DK0749481T3 - Humaniserede monoklonale antistoffer mod human interleukin-4 - Google Patents

Humaniserede monoklonale antistoffer mod human interleukin-4

Info

Publication number
DK0749481T3
DK0749481T3 DK95912620T DK95912620T DK0749481T3 DK 0749481 T3 DK0749481 T3 DK 0749481T3 DK 95912620 T DK95912620 T DK 95912620T DK 95912620 T DK95912620 T DK 95912620T DK 0749481 T3 DK0749481 T3 DK 0749481T3
Authority
DK
Denmark
Prior art keywords
monoclonal antibodies
human
humanized monoclonal
human interleukin
antibodies
Prior art date
Application number
DK95912620T
Other languages
Danish (da)
English (en)
Inventor
Stephen Tindall
Barbara Dalie
Kenneth Miller
Nicholas Murgolo
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DK0749481T3 publication Critical patent/DK0749481T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK95912620T 1994-03-10 1995-03-08 Humaniserede monoklonale antistoffer mod human interleukin-4 DK0749481T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/208,886 US5597710A (en) 1994-03-10 1994-03-10 Humanized monoclonal antibodies against human interleukin-4
PCT/US1995/002400 WO1995024481A2 (en) 1994-03-10 1995-03-08 Humanized monoclonal antibodies against human interleukin-4

Publications (1)

Publication Number Publication Date
DK0749481T3 true DK0749481T3 (da) 1999-06-14

Family

ID=22776442

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95912620T DK0749481T3 (da) 1994-03-10 1995-03-08 Humaniserede monoklonale antistoffer mod human interleukin-4

Country Status (10)

Country Link
US (1) US5597710A (de)
EP (1) EP0749481B1 (de)
JP (1) JPH09510095A (de)
AT (1) ATE171473T1 (de)
AU (1) AU1971295A (de)
CA (1) CA2185112C (de)
DE (1) DE69504959T2 (de)
DK (1) DK0749481T3 (de)
ES (1) ES2121358T3 (de)
WO (1) WO1995024481A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US20020193575A1 (en) * 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US5914110A (en) * 1993-09-07 1999-06-22 Smithkline Beecham Corporation Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
AU6703198A (en) 1997-03-21 1998-10-20 Brigham And Women's Hospital Immunotherapeutic ctla-4 binding peptides
US6172213B1 (en) 1997-07-02 2001-01-09 Genentech, Inc. Anti-IgE antibodies and method of improving polypeptides
US5994511A (en) 1997-07-02 1999-11-30 Genentech, Inc. Anti-IgE antibodies and methods of improving polypeptides
US7083950B2 (en) * 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. High affinity fusion proteins and therapeutic and diagnostic methods for use
US7994278B1 (en) * 1999-08-06 2011-08-09 Nobel Biosciences Llc Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA)
JP2001275677A (ja) * 2000-03-30 2001-10-09 Canon Inc 核酸断片プライマーまたはプローブ、およびこれを用いたポリヒドロキシアルカノエート合成微生物の検出方法
US20070104710A1 (en) * 2002-06-28 2007-05-10 Domants Limited Ligand that has binding specificity for IL-4 and/or IL-13
US20110223168A1 (en) * 2002-12-27 2011-09-15 Greg Winter Ligand that has binding specificity for il-4 and/or il-13
AR050044A1 (es) * 2004-08-03 2006-09-20 Novartis Ag Anticuerpo especifico de il-4
AR060017A1 (es) * 2006-01-13 2008-05-21 Novartis Ag Composiciones y metodos de uso para anticuerpos de dickkopf -1
EP2050764A1 (de) * 2007-10-15 2009-04-22 sanofi-aventis Neues polyvalentes bispezifisches Antikörperformat und Verwendung
MX2015013901A (es) * 2013-04-05 2015-12-11 Genentech Inc Anticuerpos anti-il-4 y anticuerpos biespecificos y sus usos.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3382317D1 (de) * 1982-03-15 1991-07-25 Schering Corp Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
US4731237A (en) * 1983-11-07 1988-03-15 The Wistar Institute Immune response to virus induced by anti-idiotype antibodies
US5041381A (en) * 1986-07-03 1991-08-20 Schering Corporation Monoclonal antibodies against human interleukin-4 and hybridomas producing the same
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
EP0397764A1 (de) * 1988-02-02 1990-11-22 Schering Biotech Corporation Methode zur verminderung der immunglobulin-e-reaktion
AU639754B2 (en) * 1989-12-20 1993-08-05 Schering Corporation Antibody antagonists of human interleukin-4
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
CA2041271A1 (en) * 1990-04-30 1991-10-31 Bradford A. Jameson Peptide analogs to proteins of the immunoglobin superfamily
JPH07502901A (ja) * 1992-02-19 1995-03-30 シェリング・コーポレーション ヒトインターロイキン−４に対するヒト化モノクローナル抗体のクローニング及び発現

Also Published As

Publication number Publication date
JPH09510095A (ja) 1997-10-14
ES2121358T3 (es) 1998-11-16
AU1971295A (en) 1995-09-25
EP0749481B1 (de) 1998-09-23
WO1995024481A3 (en) 1995-10-19
US5597710A (en) 1997-01-28
EP0749481A1 (de) 1996-12-27
DE69504959T2 (de) 1999-02-18
CA2185112C (en) 2000-10-31
ATE171473T1 (de) 1998-10-15
DE69504959D1 (de) 1998-10-29
WO1995024481A2 (en) 1995-09-14
CA2185112A1 (en) 1995-09-14

Similar Documents

Publication Publication Date Title
ATE171472T1 (de) Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4
DK101890A (da) Monoklonale antistoffer mod human interleukin-4 og hybridomaer, der producerer saadanne
DK0749481T3 (da) Humaniserede monoklonale antistoffer mod human interleukin-4
ATE177754T1 (de) Fragmente von prion proteinen.
ATE303161T1 (de) Humanisierung von anti-carcinoembryonalen antigen anti-idiotypischen antikörper und dessen verwendung als tumorvakzin und zur markierung
DK0980429T3 (da) Human Toll-lignende receptorproteiner, beslægtede reagenser og fremgangsmåder
DE69233191D1 (de) Cyclin d1 und seine cdna
ES2133813T3 (es) Cadenas de lamininas: diagnostico y uso terapeutico.
DE3750342D1 (de) Menschliches gamma-interferon-spezifisches Rezeptorprotein, Antikörper gegen dieses Protein, Verfahren zur Herstellung dieses Proteins und dieses Antikörpers und dieses Protein und diesen Antikörper enthaltende Zusammensetzungen.
DE68925226D1 (de) Monoklonale Antikörper
DE69531958D1 (de) (1-3)-beta-d-glukon-bindungsprotein, antikörper der dieses protein erkennt undverwendung des proteins und antikörper
IT1207589B (it) Composizione di anticorpi monoclonali umani cross-protettivi.
DE3689948D1 (de) Monoklonale antikörper und testverfahren.
ATE191568T1 (de) Spezifische bindungssubstanzen für antikörper und deren verwendung für immunoassays oder vakzine
IT1231727B (it) Peptidi utili per la determinazione e la purificazione di anticorpi anti gamma interferone.
DE69728897D1 (de) Saeugetierchemokine
ATE71149T1 (de) Monoklonale antikoerper.
DE3888604D1 (de) Monoklonale Antikörper gegen Antithrombinbindende Substanz und seine Verwendungen.
DE3580482D1 (de) Monoklonale antikoerper und immunisierung damit.
DE3785175D1 (de) A-assoziierte h-antigene, spezifische monoklonale antikoerper und methoden zu deren verwendung zur blutgruppenbestimmung.
DE68907377D1 (de) Agens und geraet zur bestimmung von antigenen oder antikoerpern.
RU94026276A (ru) Рецепторы интерлейкина-12 и антител
FI956041A (fi) Kompositiot ja diagnostiset menetelmät, joissa käytetään monoklonaalisia vasta-aineita CD44V6 vastaan
IT9006602A0 (it) Test immunoenzimatico per la ricerca e determinazione degli anticorpi anti-ss-dna.
ATE58173T1 (de) Monoklonale antikoerper und immunisierung damit.