DK0775745T3 - Cathepsin G-inhiberende aptamerer - Google Patents

Cathepsin G-inhiberende aptamerer

Info

Publication number
DK0775745T3
DK0775745T3 DK96118661T DK96118661T DK0775745T3 DK 0775745 T3 DK0775745 T3 DK 0775745T3 DK 96118661 T DK96118661 T DK 96118661T DK 96118661 T DK96118661 T DK 96118661T DK 0775745 T3 DK0775745 T3 DK 0775745T3
Authority
DK
Denmark
Prior art keywords
cathepsin
aptamers
inhibitory aptamers
nucleotides
inhibitory
Prior art date
Application number
DK96118661T
Other languages
Danish (da)
English (en)
Inventor
Franzpeter Bracht
Karsten Prof Dr Med Schroer
Original Assignee
Gentium Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentium Spa filed Critical Gentium Spa
Application granted granted Critical
Publication of DK0775745T3 publication Critical patent/DK0775745T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
DK96118661T 1995-11-24 1996-11-21 Cathepsin G-inhiberende aptamerer DK0775745T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19543750A DE19543750C2 (de) 1995-11-24 1995-11-24 Cathepsin G inhibierende Aptamere

Publications (1)

Publication Number Publication Date
DK0775745T3 true DK0775745T3 (da) 2004-06-01

Family

ID=7778263

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96118661T DK0775745T3 (da) 1995-11-24 1996-11-21 Cathepsin G-inhiberende aptamerer

Country Status (8)

Country Link
US (1) US5780449A (fr)
EP (1) EP0775745B1 (fr)
JP (1) JP4257939B2 (fr)
AT (1) ATE258597T1 (fr)
DE (2) DE19543750C2 (fr)
DK (1) DK0775745T3 (fr)
ES (1) ES2217297T3 (fr)
PT (1) PT775745E (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6682886B1 (en) * 1994-04-28 2004-01-27 Gilead Sciences, Inc. Bivalent binding molecules of 7 transmembrane G protein-coupled receptors
WO1999050462A1 (fr) * 1998-03-27 1999-10-07 President And Fellows Of Harvard College Systemes d'inhibition bacteriens a base d'aptameres (abbis)
US6458559B1 (en) 1998-04-22 2002-10-01 Cornell Research Foundation, Inc. Multivalent RNA aptamers and their expression in multicellular organisms
DE19916417A1 (de) * 1999-04-01 2000-10-19 Schering Ag Amyloidspezifisches Aptamer
EP2351855A1 (fr) * 2000-09-26 2011-08-03 Duke University Aptamères d'ARN et leurs procédés d'identification
DE60237768D1 (de) * 2001-05-25 2010-11-04 Univ Duke Modulatoren pharmakologischer mittel
ATE419536T1 (de) * 2002-03-05 2009-01-15 Univ Texas Biospezifische kontrastmittel
US7435542B2 (en) 2002-06-24 2008-10-14 Cornell Research Foundation, Inc. Exhaustive selection of RNA aptamers against complex targets
WO2004097417A1 (fr) * 2003-05-02 2004-11-11 Canon Kabushiki Kaisha Construction structuree, et procede de production a cet effet
EP1493810A1 (fr) 2003-06-30 2005-01-05 Gentium S.p.A. Aptamères pour la cathepsine G basés sur de l'ADN
JP4533044B2 (ja) * 2003-08-27 2010-08-25 キヤノン株式会社 センサ
CN1980947B (zh) * 2004-04-22 2013-01-30 雷加多生物科学公司 改良的凝血因子调节物
EP1774575A2 (fr) * 2004-05-17 2007-04-18 Cambrios Technology Corp. Biofabrication de transistors y compris des transistors a effet de champ
US8501912B2 (en) 2007-12-03 2013-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Filipil compositions and methods for treating cancer
US20100018674A1 (en) * 2008-07-22 2010-01-28 Donald John Enzinna Reservoir with moveable partition for quick recovery
CN111712573B (zh) * 2018-02-12 2023-10-20 安沛治疗有限公司 针对骨硬化蛋白的适体及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217951A (en) * 1986-12-24 1993-06-08 John Lezdey Treatment of inflammation
US5290762A (en) * 1986-12-24 1994-03-01 John Lezdey Treatment of inflammation
US5612194A (en) * 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
ES2110444T3 (es) * 1990-06-11 1998-02-16 Nexstar Pharmaceuticals Inc Ligandos de acidos nucleicos.
WO1992014843A1 (fr) * 1991-02-21 1992-09-03 Gilead Sciences, Inc. Aptamere specifique de biomolecules et procede de production
EP0587799B1 (fr) * 1991-05-23 1999-07-07 Merrell Pharmaceuticals Inc. Inhibiteurs de la cathepsine g et de l'elastase empechant la degradation du tissu conjonctif
US5514694A (en) * 1992-09-21 1996-05-07 Georgia Tech Research Corp Peptidyl ketoamides

Also Published As

Publication number Publication date
DE69631409T2 (de) 2004-12-02
DE69631409D1 (de) 2004-03-04
ES2217297T3 (es) 2004-11-01
JPH09216895A (ja) 1997-08-19
DE19543750A1 (de) 1997-07-03
PT775745E (pt) 2004-06-30
JP4257939B2 (ja) 2009-04-30
EP0775745A2 (fr) 1997-05-28
ATE258597T1 (de) 2004-02-15
EP0775745A3 (fr) 1999-10-13
US5780449A (en) 1998-07-14
EP0775745B1 (fr) 2004-01-28
DE19543750C2 (de) 1997-10-23

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