DK0635011T3 - Hydrazid-derivater af 3,4-dihydro-2H-1-benzopyraner - Google Patents

Hydrazid-derivater af 3,4-dihydro-2H-1-benzopyraner

Info

Publication number
DK0635011T3
DK0635011T3 DK93907486.0T DK93907486T DK0635011T3 DK 0635011 T3 DK0635011 T3 DK 0635011T3 DK 93907486 T DK93907486 T DK 93907486T DK 0635011 T3 DK0635011 T3 DK 0635011T3
Authority
DK
Denmark
Prior art keywords
alkyl
benzopyrans
dihydro
free radical
radical scavengers
Prior art date
Application number
DK93907486.0T
Other languages
Danish (da)
English (en)
Inventor
Margaret A Petty
Frank Bolkenius
Martin J Grisar
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0635011T3 publication Critical patent/DK0635011T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
DK93907486.0T 1992-04-07 1993-03-12 Hydrazid-derivater af 3,4-dihydro-2H-1-benzopyraner DK0635011T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92400972 1992-04-07

Publications (1)

Publication Number Publication Date
DK0635011T3 true DK0635011T3 (da) 1997-01-06

Family

ID=8211648

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93907486.0T DK0635011T3 (da) 1992-04-07 1993-03-12 Hydrazid-derivater af 3,4-dihydro-2H-1-benzopyraner

Country Status (19)

Country Link
EP (1) EP0635011B1 (enExample)
JP (1) JP3226174B2 (enExample)
KR (1) KR950700680A (enExample)
AT (1) ATE146466T1 (enExample)
AU (1) AU675784B2 (enExample)
CA (1) CA2132831C (enExample)
DE (1) DE69306770T2 (enExample)
DK (1) DK0635011T3 (enExample)
ES (1) ES2098730T3 (enExample)
FI (1) FI944678A7 (enExample)
GR (1) GR3022122T3 (enExample)
HU (1) HU215912B (enExample)
IL (1) IL105319A (enExample)
MX (1) MX9301979A (enExample)
NO (1) NO943760L (enExample)
NZ (1) NZ251174A (enExample)
TW (1) TW278076B (enExample)
WO (1) WO1993020059A1 (enExample)
ZA (1) ZA932414B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
US5416098A (en) * 1993-12-30 1995-05-16 Zymogenetics, Inc. Method for treating dermatitis and related conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010505A1 (de) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen Chromanderivate, verfahren zu ihrer herstellung, ihre verwendung als stabilisatoren von organischen materialien sowie diese stabilisatoren enthaltende organische materialien
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
EP0369083A1 (en) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs
EP0412939A3 (en) * 1989-08-11 1991-09-04 Ciba-Geigy Ag Certain benzopyran and benzothiopyran derivatives
DE4000397A1 (de) * 1990-01-09 1991-07-11 Hoechst Ag Lipidselektive antioxidantien sowie deren herstellung und verwendung
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터

Also Published As

Publication number Publication date
EP0635011B1 (en) 1996-12-18
FI944678A0 (fi) 1994-10-06
WO1993020059A1 (en) 1993-10-14
CA2132831A1 (en) 1993-10-14
DE69306770D1 (de) 1997-01-30
JPH07505625A (ja) 1995-06-22
HU215912B (hu) 1999-03-29
DE69306770T2 (de) 1997-06-12
NZ251174A (en) 1996-01-26
TW278076B (enExample) 1996-06-11
MX9301979A (es) 1993-11-01
ZA932414B (en) 1993-10-22
GR3022122T3 (en) 1997-03-31
IL105319A (en) 1998-02-22
ES2098730T3 (es) 1997-05-01
AU675784B2 (en) 1997-02-20
HUT68833A (en) 1995-08-28
HU9402882D0 (en) 1995-01-30
EP0635011A1 (en) 1995-01-25
NO943760L (no) 1994-12-06
FI944678L (fi) 1994-10-06
FI944678A7 (fi) 1994-10-06
ATE146466T1 (de) 1997-01-15
JP3226174B2 (ja) 2001-11-05
AU3807293A (en) 1993-11-08
NO943760D0 (no) 1994-10-06
KR950700680A (ko) 1995-02-20
IL105319A0 (en) 1993-08-18
CA2132831C (en) 1998-06-16

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