DK0719154T3 - Aktiveret faktor VIII som terapeutisk middel og metode til behandling af faktor VIII-mangel - Google Patents
Aktiveret faktor VIII som terapeutisk middel og metode til behandling af faktor VIII-mangelInfo
- Publication number
- DK0719154T3 DK0719154T3 DK94926591T DK94926591T DK0719154T3 DK 0719154 T3 DK0719154 T3 DK 0719154T3 DK 94926591 T DK94926591 T DK 94926591T DK 94926591 T DK94926591 T DK 94926591T DK 0719154 T3 DK0719154 T3 DK 0719154T3
- Authority
- DK
- Denmark
- Prior art keywords
- factor viii
- therapeutic agent
- activated
- deficiency
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/120,894 US5576291A (en) | 1993-09-13 | 1993-09-13 | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
PCT/US1994/009613 WO1995007713A1 (en) | 1993-09-13 | 1994-08-26 | Activated factor viii as a therapeutic agent and method of treating factor viii deficiency |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0719154T3 true DK0719154T3 (da) | 2001-11-26 |
Family
ID=22393146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94926591T DK0719154T3 (da) | 1993-09-13 | 1994-08-26 | Aktiveret faktor VIII som terapeutisk middel og metode til behandling af faktor VIII-mangel |
Country Status (10)
Country | Link |
---|---|
US (1) | US5576291A (da) |
EP (1) | EP0719154B1 (da) |
JP (1) | JPH09502714A (da) |
AT (1) | ATE207759T1 (da) |
AU (1) | AU686661B2 (da) |
CA (1) | CA2168332A1 (da) |
DE (1) | DE69428905T2 (da) |
DK (1) | DK0719154T3 (da) |
ES (1) | ES2166783T3 (da) |
WO (1) | WO1995007713A1 (da) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995003332A1 (en) * | 1993-07-23 | 1995-02-02 | Baxter International Inc. | Activated human factor viii and method of preparation |
GB9501040D0 (en) * | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
US7253262B2 (en) * | 1995-01-19 | 2007-08-07 | Quandrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
US7244824B2 (en) * | 1995-01-19 | 2007-07-17 | Quadrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
SE9501189D0 (sv) * | 1995-03-31 | 1995-03-31 | Pharmacia Ab | Protein formulation |
US6586573B1 (en) | 1999-02-22 | 2003-07-01 | Baxter International Inc. | Albumin-free Factor VIII formulations |
CA2378751C (en) * | 1999-07-13 | 2012-11-06 | Biovitrum Ab | Stable factor viii compositions |
JP4643783B2 (ja) * | 1999-12-24 | 2011-03-02 | 一般財団法人化学及血清療法研究所 | フォンヴィルブランド因子を主成分とする血小板減少に伴う出血疾患の予防・治療用医薬組成物 |
EP1458408B1 (en) | 2001-12-21 | 2009-04-15 | Novo Nordisk Health Care AG | Liquid composition of factor vii polypeptides |
KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
CN1671410B (zh) | 2002-06-21 | 2010-05-12 | 诺和诺德医疗保健公司 | 因子ⅶ多肽的稳定化固体组合物 |
JP2006524195A (ja) * | 2003-03-18 | 2006-10-26 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドの液状水性医薬組成物 |
US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
KR20060015574A (ko) * | 2003-05-23 | 2006-02-17 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 용액 중 단백질 안정화 |
JP4658041B2 (ja) * | 2003-06-25 | 2011-03-23 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドの液体組成物 |
WO2005002615A1 (en) * | 2003-07-01 | 2005-01-13 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical composition of factor vii polypeptides |
AU2004264282B2 (en) | 2003-08-14 | 2010-10-14 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical composition of Factor VII polypeptides |
WO2005055930A2 (en) * | 2003-12-03 | 2005-06-23 | University Of Rochester | Recombinant factor viii having increased specific activity |
MXPA06006886A (es) * | 2003-12-19 | 2006-09-04 | Novo Nordisk Healthcare Ag | Composiciones estabilizadas de polipeptidos del factor vii. |
WO2007005482A1 (en) * | 2005-06-30 | 2007-01-11 | Ge Healthcare Bio-Sciences Corp. | Detection method for gene expression |
US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
EP2150264A4 (en) * | 2007-04-26 | 2014-09-24 | Bayer Healthcare Llc | STABILIZATION OF LIQUID SOLUTIONS OF A RECOMBINANT PROTEIN FOR FROZEN STORAGE |
CN101965409A (zh) * | 2007-11-01 | 2011-02-02 | 罗切斯特大学 | 具有增加的稳定性的重组因子viii |
ES2706296T3 (es) | 2008-11-07 | 2019-03-28 | Univ Connecticut | Formulaciones de Factor VIII |
NZ628987A (en) | 2009-02-03 | 2015-11-27 | Amunix Operating Inc | Extended recombinant polypeptides and compositions comprising same |
WO2011028228A1 (en) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor vii compositions and methods of making and using same |
US20130017997A1 (en) * | 2010-08-19 | 2013-01-17 | Amunix Operating Inc. | Factor VIII Compositions and Methods of Making and Using Same |
CN104487452A (zh) | 2012-02-15 | 2015-04-01 | 阿穆尼克斯运营公司 | 因子viii组合物及其制备和使用方法 |
NZ628014A (en) | 2012-02-15 | 2016-09-30 | Biogen Ma Inc | Recombinant factor viii proteins |
EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
EP3292407A4 (en) * | 2015-05-06 | 2019-01-02 | Prescient Medicine Holdings, LLC | Development of novel automated screening method for detection of fviii inhibitors |
EA201890423A1 (ru) | 2015-08-03 | 2018-07-31 | Биовератив Терапьютикс Инк. | Слитые белки фактора ix, способы их получения и применения |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2460305A2 (fr) * | 1979-06-29 | 1981-01-23 | Merieux Inst | Procede de preparation d'un concentre de facteur viii |
US4386068A (en) * | 1980-02-26 | 1983-05-31 | Cutter Laboratories, Inc. | Antihemophilic factor concentrate and method for preparation |
AT369263B (de) * | 1980-08-27 | 1982-12-27 | Immuno Ag | Verfahren zur herstellung eines faktor viii(ahf) -hochkonzentrates |
US4857635A (en) * | 1983-03-31 | 1989-08-15 | Scripps Clinic And Research Foundation | Factor VIII coagulant polypeptides and monoclonal antibodies tof them |
US4649132A (en) * | 1983-03-31 | 1987-03-10 | Scripps Clinic And Research Foundation | Treatment of Factor VIII inhibitors |
US5101016A (en) * | 1983-03-31 | 1992-03-31 | Scripps Clinic And Research Foundation | Factor VIII coagulant polypeptides and monoclonal antibodies to them |
ZA842418B (en) * | 1983-03-31 | 1984-11-28 | Scripps Clinic Res | Factor viii coagulant polypeptides and monoclonal antibodies to them |
US4657894A (en) * | 1983-03-31 | 1987-04-14 | Scripps Clinic & Research Foundation | New factor VIII coagulant polypeptides |
US4757006A (en) * | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
US4508709A (en) * | 1983-12-05 | 1985-04-02 | Armour Pharmaceutical Company | Process for purifying factor VIII:C |
US4965199A (en) * | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
DK525384D0 (da) * | 1984-11-05 | 1984-11-05 | Nordisk Insulinlab | Praeparat paa basis af faktor viii til behandling af haemofili a inhibitorpatienter samt fremgangsmaade til fremstilling af et saadan praeparat |
SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
ATE72838T1 (de) * | 1985-04-12 | 1992-03-15 | Genetics Inst | Neue prokoagulierungsproteine. |
US4769336A (en) * | 1985-05-24 | 1988-09-06 | Scripps Clinic And Research Foundation | Treatment of factor VIII inhibitors |
US4758657A (en) * | 1985-07-11 | 1988-07-19 | Armour Pharmaceutical Company | Method of purifying Factor VIII:C |
US4980456A (en) * | 1987-04-06 | 1990-12-25 | Scripps Clinic And Research Foundation | Recombinant factor VIIIC derived fragments |
CA1331157C (en) * | 1987-04-06 | 1994-08-02 | Randal J. Kaufman | Method for producing factor viii:c-type proteins |
IL86693A (en) * | 1987-06-12 | 1994-06-24 | Stichting Centraal Lab | Proteins that have the activity IIIV of the blood, a process for their preparation that uses cells are produced through genetic engineering and pharmaceutical preparations that contain them |
US4795806A (en) * | 1987-07-16 | 1989-01-03 | Miles Laboratories, Inc. | Phospholipid affinity purification of Factor VIII:C |
US4981951A (en) * | 1988-04-14 | 1991-01-01 | Miles Inc. | Lectin affinity chromatography of factor VIII |
US5149687A (en) * | 1991-04-01 | 1992-09-22 | United Technologies Corporation | Method for making oriented bismuth and thallium superconductors comprising cold pressing at 700 MPa |
-
1993
- 1993-09-13 US US08/120,894 patent/US5576291A/en not_active Expired - Fee Related
-
1994
- 1994-08-26 DE DE69428905T patent/DE69428905T2/de not_active Expired - Fee Related
- 1994-08-26 CA CA002168332A patent/CA2168332A1/en not_active Abandoned
- 1994-08-26 AT AT94926591T patent/ATE207759T1/de not_active IP Right Cessation
- 1994-08-26 EP EP94926591A patent/EP0719154B1/en not_active Expired - Lifetime
- 1994-08-26 AU AU76380/94A patent/AU686661B2/en not_active Ceased
- 1994-08-26 JP JP7509198A patent/JPH09502714A/ja not_active Ceased
- 1994-08-26 WO PCT/US1994/009613 patent/WO1995007713A1/en active IP Right Grant
- 1994-08-26 DK DK94926591T patent/DK0719154T3/da active
- 1994-08-26 ES ES94926591T patent/ES2166783T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1995007713A1 (en) | 1995-03-23 |
EP0719154A1 (en) | 1996-07-03 |
AU7638094A (en) | 1995-04-03 |
JPH09502714A (ja) | 1997-03-18 |
ATE207759T1 (de) | 2001-11-15 |
DE69428905T2 (de) | 2002-05-29 |
US5576291A (en) | 1996-11-19 |
CA2168332A1 (en) | 1995-03-23 |
AU686661B2 (en) | 1998-02-12 |
DE69428905D1 (de) | 2001-12-06 |
EP0719154B1 (en) | 2001-10-31 |
ES2166783T3 (es) | 2002-05-01 |
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