DK0674900T3 - Transdermalt matrixsystem på basis af EVA til indgivelse af et estrogen og/eller et gestagen - Google Patents
Transdermalt matrixsystem på basis af EVA til indgivelse af et estrogen og/eller et gestagenInfo
- Publication number
- DK0674900T3 DK0674900T3 DK95400573T DK95400573T DK0674900T3 DK 0674900 T3 DK0674900 T3 DK 0674900T3 DK 95400573 T DK95400573 T DK 95400573T DK 95400573 T DK95400573 T DK 95400573T DK 0674900 T3 DK0674900 T3 DK 0674900T3
- Authority
- DK
- Denmark
- Prior art keywords
- pts
- eva
- progestagen
- estrogen
- administration
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 3
- WAHQVRCNDCHDIB-QZYSPNBYSA-N [(3s,8r,9s,10r,13s,14s,17r)-17-acetyl-17-acetyloxy-6,10,13-trimethyl-1,2,3,8,9,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-yl] 3-cyclopentylpropanoate Chemical compound O([C@@H]1C=C2C(C)=C[C@H]3[C@@H]4CC[C@]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)(OC(=O)C)C(C)=O)C(=O)CCC1CCCC1 WAHQVRCNDCHDIB-QZYSPNBYSA-N 0.000 title 1
- 239000000262 estrogen Substances 0.000 title 1
- 229940011871 estrogen Drugs 0.000 title 1
- 239000000583 progesterone congener Substances 0.000 title 1
- 239000000853 adhesive Substances 0.000 abstract 2
- DNTGGZPQPQTDQF-XBXARRHUSA-N crotamiton Chemical compound C/C=C/C(=O)N(CC)C1=CC=CC=C1C DNTGGZPQPQTDQF-XBXARRHUSA-N 0.000 abstract 2
- 239000005038 ethylene vinyl acetate Substances 0.000 abstract 2
- 229940088597 hormone Drugs 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 abstract 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229960003338 crotamiton Drugs 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 230000001072 progestational effect Effects 0.000 abstract 1
- 150000003953 γ-lactams Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9403598A FR2717688B1 (fr) | 1994-03-28 | 1994-03-28 | Système matriciel transdermique d'administration d'un oestrogène et/ou un progestatif à base d'EVA. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0674900T3 true DK0674900T3 (da) | 1999-06-23 |
Family
ID=9461478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95400573T DK0674900T3 (da) | 1994-03-28 | 1995-03-15 | Transdermalt matrixsystem på basis af EVA til indgivelse af et estrogen og/eller et gestagen |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5605702A (cs) |
| EP (1) | EP0674900B1 (cs) |
| JP (1) | JPH07309762A (cs) |
| KR (1) | KR950031056A (cs) |
| CN (1) | CN1114587A (cs) |
| AT (1) | ATE173617T1 (cs) |
| AU (1) | AU684601B2 (cs) |
| CA (1) | CA2145579A1 (cs) |
| CZ (1) | CZ289211B6 (cs) |
| DE (1) | DE69506156T2 (cs) |
| DK (1) | DK0674900T3 (cs) |
| ES (1) | ES2127484T3 (cs) |
| FI (1) | FI951425A7 (cs) |
| FR (1) | FR2717688B1 (cs) |
| GR (1) | GR3029402T3 (cs) |
| HU (1) | HU219245B (cs) |
| LV (1) | LV10930B (cs) |
| NO (1) | NO308124B1 (cs) |
| NZ (1) | NZ270810A (cs) |
| PL (1) | PL179022B1 (cs) |
| RU (1) | RU2144818C1 (cs) |
| SK (1) | SK281234B6 (cs) |
| ZA (1) | ZA952468B (cs) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0573133A1 (de) * | 1988-10-27 | 1993-12-08 | Schering Aktiengesellschaft | Mittel zur transdermalen Applikation das Gestoden enthält |
| KR970706805A (ko) * | 1994-11-18 | 1997-12-01 | 나까토미 히로타카 | 경피흡수첩부제(percutaneously absorbable patch) |
| FR2739032B1 (fr) * | 1995-09-27 | 1997-11-21 | Lhd Lab Hygiene Dietetique | Systeme matriciel transdermique d'administration d'un oestrogene et/ou d'un progestatif a base d'eva, procede de preparation et utilisation en therapeutique |
| ES2248847T3 (es) | 1996-05-24 | 2006-03-16 | Angiotech Pharmaceuticals, Inc. | Composiciones y metodos para tratar o prevenir enfermedades de las vias de conduccion del cuerpo. |
| US5783208A (en) * | 1996-07-19 | 1998-07-21 | Theratech, Inc. | Transdermal drug delivery matrix for coadministering estradiol and another steroid |
| DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| DE19700913C2 (de) * | 1997-01-14 | 2001-01-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System zur Abgabe von Hormonen |
| IL123813A0 (en) * | 1997-04-11 | 1998-10-30 | Akzo Nobel Nv | Drug delivery system for two or more active substances |
| US6028057A (en) * | 1998-02-19 | 2000-02-22 | Thorn Bioscience, Llc | Regulation of estrus and ovulation in gilts |
| DE19906152B4 (de) * | 1999-02-10 | 2005-02-10 | Jenapharm Gmbh & Co. Kg | Wirkstoffhaltige Laminate für Transdermalsysteme |
| DE10025970C2 (de) * | 2000-05-25 | 2002-04-25 | Lohmann Therapie Syst Lts | Estrogenhaltiges Pflaster mit einem Wirkstoffreservoir auf der Basis von Ethylcellulose und einem Ethylen-Vinylacetat-Vinylpyrrolidon-Copolymer und seine Verwendung |
| DE10118282A1 (de) * | 2001-04-12 | 2002-12-05 | Lohmann Therapie Syst Lts | Haftkleber auf Basis von Ethylen-Vinylacetat-Copolymeren und Klebharzen, für medizinische Verwendungszwecke |
| DE602004026173D1 (de) * | 2003-04-29 | 2010-05-06 | Gen Hospital Corp | Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln |
| PL1684782T3 (pl) * | 2003-10-03 | 2016-03-31 | Thorn Bioscience Llc | Sposób synchronizacji owulacji dla zsynchronizowanego rozmnażania bez wykrywania rui |
| US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US20070197435A1 (en) * | 2006-02-17 | 2007-08-23 | Webel Stephen K | Process for the synchronization of ovulation for timed breeding without heat detection |
| TW200833840A (en) * | 2006-10-25 | 2008-08-16 | Amgen Inc | Toxin peptide therapeutic agents |
| CA2840407A1 (en) | 2007-05-22 | 2008-12-18 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| CN102596215B (zh) | 2009-04-23 | 2015-04-29 | 佩纳特克有限责任公司 | 用于同步授精时间的方法和组合物 |
| CN103930437A (zh) | 2011-03-16 | 2014-07-16 | 安姆根有限公司 | Nav1.3和Nav1.7的强效及选择性抑制剂 |
| RS62297B1 (sr) | 2011-11-23 | 2021-09-30 | Therapeuticsmd Inc | Prirodne kombinovane hormonske supstitucione formulacije i terapije |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| CN113398243A (zh) | 2012-11-28 | 2021-09-17 | 联合动物健康第二有限责任公司 | 用于同步小母猪的授精时间的方法 |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| EP2970408B1 (en) | 2013-03-12 | 2018-01-10 | Amgen Inc. | Potent and selective inhibitors of nav1.7 |
| JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然の併用ホルモン補充療法剤及び療法 |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| US11318190B2 (en) | 2017-05-05 | 2022-05-03 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating liver disease |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4060084A (en) * | 1976-09-07 | 1977-11-29 | Alza Corporation | Method and therapeutic system for providing chemotherapy transdermally |
| US4752612A (en) * | 1983-07-01 | 1988-06-21 | Nitto Electrical Industrial Co., Ltd. | Method and percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent |
| FR2612785A1 (fr) * | 1987-03-25 | 1988-09-30 | Lhd Lab Hygiene Dietetique | Dispositif auto-adhesif d'administration d'un principe actif par voie percutanee |
| US4994267A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
| US5032402A (en) * | 1988-10-27 | 1991-07-16 | The University Of Kentucky Research Foundation | 3-hydroxy-N-methylpyrrolidone and use as transdermal enhancer |
| AU4745390A (en) * | 1988-12-01 | 1990-06-26 | Schering Corporation | Compositions for transdermal delivery of estradiol |
| US5248676A (en) * | 1990-05-17 | 1993-09-28 | Hisamitsu Pharmaceutical Co., Inc. | Estradiol percutaneous administration preparations |
-
1994
- 1994-03-28 FR FR9403598A patent/FR2717688B1/fr not_active Expired - Fee Related
-
1995
- 1995-03-15 EP EP95400573A patent/EP0674900B1/fr not_active Expired - Lifetime
- 1995-03-15 AT AT95400573T patent/ATE173617T1/de not_active IP Right Cessation
- 1995-03-15 DE DE69506156T patent/DE69506156T2/de not_active Expired - Fee Related
- 1995-03-15 ES ES95400573T patent/ES2127484T3/es not_active Expired - Lifetime
- 1995-03-15 DK DK95400573T patent/DK0674900T3/da active
- 1995-03-21 AU AU14979/95A patent/AU684601B2/en not_active Ceased
- 1995-03-21 LV LVP-95-77A patent/LV10930B/en unknown
- 1995-03-24 FI FI951425A patent/FI951425A7/fi unknown
- 1995-03-24 NO NO951125A patent/NO308124B1/no not_active IP Right Cessation
- 1995-03-27 CA CA002145579A patent/CA2145579A1/en not_active Abandoned
- 1995-03-27 CZ CZ1995768A patent/CZ289211B6/cs not_active IP Right Cessation
- 1995-03-27 RU RU95104224A patent/RU2144818C1/ru active
- 1995-03-27 SK SK391-95A patent/SK281234B6/sk unknown
- 1995-03-27 PL PL95307889A patent/PL179022B1/pl unknown
- 1995-03-27 NZ NZ270810A patent/NZ270810A/en unknown
- 1995-03-27 HU HU9500881A patent/HU219245B/hu not_active IP Right Cessation
- 1995-03-27 ZA ZA952468A patent/ZA952468B/xx unknown
- 1995-03-28 JP JP7069472A patent/JPH07309762A/ja active Pending
- 1995-03-28 KR KR1019950006674A patent/KR950031056A/ko not_active Withdrawn
- 1995-03-28 US US08/413,208 patent/US5605702A/en not_active Expired - Fee Related
- 1995-03-28 CN CN95103765A patent/CN1114587A/zh active Pending
-
1999
- 1999-02-15 GR GR990400485T patent/GR3029402T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9500881D0 (en) | 1995-05-29 |
| AU1497995A (en) | 1995-10-05 |
| NO951125D0 (no) | 1995-03-24 |
| FR2717688A1 (fr) | 1995-09-29 |
| EP0674900A1 (fr) | 1995-10-04 |
| NZ270810A (en) | 1996-05-28 |
| FI951425A7 (fi) | 1995-09-29 |
| ATE173617T1 (de) | 1998-12-15 |
| GR3029402T3 (en) | 1999-05-28 |
| HU219245B (en) | 2001-03-28 |
| KR950031056A (ko) | 1995-12-18 |
| FR2717688B1 (fr) | 1996-07-05 |
| NO951125L (no) | 1995-09-29 |
| ES2127484T3 (es) | 1999-04-16 |
| CN1114587A (zh) | 1996-01-10 |
| LV10930B (en) | 1996-08-20 |
| PL307889A1 (en) | 1995-10-02 |
| LV10930A (lv) | 1995-12-20 |
| JPH07309762A (ja) | 1995-11-28 |
| DE69506156T2 (de) | 1999-07-22 |
| HUT75237A (en) | 1997-05-28 |
| SK281234B6 (sk) | 2001-01-18 |
| SK39195A3 (en) | 1995-10-11 |
| ZA952468B (en) | 1995-12-19 |
| CA2145579A1 (en) | 1995-09-29 |
| NO308124B1 (no) | 2000-07-31 |
| CZ76895A3 (en) | 1995-10-18 |
| RU2144818C1 (ru) | 2000-01-27 |
| EP0674900B1 (fr) | 1998-11-25 |
| PL179022B1 (en) | 2000-07-31 |
| AU684601B2 (en) | 1997-12-18 |
| DE69506156D1 (de) | 1999-01-07 |
| US5605702A (en) | 1997-02-25 |
| CZ289211B6 (cs) | 2001-12-12 |
| FI951425A0 (fi) | 1995-03-24 |
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