DK0756638T3 - Midler til behandling af forstyrrelser i blodkoagulationskaskaden - Google Patents
Midler til behandling af forstyrrelser i blodkoagulationskaskadenInfo
- Publication number
- DK0756638T3 DK0756638T3 DK95916845T DK95916845T DK0756638T3 DK 0756638 T3 DK0756638 T3 DK 0756638T3 DK 95916845 T DK95916845 T DK 95916845T DK 95916845 T DK95916845 T DK 95916845T DK 0756638 T3 DK0756638 T3 DK 0756638T3
- Authority
- DK
- Denmark
- Prior art keywords
- apc
- pct
- factor
- cleavage sites
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94201116 | 1994-04-22 | ||
PCT/NL1995/000149 WO1995029259A1 (fr) | 1994-04-22 | 1995-04-21 | Procede et systeme de detection et de traitement des anomalies des reactions enzymatiques en cascade dans la coagulation sanguine |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0756638T3 true DK0756638T3 (da) | 2001-07-23 |
Family
ID=8216820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95916845T DK0756638T3 (da) | 1994-04-22 | 1995-04-21 | Midler til behandling af forstyrrelser i blodkoagulationskaskaden |
Country Status (11)
Country | Link |
---|---|
US (1) | US6083905A (fr) |
EP (1) | EP0756638B1 (fr) |
JP (1) | JP3810080B2 (fr) |
AT (1) | ATE200225T1 (fr) |
AU (1) | AU697205B2 (fr) |
CA (1) | CA2188463C (fr) |
DE (1) | DE69520569T2 (fr) |
DK (1) | DK0756638T3 (fr) |
ES (1) | ES2157326T3 (fr) |
GR (1) | GR3036000T3 (fr) |
WO (1) | WO1995029259A1 (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2159907C (fr) | 1994-02-14 | 2006-12-12 | Rogier Maria Bertina | Procede de depistage d'une anomalie genetique asssocie a la trombose et/ou a une mauvaise reponse anticoagulante a la proteine c activee |
US5705395A (en) * | 1994-11-14 | 1998-01-06 | The Scripps Research Institute | Method for diagnosis of thrombotic disorders |
US6531455B1 (en) * | 1995-03-24 | 2003-03-11 | The Regents Of The University Of California | Delivery of polynucleotides by secretory gland expression |
US5885971A (en) * | 1995-03-24 | 1999-03-23 | The Regents Of The University Of California | Gene therapy by secretory gland expression |
US5874256A (en) * | 1995-06-06 | 1999-02-23 | Rijks Universiteit Leiden | Method for diagnosing an increased risk for thrombosis or a genetic defect causing thrombosis and kit for use with the same |
GB9604267D0 (en) * | 1996-02-29 | 1996-05-01 | Royal Infirmary Of Edinburgh N | Mutation assay |
ES2162361T3 (es) * | 1998-03-19 | 2001-12-16 | Instrumentation Lab Spa | Metodos, kits y reactivos mejorados para el muestreo de defectos de la coagulacion sanguinea. |
DE19858278A1 (de) * | 1998-12-17 | 2000-06-21 | Dade Behring Marburg Gmbh | Verfahren zum Lokalisieren von Defekten im Gerinnungssystem |
JP4676585B2 (ja) * | 1999-12-24 | 2011-04-27 | 一般財団法人化学及血清療法研究所 | 血液凝固異常に基づく疾患の治療・予防用医薬組成物 |
US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
AU2002248329B2 (en) * | 2001-01-12 | 2007-06-28 | The American National Red Cross | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII |
US7125846B2 (en) * | 2001-11-09 | 2006-10-24 | Novo Nordisk Healthcare A/G | Pharmaceutical composition comprising factor VII polypeptides and factor V polypeptides |
PL370634A1 (en) * | 2001-11-09 | 2005-05-30 | Novo Nordisk Health Care Ag | Pharmaceutical composition comprising factor vii polypeptides and factor v polypeptides |
US7375100B2 (en) | 2003-06-04 | 2008-05-20 | Pfizer Inc | 2-amino-pyridine derivatives useful for the treatment of diseases |
US7067541B2 (en) | 2003-06-04 | 2006-06-27 | Pfizer Inc | 2-amino-pyridine derivatives useful for the treatment of diseases |
US7211559B2 (en) | 2003-10-31 | 2007-05-01 | University Of Maryland, Baltimore | Factor VIII compositions and methods |
US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
AU2005225458B2 (en) | 2004-03-25 | 2008-12-04 | The Feinstein Institutes For Medical Research | Neural tourniquet |
WO2006027111A1 (fr) * | 2004-09-06 | 2006-03-16 | Zlb Behring Gmbh | Facteur viii de coagulation modifie presentant une meilleure stabilite |
ATE489132T1 (de) | 2004-12-27 | 2010-12-15 | The Feinstein Inst Medical Res | Behandlung von entzündlichen erkrankungen durch elektrische stimulation des vagus-nervs |
US11207518B2 (en) | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
ATE510545T1 (de) | 2005-11-09 | 2011-06-15 | Alnylam Pharmaceuticals Inc | Zusammensetzungen und verfahren zur hemmung der expression von faktor v leiden mutationsgen |
US20100144620A1 (en) * | 2006-11-16 | 2010-06-10 | Crucell Holland B.V. | Complementation of factor xi deficeincy by factor v mutants |
WO2008059043A2 (fr) * | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Combinaison du facteur viii avec le facteur v résistant à l'apc |
WO2008059009A2 (fr) * | 2006-11-16 | 2008-05-22 | Crucell Holland B.V. | Mutants de facteur v pour une hémostase dans l'hémophilie |
US8391970B2 (en) | 2007-08-27 | 2013-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
CN101969984A (zh) * | 2007-12-20 | 2011-02-09 | 昆士兰大学 | 调节止血的组合物及其用途 |
US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
WO2009146030A1 (fr) | 2008-03-31 | 2009-12-03 | The Feinstein Institute For Medical Research | Méthodes et systèmes de réduction d’une inflammation par neuromodulation de l’activité des lymphocytes t |
AU2009316801C1 (en) | 2008-11-18 | 2015-12-24 | Setpoint Medical Corporation | Devices and methods for optimizing electrode placement for anti-inflammatory stimulation |
US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
EP2440284B1 (fr) | 2009-06-09 | 2018-09-12 | Setpoint Medical Corporation | Manchon pour nerf muni d'une poche pour stimulateur sans fil |
WO2014169145A1 (fr) | 2013-04-10 | 2014-10-16 | Setpoint Medical Corporation | Stimulation de nerf vague en boucle fermée |
US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
EP3636314B1 (fr) | 2009-12-23 | 2021-09-08 | Setpoint Medical Corporation | Dispositifs et systèmes de stimulation neuronale pour le traitement de l'inflammation chronique |
ITFI20110084A1 (it) | 2011-04-22 | 2012-10-23 | Kedrion Spa | Nuovo processo per la preparazione di un concentrato di fv virus inattivato a partire da plasma umano, scalabile a livello industriale. |
WO2012154865A2 (fr) | 2011-05-09 | 2012-11-15 | Setpoint Medical Corporation | Activation d'impulsions uniques de la voie anti-inflammatoire cholinergique pour traiter l'inflammation chronique |
US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
WO2016126807A1 (fr) | 2015-02-03 | 2016-08-11 | Setpoint Medical Corporation | Appareil et procédé de rappel, d'incitation ou d'alerte d'un patient ayant un stimulateur implanté |
US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
US10695569B2 (en) | 2016-01-20 | 2020-06-30 | Setpoint Medical Corporation | Control of vagal stimulation |
WO2017127758A1 (fr) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Microstimulateurs implantables et systèmes de recharge par induction |
US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
US11173307B2 (en) | 2017-08-14 | 2021-11-16 | Setpoint Medical Corporation | Vagus nerve stimulation pre-screening test |
US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
JP2023526080A (ja) | 2020-05-21 | 2023-06-20 | ザ・フェインステイン・インスティチュート・フォー・メディカル・リサーチ | 迷走神経刺激のためのシステムおよび方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5451521A (en) * | 1986-05-29 | 1995-09-19 | Genetics Institute, Inc. | Procoagulant proteins |
-
1995
- 1995-04-21 CA CA002188463A patent/CA2188463C/fr not_active Expired - Fee Related
- 1995-04-21 WO PCT/NL1995/000149 patent/WO1995029259A1/fr active IP Right Grant
- 1995-04-21 JP JP52755095A patent/JP3810080B2/ja not_active Expired - Fee Related
- 1995-04-21 DE DE69520569T patent/DE69520569T2/de not_active Expired - Lifetime
- 1995-04-21 US US08/722,240 patent/US6083905A/en not_active Expired - Fee Related
- 1995-04-21 EP EP95916845A patent/EP0756638B1/fr not_active Expired - Lifetime
- 1995-04-21 DK DK95916845T patent/DK0756638T3/da active
- 1995-04-21 AT AT95916845T patent/ATE200225T1/de not_active IP Right Cessation
- 1995-04-21 AU AU23194/95A patent/AU697205B2/en not_active Ceased
- 1995-04-21 ES ES95916845T patent/ES2157326T3/es not_active Expired - Lifetime
-
2001
- 2001-06-06 GR GR20010400853T patent/GR3036000T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69520569D1 (de) | 2001-05-10 |
WO1995029259A1 (fr) | 1995-11-02 |
US6083905A (en) | 2000-07-04 |
AU2319495A (en) | 1995-11-16 |
JPH09512425A (ja) | 1997-12-16 |
CA2188463A1 (fr) | 1995-11-02 |
ES2157326T3 (es) | 2001-08-16 |
JP3810080B2 (ja) | 2006-08-16 |
ATE200225T1 (de) | 2001-04-15 |
CA2188463C (fr) | 2007-12-11 |
EP0756638A1 (fr) | 1997-02-05 |
GR3036000T3 (en) | 2001-09-28 |
DE69520569T2 (de) | 2001-10-04 |
EP0756638B1 (fr) | 2001-04-04 |
AU697205B2 (en) | 1998-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0756638T3 (da) | Midler til behandling af forstyrrelser i blodkoagulationskaskaden | |
EA200200755A1 (ru) | Опосредованная рецептором nogo блокада роста аксонов | |
ATE195149T1 (de) | Protein-antagonisten der blut-koagulation und ihre verwendung | |
CY1116336T1 (el) | Αντισωματα εναντι ανασυνδυασμενης γλυκοπρωτεϊνης vi του υποδοχεα αιμοπεταλιων κολλαγονου | |
AU7026601A (en) | Thymic stromal lymphopoietin receptor molecules and uses thereof | |
SE8902532D0 (sv) | Bestaemning av plasmaproteiner | |
PT1214600E (pt) | Determinacao de proteinas de ligacao a adrenomedulina | |
DE69938183D1 (de) | Verwendungen eines borreliaziden epitops des aussermembranproteins c von borrelia burgdorferi (ospc) als impstoff | |
DE69333738T2 (de) | Therapeutische domänen des von willebrand-faktor | |
DE69033511D1 (de) | Verfahren zum Nachweis von Knochen- und anderen Bindegewebeerkrankungen in Menschen und Tieren | |
EP2083018A3 (fr) | Compositions et procédés associés à STOP-1 | |
DE60024997D1 (de) | Vgf polypeptide und verfahren zur behandlung von vgf-erkrankungen | |
AU2904197A (en) | Diagnostic method and apparatus based on polymorphism in an IL-6 gene | |
WO1999058098A3 (fr) | Antithrombines iii humaines et procedes connexes | |
DE59909356D1 (de) | Pharmazeutische präparation, enthaltend einen rezeptor-antagonisten zur behandlung von blutgerinnungsstörungen | |
Kumar et al. | Biomedical Potentials of Protein Z: An Insight | |
Wyatt et al. | Defective fibrinogen polymerization associated with a novel γ279Ala→ Asp mutation | |
WO2002058323A3 (fr) | Dosage | |
BR9913991A (pt) | Métodos de sub-regulação da resposta imune a proteìnas terapêuticas | |
WO2003025197A3 (fr) | Compositions a base de proteine mutante de liaison a sh3 et methodes associees | |
ATE324881T1 (de) | Antagonisten der defektiven magnesiumbindung als therapeutische mittel und methoden zur behandlung von abnormalen physiologischen zuständen | |
DE69635989D1 (de) | Diagnostischer test für von pferdearthritisvirus verursachte krankheiten | |
Hildebrandt | The Effects of Neurofibromatosis Type 1 on Pseudoarthrosis and the Forensic Implications | |
Ivaskevicius et al. | Establishment of an International Registry of Patients with Congenital FXIII Deficiency | |
Jaiswala et al. | Sperm capacitation is, after all, a prerequisite for both partial and complete acrosome reaction |