DK0698611T3 - Fremgangsmåde til fremstilling af N-acyl-5-fluorcytidinderivater - Google Patents
Fremgangsmåde til fremstilling af N-acyl-5-fluorcytidinderivaterInfo
- Publication number
- DK0698611T3 DK0698611T3 DK95112521T DK95112521T DK0698611T3 DK 0698611 T3 DK0698611 T3 DK 0698611T3 DK 95112521 T DK95112521 T DK 95112521T DK 95112521 T DK95112521 T DK 95112521T DK 0698611 T3 DK0698611 T3 DK 0698611T3
- Authority
- DK
- Denmark
- Prior art keywords
- acyl
- preparation
- pref
- methanol
- formula
- Prior art date
Links
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 6
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- GQHTUMJGOHRCHB-UHFFFAOYSA-N 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine Chemical compound C1CCCCN2CCCN=C21 GQHTUMJGOHRCHB-UHFFFAOYSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal alkoxide Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/296,842 US5476932A (en) | 1994-08-26 | 1994-08-26 | Process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0698611T3 true DK0698611T3 (da) | 2000-03-27 |
Family
ID=23143805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95112521T DK0698611T3 (da) | 1994-08-26 | 1995-08-09 | Fremgangsmåde til fremstilling af N-acyl-5-fluorcytidinderivater |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5476932A (ko) |
| EP (1) | EP0698611B1 (ko) |
| JP (1) | JP3986574B2 (ko) |
| KR (1) | KR100335542B1 (ko) |
| CN (1) | CN1053194C (ko) |
| AT (1) | ATE185811T1 (ko) |
| DE (1) | DE69512851T2 (ko) |
| DK (1) | DK0698611T3 (ko) |
| ES (1) | ES2138691T3 (ko) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ330360A (en) * | 1997-06-02 | 1999-03-29 | Hoffmann La Roche | 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents |
| KR100631754B1 (ko) * | 2000-08-09 | 2006-10-09 | 주식회사 코오롱 | Ｎ-알킬옥시카르보닐-5-플루오로사이토신 유도체 및 그의제조방법 |
| WO2003097609A1 (en) | 2002-05-15 | 2003-11-27 | Janssen Pharmaceutica N.V. | N-substituted tricyclic 3-aminopyrazoles as pdfg receptor inhibitors |
| DE602004015331D1 (de) * | 2003-12-22 | 2008-09-04 | Hoffmann La Roche | Verfahren für fluorcytidinderivate |
| CN100383128C (zh) * | 2004-02-23 | 2008-04-23 | 上海迪赛诺医药发展有限公司 | N4－氧羰基胞嘧啶衍生物及制备方法与应用 |
| US20050192433A1 (en) * | 2004-02-26 | 2005-09-01 | Mitsui Chemicals, Inc. | Metallic salt of N4-acylcytidine derivatives, and a method for producing N4-acylcytidine derivatives using the same |
| CA2594474C (en) | 2005-01-21 | 2016-03-29 | Astex Therapeutics Limited | Pharmaceutical compounds |
| AU2006210572B2 (en) | 2005-02-03 | 2011-08-04 | The General Hospital Corporation | Method for treating gefitinib resistant cancer |
| EP1868608A2 (en) * | 2005-04-01 | 2007-12-26 | F. Hoffmann-Roche AG | Method for administration of capecitabine |
| CN100569790C (zh) * | 2005-07-15 | 2009-12-16 | 上海奥锐特国际贸易有限公司 | 合成n4-酰基-5＇-脱氧-5-氟胞苷衍生物的方法 |
| EP3488866A1 (en) | 2005-11-04 | 2019-05-29 | Wyeth LLC | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
| US20080085310A1 (en) * | 2006-10-06 | 2008-04-10 | Maria Oksana Bachynsky | Capecitabine rapidly disintegrating tablets |
| WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| JP5528806B2 (ja) | 2006-10-12 | 2014-06-25 | アステックス、セラピューティックス、リミテッド | 複合薬剤 |
| CN100425617C (zh) * | 2006-10-31 | 2008-10-15 | 浙江海正药业股份有限公司 | 一种含氟嘧啶类化合物烷氧羰酰化的方法 |
| ITMI20070435A1 (it) | 2007-03-05 | 2008-09-06 | Innovate Biotechnology Srl | 2',3'-di-o-acil-5-fluoronucleosidi |
| JP5235886B2 (ja) * | 2007-08-15 | 2013-07-10 | 大王製紙株式会社 | 吸収体製品 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| KR101013312B1 (ko) * | 2007-11-19 | 2011-02-09 | 한미홀딩스 주식회사 | 카페시타빈의 제조방법 및 이에 사용되는 β-아노머가강화된 트리알킬카보네이트 화합물의 제조방법 |
| AR064165A1 (es) | 2007-12-06 | 2009-03-18 | Richmond Sa Com Ind Y Financie | Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento |
| WO2009094847A1 (fr) * | 2007-12-28 | 2009-08-06 | Topharman Shanghai Co., Ltd. | Dérivé hydroxyle de capécitabine, procédés de préparation et d' utilisation de la capécitabine |
| WO2009082846A1 (fr) * | 2007-12-28 | 2009-07-09 | Topharman Shanghai Co., Ltd. | Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine |
| CN101469008B (zh) * | 2007-12-29 | 2013-08-07 | 上海特化医药科技有限公司 | 卡培他滨羟基衍生物、其制备方法和用于制备卡培他滨 |
| WO2009082844A1 (fr) * | 2007-12-28 | 2009-07-09 | Topharman Shanghai Co., Ltd | Dérivé hydroxyle de la capécitabine, ses procédés de préparation et ses utilisations pour préparer la capécitabine |
| US20090209754A1 (en) * | 2008-01-03 | 2009-08-20 | Macdonald Peter Lindsay | Process for the preparation of capecitabine |
| HUE028327T2 (en) * | 2008-06-06 | 2017-02-28 | Neurmedix Inc | A process for the preparation of 17-alkynyl-7-hydroxy steroids and related compounds |
| RU2492860C2 (ru) | 2008-06-17 | 2013-09-20 | УАЙТ ЭлЭлСи | Антиопластические комбинации, содержащие нкi-272 и винорелбин |
| PL3175853T3 (pl) | 2008-08-04 | 2024-03-25 | Wyeth Llc | Przeciwnowotworowe połączenia neratynibu i kapecytabiny |
| PL3000467T3 (pl) | 2009-04-06 | 2023-05-02 | Wyeth Llc | Schemat leczenia wykorzystujący neratynib dla raka sutka |
| WO2011067588A1 (en) | 2009-12-04 | 2011-06-09 | Generics [Uk] Limited | Cyclic sulphinyl esters of cytidine |
| WO2011104540A1 (en) | 2010-02-24 | 2011-09-01 | Generics [Uk] Limited | One step process for the preparation of capecitabine |
| CN102260309B (zh) * | 2010-05-24 | 2014-10-22 | 重庆福安药业(集团)股份有限公司 | 一种高纯度卡培他滨的制备方法 |
| CN103857403B (zh) | 2011-10-03 | 2019-04-12 | Mx佐剂股份公司 | 纳米颗粒、制备方法以及其应用 |
| TWI560195B (en) * | 2012-01-13 | 2016-12-01 | Pharmaessentia Corp | Novel synthesis of 5-deoxy-5'-fluorocytidine compounds |
| US9907846B2 (en) | 2013-04-01 | 2018-03-06 | Mx Adjuvac Ab | Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions |
| CN104926901B (zh) * | 2015-06-15 | 2018-04-20 | 广安凯特制药有限公司 | 一种卡培他滨关键中间体的合成方法 |
| EP4046989A1 (en) | 2017-01-09 | 2022-08-24 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
| US10435429B2 (en) | 2017-10-03 | 2019-10-08 | Nucorion Pharmaceuticals, Inc. | 5-fluorouridine monophosphate cyclic triester compounds |
| EP3737376B1 (en) | 2018-01-09 | 2024-04-17 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human diseases |
| US11427550B2 (en) | 2018-01-19 | 2022-08-30 | Nucorion Pharmaceuticals, Inc. | 5-fluorouracil compounds |
| WO2019143860A1 (en) * | 2018-01-19 | 2019-07-25 | Nucorion Pharmaceuticals, Inc. | 5-fluorouracil compounds |
| EP3669890A1 (en) | 2018-12-18 | 2020-06-24 | Croda International PLC | Filamentous nanoparticles having vaccine adjuvant effect |
| WO2021216427A1 (en) | 2020-04-21 | 2021-10-28 | Ligand Pharmaceuticals, Inc. | Nucleotide prodrug compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982000997A1 (en) * | 1980-09-22 | 1982-04-01 | Johannson R | Carriage assembly with shiftable forks |
| CA1327358C (en) * | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
| AU671491B2 (en) * | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
| TW254946B (ko) * | 1992-12-18 | 1995-08-21 | Hoffmann La Roche |
-
1994
- 1994-08-26 US US08/296,842 patent/US5476932A/en not_active Expired - Lifetime
-
1995
- 1995-08-09 DE DE69512851T patent/DE69512851T2/de not_active Expired - Lifetime
- 1995-08-09 ES ES95112521T patent/ES2138691T3/es not_active Expired - Lifetime
- 1995-08-09 EP EP95112521A patent/EP0698611B1/en not_active Expired - Lifetime
- 1995-08-09 DK DK95112521T patent/DK0698611T3/da active
- 1995-08-09 AT AT95112521T patent/ATE185811T1/de active
- 1995-08-21 JP JP21157995A patent/JP3986574B2/ja not_active Expired - Lifetime
- 1995-08-25 KR KR1019950026517A patent/KR100335542B1/ko not_active IP Right Cessation
- 1995-08-25 CN CN95109396A patent/CN1053194C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0698611B1 (en) | 1999-10-20 |
| US5476932A (en) | 1995-12-19 |
| CN1053194C (zh) | 2000-06-07 |
| KR100335542B1 (ko) | 2002-11-08 |
| DE69512851D1 (de) | 1999-11-25 |
| JPH0859687A (ja) | 1996-03-05 |
| EP0698611A1 (en) | 1996-02-28 |
| ATE185811T1 (de) | 1999-11-15 |
| KR960007610A (ko) | 1996-03-22 |
| ES2138691T3 (es) | 2000-01-16 |
| DE69512851T2 (de) | 2000-05-04 |
| JP3986574B2 (ja) | 2007-10-03 |
| CN1126726A (zh) | 1996-07-17 |
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