DK0719154T3 - Aktiveret faktor VIII som terapeutisk middel og metode til behandling af faktor VIII-mangel - Google Patents
Aktiveret faktor VIII som terapeutisk middel og metode til behandling af faktor VIII-mangelInfo
- Publication number
- DK0719154T3 DK0719154T3 DK94926591T DK94926591T DK0719154T3 DK 0719154 T3 DK0719154 T3 DK 0719154T3 DK 94926591 T DK94926591 T DK 94926591T DK 94926591 T DK94926591 T DK 94926591T DK 0719154 T3 DK0719154 T3 DK 0719154T3
- Authority
- DK
- Denmark
- Prior art keywords
- factor viii
- therapeutic agent
- activated
- deficiency
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/120,894 US5576291A (en) | 1993-09-13 | 1993-09-13 | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
PCT/US1994/009613 WO1995007713A1 (en) | 1993-09-13 | 1994-08-26 | Activated factor viii as a therapeutic agent and method of treating factor viii deficiency |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0719154T3 true DK0719154T3 (da) | 2001-11-26 |
Family
ID=22393146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94926591T DK0719154T3 (da) | 1993-09-13 | 1994-08-26 | Aktiveret faktor VIII som terapeutisk middel og metode til behandling af faktor VIII-mangel |
Country Status (10)
Country | Link |
---|---|
US (1) | US5576291A (de) |
EP (1) | EP0719154B1 (de) |
JP (1) | JPH09502714A (de) |
AT (1) | ATE207759T1 (de) |
AU (1) | AU686661B2 (de) |
CA (1) | CA2168332A1 (de) |
DE (1) | DE69428905T2 (de) |
DK (1) | DK0719154T3 (de) |
ES (1) | ES2166783T3 (de) |
WO (1) | WO1995007713A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995003332A1 (en) * | 1993-07-23 | 1995-02-02 | Baxter International Inc. | Activated human factor viii and method of preparation |
GB9501040D0 (en) * | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
US7253262B2 (en) * | 1995-01-19 | 2007-08-07 | Quandrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
US7244824B2 (en) * | 1995-01-19 | 2007-07-17 | Quadrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
SE9501189D0 (sv) * | 1995-03-31 | 1995-03-31 | Pharmacia Ab | Protein formulation |
CN100553678C (zh) | 1999-02-22 | 2009-10-28 | 巴克斯特国际有限公司 | 新的无白蛋白的因子ⅷ制剂 |
ES2252028T3 (es) * | 1999-07-13 | 2006-05-16 | Biovitrum Ab | Composiciones estables del factor viii. |
JP4643783B2 (ja) * | 1999-12-24 | 2011-03-02 | 一般財団法人化学及血清療法研究所 | フォンヴィルブランド因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物 |
BR0215216A (pt) * | 2001-12-21 | 2004-11-16 | Novo Nordisk Healthcare Ag | Composição aquosa lìquida, método para preparar uma composição aquosa lìquida de um polipeptìdeo de fator vii, uso de uma composição aquosa lìquida, e, método para o tratamento de uma sìndrome de resposta ao fator vii |
KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
ES2523655T5 (es) | 2002-06-21 | 2018-04-23 | Novo Nordisk Health Care Ag | Composiciones sólidas estabilizadas de polipéptidos del Factor VIIa |
WO2004082708A2 (en) * | 2003-03-18 | 2004-09-30 | Novo Nordisk Health Care Ag | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
EP1628677B1 (de) * | 2003-05-23 | 2010-01-13 | Novo Nordisk Health Care AG | Stabilisierung von proteinen in lösung |
ATE547114T1 (de) * | 2003-06-25 | 2012-03-15 | Novo Nordisk Healthcare Ag | Flüssige zusammensetzungen von factor vii polypeptiden |
ES2335994T3 (es) * | 2003-07-01 | 2010-04-07 | Novo Nordisk Health Care Ag | Composicion farmaceutica liquida, acuosa de polipeptidos factor vii. |
EP1656158B1 (de) | 2003-08-14 | 2016-03-09 | Novo Nordisk Health Care AG | Flüssige, wässrige pharmazeutische zusammensetzung von faktor-vii-polypeptiden |
EP1699469B1 (de) * | 2003-12-03 | 2010-04-07 | University of Rochester | Rekombinanter faktor viii mit erhöhter spezifischer aktivität |
EP2311437A1 (de) * | 2003-12-19 | 2011-04-20 | Novo Nordisk Health Care AG | Stabilisierte Zusammensetzungen von Faktor-VII-Polypeptiden |
ATE490343T1 (de) * | 2005-06-30 | 2010-12-15 | Ge Healthcare Bio Sciences | Nachweisverfahren für die genexpression |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
WO2008134310A1 (en) * | 2007-04-26 | 2008-11-06 | Bayer Healthcare Llc | Stabilization of liquid solutions of recombinant protein for frozen storage |
WO2009058446A1 (en) * | 2007-11-01 | 2009-05-07 | University Of Rochester | Recombinant factor viii having increased stability |
JP5779780B2 (ja) | 2008-11-07 | 2015-09-16 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 第viii因子製剤 |
CN116925238A (zh) | 2009-02-03 | 2023-10-24 | 阿穆尼克斯制药公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
CN102741422B (zh) | 2009-08-24 | 2016-06-08 | 阿穆尼克斯运营公司 | 凝血因子ⅶ组合物及其制备和使用方法 |
US20130017997A1 (en) * | 2010-08-19 | 2013-01-17 | Amunix Operating Inc. | Factor VIII Compositions and Methods of Making and Using Same |
JP6383666B2 (ja) | 2012-02-15 | 2018-08-29 | バイオベラティブ セラピューティクス インコーポレイテッド | 組換え第viii因子タンパク質 |
JP6256882B2 (ja) | 2012-02-15 | 2018-01-10 | アムニクス オペレーティング インコーポレイテッド | 第viii因子組成物、ならびに組成物の作製方法および用途 |
US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
EP3292407A4 (de) * | 2015-05-06 | 2019-01-02 | Prescient Medicine Holdings, LLC | Entwicklung eines neuartigen automatisierten screeningverfahrens zum nachweis von fviii-inhibitoren |
BR112018002150A2 (pt) | 2015-08-03 | 2018-09-18 | Bioverativ Therapeutics Inc | proteínas de fusão do fator ix e métodos de fabricação e uso das mesmas |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2460305A2 (fr) * | 1979-06-29 | 1981-01-23 | Merieux Inst | Procede de preparation d'un concentre de facteur viii |
US4386068A (en) * | 1980-02-26 | 1983-05-31 | Cutter Laboratories, Inc. | Antihemophilic factor concentrate and method for preparation |
AT369263B (de) * | 1980-08-27 | 1982-12-27 | Immuno Ag | Verfahren zur herstellung eines faktor viii(ahf) -hochkonzentrates |
US5101016A (en) * | 1983-03-31 | 1992-03-31 | Scripps Clinic And Research Foundation | Factor VIII coagulant polypeptides and monoclonal antibodies to them |
US4657894A (en) * | 1983-03-31 | 1987-04-14 | Scripps Clinic & Research Foundation | New factor VIII coagulant polypeptides |
US4857635A (en) * | 1983-03-31 | 1989-08-15 | Scripps Clinic And Research Foundation | Factor VIII coagulant polypeptides and monoclonal antibodies tof them |
US4649132A (en) * | 1983-03-31 | 1987-03-10 | Scripps Clinic And Research Foundation | Treatment of Factor VIII inhibitors |
AU572128B2 (en) * | 1983-03-31 | 1988-05-05 | Scripps Clinic And Research Foundation | New factor viii, coagulant polypeptides and monoclonal antibodies |
US4757006A (en) * | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
US4508709A (en) * | 1983-12-05 | 1985-04-02 | Armour Pharmaceutical Company | Process for purifying factor VIII:C |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
DK525384D0 (da) * | 1984-11-05 | 1984-11-05 | Nordisk Insulinlab | Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat |
SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
DE3683980D1 (de) * | 1985-04-12 | 1992-04-02 | Genetics Inst | Neue prokoagulierungsproteine. |
US4769336A (en) * | 1985-05-24 | 1988-09-06 | Scripps Clinic And Research Foundation | Treatment of factor VIII inhibitors |
US4758657A (en) * | 1985-07-11 | 1988-07-19 | Armour Pharmaceutical Company | Method of purifying Factor VIII:C |
US4980456A (en) * | 1987-04-06 | 1990-12-25 | Scripps Clinic And Research Foundation | Recombinant factor VIIIC derived fragments |
CA1331157C (en) * | 1987-04-06 | 1994-08-02 | Randal J. Kaufman | Method for producing factor viii:c-type proteins |
US5171844A (en) * | 1987-06-12 | 1992-12-15 | Gist-Brocades N.W. | Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them |
US4795806A (en) * | 1987-07-16 | 1989-01-03 | Miles Laboratories, Inc. | Phospholipid affinity purification of Factor VIII:C |
US4981951A (en) * | 1988-04-14 | 1991-01-01 | Miles Inc. | Lectin affinity chromatography of factor VIII |
US5149687A (en) * | 1991-04-01 | 1992-09-22 | United Technologies Corporation | Method for making oriented bismuth and thallium superconductors comprising cold pressing at 700 MPa |
-
1993
- 1993-09-13 US US08/120,894 patent/US5576291A/en not_active Expired - Fee Related
-
1994
- 1994-08-26 CA CA002168332A patent/CA2168332A1/en not_active Abandoned
- 1994-08-26 AU AU76380/94A patent/AU686661B2/en not_active Ceased
- 1994-08-26 AT AT94926591T patent/ATE207759T1/de not_active IP Right Cessation
- 1994-08-26 EP EP94926591A patent/EP0719154B1/de not_active Expired - Lifetime
- 1994-08-26 WO PCT/US1994/009613 patent/WO1995007713A1/en active IP Right Grant
- 1994-08-26 JP JP7509198A patent/JPH09502714A/ja not_active Ceased
- 1994-08-26 ES ES94926591T patent/ES2166783T3/es not_active Expired - Lifetime
- 1994-08-26 DE DE69428905T patent/DE69428905T2/de not_active Expired - Fee Related
- 1994-08-26 DK DK94926591T patent/DK0719154T3/da active
Also Published As
Publication number | Publication date |
---|---|
ATE207759T1 (de) | 2001-11-15 |
EP0719154B1 (de) | 2001-10-31 |
ES2166783T3 (es) | 2002-05-01 |
JPH09502714A (ja) | 1997-03-18 |
DE69428905D1 (de) | 2001-12-06 |
US5576291A (en) | 1996-11-19 |
AU686661B2 (en) | 1998-02-12 |
CA2168332A1 (en) | 1995-03-23 |
WO1995007713A1 (en) | 1995-03-23 |
EP0719154A1 (de) | 1996-07-03 |
DE69428905T2 (de) | 2002-05-29 |
AU7638094A (en) | 1995-04-03 |
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