MX9604391A - Anticuerpos monoclonales que reconocen el receptor de tie y su uso. - Google Patents
Anticuerpos monoclonales que reconocen el receptor de tie y su uso.Info
- Publication number
- MX9604391A MX9604391A MX9604391A MX9604391A MX9604391A MX 9604391 A MX9604391 A MX 9604391A MX 9604391 A MX9604391 A MX 9604391A MX 9604391 A MX9604391 A MX 9604391A MX 9604391 A MX9604391 A MX 9604391A
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- tie
- monoclonal antibodies
- useful
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se describen anticuerpos novedosos, los cuales son reactivos con Tie, una cinasa de tirosina receptora encontrada en células endoteliales y en ciertas poblaciones celulares tumorosas. Se describen los anticuerpos monoclonales de anti-Tie y se proporciona el anticuerpo monoclonal 3C4C7G6, así como la línea celular de hibridoma (DSM ACCC2159) que lo produce. Los anticuerpos son utiles como herramientas de diagnostico para la deteccion de enfermedades neoplásticas que involucran angiogénesis tumorosa, curacion de heridas y una variedad de otras enfermedades asociadas con angiogénesis y para la representacion radiologica de los vasos sanguíneos. Además, los anticuerpos expuestos son utiles como agentes terapéuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/220,240 US5955291A (en) | 1992-01-09 | 1994-03-29 | Antibodies recognizing tie receptor tyrosine kinase and uses thereof |
PCT/FI1995/000170 WO1995026364A1 (en) | 1994-03-29 | 1995-03-29 | Monoclonal antibodies recognizing tie-receptor and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9604391A true MX9604391A (es) | 1997-07-31 |
Family
ID=22822698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9604391A MX9604391A (es) | 1994-03-29 | 1995-03-29 | Anticuerpos monoclonales que reconocen el receptor de tie y su uso. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5955291A (es) |
EP (1) | EP0753015B1 (es) |
JP (1) | JP3683270B2 (es) |
AT (1) | ATE195533T1 (es) |
AU (1) | AU697185B2 (es) |
CA (1) | CA2185043C (es) |
DE (1) | DE69518406T2 (es) |
DK (1) | DK0753015T3 (es) |
ES (1) | ES2151595T3 (es) |
MX (1) | MX9604391A (es) |
NO (1) | NO319586B1 (es) |
NZ (1) | NZ283366A (es) |
WO (1) | WO1995026364A1 (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5955291A (en) * | 1992-01-09 | 1999-09-21 | Alitalo; Kari | Antibodies recognizing tie receptor tyrosine kinase and uses thereof |
US6818220B1 (en) | 1994-11-14 | 2004-11-16 | Licentia Ltd. | Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof |
ATE273384T1 (de) | 1995-04-06 | 2004-08-15 | Regeneron Pharma | Tie-2 liganden, herstellungsverfahren und verwendung |
US6361946B1 (en) | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
US7423125B2 (en) | 1995-08-01 | 2008-09-09 | Vegenics Limited | Antibodies to VEGF-C |
US7063965B2 (en) | 1996-04-05 | 2006-06-20 | Regeneron Pharmaceuticals, Inc. | Nucleic acid encoding TIE-2 ligand |
US5851797A (en) * | 1996-06-19 | 1998-12-22 | Regeneron Pharmaceuticals, Inc. | Tie ligand-3, methods of making and uses thereof |
US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
US5972338A (en) | 1997-09-19 | 1999-10-26 | Genentech, Inc. | Tie ligands homologues |
US6057435A (en) * | 1997-09-19 | 2000-05-02 | Genentech, Inc. | Tie ligand homologues |
US6350450B1 (en) | 1997-09-19 | 2002-02-26 | Genentech, Inc. | TIE ligand homologue antibody |
US6348350B1 (en) | 1997-09-19 | 2002-02-19 | Genentech, Inc. | Ligand homologues |
US6030831A (en) * | 1997-09-19 | 2000-02-29 | Genetech, Inc. | Tie ligand homologues |
FR2783325A1 (fr) * | 1998-09-11 | 2000-03-17 | Inst Nat Sante Rech Med | Moyens pour le controle de la regulation negative d'une activation transmise par un rtk |
US6365154B1 (en) * | 1998-09-28 | 2002-04-02 | Smithkline Beecham Corporation | Tie2 agonist antibodies |
US6376653B1 (en) * | 1998-09-28 | 2002-04-23 | Smithkline Beecham Plc | Tie2 antagonist antibodies |
US7488590B2 (en) * | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
AU783960B2 (en) | 1999-06-07 | 2006-01-05 | Immunex Corporation | Tek antagonists |
US6521424B2 (en) * | 1999-06-07 | 2003-02-18 | Immunex Corporation | Recombinant expression of Tek antagonists |
US6346247B1 (en) | 1999-10-28 | 2002-02-12 | Promega Corporation | Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies |
DE60131146T2 (de) | 2000-02-25 | 2008-03-06 | Ludwig Institute For Cancer Research | Material und verfahren die hybridvaskularendothelwachstumfaktoren dns und proteine enthalten und screeningverfahren für modulatoren |
WO2001072339A2 (en) * | 2000-03-30 | 2001-10-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of treatment of conditions involving obstruction of blood flow |
WO2002036771A2 (en) | 2000-11-06 | 2002-05-10 | Cancer Research Technology Limited | Imaging, diagnosis and treatment of disease |
US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7205275B2 (en) * | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
US7658924B2 (en) * | 2001-10-11 | 2010-02-09 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7138370B2 (en) * | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
US20050152899A1 (en) * | 2002-05-10 | 2005-07-14 | Kinch Michael S. | EphA2 agonistic monoclonal antibodies and methods of use thereof |
WO2003094859A2 (en) * | 2002-05-10 | 2003-11-20 | Medimmune, Inc. | Epha2 monoclonal antibodies and methods of use thereof |
JP4585968B2 (ja) * | 2002-05-10 | 2010-11-24 | パーデュー・リサーチ・ファウンデーション | EphA2アゴニストモノクローナル抗体およびその使用法 |
DK1458853T3 (da) * | 2002-05-16 | 2010-04-06 | Absorber Ab | Fremgangsmåde til donorspecifik krydsmatchning |
EP1565491B1 (en) | 2002-11-20 | 2010-03-31 | Cancer Research Technology Limited | Antibodies binding to human magic roundabout (mr), polypeptides and uses thereof for inhibition of angiogenesis |
CA2521594A1 (en) * | 2003-04-11 | 2004-10-28 | Medimmune, Inc. | Epha2 and non-neoplastic hyperproliferative cell disorders |
EP1618184A4 (en) * | 2003-04-11 | 2006-06-21 | Medimmune Inc | EPHA2, HYPOPROLIFERATIVE CELL DISORDERS, AND EPITHELIAL AND ENDOTHELIAL RECONSTITUTION |
EP1479760A1 (de) * | 2003-05-19 | 2004-11-24 | ProBioGen AG | Künstliches Immunorgan |
WO2005019267A2 (en) * | 2003-08-12 | 2005-03-03 | Dyax Corp. | Tie1-binding ligands |
US7485297B2 (en) * | 2003-08-12 | 2009-02-03 | Dyax Corp. | Method of inhibition of vascular development using an antibody |
US7871610B2 (en) * | 2003-08-12 | 2011-01-18 | Dyax Corp. | Antibodies to Tie1 ectodomain |
CA2550551C (en) * | 2004-01-16 | 2013-10-29 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
US8298532B2 (en) | 2004-01-16 | 2012-10-30 | Regeneron Pharmaceuticals, Inc. | Fusion polypeptides capable of activating receptors |
CA2559110A1 (en) * | 2004-03-09 | 2005-09-15 | Absorber Ab | Endothelial progenitor cells and methods of use thereof |
EP1789451A4 (en) * | 2004-08-12 | 2009-12-02 | Dyax Corp | TIE COMPLEX BINDING PROTEINS |
US20090170769A1 (en) * | 2005-05-13 | 2009-07-02 | Pei Jin | Cell surface receptor isoforms and methods of identifying and using the same |
US20080213253A1 (en) * | 2007-01-12 | 2008-09-04 | Dyax Corp. | Combination therapy for the treatment of cancer |
JO2913B1 (en) | 2008-02-20 | 2015-09-15 | امجين إنك, | Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses |
US9896933B1 (en) | 2011-02-07 | 2018-02-20 | Ameriband, Llc | Continuously variable displacement engine |
US9540932B1 (en) | 2011-02-07 | 2017-01-10 | Ameriband, Llc | Continuously variable displacement engine |
US9109446B1 (en) | 2011-02-07 | 2015-08-18 | Ameriband, Llc | Continuously variable displacement engine |
US10041405B1 (en) | 2011-02-07 | 2018-08-07 | Ameriband, Llc | Continuously variable displacement engine |
US9581057B1 (en) | 2014-08-20 | 2017-02-28 | Ameriband, Llc | Valve actuator system capable of operating multiple valves with a single cam |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5955291A (en) * | 1992-01-09 | 1999-09-21 | Alitalo; Kari | Antibodies recognizing tie receptor tyrosine kinase and uses thereof |
EP0620826A1 (en) * | 1992-01-09 | 1994-10-26 | Helsinki University Holding, Ltd. | Tie, a novel endothelial cell receptor tyrosine kinase |
-
1994
- 1994-03-29 US US08/220,240 patent/US5955291A/en not_active Expired - Lifetime
-
1995
- 1995-03-29 DE DE69518406T patent/DE69518406T2/de not_active Expired - Lifetime
- 1995-03-29 MX MX9604391A patent/MX9604391A/es not_active IP Right Cessation
- 1995-03-29 AT AT95914366T patent/ATE195533T1/de active
- 1995-03-29 ES ES95914366T patent/ES2151595T3/es not_active Expired - Lifetime
- 1995-03-29 AU AU21392/95A patent/AU697185B2/en not_active Ceased
- 1995-03-29 NZ NZ283366A patent/NZ283366A/en not_active IP Right Cessation
- 1995-03-29 DK DK95914366T patent/DK0753015T3/da active
- 1995-03-29 WO PCT/FI1995/000170 patent/WO1995026364A1/en active IP Right Grant
- 1995-03-29 JP JP52498895A patent/JP3683270B2/ja not_active Expired - Fee Related
- 1995-03-29 EP EP95914366A patent/EP0753015B1/en not_active Expired - Lifetime
- 1995-03-29 CA CA002185043A patent/CA2185043C/en not_active Expired - Fee Related
-
1996
- 1996-09-24 NO NO19964013A patent/NO319586B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69518406D1 (de) | 2000-09-21 |
NO964013D0 (no) | 1996-09-24 |
NO319586B1 (no) | 2005-08-29 |
DE69518406T2 (de) | 2001-03-15 |
WO1995026364A1 (en) | 1995-10-05 |
JP3683270B2 (ja) | 2005-08-17 |
EP0753015A1 (en) | 1997-01-15 |
ES2151595T3 (es) | 2001-01-01 |
CA2185043A1 (en) | 1995-10-05 |
EP0753015B1 (en) | 2000-08-16 |
NO964013L (no) | 1996-09-24 |
AU2139295A (en) | 1995-10-17 |
ATE195533T1 (de) | 2000-09-15 |
US5955291A (en) | 1999-09-21 |
AU697185B2 (en) | 1998-10-01 |
JPH09511141A (ja) | 1997-11-11 |
DK0753015T3 (da) | 2000-11-13 |
NZ283366A (en) | 1998-04-27 |
CA2185043C (en) | 2008-03-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: LICENTIA LTD. |
|
MM | Annulment or lapse due to non-payment of fees |