DK0655454T3 - Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere - Google Patents

Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere

Info

Publication number
DK0655454T3
DK0655454T3 DK94308806T DK94308806T DK0655454T3 DK 0655454 T3 DK0655454 T3 DK 0655454T3 DK 94308806 T DK94308806 T DK 94308806T DK 94308806 T DK94308806 T DK 94308806T DK 0655454 T3 DK0655454 T3 DK 0655454T3
Authority
DK
Denmark
Prior art keywords
alpha
acetals
silyloxy
dioxolane
difluoro
Prior art date
Application number
DK94308806T
Other languages
Danish (da)
English (en)
Inventor
Thomas Charles Britton
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of DK0655454T3 publication Critical patent/DK0655454T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DK94308806T 1993-11-30 1994-11-29 Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere DK0655454T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16054993A 1993-11-30 1993-11-30
US30712294A 1994-09-16 1994-09-16

Publications (1)

Publication Number Publication Date
DK0655454T3 true DK0655454T3 (da) 2001-10-08

Family

ID=26856978

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94308806T DK0655454T3 (da) 1993-11-30 1994-11-29 Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere

Country Status (14)

Country Link
US (1) US5618951A (sv)
EP (1) EP0655454B1 (sv)
JP (1) JP3615253B2 (sv)
KR (2) KR100344363B1 (sv)
AT (1) ATE204283T1 (sv)
BR (1) BR9404776A (sv)
CA (1) CA2136788C (sv)
DE (1) DE69427955T2 (sv)
DK (1) DK0655454T3 (sv)
ES (1) ES2159296T3 (sv)
FI (1) FI115461B (sv)
HU (2) HU224710B1 (sv)
IL (1) IL111793A (sv)
PT (1) PT655454E (sv)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001994A (en) * 1995-12-13 1999-12-14 Eli Lilly And Company Process for making gemcitabine hydrochloride
US5756775A (en) * 1995-12-13 1998-05-26 Eli Lilly And Company Process to make α,α-difluoro-β-hydroxyl thiol esters
EP0779275A2 (en) 1995-12-13 1997-06-18 Eli Lilly And Company Alpha, Alpha - Difluoro-beta -hydroxy thiol esters and their synthesis
US7067600B2 (en) * 2001-08-16 2006-06-27 The Goodyear Tire & Rubber Company Modified silane compounds
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
EP2086944B1 (de) * 2006-11-03 2010-01-13 Basf Se Verfahren zur herstellung von difluormethylpyrazolylcarboxylaten
US7994207B2 (en) * 2006-12-21 2011-08-09 Basf Se Process for preparing fluoromethyl-substituted heterocyclic compounds
WO2009106619A1 (en) 2008-02-29 2009-09-03 Basf Se Process for preparing alkyl 2-alkoxymethylene-4,4-difluoro-3-oxobutyrates
BRPI0911898A2 (pt) 2008-05-02 2015-10-13 Basf Se processo para preparar compostos, e, composto.
KR20110010621A (ko) * 2008-05-02 2011-02-01 바스프 에스이 할로겐-치환된 2-(아미노메틸리덴)-3-옥소부티르산 에스테르의 제조 방법
MX2010011433A (es) * 2008-05-05 2010-11-12 Basf Se Procedimiento para la preparacion de compuestos pirazolicos sustituidos en posiciones 1,3,4.
BRPI0912383A2 (pt) 2008-05-08 2015-07-28 Basf Se Processo para preparar aril carboxamidas
KR20110031501A (ko) * 2008-07-21 2011-03-28 바스프 에스이 1,3-이치환된 피라졸카르복실산 에스테르의 제조 방법
JP5540776B2 (ja) * 2010-03-05 2014-07-02 セントラル硝子株式会社 ジフルオロ酢酸エステルの製造方法
CN113603669A (zh) * 2021-08-06 2021-11-05 江苏八巨药业有限公司 一种吉西他滨关键中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4508880A (en) * 1981-06-30 1985-04-02 E. I. Du Pont De Nemours And Company "Living" polymers and process for their preparation
US4417034A (en) * 1981-06-30 1983-11-22 E. I. Du Pont De Nemours & Co. Living polymers and process for their preparation
US4414372A (en) * 1982-06-17 1983-11-08 E. I. Du Pont De Nemours & Co. Process for preparing living polymers
US4482729A (en) * 1984-03-04 1984-11-13 Daikin Kogyo Co., Ltd. Fluoroalkyl silyl ketene acetals and a process for preparing the same
US4780554A (en) * 1984-11-20 1988-10-25 Union Carbide Corporation O-silylated ketene acetals and enol ethers and method of preparation
US4754046A (en) * 1987-06-25 1988-06-28 Dow Corning Corporation Stabilized silyl ketene acetals
US4824981A (en) * 1987-07-06 1989-04-25 Dow Corning Corporation Process to produce silyl ketene acetals
US4746750A (en) * 1987-08-31 1988-05-24 Dow Corning Corporation Synthesis of silyl ketene acetal from allyl 2-organoacrylates
JP2594605B2 (ja) * 1988-03-12 1997-03-26 鹿島石油株式会社 光学活性なα，α−ジフルオロ−β−ヒドロキシカルボニル化合物
US4824980A (en) * 1988-09-02 1989-04-25 Dow Corning Corporation Process to produce O-silyl O,N-ketene acetals
JPH0267250A (ja) * 1988-09-02 1990-03-07 Asahi Glass Co Ltd ２，２‐ジフルオロ‐３‐ヒドロキシカルボン酸誘導体の製造法
US5041587A (en) * 1989-02-14 1991-08-20 Mitsui Toatsu Chemicals, Inc. Process for preparing organic silicon compound
JPH02270841A (ja) * 1989-04-12 1990-11-05 Asahi Glass Co Ltd ２，２―ジフルオロ―３，４，５―トリヒドロキシカルボン酸誘導体の製造法

Also Published As

Publication number Publication date
KR950014125A (ko) 1995-06-15
ES2159296T3 (es) 2001-10-01
KR100332322B1 (ko) 2002-04-13
CA2136788C (en) 2005-01-25
BR9404776A (pt) 1995-11-21
IL111793A0 (en) 1995-01-24
JP3615253B2 (ja) 2005-02-02
CA2136788A1 (en) 1995-05-31
JPH07188260A (ja) 1995-07-25
HUT70178A (en) 1995-09-28
EP0655454B1 (en) 2001-08-16
FI115461B (sv) 2005-05-13
DE69427955T2 (de) 2002-04-18
HU9403423D0 (en) 1995-02-28
EP0655454A1 (en) 1995-05-31
ATE204283T1 (de) 2001-09-15
HU224710B1 (en) 2006-01-30
IL111793A (en) 1998-12-06
DE69427955D1 (de) 2001-09-20
FI945626A (sv) 1995-05-31
KR100344363B1 (ko) 2002-11-30
US5618951A (en) 1997-04-08
FI945626A0 (sv) 1994-11-29
HU219466B (hu) 2001-04-28
HU9904356D0 (en) 2000-02-28
PT655454E (pt) 2001-12-28

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