Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abbott Japan Co Ltd
Original Assignee
Hokuriku Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Hokuriku Pharmaceutical Co LtdfiledCriticalHokuriku Pharmaceutical Co Ltd
Priority to JP22643587ApriorityCriticalpatent/JPS6470484A/en
Publication of JPS6470484ApublicationCriticalpatent/JPS6470484A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I (R1 is H, lower alkyl, lower alkanoyl or halogeno-lower alkanoyl; R is H or Cl) and salt thereof. EXAMPLE:1-Cyclopropyl-6-fluoro-7-( 3-fluoromethyl-1-piperazinyl )-1, 4-dihydro-4- oxoquinoline-3-carboxylic acid.hydrochloride. USE:An antimicrobial agent. PREPARATION:A 7-halogenoquinoline-3-carboxylic acid derivative expressed by formula II (X is halogen) [e.g. 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4- oxoquinolie-3-carb-oxylic acid) is reacted with a piperazine derivative expressed by formula III (e.g. 2-fluoromethylpiperazine), as necessary, in the presence of a solvent and a base as a deacidifying agent.
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)-quinoline-3-carboxylic acids and their derivatives,their preparation and antibacterial agents containing them
Quinolinecarboxylic acid derivatives, a composition comprising the same, process for preparing the same, and the use of the same for the manufacture of medicaments