DK0649312T3 - Anthracyclinkonjugater, deres fremstilling og deres anvendelse som antitumormidler - Google Patents

Anthracyclinkonjugater, deres fremstilling og deres anvendelse som antitumormidler

Info

Publication number
DK0649312T3
DK0649312T3 DK94913560T DK94913560T DK0649312T3 DK 0649312 T3 DK0649312 T3 DK 0649312T3 DK 94913560 T DK94913560 T DK 94913560T DK 94913560 T DK94913560 T DK 94913560T DK 0649312 T3 DK0649312 T3 DK 0649312T3
Authority
DK
Denmark
Prior art keywords
pct
mol
image
preparation
residue
Prior art date
Application number
DK94913560T
Other languages
Danish (da)
English (en)
Inventor
Francesco Angelucci
Maria Grandi
Antonino Suarato
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Application granted granted Critical
Publication of DK0649312T3 publication Critical patent/DK0649312T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polyamides (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DK94913560T 1993-05-11 1994-04-08 Anthracyclinkonjugater, deres fremstilling og deres anvendelse som antitumormidler DK0649312T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939309663A GB9309663D0 (en) 1993-05-11 1993-05-11 Biologically active compounds
PCT/EP1994/001100 WO1994026311A1 (en) 1993-05-11 1994-04-08 Anthracycline conjugates, their preparation and their use as antitumor agents

Publications (1)

Publication Number Publication Date
DK0649312T3 true DK0649312T3 (da) 2001-11-12

Family

ID=10735264

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94913560T DK0649312T3 (da) 1993-05-11 1994-04-08 Anthracyclinkonjugater, deres fremstilling og deres anvendelse som antitumormidler

Country Status (25)

Country Link
US (1) US5571785A (ru)
EP (1) EP0649312B1 (ru)
JP (1) JPH08502519A (ru)
KR (1) KR100330635B1 (ru)
CN (1) CN1098106C (ru)
AT (1) ATE203414T1 (ru)
AU (1) AU671741B2 (ru)
CA (1) CA2136438C (ru)
DE (1) DE69427799T2 (ru)
DK (1) DK0649312T3 (ru)
ES (1) ES2161764T3 (ru)
FI (1) FI112602B (ru)
GB (1) GB9309663D0 (ru)
GR (1) GR3036978T3 (ru)
HU (2) HUT70509A (ru)
IL (1) IL109528A (ru)
MY (1) MY110974A (ru)
NZ (1) NZ265266A (ru)
PL (1) PL175325B1 (ru)
PT (1) PT649312E (ru)
RU (1) RU2145965C1 (ru)
TW (1) TW268015B (ru)
UA (1) UA42695C2 (ru)
WO (1) WO1994026311A1 (ru)
ZA (1) ZA943212B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
GB9721070D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Bioactive derivatives of camptothecin
CA2445985A1 (en) * 2001-05-04 2002-11-14 University Of Utah Research Foundation Hyaluronic acid containing bioconjugates: targeted delivery of anti-cancer drugs to cancer cells
WO2003037915A1 (en) * 2001-10-31 2003-05-08 Biopolymed Inc. Biocompatible polymers including peptide spacer
CA2483696A1 (en) * 2002-05-06 2003-11-20 University Of Utah Research Foundation Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
US9737556B2 (en) 2014-06-13 2017-08-22 Trustees Of Tufts College FAP-activated therapeutic agents, and uses related thereto
PL3154594T3 (pl) 2014-06-13 2023-10-09 Bach Biosciences, Llc Środki terapeutyczne aktywowane FAP i związane z nimi zastosowania

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162512A (en) * 1982-03-09 1992-11-10 Cytogen Corporation Amine derivatives of anthracycline antibodies
JPS60246400A (ja) * 1984-05-22 1985-12-06 Ajinomoto Co Inc アントラサイクリン系化合物及び制ガン剤
US5169937A (en) * 1986-11-18 1992-12-08 The Scripps Research Institute Method for producing stable glycosylated hemoglobin
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents

Also Published As

Publication number Publication date
WO1994026311A1 (en) 1994-11-24
FI946128A (fi) 1994-12-28
DE69427799T2 (de) 2002-05-02
PT649312E (pt) 2002-01-30
FI946128A0 (fi) 1994-12-28
IL109528A0 (en) 1994-08-26
NZ265266A (en) 1996-06-25
DE69427799D1 (de) 2001-08-30
PL306861A1 (en) 1995-04-18
ES2161764T3 (es) 2001-12-16
TW268015B (ru) 1996-01-11
RU2145965C1 (ru) 2000-02-27
MY110974A (en) 1999-07-31
CN1108454A (zh) 1995-09-13
CA2136438A1 (en) 1994-11-24
CA2136438C (en) 2004-09-14
GB9309663D0 (en) 1993-06-23
HUT70509A (en) 1995-10-30
AU6566694A (en) 1994-12-12
ATE203414T1 (de) 2001-08-15
JPH08502519A (ja) 1996-03-19
CN1098106C (zh) 2003-01-08
AU671741B2 (en) 1996-09-05
HU211538A9 (en) 1995-12-28
EP0649312A1 (en) 1995-04-26
FI112602B (fi) 2003-12-31
IL109528A (en) 1998-08-16
ZA943212B (en) 1995-01-18
US5571785A (en) 1996-11-05
HU9403811D0 (en) 1995-03-28
RU94046336A (ru) 1996-10-27
UA42695C2 (ru) 2001-11-15
KR100330635B1 (ko) 2002-09-17
PL175325B1 (pl) 1998-12-31
KR950702201A (ko) 1995-06-19
EP0649312B1 (en) 2001-07-25
GR3036978T3 (en) 2002-01-31

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