DK0625166T3 - Sulfaterede polysaccharider, fremgangsmåde til deres fremstilling og farmaceutiske præparater deraf - Google Patents

Sulfaterede polysaccharider, fremgangsmåde til deres fremstilling og farmaceutiske præparater deraf

Info

Publication number
DK0625166T3
DK0625166T3 DK93904154.7T DK93904154T DK0625166T3 DK 0625166 T3 DK0625166 T3 DK 0625166T3 DK 93904154 T DK93904154 T DK 93904154T DK 0625166 T3 DK0625166 T3 DK 0625166T3
Authority
DK
Denmark
Prior art keywords
processes
preparation
pharmaceutical compositions
sulfated polysaccharides
daltons
Prior art date
Application number
DK93904154.7T
Other languages
Danish (da)
English (en)
Inventor
Andre Uzan
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of DK0625166T3 publication Critical patent/DK0625166T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
DK93904154.7T 1992-02-07 1993-02-04 Sulfaterede polysaccharider, fremgangsmåde til deres fremstilling og farmaceutiske præparater deraf DK0625166T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201383A FR2687158B1 (fr) 1992-02-07 1992-02-07 Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.

Publications (1)

Publication Number Publication Date
DK0625166T3 true DK0625166T3 (da) 1998-02-02

Family

ID=9426428

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93904154.7T DK0625166T3 (da) 1992-02-07 1993-02-04 Sulfaterede polysaccharider, fremgangsmåde til deres fremstilling og farmaceutiske præparater deraf

Country Status (17)

Country Link
EP (1) EP0625166B1 (fi)
JP (1) JP3218039B2 (fi)
KR (1) KR950700334A (fi)
AT (1) ATE157991T1 (fi)
AU (1) AU671817B2 (fi)
CA (1) CA2126241C (fi)
DE (1) DE69313826T2 (fi)
DK (1) DK0625166T3 (fi)
ES (1) ES2109478T3 (fi)
FI (1) FI106034B (fi)
FR (1) FR2687158B1 (fi)
GR (1) GR3024695T3 (fi)
HU (1) HU214327B (fi)
MX (1) MX9300584A (fi)
NO (1) NO307466B1 (fi)
NZ (1) NZ249165A (fi)
WO (1) WO1993016112A1 (fi)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
GB2299998B (en) * 1995-03-31 1997-03-26 Hamilton Civic Hospitals Res Compositions for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
AU7753898A (en) * 1997-06-06 1998-12-21 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
EP2402753A1 (en) 2002-03-11 2012-01-04 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
WO2007140231A2 (en) 2006-05-25 2007-12-06 Momenta Pharmaceutical, Inc. Low molecular weight heparin composition and uses thereof
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
CA2811186C (en) * 2010-09-14 2018-12-04 Michio Muguruma High purity heparin and production method therefor
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2945595A1 (de) * 1979-11-12 1981-05-21 Sandoz-Patent-GmbH, 7850 Lörrach Verfahren zur herstellung von niedermolekularem heparin bzw. seinen salzen
FR2622450B1 (fr) * 1987-11-03 1991-02-22 Sanofi Sa Association heparine/dermatane sulfate
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
FR2663639B1 (fr) * 1990-06-26 1994-03-18 Rhone Poulenc Sante Melanges de polysaccharides de bas poids moleculaires procede de preparation et utilisation.
FR2675806B1 (fr) * 1991-04-23 1994-06-10 Rhone Poulenc Rorer Sa Polysaccharides sulfates, procede de preparation, composition pharmaceutique et utilisation.

Also Published As

Publication number Publication date
ES2109478T3 (es) 1998-01-16
ATE157991T1 (de) 1997-09-15
GR3024695T3 (en) 1997-12-31
FI943642A0 (fi) 1994-08-05
NZ249165A (en) 1996-01-26
HU214327B (hu) 1998-03-02
EP0625166B1 (fr) 1997-09-10
CA2126241A1 (fr) 1993-08-19
FR2687158B1 (fr) 1995-06-30
MX9300584A (es) 1993-08-01
WO1993016112A1 (fr) 1993-08-19
NO942897L (no) 1994-08-04
HU9401994D0 (en) 1994-09-28
DE69313826D1 (de) 1997-10-16
FR2687158A1 (fr) 1993-08-13
DE69313826T2 (de) 1998-02-12
JP3218039B2 (ja) 2001-10-15
NO307466B1 (no) 2000-04-10
KR950700334A (ko) 1995-01-16
AU671817B2 (en) 1996-09-12
CA2126241C (fr) 2004-06-22
NO942897D0 (fi) 1994-08-04
AU3505193A (en) 1993-09-03
FI943642A (fi) 1994-08-05
HUT67878A (en) 1995-05-29
JPH07503496A (ja) 1995-04-13
EP0625166A1 (fr) 1994-11-23
FI106034B (fi) 2000-11-15

Similar Documents

Publication Publication Date Title
IL61201A (en) Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
DK597983A (da) Depolymeriseret og oversulfateret heparin, fremgangsmaade til fremstilling deraf og farmaceutisk middel indeholdende naevnte heparin
DK0625166T3 (da) Sulfaterede polysaccharider, fremgangsmåde til deres fremstilling og farmaceutiske præparater deraf
NO973311L (no) Ikke-farmasöytisk polysakkaridkonjugat
IT8921066A0 (it) Composizioni polimeriche autoestinguenti.
IT8747630A0 (it) Derivati di dicloroanilina, composizioni farmaceutiche che li contengono e procedimento per produrli
IT8920486A0 (it) Composizioni farmaceutiche.
DE68908297T2 (de) Formgepresste Zusammensetzungen.
DK0912613T3 (da) Syntetiske polysaccharider, fremgangsmåde til deres fremstilling og farmaceutiske præparater, der indeholder dem
IT8219908A0 (it) Derivati di ferro biodisponibile esenti da gastrolesivita',procedimento di preparazione e relative composizioni farmaceutiche.
BR9100297A (pt) Derivados da pirazolina substituidos,processo para sua preparacao,composicao praguicida,processo para combater pragas e para a preparacao de composicoes
IT1238685B (it) Polisaccaridi ad azione immunomodulatrice da astragalus membranaceous e composizioni farmaceutiche che li contengono
DK0711302T3 (da) Byggeeblokke med carbamat-internukleosidbindinger og hidtil ukendte oligonukleotider afledt deraf
EP0435211A3 (en) Photo-curable, urethane-containing compositions
FI962979A0 (fi) Hirudiinia sisältävät farmaseuttiset koostumukset
NO943826D0 (no) Heteroarylpiperidiner, fremgangsmåte for fremstilling og farmasöytiske blandinger hvor de er tilstede
IT8721958A0 (it) Derivato di taurina, sua preparazione e composizioni farmaceutiche relative
IT9021332A0 (it) Expolimero ottenuto a partire da ceppi selezionati del genere bifidobacterium, suo procedimento di preparazione e composizioni farmaceutiche che lo contengono
GB8907057D0 (en) Polysaccharide compositions
FR2708855B1 (fr) Compositions pharmaceutiques immunoadjuvantes ou immunostimulantes.
IT1243921B (it) Derivati di selenofene, un procedimento per la loro preparazione e composizioni che li contengono.
IT8422898A0 (it) Derivati di 1,4-diidropiridina e composizioni farmaceutiche che licontengono.
IT8921562A0 (it) Composizioni polimeriche autoestinguenti.
IT8820226A0 (it) Fosfatidil n_acetil_l_serina, composizioni farmaceutiche che la contengono e processo per la sua preparazione.
IT8620658A0 (it) Frazione ottenuta da propionibacterium ances avente azione terapeutica immunomodulante, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono.