DK0763057T3 - Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf - Google Patents

Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf

Info

Publication number
DK0763057T3
DK0763057T3 DK95918912T DK95918912T DK0763057T3 DK 0763057 T3 DK0763057 T3 DK 0763057T3 DK 95918912 T DK95918912 T DK 95918912T DK 95918912 T DK95918912 T DK 95918912T DK 0763057 T3 DK0763057 T3 DK 0763057T3
Authority
DK
Denmark
Prior art keywords
cells
proliferating
differentiating
present
provides methods
Prior art date
Application number
DK95918912T
Other languages
Danish (da)
English (en)
Inventor
Marilyn Kehry
Brian E Castle
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK0763057T3 publication Critical patent/DK0763057T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0635—B lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/52—CD40, CD40-ligand (CD154)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK95918912T 1994-04-28 1995-04-28 Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf DK0763057T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23458094A 1994-04-28 1994-04-28

Publications (1)

Publication Number Publication Date
DK0763057T3 true DK0763057T3 (da) 2006-03-27

Family

ID=22881963

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95918912T DK0763057T3 (da) 1994-04-28 1995-04-28 Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf

Country Status (10)

Country Link
US (2) US5817516A (de)
EP (1) EP0763057B1 (de)
JP (1) JP3881691B2 (de)
AT (1) ATE309267T1 (de)
CA (1) CA2188165C (de)
DE (1) DE69534595T2 (de)
DK (1) DK0763057T3 (de)
ES (1) ES2251719T3 (de)
MX (1) MX9605088A (de)
WO (1) WO1995029935A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962406A (en) * 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
US7405270B2 (en) * 1991-10-25 2008-07-29 Immunex Corporation CD40-Ligand lacking native-pattern glycosylation
DK0763057T3 (da) * 1994-04-28 2006-03-27 Boehringer Ingelheim Pharma Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf
US6465251B1 (en) 1996-11-13 2002-10-15 Dana-Farber Cancer Institute, Inc. Method of promoting b-cell proliferation and activation with CD40 ligand and cyclosporin
AU5590198A (en) * 1996-11-12 1998-06-03 Dana-Farber Cancer Institute Method of promoting b-cell proliferation and activation and of modulating the immune system
US7070771B1 (en) * 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
EP1181050A4 (de) 1999-04-30 2005-05-18 Jolla Inst Allergy Immunolog Methoden zur verhinderung der reaktivierung von latenten viren und zur kontrolleder virusreplikation
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
EP2141228A1 (de) 2001-12-18 2010-01-06 Cancer Research Technology Limited Methode zur Herstellung von proliferierenden und differenzierenden B-Zelllinien
US7495090B2 (en) * 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
MXPA05006522A (es) * 2002-12-23 2006-02-17 Bristol Myers Squibb Co Mejora en la calidad de producto en procesos de cultivo en celulas de mamiferos para la produccion de proteina.
AU2005325801A1 (en) * 2005-01-31 2006-08-03 Ablynx N.V. Method for generating variable domain sequences of heavy chain antibodies
CA2619784A1 (en) 2005-08-23 2007-06-07 Iq Corporation Methods of producing stable b-lymphocytes
ES2599905T3 (es) 2007-11-01 2017-02-06 The Board Of Trustees Of The University Of Arkansas Composiciones y métodos para aumentar las respuestas inmunitarias a Eimeria
US8703486B2 (en) 2008-09-23 2014-04-22 UNIVERSITé LAVAL Method for polyclonal immunoglobulin G production by human B cells
JP5550132B2 (ja) 2009-10-30 2014-07-16 学校法人東京理科大学 抗原特異的ｂ細胞集団の製造方法
EP2956165B1 (de) 2013-02-14 2019-09-11 The Board of Trustees of the University of Arkansas Zusammensetzungen und verfahren zur verstärkung von immunreaktionen gegenüber eimeria oder zur begrenzung von eimeria-infektionen
WO2016002760A1 (ja) 2014-07-02 2016-01-07 学校法人東京理科大学 Ｂ細胞集団の製造方法
US11043823B2 (en) * 2017-04-06 2021-06-22 Tesla, Inc. System and method for facilitating conditioning and testing of rechargeable battery cells
GB201707238D0 (en) 2017-05-05 2017-06-21 Univ Oxford Innovation Ltd Composition
KR102539610B1 (ko) * 2020-01-22 2023-06-02 한국생명공학연구원 메모리 b 세포 특이적 분화 유도 방법 및 이의 활용
TW202309270A (zh) * 2021-04-19 2023-03-01 美商步行魚醫療公司 用於細胞療法的ｂ細胞擴增之方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989008114A1 (en) 1988-02-25 1989-09-08 The General Hospital Corporation Rapid immunoselection cloning method
EP0434879A1 (de) * 1989-12-14 1991-07-03 Schering-Plough Verfahren zur Herstellung von faktorabhÀ¤ngigen menschlichen B-Zellinien
WO1992020783A1 (de) 1991-05-16 1992-11-26 Idt Ag Für In Vivo Diagnostik Und Therapie Verfahren zur bereitstellung von antigen-spezifischen b- und t-lymphozyten sowie davon erhaltene monoklonale antikörper
DE69233051T2 (de) 1991-10-25 2004-03-11 Immunex Corp., Seattle Antikörper gegen CD40-L
US5474771A (en) 1991-11-15 1995-12-12 The Trustees Of Columbia University In The City Of New York Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same
CA2089229C (en) 1992-02-14 2010-04-13 Alejandro A. Aruffo Cd40cr receptor and ligands therefor
DE4322330A1 (de) 1992-08-31 1994-03-03 Behringwerke Ag Verwendung des IL-4-Rezeptors zur Therapie, Prophylaxe und Diagnose von allergischen, viralen, parasitären und bakteriellen Erkrankungen sowie von Pilzinfektionen
US5516657A (en) * 1992-05-11 1996-05-14 Cambridge Biotech Corporation Baculovirus vectors for expression of secretory and membrane-bound proteins
WO1994004570A1 (en) 1992-08-21 1994-03-03 Schering Corporation Cd40 ligand, anti cd40 antibodies, and soluble cd40
US5540926A (en) 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
DK0763057T3 (da) * 1994-04-28 2006-03-27 Boehringer Ingelheim Pharma Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf

Also Published As

Publication number Publication date
US5817516A (en) 1998-10-06
JP3881691B2 (ja) 2007-02-14
EP0763057A4 (de) 1998-11-11
US6297052B1 (en) 2001-10-02
DE69534595T2 (de) 2006-05-24
DE69534595D1 (de) 2005-12-15
CA2188165A1 (en) 1995-11-09
WO1995029935A1 (en) 1995-11-09
ATE309267T1 (de) 2005-11-15
ES2251719T3 (es) 2006-05-01
MX9605088A (es) 1997-08-30
CA2188165C (en) 2007-08-28
EP0763057B1 (de) 2005-11-09
EP0763057A1 (de) 1997-03-19
JPH09512441A (ja) 1997-12-16

Similar Documents

Publication Publication Date Title
DK0763057T3 (da) Fremgangsmåde til proliferering og differentiering af B celler og anvendelse deraf
DK455084A (da) Fremgangsmaade og anlaeg til kondensering af naturgas
DE69019009D1 (de) Zellkulturverfahren.
DK156904C (da) Akustikplade og fremgangsmaade til fremstilling af samme
DK0807166T3 (da) Metode til forberedelse af en udifferentieret celle
DK498083A (da) Fremgangsmaade til bestemmelse eller isolering af maligne humane celler, antistof eller antigent oligopeptid og fremgangsmaade til fremstilling af samme
DK0414475T3 (da) Fremgangsmåder til dyrkning af HCV i B- eller T-lymfocyt-cellelinier
DK459080A (da) Fremgangsmaade og anlaeg til forbraending af kemisk affald lagret i fade
NO975557D0 (no) Immortalisering og dismortalisering av celler
DK526783A (da) Forbedret stamme af clostridium acetobutylicum og fremgangsmaade til fremstilling af samme
DK226477A (da) Fremgangsmade til massedyrkning af celler og kammersystem til udovelse af fremgangsmaden
TW358962B (en) Method for designing an architectural system
DK276780A (da) Fremgangsmaade til fremstilling af hydrogenholdig gas
DK463587D0 (da) Fremgangsmaade og middel til fremstilling af mikroorganismecellemasse
DK494188D0 (da) Aetermoplast-formstykker, samt fremgangsmaade til fremstilling af disse
DK333181A (da) Fremgangsmaade og apparat til produktion af gas udfra isaer landbrugsaffaldsstoffer
DK286784D0 (da) Fremgangsmaade og system til produktion af naturgas fra broende paa havbunden
DK9282A (da) Fremgangsmaade til fremstilling af broendsel
DK439086D0 (da) Fremgangsmaader til anvendelse af cellelinier, der mangler humane klasseii histokompatibilitetsantigener
DK0800426T3 (da) Fremgangsmåde til fremstilling af plane dele og plane dele fremstillet ifølge fremgangsmåden
DK95391D0 (da) Fremgangsmaade til fremstilling af hydrogenholdig gas
DK246284D0 (da) Fremgangsmaade og middel til isolering af elementer af hvide blodlegemer
AU2900184A (en) Membrane antigens generated from pooled cells and monoclonal antibodies
NO176614C (no) Monoklonalt antistoff og cellelinje som produserer antistoff
DK664288A (da) Humant interleukin-3-producerende celler og fremgangsmaade til fremstilling af humant interleukin-3