DK0735043T3 - Fremgangsmåde til fremstilling af 2-substitueret 3,3-difluorfuran - Google Patents

Fremgangsmåde til fremstilling af 2-substitueret 3,3-difluorfuran

Info

Publication number
DK0735043T3
DK0735043T3 DK96301685T DK96301685T DK0735043T3 DK 0735043 T3 DK0735043 T3 DK 0735043T3 DK 96301685 T DK96301685 T DK 96301685T DK 96301685 T DK96301685 T DK 96301685T DK 0735043 T3 DK0735043 T3 DK 0735043T3
Authority
DK
Denmark
Prior art keywords
difluorofuran
substituted
preparation
Prior art date
Application number
DK96301685T
Other languages
Danish (da)
English (en)
Inventor
Douglas Patton Kjell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0735043T3 publication Critical patent/DK0735043T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96301685T 1995-03-24 1996-03-12 Fremgangsmåde til fremstilling af 2-substitueret 3,3-difluorfuran DK0735043T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/410,258 US5633367A (en) 1995-03-24 1995-03-24 Process for the preparation of a 2-substituted 3,3-difluorofuran

Publications (1)

Publication Number Publication Date
DK0735043T3 true DK0735043T3 (da) 1998-10-07

Family

ID=23623945

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96301685T DK0735043T3 (da) 1995-03-24 1996-03-12 Fremgangsmåde til fremstilling af 2-substitueret 3,3-difluorfuran

Country Status (7)

Country Link
US (1) US5633367A (ja)
EP (1) EP0735043B1 (ja)
JP (1) JPH08269081A (ja)
CA (1) CA2171522A1 (ja)
DE (1) DE69600280T2 (ja)
DK (1) DK0735043T3 (ja)
ES (1) ES2117893T3 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9908270A (pt) 1998-02-25 2004-06-29 Univ Emory 2-fluoro-nucleosìdeos, composições farmacêuticas e seus usos
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
US20070191598A1 (en) * 2006-02-07 2007-08-16 Chemagis Ltd. Process for Preparing Gemcitabine and Associated Intermediates
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
US20220033430A1 (en) * 2018-11-25 2022-02-03 Tnt Medical Corporation Orally active prodrug of gemcitabine
GB202203421D0 (en) * 2022-03-11 2022-04-27 Laevoroc Chemotherapy Ag Orally active prodrug of gemcitabine
CN115745953B (zh) * 2022-06-29 2024-06-11 上海凌凯医药科技有限公司 一种羟基氟代试剂及羟基氟代方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3854110T2 (de) * 1987-03-19 1995-11-30 Yamasa Shoyu Kk 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5223608A (en) * 1987-08-28 1993-06-29 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US4921950A (en) * 1988-06-09 1990-05-01 Burroughs Wellcome Co. Preparation of 3'azido-3-'-deoxythymidine
CZ123493A3 (en) * 1992-06-22 1994-02-16 Lilly Co Eli Stereoselective anionic glycosylation process
HU214980B (hu) * 1992-09-01 1998-08-28 Eli Lilly And Co. Eljárás nukleozidok anomerizálására

Also Published As

Publication number Publication date
JPH08269081A (ja) 1996-10-15
US5633367A (en) 1997-05-27
EP0735043A1 (en) 1996-10-02
CA2171522A1 (en) 1996-09-25
EP0735043B1 (en) 1998-05-13
DE69600280T2 (de) 1998-10-08
DE69600280D1 (de) 1998-06-18
ES2117893T3 (es) 1998-08-16

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