK 95938644T DK 95938644 T DK95938644 T DK 95938644T DK 0805156 T3 DK0805156 T3 DK 0805156T3
Authority
DK
Denmark
Prior art keywords
excellent stability
alkoxyquinolone
carboxylic acid
acid hydrate
preparing same
Prior art date
Application number
DK95938644T
Other languages
Danish (da)
English (en)
Inventor
Toyomi Matsumoto
Masamoto Hara
Kunio Miyashita
Yukihiro Kato
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18290056&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0805156(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Application granted granted Critical
Publication of DK0805156T3 publication Critical patent/DK0805156T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
DK95938644T 1994-12-21 1995-12-05 8-alkoxyquinoloncarboxylsyrehydrat med fremragende stabilitet og fremgangsmåde til fremstilling af samme DK0805156T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33556994A JP3449658B2 (ja) 1994-12-21 1994-12-21 安定性に優れた８−アルコキシキノロンカルボン酸水和物並びにその製造方法
PCT/JP1995/002477 WO1996019472A1 (fr) 1994-12-21 1995-12-05 Hydrate d'acide 8-alcoxyquinolonecarboxylique ayant une excellente stabilite et procede de fabrication

Publications (1)

Publication Number Publication Date
DK0805156T3 true DK0805156T3 (da) 2002-05-06

Family

ID=18290056

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95938644T DK0805156T3 (da) 1994-12-21 1995-12-05 8-alkoxyquinoloncarboxylsyrehydrat med fremragende stabilitet og fremgangsmåde til fremstilling af samme

Country Status (15)

Country Link
US (1) US5880283A (hu)
EP (1) EP0805156B1 (hu)
JP (1) JP3449658B2 (hu)
KR (1) KR100381644B1 (hu)
CN (1) CN1137890C (hu)
AT (1) ATE216381T1 (hu)
AU (1) AU694946B2 (hu)
CA (1) CA2208704C (hu)
DE (1) DE69526453T2 (hu)
DK (1) DK0805156T3 (hu)
ES (1) ES2173982T3 (hu)
HU (1) HU227795B1 (hu)
PT (1) PT805156E (hu)
TW (1) TW393479B (hu)
WO (1) WO1996019472A1 (hu)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9820405D0 (en) 1998-09-18 1998-11-11 Smithkline Beecham Plc Process
GB9920919D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel compound
GB9920917D0 (en) 1999-09-03 1999-11-10 Sb Pharmco Inc Novel process
TWI287987B (en) * 2000-08-14 2007-10-11 Senju Pharma Co Cytokine inhibitor
US6413969B1 (en) * 2000-09-13 2002-07-02 Bristol-Myers Squibb Company Gatifloxacin pentahydrate
JP2002363172A (ja) * 2001-06-05 2002-12-18 Showa Denko Kk ５−アルキルオキサゾリジン−２，４−ジオンの製造方法
US6589955B2 (en) 2001-06-20 2003-07-08 Bristol-Myers Squibb Company Pediatric formulation of gatifloxacin
ES2248743T3 (es) * 2002-04-08 2006-03-16 Dr. Reddy's Laboratories Ltd. Formas cristalinas anhidras i y ii del acido 1-ciclopropil-6-fluoro-8-metoxi-7-(-3-metil-1-piperazinil)-4-oxo-1,4-dihidroquinolin-3-carboxilico (gatifloxacina).
KR100517638B1 (ko) 2002-04-08 2005-09-28 주식회사 엘지생명과학 게미플록사신 산염의 새로운 제조방법
EP1645274A1 (en) * 2002-05-10 2006-04-12 Teva Pharmaceutical Industries Ltd. Process for making gatifloxacin form omega
US7423153B2 (en) * 2002-05-10 2008-09-09 Teva Pharmaceutical Industries Ltd. Crystalline forms of gatifloxacin
CN1665504A (zh) * 2002-05-10 2005-09-07 特瓦制药工业有限公司 新晶型的加替沙星
CN1674902A (zh) 2002-06-14 2005-09-28 特瓦制药工业有限公司 新晶型的加替沙星
EP1545530A1 (en) * 2002-08-06 2005-06-29 Teva Pharmaceutical Industries Limited Novel crystalline forms of gatifloxacin
WO2004069825A1 (en) * 2002-08-14 2004-08-19 Teva Pharmaceutical Industries Ltd. Synthesis of gatifloxacin
WO2004054583A1 (en) * 2002-12-12 2004-07-01 Teva Pharmaceutical Industries Ltd. Crystalline forms of gatifloxacin and processes for preparation
WO2004087688A1 (en) * 2003-04-02 2004-10-14 Hetero Drugs Limited Novel crystalline forms of gatifloxacin
WO2004101547A1 (en) * 2003-05-19 2004-11-25 Hetero Drugs Limited Purification methods of gatifloxacin and a novel form of gatifloxacin
WO2005021000A1 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Solid oral dosage forms of gatifloxacin
ES2232310B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Formula cristalina no higroscopica de gatifloxacino.
ES2232311B1 (es) * 2003-11-13 2006-08-01 Quimica Sintetica, S.A. Forma cristalina de gatifloxacino.
US7781585B2 (en) 2004-06-04 2010-08-24 Matrix Laboratories Ltd Crystalline forms of Gatifloxacin
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US20060247255A1 (en) * 2005-05-02 2006-11-02 Patel Satishkumar A Method for preparing a stable gatifloxacin composition
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
CA2621616A1 (en) * 2007-02-19 2008-08-19 Alcon Research, Ltd. Topical gatifloxacin formulations
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US7884099B2 (en) * 2007-11-16 2011-02-08 Cumbre Ip Ventures, L.P. Quinolone carboxylic acid-substituted rifamycin derivatives
WO2011054182A1 (zh) * 2009-11-03 2011-05-12 Liu Li 丹参酮ⅱa磺酸钠水合物及其制备方法和用途
CN102757419B (zh) * 2012-08-08 2015-03-11 四川百利药业有限责任公司 一种加替沙星的纯化方法
EP3496662A4 (en) 2016-08-12 2019-10-30 Silk Technologies Ltd. PROTEIN DERIVED FROM SILK FOR THE TREATMENT OF INFLAMMATION

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
JPS57134482A (en) * 1981-02-13 1982-08-19 Dainippon Pharmaceut Co Ltd 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8- naphthyridine-3-carboxylic acid-3/2 hydrate and its preparation
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
NO871333L (no) * 1986-03-31 1987-10-01 Sankyo Co Kinolin-3-karboksylsyrederivater, fremgangsmaate til fremstilling og anvendelse derav.
JPS63198664A (ja) * 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
ATE207479T1 (de) * 1992-01-31 2001-11-15 Chugai Pharmaceutical Co Ltd Kristalle von derivaten von chinozon carbonsäure- hydraten

Also Published As

Publication number Publication date
CA2208704A1 (en) 1996-06-27
US5880283A (en) 1999-03-09
WO1996019472A1 (fr) 1996-06-27
AU694946B2 (en) 1998-08-06
ATE216381T1 (de) 2002-05-15
EP0805156A4 (en) 1998-04-15
DE69526453T2 (de) 2002-12-12
AU3994695A (en) 1996-07-10
TW393479B (en) 2000-06-11
CA2208704C (en) 2005-05-03
JP3449658B2 (ja) 2003-09-22
JPH08176143A (ja) 1996-07-09
ES2173982T3 (es) 2002-11-01
HU227795B1 (en) 2012-03-28
EP0805156A1 (en) 1997-11-05
DE69526453D1 (de) 2002-05-23
CN1171108A (zh) 1998-01-21
EP0805156B1 (en) 2002-04-17
HUT77945A (hu) 1998-12-28
KR100381644B1 (ko) 2003-08-30
PT805156E (pt) 2002-09-30
CN1137890C (zh) 2004-02-11

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