ATE229035T1 - Modifiziertes radio-antikörper fragment zur reduzierten renalen aufnahme - Google Patents

Modifiziertes radio-antikörper fragment zur reduzierten renalen aufnahme

Info

Publication number
ATE229035T1
ATE229035T1 AT95934406T AT95934406T ATE229035T1 AT E229035 T1 ATE229035 T1 AT E229035T1 AT 95934406 T AT95934406 T AT 95934406T AT 95934406 T AT95934406 T AT 95934406T AT E229035 T1 ATE229035 T1 AT E229035T1
Authority
AT
Austria
Prior art keywords
antibodie
fragment
renal uptake
reduced renal
modified radio
Prior art date
Application number
AT95934406T
Other languages
English (en)
Inventor
Gary L Griffiths
Hans J Hansen
Habibe Karacay
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Application granted granted Critical
Publication of ATE229035T1 publication Critical patent/ATE229035T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT95934406T 1994-09-20 1995-09-18 Modifiziertes radio-antikörper fragment zur reduzierten renalen aufnahme ATE229035T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/309,319 US5670132A (en) 1994-09-20 1994-09-20 Modified radioantibody fragments for reduced renal uptake
PCT/US1995/011406 WO1996009325A1 (en) 1994-09-20 1995-09-18 Modified radioantibody fragments for reduced renal uptake

Publications (1)

Publication Number Publication Date
ATE229035T1 true ATE229035T1 (de) 2002-12-15

Family

ID=23197701

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95934406T ATE229035T1 (de) 1994-09-20 1995-09-18 Modifiziertes radio-antikörper fragment zur reduzierten renalen aufnahme

Country Status (11)

Country Link
US (1) US5670132A (de)
EP (1) EP0784634B1 (de)
JP (1) JPH10508832A (de)
AT (1) ATE229035T1 (de)
AU (1) AU3674995A (de)
CA (1) CA2200482C (de)
DE (1) DE69529084T2 (de)
DK (1) DK0784634T3 (de)
ES (1) ES2188671T3 (de)
IL (1) IL115255A (de)
WO (1) WO1996009325A1 (de)

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US7005504B2 (en) * 1998-01-22 2006-02-28 Genentech, Inc. Antibody fragment-peg conjugates
US6333396B1 (en) 1998-10-20 2001-12-25 Enzon, Inc. Method for targeted delivery of nucleic acids
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US6773916B1 (en) * 1999-01-05 2004-08-10 The Flinders University Of South Australia Agents and methods for treatment and diagnosis of ocular disorders
US7067111B1 (en) 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
EP2316494A1 (de) * 2000-06-02 2011-05-04 Board Of Regents, The University Of Texas Ethylenedicysteine (EC)-Neomycin Konjugate und deren Verwendung in Imaging
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
US20030003048A1 (en) * 2001-04-26 2003-01-02 Chun Li Diagnostic imaging compositions, their methods of synthesis and use
US20040143094A1 (en) * 2003-02-10 2004-07-22 Alena Donda Multicomponent conjugates which bind to target molecules and stimulate T cell lysis
US20040068100A1 (en) * 2001-05-24 2004-04-08 Jean-Pierre Mach Multicomponent conjugates which bind to target molecules and stimulate cell lysis
US7261875B2 (en) * 2001-12-21 2007-08-28 Board Of Regents, The University Of Texas System Dendritic poly (amino acid) carriers and methods of use
EP1527346B1 (de) * 2002-08-07 2011-06-08 Ablynx N.V. Modulation der blutplättchen-adhäsion basierend auf dem oberflächen-exponierten beta-switch loop des blutplättchen-glycoproteins ib-alpha
DE10237317B4 (de) * 2002-08-15 2010-04-08 3M Espe Ag Enzymhaltige Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung
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EP2390270A1 (de) 2003-01-10 2011-11-30 Ablynx N.V. Therapeutische Polypeptide, Homologe davon, Fragmente davon und Verwendung bei modulierender plättchenvermittelter Aggregation
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GB2409456B (en) * 2003-10-30 2006-01-04 Proimmune Ltd Oligomeric receptor ligand pair member complexes
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US20050214286A1 (en) * 2004-01-27 2005-09-29 University Of Southern California Polymer-bound antibody cancer therapeutic agent
EP1600141B1 (de) * 2004-05-24 2013-04-17 3M Deutschland GmbH Zusammensetzungen mit kollagenolytisch aktivem Enzym zur Behandlung von Karies
CA2593328C (en) * 2005-01-14 2018-02-06 Ablynx N.V. Methods and assays for distinguishing between different forms of diseases and disorders characterized by thrombocytopenia and/or by spontaneous interaction between von willebrand factor (vwf) and platelets
US7807162B2 (en) * 2005-05-20 2010-10-05 Ablynx N.V. Single domain VHH antibodies against von Willebrand factor
EP1754464A1 (de) * 2005-08-17 2007-02-21 3M Innovative Properties Company Enzym-haltige Zusammensetzung für den dentalen Gebrauch
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US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
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US10925977B2 (en) 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
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US20110158996A1 (en) * 2008-03-21 2011-06-30 Ablynx N.V. Von willebrand factor specific binders and methods of use therefor
PT2349314E (pt) * 2008-10-21 2013-05-28 Baxter Int Formulações de vwf recombinante liofilizado
AU2010281403B2 (en) 2009-07-28 2016-03-10 Takeda Pharmaceutical Company Limited Compositions and methods for treating Gaucher disease
JP2014525904A (ja) 2011-06-28 2014-10-02 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ タンパク質連結用クリックケミストリーハンドルを設置するためのソルターゼの使用
EP2863941B1 (de) 2012-03-02 2018-12-19 Shire Human Genetic Therapies, Inc. Velaglucerase zur behandlung von morbus gaucher typ iii
JP6603209B2 (ja) 2013-05-10 2019-11-06 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ ソルターゼ（Ｓｏｒｔａｓｅ）を用いた生存細胞のタンパク質修飾
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Also Published As

Publication number Publication date
EP0784634B1 (de) 2002-12-04
WO1996009325A1 (en) 1996-03-28
IL115255A (en) 1999-08-17
IL115255A0 (en) 1995-12-31
EP0784634A4 (de) 1999-08-04
EP0784634A1 (de) 1997-07-23
ES2188671T3 (es) 2003-07-01
DK0784634T3 (da) 2003-03-10
DE69529084T2 (de) 2003-08-21
US5670132A (en) 1997-09-23
JPH10508832A (ja) 1998-09-02
DE69529084D1 (de) 2003-01-16
CA2200482C (en) 2001-01-30
AU3674995A (en) 1996-04-09
CA2200482A1 (en) 1996-03-28

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