AU675784B2 - Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans - Google Patents

Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans Download PDF

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Publication number
AU675784B2
AU675784B2 AU38072/93A AU3807293A AU675784B2 AU 675784 B2 AU675784 B2 AU 675784B2 AU 38072/93 A AU38072/93 A AU 38072/93A AU 3807293 A AU3807293 A AU 3807293A AU 675784 B2 AU675784 B2 AU 675784B2
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AU
Australia
Prior art keywords
alkyl
compounds
international
document
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU38072/93A
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English (en)
Other versions
AU3807293A (en
Inventor
Frank Bolkenius
J. Martin Grisar
Margaret A. Petty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of AU3807293A publication Critical patent/AU3807293A/en
Application granted granted Critical
Publication of AU675784B2 publication Critical patent/AU675784B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
AU38072/93A 1992-04-07 1993-03-12 Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans Ceased AU675784B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP92400972 1992-04-07
EP92400972 1992-04-07
PCT/US1993/002311 WO1993020059A1 (en) 1992-04-07 1993-03-12 Hydrazide derivatives of 3,4-dihydro-2h-1-benzopyrans

Publications (2)

Publication Number Publication Date
AU3807293A AU3807293A (en) 1993-11-08
AU675784B2 true AU675784B2 (en) 1997-02-20

Family

ID=8211648

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38072/93A Ceased AU675784B2 (en) 1992-04-07 1993-03-12 Hydrazide derivatives of 3,4-dihydro-2H-1-benzopyrans

Country Status (19)

Country Link
EP (1) EP0635011B1 (enExample)
JP (1) JP3226174B2 (enExample)
KR (1) KR950700680A (enExample)
AT (1) ATE146466T1 (enExample)
AU (1) AU675784B2 (enExample)
CA (1) CA2132831C (enExample)
DE (1) DE69306770T2 (enExample)
DK (1) DK0635011T3 (enExample)
ES (1) ES2098730T3 (enExample)
FI (1) FI944678A7 (enExample)
GR (1) GR3022122T3 (enExample)
HU (1) HU215912B (enExample)
IL (1) IL105319A (enExample)
MX (1) MX9301979A (enExample)
NO (1) NO943760L (enExample)
NZ (1) NZ251174A (enExample)
TW (1) TW278076B (enExample)
WO (1) WO1993020059A1 (enExample)
ZA (1) ZA932414B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510373A (en) * 1992-04-06 1996-04-23 Merrell Pharmaceuticals Inc. Cardioprotective agents
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
US5451603A (en) * 1993-03-11 1995-09-19 Zymogenetics, Inc. 3,4-diarylchromans for treatment of dermatitis
US5416098A (en) * 1993-12-30 1995-05-16 Zymogenetics, Inc. Method for treating dermatitis and related conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6089590A (en) * 1989-08-11 1991-02-14 Ciba-Geigy Ag Certain benzopyran and benzothiopyran derivatives
AU6921791A (en) * 1990-01-09 1991-09-05 Hoechst Aktiengesellschaft Lipid-selective antioxidants and their preparation and use
AU7798691A (en) * 1990-04-20 1991-11-11 Pfizer Inc. Antiinflammatory hydroxamic acids and n-hydroxyureas

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010505A1 (de) * 1980-03-19 1981-10-01 Basf Ag, 6700 Ludwigshafen Chromanderivate, verfahren zu ihrer herstellung, ihre verwendung als stabilisatoren von organischen materialien sowie diese stabilisatoren enthaltende organische materialien
CA1338012C (en) * 1987-04-27 1996-01-30 John Michael Mccall Pharmaceutically active amines
EP0369083A1 (en) * 1988-11-14 1990-05-23 Merrell Dow Pharmaceuticals Inc. Cardioprotective tocopherol analogs

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6089590A (en) * 1989-08-11 1991-02-14 Ciba-Geigy Ag Certain benzopyran and benzothiopyran derivatives
AU6921791A (en) * 1990-01-09 1991-09-05 Hoechst Aktiengesellschaft Lipid-selective antioxidants and their preparation and use
AU7798691A (en) * 1990-04-20 1991-11-11 Pfizer Inc. Antiinflammatory hydroxamic acids and n-hydroxyureas

Also Published As

Publication number Publication date
EP0635011B1 (en) 1996-12-18
FI944678A0 (fi) 1994-10-06
WO1993020059A1 (en) 1993-10-14
CA2132831A1 (en) 1993-10-14
DE69306770D1 (de) 1997-01-30
JPH07505625A (ja) 1995-06-22
HU215912B (hu) 1999-03-29
DE69306770T2 (de) 1997-06-12
NZ251174A (en) 1996-01-26
TW278076B (enExample) 1996-06-11
MX9301979A (es) 1993-11-01
ZA932414B (en) 1993-10-22
GR3022122T3 (en) 1997-03-31
IL105319A (en) 1998-02-22
ES2098730T3 (es) 1997-05-01
HUT68833A (en) 1995-08-28
HU9402882D0 (en) 1995-01-30
DK0635011T3 (da) 1997-01-06
EP0635011A1 (en) 1995-01-25
NO943760L (no) 1994-12-06
FI944678L (fi) 1994-10-06
FI944678A7 (fi) 1994-10-06
ATE146466T1 (de) 1997-01-15
JP3226174B2 (ja) 2001-11-05
AU3807293A (en) 1993-11-08
NO943760D0 (no) 1994-10-06
KR950700680A (ko) 1995-02-20
IL105319A0 (en) 1993-08-18
CA2132831C (en) 1998-06-16

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired