DK0687260T3 - Fremgangsmåde til fremstillingen af 9-desoxotaxaner - Google Patents
Fremgangsmåde til fremstillingen af 9-desoxotaxanerInfo
- Publication number
- DK0687260T3 DK0687260T3 DK94911465T DK94911465T DK0687260T3 DK 0687260 T3 DK0687260 T3 DK 0687260T3 DK 94911465 T DK94911465 T DK 94911465T DK 94911465 T DK94911465 T DK 94911465T DK 0687260 T3 DK0687260 T3 DK 0687260T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- deoxotaxanes
- preparation
- sec
- date
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/026,978 US5990325A (en) | 1993-03-05 | 1993-03-05 | Process for the preparation of 9-desoxotaxol, 9-desoxobaccatin III and analogs thereof |
US9508793A | 1993-07-20 | 1993-07-20 | |
PCT/US1994/002382 WO1994020485A1 (en) | 1993-03-05 | 1994-03-04 | Process for the preparation of 9-desoxotaxanes |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0687260T3 true DK0687260T3 (da) | 2003-06-10 |
Family
ID=26701882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94911465T DK0687260T3 (da) | 1993-03-05 | 1994-03-04 | Fremgangsmåde til fremstillingen af 9-desoxotaxaner |
Country Status (11)
Country | Link |
---|---|
US (1) | US6066747A (es) |
EP (1) | EP0687260B1 (es) |
JP (2) | JP3892481B2 (es) |
AT (1) | ATE232854T1 (es) |
AU (1) | AU689770B2 (es) |
CA (1) | CA2157114C (es) |
DE (1) | DE69432140T2 (es) |
DK (1) | DK0687260T3 (es) |
ES (1) | ES2193154T3 (es) |
PT (1) | PT687260E (es) |
WO (1) | WO1994020485A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6794523B2 (en) | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
US6495704B1 (en) * | 1991-09-23 | 2002-12-17 | Florida State University | 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes |
US5710287A (en) | 1991-09-23 | 1998-01-20 | Florida State University | Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them |
US6710191B2 (en) | 1993-03-05 | 2004-03-23 | Florida State University | 9β-hydroxytetracyclic taxanes |
US5677470A (en) * | 1994-06-28 | 1997-10-14 | Tanabe Seiyaku Co., Ltd. | Baccatin derivatives and processes for preparing the same |
CA2162759A1 (en) * | 1994-11-17 | 1996-05-18 | Kenji Tsujihara | Baccatin derivatives and processes for preparing the same |
CA2253513A1 (en) * | 1996-05-06 | 1997-11-13 | Florida State University | 1-deoxy baccatin iii, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
US5635531A (en) * | 1996-07-08 | 1997-06-03 | Bristol-Myers Squibb Company | 3'-aminocarbonyloxy paclitaxels |
US5773464A (en) * | 1996-09-30 | 1998-06-30 | Bristol-Myers Squibb Company | C-10 epoxy taxanes |
US5977386A (en) * | 1996-12-24 | 1999-11-02 | Bristol-Myers Squibb Company | 6-thio-substituted paclitaxels |
US5739359A (en) * | 1997-01-24 | 1998-04-14 | Virginia Tech Intellectual Properties, Inc. | Methods for preparing 1-deoxy paclitaxels |
US5902822A (en) * | 1997-02-28 | 1999-05-11 | Bristol-Myers Squibb Company | 7-methylthiooxomethyl and 7-methylthiodioxomethyl paclitaxels |
US5912264A (en) * | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
US6017935A (en) * | 1997-04-24 | 2000-01-25 | Bristol-Myers Squibb Company | 7-sulfur substituted paclitaxels |
JP4502338B2 (ja) * | 1999-09-17 | 2010-07-14 | 株式会社横浜国際バイオ研究所 | タキソイド化合物の製造法 |
CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
CN1886400A (zh) | 2003-09-25 | 2006-12-27 | 泰普斯特医药公司 | 9,10-α,α-OH紫杉烷类似物及其制备方法 |
EP1894921A3 (en) * | 2003-09-25 | 2008-03-12 | Tapestry Pharmaceuticals, Inc. | 9, 10-Alpha, Alpha-Oh-Taxane analogs and methods for production thereof |
US7847111B2 (en) * | 2006-06-19 | 2010-12-07 | Canada Inc. | Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III |
WO2008106621A1 (en) | 2007-02-28 | 2008-09-04 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
CA2723654A1 (en) * | 2008-05-07 | 2009-11-12 | Ivax Research, Llc | Processes for preparation of taxanes and intermediates thereof |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1256444A (en) * | 1986-04-30 | 1989-06-27 | Kazunori Kan | Process for preparing 4-acetoxy-3- hydroxyethylazetidin-2-one derivatives |
FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
US4876399A (en) * | 1987-11-02 | 1989-10-24 | Research Corporation Technologies, Inc. | Taxols, their preparation and intermediates thereof |
US4942184A (en) * | 1988-03-07 | 1990-07-17 | The United States Of America As Represented By The Department Of Health And Human Services | Water soluble, antineoplastic derivatives of taxol |
FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
US4921974A (en) * | 1988-09-29 | 1990-05-01 | Merck & Co., Inc. | Intermediates and processes in the preparation of 5-oxygenated HMG-COA reductase inhibitors |
US4960790A (en) * | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
MY110249A (en) * | 1989-05-31 | 1998-03-31 | Univ Florida State | Method for preparation of taxol using beta lactam |
US5015744A (en) * | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
US5059699A (en) * | 1990-08-28 | 1991-10-22 | Virginia Tech Intellectual Properties, Inc. | Water soluble derivatives of taxol |
MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
FR2679230B1 (fr) * | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
US5430160A (en) * | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
US5250683A (en) * | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
US5338872A (en) * | 1993-01-15 | 1994-08-16 | Florida State University | Process for the preparation of 10-desacetoxybaccatin III and 10-desacetoxytaxol and derivatives thereof |
US5274124A (en) * | 1991-09-23 | 1993-12-28 | Florida State University | Metal alkoxides |
US5283253A (en) * | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
US5243045A (en) * | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
US5350866A (en) * | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
US5284865A (en) * | 1991-09-23 | 1994-02-08 | Holton Robert A | Cyclohexyl substituted taxanes and pharmaceutical compositions containing them |
US5399726A (en) * | 1993-01-29 | 1995-03-21 | Florida State University | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
US5229526A (en) * | 1991-09-23 | 1993-07-20 | Florida State University | Metal alkoxides |
IT1254517B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
US5254703A (en) * | 1992-04-06 | 1993-10-19 | Florida State University | Semi-synthesis of taxane derivatives using metal alkoxides and oxazinones |
US5440056A (en) * | 1992-04-17 | 1995-08-08 | Abbott Laboratories | 9-deoxotaxane compounds |
DK0639186T3 (da) * | 1992-04-17 | 1999-12-13 | Abbott Lab | Taxolderivater |
FR2697019B1 (fr) * | 1992-10-15 | 1994-11-25 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
US5405972A (en) * | 1993-07-20 | 1995-04-11 | Florida State University | Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes |
-
1994
- 1994-03-04 DK DK94911465T patent/DK0687260T3/da active
- 1994-03-04 JP JP52020494A patent/JP3892481B2/ja not_active Expired - Fee Related
- 1994-03-04 US US08/522,307 patent/US6066747A/en not_active Expired - Lifetime
- 1994-03-04 ES ES94911465T patent/ES2193154T3/es not_active Expired - Lifetime
- 1994-03-04 WO PCT/US1994/002382 patent/WO1994020485A1/en active IP Right Grant
- 1994-03-04 PT PT94911465T patent/PT687260E/pt unknown
- 1994-03-04 AT AT94911465T patent/ATE232854T1/de not_active IP Right Cessation
- 1994-03-04 AU AU63971/94A patent/AU689770B2/en not_active Ceased
- 1994-03-04 CA CA002157114A patent/CA2157114C/en not_active Expired - Fee Related
- 1994-03-04 EP EP94911465A patent/EP0687260B1/en not_active Expired - Lifetime
- 1994-03-04 DE DE69432140T patent/DE69432140T2/de not_active Expired - Fee Related
-
2003
- 2003-07-09 JP JP2003272410A patent/JP4101131B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4101131B2 (ja) | 2008-06-18 |
EP0687260A1 (en) | 1995-12-20 |
EP0687260B1 (en) | 2003-02-19 |
EP0687260A4 (en) | 1995-11-06 |
ATE232854T1 (de) | 2003-03-15 |
JP3892481B2 (ja) | 2007-03-14 |
US6066747A (en) | 2000-05-23 |
AU689770B2 (en) | 1998-04-09 |
ES2193154T3 (es) | 2003-11-01 |
JP2004002456A (ja) | 2004-01-08 |
JPH08507526A (ja) | 1996-08-13 |
WO1994020485A1 (en) | 1994-09-15 |
DE69432140T2 (de) | 2003-07-31 |
CA2157114C (en) | 2003-12-16 |
PT687260E (pt) | 2003-07-31 |
AU6397194A (en) | 1994-09-26 |
DE69432140D1 (de) | 2003-03-27 |
CA2157114A1 (en) | 1994-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0687260T3 (da) | Fremgangsmåde til fremstillingen af 9-desoxotaxaner | |
DE69530081D1 (de) | Gastrin- und cck-antagonisten | |
DK0699207T3 (da) | Mellemprodukt til azithromycin | |
YU70294A (sh) | Kristalni hidranti derivati 3,4,4-trisupstituisanih-piperidinil-n-alkilkarbok silata, njihovi intermedijari i postupak za dobijanje | |
DE69516866D1 (de) | Stereochemische wortmanninderivate | |
BR9807674A (pt) | Inibidores bicìclicos da proteìna farnesil transferase | |
DK0632805T3 (da) | Melaminderivater til anvendelse i behandlingen af cancer | |
FI964045A (fi) | CCK:ta tai gastriinia säätelevä 5-heterosykli-1,5-bentsodiatsepiinejä | |
MX9706744A (es) | Proceso novedosos para preparar derivados de 2,3-dihidro-benzofuranol. | |
AU648285B2 (en) | Coating material, process for producing it and its use | |
TW330933B (en) | Furanoeremophilane and eremophilanolide sesquiterpenes for treatment of diabetes | |
DE69216861D1 (de) | Warmaushärtende überzugszusammensetzungen | |
FI964278A (fi) | Menetelmä 5,6-dihydroksi-2-amino-1,2,3,4-tetrahydronaftaleenin johdannaisten valmistamiseksi | |
ATE184305T1 (de) | Monoazopigmente | |
MX9900914A (es) | ||
DK0665221T3 (da) | Vitamin D derivat og fremgangsmåde til fremstilling af dette | |
GR1001309B (el) | Μεθοδος παρασκευης παραγωγου ενωσεως της διχλωροανιλινης. | |
DK0850225T3 (da) | Mellemprodukt til fremstilling af en farmaceutisk aktiv forbindelse | |
YU49004B (sh) | LANOSTA-7,9-DIEN-3Гџ, 32-DIOL I POSTUPAK ZA NJEGOVO DOBIJANJE | |
TW349092B (en) | Substituted indole derivatives | |
RO116896B1 (ro) | Derivaţi pseudocarbaciclinici şi procedeu pentru prepararea acestora |