US6303121B1
(en)
*
|
1992-07-30 |
2001-10-16 |
Advanced Research And Technology |
Method of using human receptor protein 4-1BB
|
US6362325B1
(en)
*
|
1988-11-07 |
2002-03-26 |
Advanced Research And Technology Institute, Inc. |
Murine 4-1BB gene
|
US20060002904A9
(en)
*
|
1988-11-07 |
2006-01-05 |
Kwon Byoung S |
Receptor and related products and methods
|
US20060063923A1
(en)
*
|
1992-07-30 |
2006-03-23 |
Kwon Byoung S |
4-1BB peptides and methods for use
|
WO1995007984A1
(en)
*
|
1993-09-16 |
1995-03-23 |
Indiana University Foundation |
Human receptor h4-1bb
|
US6210669B1
(en)
*
|
1996-10-11 |
2001-04-03 |
Bristol-Myers Squibb Co. |
Methods and compositions for immunomodulation
|
US6051228A
(en)
*
|
1998-02-19 |
2000-04-18 |
Bristol-Myers Squibb Co. |
Antibodies against human CD40
|
US20030096976A1
(en)
*
|
1998-11-17 |
2003-05-22 |
Hong Hyo Jeong |
Humanized antibodies LB-00503 and LB-00506 specific for human 4-1BB and pharmaceutical compositions comprising said humanized antibodies
|
KR20000034847A
(ko)
*
|
1998-11-17 |
2000-06-26 |
성재갑 |
인간 4-1비비 분자에 대한 인간화 항체 및 이를 포함하는 약학조성물
|
US20040001863A1
(en)
*
|
1998-12-03 |
2004-01-01 |
Shau-Chi Chi |
Immortal cell line derived from grouper Epinephelus coioides and its applications therein
|
ES2629683T3
(es)
|
1999-11-30 |
2017-08-14 |
Mayo Foundation For Medical Education And Research |
B7-H1, una nueva molécula inmunorreguladora
|
IL152450A0
(en)
|
2000-05-12 |
2003-05-29 |
Genzyme Corp |
COMPOUNDS HAVING TNF-alpha SIGNAL MODULATING ACTIVITY
|
US7320789B2
(en)
*
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
WO2003049755A1
(en)
|
2001-10-09 |
2003-06-19 |
Mayo Foundation For Medical Education And Research |
Enhancement of immune responses by 4-1bb-binding agents
|
CN1688603A
(zh)
*
|
2002-07-15 |
2005-10-26 |
马约医学教育与研究基金会 |
使用4-1bb结合剂的治疗和预防
|
PL375144A1
(en)
*
|
2002-07-30 |
2005-11-28 |
Bristol-Myers Squibb Company |
Humanized antibodies against human 4-1bb
|
EP1388544A1
(de)
*
|
2002-07-31 |
2004-02-11 |
D. Collen Research Foundation vzw |
Anti-Idiotypische Antikörper gegen Factor VIII-Inhibitor und Verwendungen davon
|
MXPA05002219A
(es)
|
2002-08-28 |
2005-07-05 |
Immunex Corp |
Composiciones y metodos para tratar una enfermedad cardiovascular.
|
US20060121030A1
(en)
*
|
2002-12-16 |
2006-06-08 |
Herbert Schwarz |
Use of cd 137 antagonists for the treatment of tumors
|
US20040197312A1
(en)
|
2003-04-02 |
2004-10-07 |
Marina Moskalenko |
Cytokine-expressing cellular vaccine combinations
|
US7288638B2
(en)
|
2003-10-10 |
2007-10-30 |
Bristol-Myers Squibb Company |
Fully human antibodies against human 4-1BB
|
US7674884B2
(en)
*
|
2003-12-10 |
2010-03-09 |
Novimmune S.A. |
Neutralizing antibodies and methods of use thereof
|
EP1810026B1
(de)
*
|
2004-10-06 |
2018-04-18 |
Mayo Foundation For Medical Education And Research |
B7-h1 und pd-1 in der behandlung von nierenzellkarzinom
|
US20080019905A9
(en)
*
|
2005-02-18 |
2008-01-24 |
Strome Scott E |
Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection
|
US20060182744A1
(en)
*
|
2005-02-15 |
2006-08-17 |
Strome Scott E |
Anti-CD137 antibody as an agent in the treatment of cancer and glycosylation variants thereof
|
DK1945666T3
(da)
*
|
2005-10-21 |
2013-07-01 |
Genzyme Corp |
Antistoffer med forøget antistofafhængig cellulær cytotoksicitetsaktivitet, fremgangsmåder til fremstilling af disse og anvendelse heraf
|
US20100015642A1
(en)
*
|
2006-01-05 |
2010-01-21 |
Kwon Eugene D |
B7-h1 and survivin in cancer
|
US20090215084A1
(en)
*
|
2006-01-05 |
2009-08-27 |
Mayo Foundation For Medical Education And Research |
B7-h1 and b7-h4 in cancer
|
WO2007124361A2
(en)
*
|
2006-04-20 |
2007-11-01 |
Mayo Foundation For Medical Education And Research |
Soluble b7-h1
|
US20110020325A1
(en)
*
|
2008-02-29 |
2011-01-27 |
Kwon Eugene D |
Methods for reducing granulomatous inflammation
|
US20110229460A1
(en)
*
|
2008-05-01 |
2011-09-22 |
Gtc Biotherapeutics, Inc. |
anti-cd137 antibody as an agent in the treatment of inflammatory conditions
|
US8475790B2
(en)
|
2008-10-06 |
2013-07-02 |
Bristol-Myers Squibb Company |
Combination of CD137 antibody and CTLA-4 antibody for the treatment of proliferative diseases
|
US8324352B2
(en)
|
2009-12-07 |
2012-12-04 |
Decimmune Therapeutics, Inc. |
Anti-inflammatory antibodies and uses therefor
|
US9409977B2
(en)
|
2013-03-12 |
2016-08-09 |
Decimmune Therapeutics, Inc. |
Humanized, anti-N2 antibodies
|
US9302005B2
(en)
|
2013-03-14 |
2016-04-05 |
Mayo Foundation For Medical Education And Research |
Methods and materials for treating cancer
|
EP3052131B1
(de)
|
2013-10-01 |
2018-12-05 |
Mayo Foundation for Medical Education and Research |
Verfahren zur krebsbehandlung bei patienten mit erhöhtem bim-spiegel
|
US20160264670A1
(en)
|
2013-11-06 |
2016-09-15 |
Bristol-Myers Squibb Company |
Immunotherapeutic dosing regimens and combinations thereof
|
TW201613635A
(en)
|
2014-02-04 |
2016-04-16 |
Pfizer |
Combination of a PD-1 antagonist and a 4-1BB agonist for treating cancer
|
WO2015179654A1
(en)
|
2014-05-22 |
2015-11-26 |
Mayo Foundation For Medical Education And Research |
Distinguishing antagonistic and agonistic anti b7-h1 antibodies
|
US10517875B2
(en)
|
2014-07-23 |
2019-12-31 |
Mayo Foundation for Medical Engineering and Research |
Targeting DNA-PKcs and B7-H1 to treat cancer
|
CN111375066B
(zh)
|
2015-07-16 |
2023-04-25 |
百欧肯治疗有限公司 |
治疗癌症的组合物及方法
|
US20180230431A1
(en)
|
2015-08-07 |
2018-08-16 |
Glaxosmithkline Intellectual Property Development Limited |
Combination Therapy
|
US20190022092A1
(en)
|
2015-09-15 |
2019-01-24 |
Acerta Pharma B.V. |
Therapeutic Combinations of a BTK Inhibitor and a GITR Binding Molecule, a 4-1BB Agonist, or an OX40 Agonist
|
WO2017075045A2
(en)
|
2015-10-30 |
2017-05-04 |
Mayo Foundation For Medical Education And Research |
Antibodies to b7-h1
|
TWI788307B
(zh)
|
2016-10-31 |
2023-01-01 |
美商艾歐凡斯生物治療公司 |
用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞
|
US10780080B2
(en)
|
2016-11-23 |
2020-09-22 |
Translational Drug Development, Llc |
Benzamide and active compound compositions and methods of use
|
KR20190104048A
(ko)
|
2017-01-06 |
2019-09-05 |
이오반스 바이오테라퓨틱스, 인크. |
종양 괴사 인자 수용체 슈퍼패밀리 (tnfrsf) 효능제를 사용한 종양 침윤 림프구 (til)의 확장 및 til과 tnfrsf 효능제의 치료 조합물
|
CN110461876B
(zh)
|
2017-01-20 |
2024-05-17 |
海德堡医药研究有限责任公司 |
用于耗尽cd137+细胞的组合物和方法
|
CA3065532A1
(en)
|
2017-06-05 |
2018-12-13 |
Iovance Biotherapeutics, Inc. |
Methods of using tumor infiltrating lymphocytes in double-refractory melanoma
|
EP3652209A2
(de)
|
2017-07-11 |
2020-05-20 |
Compass Therapeutics LLC |
Agonistische antikörper zur bindung von humanem cd137 und verwendungen davon
|
WO2019036855A1
(en)
|
2017-08-21 |
2019-02-28 |
Adagene Inc. |
ANTI-CD137 MOLECULES AND THEIR USE
|
US11718679B2
(en)
|
2017-10-31 |
2023-08-08 |
Compass Therapeutics Llc |
CD137 antibodies and PD-1 antagonists and uses thereof
|
TWI701259B
(zh)
*
|
2017-11-09 |
2020-08-11 |
大陸商上海懷越生物科技有限公司 |
4﹘1bb抗體及其製備方法和應用
|
KR20200100060A
(ko)
|
2017-11-17 |
2020-08-25 |
이오반스 바이오테라퓨틱스, 인크. |
미세 바늘 흡인물 및 소형 생검물로부터의 til 확장
|
WO2019100052A2
(en)
|
2017-11-20 |
2019-05-23 |
Compass Therapeutics Llc |
Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof
|
US20220204932A1
(en)
|
2018-01-08 |
2022-06-30 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products enriched for tumor antigen-specific t-cells
|
WO2019136459A1
(en)
|
2018-01-08 |
2019-07-11 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products enriched for tumor antigen-specific t-cells
|
US11713446B2
(en)
|
2018-01-08 |
2023-08-01 |
Iovance Biotherapeutics, Inc. |
Processes for generating TIL products enriched for tumor antigen-specific T-cells
|
US20210363266A1
(en)
*
|
2018-01-22 |
2021-11-25 |
Jiangsu Hengrui Medicine Co., Ltd. |
Anti-4-1bb antibody, antigen-binding fragment thereof and medical use thereof
|
WO2019148445A1
(en)
|
2018-02-02 |
2019-08-08 |
Adagene Inc. |
Precision/context-dependent activatable antibodies, and methods of making and using the same
|
CA3090795A1
(en)
|
2018-02-13 |
2019-08-22 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes (tils) with adenosine a2a receptor antagonists and therapeutic combinations of tils and adenosine a2a receptor antagonists
|
AU2018415814A1
(en)
|
2018-03-29 |
2020-10-22 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
WO2019196868A1
(en)
*
|
2018-04-10 |
2019-10-17 |
Wuxi Biologics (Shanghai) Co., Ltd. |
A monoclonal antibody against human 4-1bb, method for preparing the same, and use thereof
|
EP3784254A1
(de)
|
2018-04-27 |
2021-03-03 |
Iovance Biotherapeutics, Inc. |
Geschlossenes verfahren zur expansion und geneditierung von tumorinfiltrierenden lymphozyten und verwendungen davon in der immuntherapie
|
WO2019217753A1
(en)
|
2018-05-10 |
2019-11-14 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
TW202031273A
(zh)
|
2018-08-31 |
2020-09-01 |
美商艾歐凡斯生物治療公司 |
抗pd-1抗體難治療性之非小細胞肺癌(nsclc)病患的治療
|
JP2022501038A
(ja)
|
2018-09-20 |
2022-01-06 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
凍結保存腫瘍サンプルからのtilの拡大培養
|
MX2021004953A
(es)
|
2018-11-05 |
2021-08-11 |
Iovance Biotherapeutics Inc |
Seleccion de celulas t reactivas al tumor mejoradas.
|
US20220033775A1
(en)
|
2018-11-05 |
2022-02-03 |
Iovance Biotherapeutics, Inc. |
Expansion of tils utilizing akt pathways inhibitors
|
JP2022512899A
(ja)
|
2018-11-05 |
2022-02-07 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
抗pd-1抗体に対して不応性のnsclc患者の治療
|
PE20211292A1
(es)
|
2018-11-05 |
2021-07-20 |
Iovance Biotherapeutics Inc |
Procesos para la produccion de linfocitos infiltrantes de tumor y usos de estos en inmunoterapia
|
EP3898949A1
(de)
|
2018-12-19 |
2021-10-27 |
Iovance Biotherapeutics, Inc. |
Verfahren zur expansion tumorinfiltrierender lymphozyten unter verwendung von manipulierten cytokin-rezeptorenpaaren und deren verwendungen
|
WO2020205662A1
(en)
|
2019-03-29 |
2020-10-08 |
Myst Therapeutics, Inc. |
Ex vivo methods for producing a t cell therapeutic and related compositions and methods
|
US20220249559A1
(en)
|
2019-05-13 |
2022-08-11 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
EP4004053A4
(de)
*
|
2019-07-26 |
2023-10-18 |
ABL Bio, Inc. |
Bispezifischer anti-egfr/anti-4-1bb-antikörper und verwendung davon
|
CA3155727A1
(en)
|
2019-10-25 |
2021-04-29 |
Cecile Chartier-Courtaud |
Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
IL293350A
(en)
|
2019-11-27 |
2022-07-01 |
Myst Therapeutics Llc |
A method for producing tumor-reactive t cells using modulatory substances
|
EP4073236A1
(de)
|
2019-12-11 |
2022-10-19 |
Iovance Biotherapeutics, Inc. |
Verfahren zur produktion von tumorinfiltrierenden lymphozyten (tils) und verfahren zur verwendung derselben
|
US20230106973A1
(en)
|
2020-02-17 |
2023-04-06 |
Board Of Regents, The University Of Texas System |
Methods for expansion of tumor infiltrating lymphocytes and use thereof
|
WO2021174208A1
(en)
|
2020-02-27 |
2021-09-02 |
Myst Therapeutics, Llc |
Methods for ex vivo enrichment and expansion of tumor reactive t cells and related compositions thereof
|
CN113563473A
(zh)
|
2020-04-29 |
2021-10-29 |
三生国健药业(上海)股份有限公司 |
四价双特异性抗体、其制备方法和用途
|
CA3177413A1
(en)
|
2020-05-04 |
2021-11-11 |
Michelle SIMPSON-ABELSON |
Selection of improved tumor reactive t-cells
|
WO2021226061A1
(en)
|
2020-05-04 |
2021-11-11 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
JP2023533755A
(ja)
*
|
2020-07-09 |
2023-08-04 |
ランケナウ・インスティテュート・フォー・メディカル・リサーチ |
ヒトido-2に対する抗体を含む組成物
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
US20230372397A1
(en)
|
2020-10-06 |
2023-11-23 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
CA3201818A1
(en)
|
2020-12-11 |
2022-06-16 |
Maria Fardis |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with braf inhibitors and/or mek inhibitors
|
WO2022133149A1
(en)
|
2020-12-17 |
2022-06-23 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocytes
|
AU2021401302A1
(en)
|
2020-12-17 |
2023-07-06 |
Iovance Biotherapeutics, Inc. |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
EP4288140A1
(de)
|
2021-02-05 |
2023-12-13 |
Iovance Biotherapeutics, Inc. |
Adjuvante therapie für krebs
|
TW202300014A
(zh)
|
2021-03-05 |
2023-01-01 |
美商艾歐凡斯生物治療公司 |
腫瘤儲存及細胞培養組成物
|
BR112023021665A2
(pt)
|
2021-04-19 |
2023-12-19 |
Iovance Biotherapeutics Inc |
Método para tratar um câncer, e, composição
|
CA3219148A1
(en)
|
2021-05-17 |
2022-11-24 |
Frederick G. Vogt |
Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
|
TW202327631A
(zh)
|
2021-07-28 |
2023-07-16 |
美商艾歐凡斯生物治療公司 |
利用腫瘤浸潤性淋巴球療法與kras抑制劑組合治療癌症患者
|
WO2023049862A1
(en)
|
2021-09-24 |
2023-03-30 |
Iovance Biotherapeutics, Inc. |
Expansion processes and agents for tumor infiltrating lymphocytes
|
TW202331735A
(zh)
|
2021-10-27 |
2023-08-01 |
美商艾歐凡斯生物治療公司 |
協調用於患者特異性免疫療法之細胞之製造的系統及方法
|
AU2022388729A1
(en)
|
2021-11-10 |
2024-05-16 |
Iovance Biotherapeutics, Inc. |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
WO2023147486A1
(en)
|
2022-01-28 |
2023-08-03 |
Iovance Biotherapeutics, Inc. |
Tumor infiltrating lymphocytes engineered to express payloads
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
WO2024030758A1
(en)
|
2022-08-01 |
2024-02-08 |
Iovance Biotherapeutics, Inc. |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|