DK0753015T3 - Monoklonale antistoffer mod Tie-receptoren og anvendelse deraf - Google Patents

Monoklonale antistoffer mod Tie-receptoren og anvendelse deraf

Info

Publication number
DK0753015T3
DK0753015T3 DK95914366T DK95914366T DK0753015T3 DK 0753015 T3 DK0753015 T3 DK 0753015T3 DK 95914366 T DK95914366 T DK 95914366T DK 95914366 T DK95914366 T DK 95914366T DK 0753015 T3 DK0753015 T3 DK 0753015T3
Authority
DK
Denmark
Prior art keywords
monoclonal antibodies
antibodies against
tie receptor
useful
angiogenesis
Prior art date
Application number
DK95914366T
Other languages
English (en)
Inventor
Kari Alitalo
Marja-Terttu Matikainen
Paeivi Karnani
Original Assignee
Kari Alitalo
Matikainen Marja Terttu
Paeivi Karnani
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kari Alitalo, Matikainen Marja Terttu, Paeivi Karnani filed Critical Kari Alitalo
Application granted granted Critical
Publication of DK0753015T3 publication Critical patent/DK0753015T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK95914366T 1994-03-29 1995-03-29 Monoklonale antistoffer mod Tie-receptoren og anvendelse deraf DK0753015T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/220,240 US5955291A (en) 1992-01-09 1994-03-29 Antibodies recognizing tie receptor tyrosine kinase and uses thereof
PCT/FI1995/000170 WO1995026364A1 (en) 1994-03-29 1995-03-29 Monoclonal antibodies recognizing tie-receptor and their use

Publications (1)

Publication Number Publication Date
DK0753015T3 true DK0753015T3 (da) 2000-11-13

Family

ID=22822698

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95914366T DK0753015T3 (da) 1994-03-29 1995-03-29 Monoklonale antistoffer mod Tie-receptoren og anvendelse deraf

Country Status (13)

Country Link
US (1) US5955291A (da)
EP (1) EP0753015B1 (da)
JP (1) JP3683270B2 (da)
AT (1) ATE195533T1 (da)
AU (1) AU697185B2 (da)
CA (1) CA2185043C (da)
DE (1) DE69518406T2 (da)
DK (1) DK0753015T3 (da)
ES (1) ES2151595T3 (da)
MX (1) MX9604391A (da)
NO (1) NO319586B1 (da)
NZ (1) NZ283366A (da)
WO (1) WO1995026364A1 (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955291A (en) * 1992-01-09 1999-09-21 Alitalo; Kari Antibodies recognizing tie receptor tyrosine kinase and uses thereof
US6818220B1 (en) 1994-11-14 2004-11-16 Licentia Ltd. Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof
ATE273384T1 (de) 1995-04-06 2004-08-15 Regeneron Pharma Tie-2 liganden, herstellungsverfahren und verwendung
US6361946B1 (en) 1997-02-05 2002-03-26 Licentia Ltd Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
US7423125B2 (en) 1995-08-01 2008-09-09 Vegenics Limited Antibodies to VEGF-C
US7063965B2 (en) 1996-04-05 2006-06-20 Regeneron Pharmaceuticals, Inc. Nucleic acid encoding TIE-2 ligand
US5851797A (en) * 1996-06-19 1998-12-22 Regeneron Pharmaceuticals, Inc. Tie ligand-3, methods of making and uses thereof
US7125714B2 (en) 1997-02-05 2006-10-24 Licentia Ltd. Progenitor cell materials and methods
US5972338A (en) 1997-09-19 1999-10-26 Genentech, Inc. Tie ligands homologues
US6057435A (en) * 1997-09-19 2000-05-02 Genentech, Inc. Tie ligand homologues
US6350450B1 (en) 1997-09-19 2002-02-26 Genentech, Inc. TIE ligand homologue antibody
US6348350B1 (en) 1997-09-19 2002-02-19 Genentech, Inc. Ligand homologues
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
FR2783325A1 (fr) * 1998-09-11 2000-03-17 Inst Nat Sante Rech Med Moyens pour le controle de la regulation negative d'une activation transmise par un rtk
US6365154B1 (en) * 1998-09-28 2002-04-02 Smithkline Beecham Corporation Tie2 agonist antibodies
US6376653B1 (en) * 1998-09-28 2002-04-23 Smithkline Beecham Plc Tie2 antagonist antibodies
US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
AU783960B2 (en) 1999-06-07 2006-01-05 Immunex Corporation Tek antagonists
US6521424B2 (en) * 1999-06-07 2003-02-18 Immunex Corporation Recombinant expression of Tek antagonists
US6346247B1 (en) 1999-10-28 2002-02-12 Promega Corporation Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies
DE60131146T2 (de) 2000-02-25 2008-03-06 Ludwig Institute For Cancer Research Material und verfahren die hybridvaskularendothelwachstumfaktoren dns und proteine enthalten und screeningverfahren für modulatoren
WO2001072339A2 (en) * 2000-03-30 2001-10-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treatment of conditions involving obstruction of blood flow
WO2002036771A2 (en) 2000-11-06 2002-05-10 Cancer Research Technology Limited Imaging, diagnosis and treatment of disease
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US20050152899A1 (en) * 2002-05-10 2005-07-14 Kinch Michael S. EphA2 agonistic monoclonal antibodies and methods of use thereof
WO2003094859A2 (en) * 2002-05-10 2003-11-20 Medimmune, Inc. Epha2 monoclonal antibodies and methods of use thereof
JP4585968B2 (ja) * 2002-05-10 2010-11-24 パーデュー・リサーチ・ファウンデーション ＥｐｈＡ２アゴニストモノクローナル抗体およびその使用法
DK1458853T3 (da) * 2002-05-16 2010-04-06 Absorber Ab Fremgangsmåde til donorspecifik krydsmatchning
EP1565491B1 (en) 2002-11-20 2010-03-31 Cancer Research Technology Limited Antibodies binding to human magic roundabout (mr), polypeptides and uses thereof for inhibition of angiogenesis
CA2521594A1 (en) * 2003-04-11 2004-10-28 Medimmune, Inc. Epha2 and non-neoplastic hyperproliferative cell disorders
EP1618184A4 (en) * 2003-04-11 2006-06-21 Medimmune Inc EPHA2, HYPOPROLIFERATIVE CELL DISORDERS, AND EPITHELIAL AND ENDOTHELIAL RECONSTITUTION
EP1479760A1 (de) * 2003-05-19 2004-11-24 ProBioGen AG Künstliches Immunorgan
WO2005019267A2 (en) * 2003-08-12 2005-03-03 Dyax Corp. Tie1-binding ligands
US7485297B2 (en) * 2003-08-12 2009-02-03 Dyax Corp. Method of inhibition of vascular development using an antibody
US7871610B2 (en) * 2003-08-12 2011-01-18 Dyax Corp. Antibodies to Tie1 ectodomain
CA2550551C (en) * 2004-01-16 2013-10-29 Regeneron Pharmaceuticals, Inc. Fusion polypeptides capable of activating receptors
US8298532B2 (en) 2004-01-16 2012-10-30 Regeneron Pharmaceuticals, Inc. Fusion polypeptides capable of activating receptors
CA2559110A1 (en) * 2004-03-09 2005-09-15 Absorber Ab Endothelial progenitor cells and methods of use thereof
EP1789451A4 (en) * 2004-08-12 2009-12-02 Dyax Corp TIE COMPLEX BINDING PROTEINS
US20090170769A1 (en) * 2005-05-13 2009-07-02 Pei Jin Cell surface receptor isoforms and methods of identifying and using the same
US20080213253A1 (en) * 2007-01-12 2008-09-04 Dyax Corp. Combination therapy for the treatment of cancer
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
US9896933B1 (en) 2011-02-07 2018-02-20 Ameriband, Llc Continuously variable displacement engine
US9540932B1 (en) 2011-02-07 2017-01-10 Ameriband, Llc Continuously variable displacement engine
US9109446B1 (en) 2011-02-07 2015-08-18 Ameriband, Llc Continuously variable displacement engine
US10041405B1 (en) 2011-02-07 2018-08-07 Ameriband, Llc Continuously variable displacement engine
US9581057B1 (en) 2014-08-20 2017-02-28 Ameriband, Llc Valve actuator system capable of operating multiple valves with a single cam

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955291A (en) * 1992-01-09 1999-09-21 Alitalo; Kari Antibodies recognizing tie receptor tyrosine kinase and uses thereof
EP0620826A1 (en) * 1992-01-09 1994-10-26 Helsinki University Holding, Ltd. Tie, a novel endothelial cell receptor tyrosine kinase

Also Published As

Publication number Publication date
DE69518406D1 (de) 2000-09-21
NO964013D0 (no) 1996-09-24
NO319586B1 (no) 2005-08-29
DE69518406T2 (de) 2001-03-15
WO1995026364A1 (en) 1995-10-05
JP3683270B2 (ja) 2005-08-17
EP0753015A1 (en) 1997-01-15
ES2151595T3 (es) 2001-01-01
CA2185043A1 (en) 1995-10-05
EP0753015B1 (en) 2000-08-16
NO964013L (no) 1996-09-24
AU2139295A (en) 1995-10-17
ATE195533T1 (de) 2000-09-15
MX9604391A (es) 1997-07-31
US5955291A (en) 1999-09-21
AU697185B2 (en) 1998-10-01
JPH09511141A (ja) 1997-11-11
NZ283366A (en) 1998-04-27
CA2185043C (en) 2008-03-18

Similar Documents

Publication Publication Date Title
DK0753015T3 (da) Monoklonale antistoffer mod Tie-receptoren og anvendelse deraf
NL300985I2 (en) mogamulizumab
ATE110172T1 (de) Antikörper gegen menschlichen progesteronrezeptor sowie diagnosematerial und -verfahren.
DE59102225D1 (de) Ultraschall-Kontrastmittel, Verfahren zu ihrer Herstellung und Verwendung derselben als Diagnostika und Therapeutika.
ATE178907T1 (de) Rezeptorbindende region des diphtherietoxius
ATE267610T1 (de) Glykosylierte igg antikörper
EP0671920A4 (en) AN ANTI-IDIOTYPICAL ANTIBODY AND ITS USE IN THE DIAGNOSIS AND THERAPY OF HIV-RELATED DISEASES.
ATE388167T1 (de) Menschlicher antikörper gegen gangliosid gd3 für die transplantationskomplementarität bestimmente regionund derivate des antikörpers gegen das gangliosid gd3
NZ333744A (en) Immunological process for detecting antibodies directed towards tissue transglutaminase (ttg), use of ttg for diagnostic purposes and therapy control, and oral pharmaceutical agent containing ttg
DK0807125T3 (da) Monoklonale antistoffer mod CD6 til behandling og diagnosticering af psoriasis
HK1029123A1 (en) Antibodies for inhibiting blood coagulation and methods of use thereof
IT8468208A1 (it) Corpo assorbente per uso igienico, quale tampone o pannolino monouso, e procedimento per la sua fabbricazione.
NO910923D0 (no) Trifunksjonell antistofflignende forbindelse som et kombinert diagnostisk og terapeutisk middel.
CA2093928A1 (en) Monoclonal antibodies for detection and treatment of cancer
DK0600930T3 (da) Diagnose og behandling af autoimmune sygdomme
CA2091967A1 (en) Monoclonal anti-ganglioside antibody, its preparation and use as a tumor therapeutic agent
MXPA03009138A (es) Produccion de anticuerpos monoespecificos policlonales, contra variantes del receptor activador del plasminogeno de tipo uroquinasa (upar) del4, del5 y del4+5 y su uso para propositos de diagnostico y terapeutico.
AU4098201A (en) Method for diagnosing efficacy of xenotypic antibody therapy
AU653332B2 (en) Synthetic peptides which contain sequences from factor VIIa, and the use thereof
DE59207362D1 (de) Monoklonale Antikörper gegen den Plasmin-Antiplasmin Komplex, Verfahren zu ihrer Herstellung sowie ihre Verwendung
李斯德 et al. STUDY OF RADIOIMMUNOIMAGING WITH MONOCLONAL ANTIBODY AGAINST THE PATIENTS WITH SCLC
ATE84069T1 (de) Murin-hybridoma lym-2 und diagnostikantikoerper, der dadurch hergestellt ist.
ATE95426T1 (de) Humanes karcinom-assoziertes antigen und an dieses antigen bindende antikoerper.
ES1021127U (es) Dispositivo para la formacion de torundas sanitarias radio-opacas.
BG105030A (en) Antibodies against ed-b domain of fibronectin, conjugates containing them, and their application for diagnostics and treatment of tumours and morbid conditions related to angiogenesis