DK0784634T3 - Modificerede radioantistoffragmenter til reduceret nyreoptagelse - Google Patents

Modificerede radioantistoffragmenter til reduceret nyreoptagelse

Info

Publication number
DK0784634T3
DK0784634T3 DK95934406T DK95934406T DK0784634T3 DK 0784634 T3 DK0784634 T3 DK 0784634T3 DK 95934406 T DK95934406 T DK 95934406T DK 95934406 T DK95934406 T DK 95934406T DK 0784634 T3 DK0784634 T3 DK 0784634T3
Authority
DK
Denmark
Prior art keywords
antibody fragments
reduced kidney
kidney uptake
modified radio
modified
Prior art date
Application number
DK95934406T
Other languages
English (en)
Inventor
Gary L Griffiths
Hans J Hansen
Habibe Karacay
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Application granted granted Critical
Publication of DK0784634T3 publication Critical patent/DK0784634T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK95934406T 1994-09-20 1995-09-18 Modificerede radioantistoffragmenter til reduceret nyreoptagelse DK0784634T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/309,319 US5670132A (en) 1994-09-20 1994-09-20 Modified radioantibody fragments for reduced renal uptake
PCT/US1995/011406 WO1996009325A1 (en) 1994-09-20 1995-09-18 Modified radioantibody fragments for reduced renal uptake

Publications (1)

Publication Number Publication Date
DK0784634T3 true DK0784634T3 (da) 2003-03-10

Family

ID=23197701

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95934406T DK0784634T3 (da) 1994-09-20 1995-09-18 Modificerede radioantistoffragmenter til reduceret nyreoptagelse

Country Status (11)

Country Link
US (1) US5670132A (da)
EP (1) EP0784634B1 (da)
JP (1) JPH10508832A (da)
AT (1) ATE229035T1 (da)
AU (1) AU3674995A (da)
CA (1) CA2200482C (da)
DE (1) DE69529084T2 (da)
DK (1) DK0784634T3 (da)
ES (1) ES2188671T3 (da)
IL (1) IL115255A (da)
WO (1) WO1996009325A1 (da)

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US7005504B2 (en) * 1998-01-22 2006-02-28 Genentech, Inc. Antibody fragment-peg conjugates
US6468532B1 (en) 1998-01-22 2002-10-22 Genentech, Inc. Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates
US6458355B1 (en) 1998-01-22 2002-10-01 Genentech, Inc. Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
US6333396B1 (en) 1998-10-20 2001-12-25 Enzon, Inc. Method for targeted delivery of nucleic acids
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US6773916B1 (en) * 1999-01-05 2004-08-10 The Flinders University Of South Australia Agents and methods for treatment and diagnosis of ocular disorders
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
BRPI0111220B8 (pt) * 2000-06-02 2021-07-27 Univ Texas conjugados de fármacos com etilenodicisteína (ec)
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
EP1389090A2 (en) * 2001-04-26 2004-02-18 Board of Regents, The University of Texas System Diagnostic imaging compositions, their methods of synthesis and use
US20040068100A1 (en) * 2001-05-24 2004-04-08 Jean-Pierre Mach Multicomponent conjugates which bind to target molecules and stimulate cell lysis
US20040143094A1 (en) * 2003-02-10 2004-07-22 Alena Donda Multicomponent conjugates which bind to target molecules and stimulate T cell lysis
US7261875B2 (en) * 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
AU2003251238A1 (en) * 2002-08-07 2004-02-25 Umc Utrecht Holding B.V. Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha
DE10237317B4 (de) * 2002-08-15 2010-04-08 3M Espe Ag Enzymhaltige Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung
CA2505537A1 (en) * 2002-11-07 2004-05-27 Board Of Regents, The University Of Texas System Ethylenedicysteine (ec)-drug conjugates, compositions and methods for tissue specific disease imaging
JP2006517789A (ja) * 2003-01-10 2006-08-03 アブリンクス エン．ヴェー． 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用
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US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
CA2554729A1 (en) * 2004-01-27 2005-08-11 University Of Southern California Polymer-bound antibody cancer therapeutic agent
EP1600141B1 (en) * 2004-05-24 2013-04-17 3M Deutschland GmbH Collagenolytic active enzyme containing compositions for the treatment of dental caries
AU2006205900B8 (en) * 2005-01-14 2012-04-05 Ablynx N.V. Methods and assays for distinguishing between different forms of diseases and disorders characterized by thrombocytopenia and/or by spontaneous interaction between Von Willebrand Factor (vWF) and platelets
CA2960105A1 (en) * 2005-05-20 2006-11-23 Ablynx Nv Single domain vhh antibodies against von willebrand factor
EP1754464A1 (en) * 2005-08-17 2007-02-21 3M Innovative Properties Company Enzyme comprising dental composition
SI1986612T1 (sl) * 2006-02-07 2013-01-31 Shire Human Genetic Therapies, Inc. Stabilizirana spojina glukocerebrosidaze
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
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US10925977B2 (en) * 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
US11197916B2 (en) 2007-12-28 2021-12-14 Takeda Pharmaceutical Company Limited Lyophilized recombinant VWF formulations
EP2244814B1 (en) * 2007-12-28 2021-06-02 Takeda Pharmaceutical Company Limited Recombinant vwf formulations
CA2718081A1 (en) * 2008-03-21 2009-09-24 Ablynx Nv Von willebrand factor specific binders and methods of use therefor
NZ592704A (en) 2008-10-21 2013-02-22 Baxter Int Lyophilized recombinant von willebrand factor (rVWF) formulation comprising buffering agents, amino acids, stabilising agents and surfactants
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WO2013003555A1 (en) 2011-06-28 2013-01-03 Whitehead Institute For Biomedical Research Using sortases to install click chemistry handles for protein ligation
KR20140138850A (ko) 2012-03-02 2014-12-04 샤이어 휴먼 지네틱 테라피즈 인크. Ｉｉｉ형 고셔병을 치료하기 위한 조성물 및 방법
ES2901383T3 (es) 2013-05-10 2022-03-22 Whitehead Inst Biomedical Res Producción in vitro de glóbulos rojos con proteínas marcables con sortasa
US10260038B2 (en) 2013-05-10 2019-04-16 Whitehead Institute For Biomedical Research Protein modification of living cells using sortase
US10556024B2 (en) 2013-11-13 2020-02-11 Whitehead Institute For Biomedical Research 18F labeling of proteins using sortases
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Also Published As

Publication number Publication date
CA2200482A1 (en) 1996-03-28
WO1996009325A1 (en) 1996-03-28
EP0784634A4 (en) 1999-08-04
IL115255A (en) 1999-08-17
EP0784634B1 (en) 2002-12-04
AU3674995A (en) 1996-04-09
CA2200482C (en) 2001-01-30
ATE229035T1 (de) 2002-12-15
ES2188671T3 (es) 2003-07-01
IL115255A0 (en) 1995-12-31
US5670132A (en) 1997-09-23
DE69529084T2 (de) 2003-08-21
EP0784634A1 (en) 1997-07-23
JPH10508832A (ja) 1998-09-02
DE69529084D1 (de) 2003-01-16

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