DK0699075T3 - Modificeret faktor VII - Google Patents
Modificeret faktor VIIInfo
- Publication number
- DK0699075T3 DK0699075T3 DK94918092T DK94918092T DK0699075T3 DK 0699075 T3 DK0699075 T3 DK 0699075T3 DK 94918092 T DK94918092 T DK 94918092T DK 94918092 T DK94918092 T DK 94918092T DK 0699075 T3 DK0699075 T3 DK 0699075T3
- Authority
- DK
- Denmark
- Prior art keywords
- factor vii
- modified
- modified factor
- treat
- factor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6437—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6572593A | 1993-05-21 | 1993-05-21 | |
PCT/US1994/005779 WO1994027631A1 (en) | 1993-05-21 | 1994-05-23 | Modified factor vii |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0699075T3 true DK0699075T3 (da) | 2002-03-11 |
Family
ID=22064676
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94918092T DK0699075T3 (da) | 1993-05-21 | 1994-05-23 | Modificeret faktor VII |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0699075B1 (hu) |
JP (1) | JPH08510746A (hu) |
AT (1) | ATE210458T1 (hu) |
AU (1) | AU703110B2 (hu) |
CA (1) | CA2162726A1 (hu) |
DE (1) | DE69429429T2 (hu) |
DK (1) | DK0699075T3 (hu) |
ES (1) | ES2169074T3 (hu) |
HU (1) | HU219682B (hu) |
PT (1) | PT699075E (hu) |
WO (1) | WO1994027631A1 (hu) |
Families Citing this family (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5817788A (en) * | 1991-02-28 | 1998-10-06 | Zymogenetics, Inc. | Modified factor VII |
US5833982A (en) * | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
US5997864A (en) | 1995-06-07 | 1999-12-07 | Novo Nordisk A/S | Modified factor VII |
US5788965A (en) * | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
US5736364A (en) * | 1995-12-04 | 1998-04-07 | Genentech, Inc. | Factor viia inhibitors |
US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US7247708B2 (en) | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
CN100488562C (zh) | 2000-02-11 | 2009-05-20 | 拜耳医药保健有限公司 | 凝血因子VⅡ或VⅡa样分子 |
JP2003530839A (ja) * | 2000-04-12 | 2003-10-21 | プリンシピア ファーマスーティカル コーポレイション | アルブミン融合タンパク質 |
US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US7812132B2 (en) | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US6905683B2 (en) | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
EP2226385B1 (en) * | 2000-09-13 | 2013-07-10 | Novo Nordisk Health Care AG | Human Coagulation Factor VII Variants |
CZ2003611A3 (cs) | 2000-09-13 | 2003-08-13 | Novo Nordisk A/S | Varianty lidského koagulačního faktoru VII |
US7173000B2 (en) | 2000-11-09 | 2007-02-06 | The Scripps Research Institute | Modified factor VIIa |
US7235638B2 (en) | 2001-03-22 | 2007-06-26 | Novo Nordisk Healthcare A/G | Coagulation factor VII derivatives |
ES2432967T3 (es) | 2001-03-22 | 2013-12-05 | Novo Nordisk Health Care Ag | Derivados del Factor VII de coagulación |
US7052868B2 (en) | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US6858587B2 (en) | 2001-11-02 | 2005-02-22 | Novo Nordisk Pharmaceuticals, Inc. | Use of tissue factor agonist or tissue factor antagonist for treatment of conditions related to apoptosis |
US6960657B2 (en) | 2001-11-02 | 2005-11-01 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
JP2005507008A (ja) * | 2001-11-02 | 2005-03-10 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | アポトーシスに関連した症状の治療のための、組織因子アゴニストまたは組織因子アンタゴニストの使用 |
IL162239A0 (en) | 2001-12-21 | 2005-11-20 | Novo Nordisk Healthcare Ag | Liquid composition of factor vii polypeptides |
US7700733B2 (en) | 2002-04-30 | 2010-04-20 | Bayer Healthcare Llc | Factor VII or VIIa polypeptide variants |
WO2004000347A1 (en) | 2002-06-21 | 2003-12-31 | Novo Nordisk A/S | Stabilised solid compositions of factor vii polypeptides |
US6911323B2 (en) | 2002-09-25 | 2005-06-28 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
US20060166874A1 (en) * | 2002-09-30 | 2006-07-27 | Haaning Jesper M | Fvii or fviia variants having increased clotting activity |
AU2003275947A1 (en) * | 2002-11-06 | 2004-06-07 | Novo Nordisk A/S | Pharmaceutical composition comprising a tissue factor antagonist and a blood glucose regulator |
US7771996B2 (en) | 2003-03-20 | 2010-08-10 | Bayer Healthcare Llc | FVII or FVIIa variants |
US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
MXPA05010773A (es) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos. |
JP5627832B2 (ja) | 2003-05-23 | 2014-11-19 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 溶液中におけるタンパク質の安定化 |
BRPI0411650A (pt) | 2003-06-19 | 2006-08-08 | Maxygen Holdings Ltd | variante polipeptìdica do fator vii (fvii) ou do fator viia (fviia), sequencia de nucleotìdeos , vetor de expressão, célula hospedeira, composição, uso de uma variante, e, método para tratar de um mamìfero tendo uma doença ou um distúrbio em que a formação de coágulo seja desejável |
JP4658041B2 (ja) | 2003-06-25 | 2011-03-23 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドの液体組成物 |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
JP5653572B2 (ja) | 2003-08-14 | 2015-01-14 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第vii因子ポリペプチドの液状水性医薬組成物 |
CN101870729A (zh) | 2003-09-09 | 2010-10-27 | 诺和诺德医疗保健公司 | 凝固因子ⅶ多肽 |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
WO2006035058A2 (en) * | 2004-09-29 | 2006-04-06 | Novo Nordisk Health Care Ag | Purification of a drug substance of a factor vii polypeptide by removal of desgla-factor vii polypeptide structures |
EP1814573B1 (en) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
ES2449195T3 (es) | 2005-01-10 | 2014-03-18 | Ratiopharm Gmbh | Factor estimulante de colonias de granulocitos glicopegilado |
WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
WO2008011633A2 (en) | 2006-07-21 | 2008-01-24 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
CN101796063B (zh) | 2007-04-03 | 2017-03-22 | 拉蒂奥法姆有限责任公司 | 使用糖聚乙二醇化g‑csf的治疗方法 |
ES2551123T3 (es) | 2007-06-12 | 2015-11-16 | Ratiopharm Gmbh | Proceso mejorado para la producción de azúcares de nucleótido |
JP5619630B2 (ja) | 2008-02-27 | 2014-11-05 | ノボ・ノルデイスク・エー/エス | 結合型第viii因子分子 |
EP3402537B1 (en) | 2016-01-15 | 2021-01-06 | Rigshospitalet | Quantitative pet imaging of tissue factor expression using 18f-labelled active site inhibited factor vii |
EP3541432A4 (en) | 2016-11-17 | 2020-08-05 | Minerva Imaging ApS | 177 LU MARKED FACTOR VII INHIBITED BY ACTIVE LOCATION |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69131292T2 (de) * | 1990-01-29 | 1999-09-30 | Zymogenetics Inc | Antikoagulierende proteine |
DE69233398D1 (de) * | 1991-02-28 | 2004-09-16 | Novo Nordisk As | Modifizierter faktor-vii |
-
1994
- 1994-05-23 CA CA002162726A patent/CA2162726A1/en not_active Abandoned
- 1994-05-23 DK DK94918092T patent/DK0699075T3/da active
- 1994-05-23 WO PCT/US1994/005779 patent/WO1994027631A1/en active IP Right Grant
- 1994-05-23 DE DE69429429T patent/DE69429429T2/de not_active Expired - Fee Related
- 1994-05-23 HU HU9503312A patent/HU219682B/hu not_active IP Right Cessation
- 1994-05-23 PT PT94918092T patent/PT699075E/pt unknown
- 1994-05-23 AT AT94918092T patent/ATE210458T1/de not_active IP Right Cessation
- 1994-05-23 JP JP7500869A patent/JPH08510746A/ja not_active Ceased
- 1994-05-23 AU AU69560/94A patent/AU703110B2/en not_active Ceased
- 1994-05-23 EP EP94918092A patent/EP0699075B1/en not_active Expired - Lifetime
- 1994-05-23 ES ES94918092T patent/ES2169074T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
HU219682B (hu) | 2001-06-28 |
AU6956094A (en) | 1994-12-20 |
EP0699075A1 (en) | 1996-03-06 |
HU9503312D0 (en) | 1996-01-29 |
ES2169074T3 (es) | 2002-07-01 |
ATE210458T1 (de) | 2001-12-15 |
DE69429429D1 (de) | 2002-01-24 |
EP0699075B1 (en) | 2001-12-12 |
WO1994027631A1 (en) | 1994-12-08 |
AU703110B2 (en) | 1999-03-18 |
HUT73329A (en) | 1996-07-29 |
PT699075E (pt) | 2002-05-31 |
JPH08510746A (ja) | 1996-11-12 |
DE69429429T2 (de) | 2002-05-16 |
CA2162726A1 (en) | 1994-12-08 |
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