DK0623144T3 - Syntetiske peptider til detoksificering af bakterielle endotoksiner og behandling af septisk shock - Google Patents

Syntetiske peptider til detoksificering af bakterielle endotoksiner og behandling af septisk shock

Info

Publication number
DK0623144T3
DK0623144T3 DK92910229T DK92910229T DK0623144T3 DK 0623144 T3 DK0623144 T3 DK 0623144T3 DK 92910229 T DK92910229 T DK 92910229T DK 92910229 T DK92910229 T DK 92910229T DK 0623144 T3 DK0623144 T3 DK 0623144T3
Authority
DK
Denmark
Prior art keywords
amino acid
septic shock
synthetic peptides
bacterial endotoxins
treating septic
Prior art date
Application number
DK92910229T
Other languages
English (en)
Inventor
Massimo Porro
Original Assignee
Massimo Porro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massimo Porro filed Critical Massimo Porro
Application granted granted Critical
Publication of DK0623144T3 publication Critical patent/DK0623144T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK92910229T 1992-01-16 1992-05-14 Syntetiske peptider til detoksificering af bakterielle endotoksiner og behandling af septisk shock DK0623144T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/819,893 US5371186A (en) 1991-02-11 1992-01-16 Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock
PCT/EP1992/001060 WO1993014115A1 (en) 1992-01-16 1992-05-14 Synthetic peptides for detoxification of bacterial endotoxins and treatment of septic shock

Publications (1)

Publication Number Publication Date
DK0623144T3 true DK0623144T3 (da) 2002-05-13

Family

ID=25229363

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92910229T DK0623144T3 (da) 1992-01-16 1992-05-14 Syntetiske peptider til detoksificering af bakterielle endotoksiner og behandling af septisk shock

Country Status (16)

Country Link
US (2) US5371186A (da)
EP (1) EP0623144B1 (da)
JP (1) JPH07505606A (da)
AT (1) ATE212355T1 (da)
AU (1) AU665945B2 (da)
CA (1) CA2123576A1 (da)
DE (1) DE69232378T2 (da)
DK (1) DK0623144T3 (da)
ES (1) ES2172506T3 (da)
FI (1) FI943396A (da)
HU (1) HUT69707A (da)
IE (1) IE920437A1 (da)
IL (1) IL100811A (da)
NZ (1) NZ241446A (da)
TW (1) TW215441B (da)
WO (1) WO1993014115A1 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5371186A (en) * 1991-02-11 1994-12-06 Biosynth S.R.L. Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock
US5652211A (en) * 1991-02-11 1997-07-29 Biosynth S.R.L. Peptides for neutralizing the toxicity of Lipid A
US5733872A (en) * 1993-03-12 1998-03-31 Xoma Corporation Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
US5610075A (en) * 1995-01-17 1997-03-11 Stahl-Rees; Marianne Competitive electrochemiluminescence assays for endotoxins using a ruthenium label
US5834430A (en) * 1995-05-31 1998-11-10 Biosynth S.R.L. Potentiation of antibiotics
WO1998035665A1 (fr) * 1997-02-14 1998-08-20 Ajinomoto Co., Inc. Antagonistes des endotoxines
CA2298101A1 (en) 1997-07-31 1999-02-11 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Novel synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome
WO1999011281A1 (en) * 1997-09-05 1999-03-11 Dana-Farber Cancer Institute The use of agents which bind g proteins for treating septic shock
US6194562B1 (en) 1998-04-22 2001-02-27 Promega Corporation Endotoxin reduction in nucleic acid purification
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
US6951652B2 (en) * 1998-07-29 2005-10-04 Biosynth S.R.L. Vaccine for prevention of gram-negative bacterial infections and endotoxin related diseases
US6116663A (en) * 1998-10-19 2000-09-12 Cercueils Vic Royal, Inc. Casket Lock
DE10117043A1 (de) * 2001-04-05 2002-11-07 Gerhard Puetz Verfahren zur Eliminierung von potentiell toxischen und/oder schädlichen Stoffen
AU2002309259A1 (en) * 2002-05-09 2003-11-11 Massimo Porro Improved polysaccharide and glycoconjugate vaccines_____________
CA2493124C (en) 2002-08-02 2014-04-29 Glaxosmithkline Biologicals S.A. Vaccine
WO2004052394A1 (en) * 2002-12-06 2004-06-24 Biosynth S.R.L. Broad-spectrum lps based vaccines of unencapsulated strains of haemophilus influenzae and other pathogenic species of gram-negative bacteria
GB2408263A (en) * 2003-11-14 2005-05-25 Pacgen Biopharmaceuticals Inc Antimicrobial peptides with reduced hemolysis and methods of their use.
US7628995B2 (en) 2003-12-23 2009-12-08 Glaxosmithkline Biologicals S.A. Outer membrane vesicles and uses thereof
US7507718B2 (en) 2005-04-11 2009-03-24 Sanofi Pasteur Polymyxin B analogs for LPS detoxification
EP1712559A1 (en) * 2005-04-11 2006-10-18 Sanofi Pasteur Polymyxin B analogs for LPS detoxification
BRPI0610701A2 (pt) * 2005-04-11 2010-07-20 Biosynth dìmero de peptìdeo saep ii, composição que o contém, seu uso, complexo de lps-peptìdeo, seu uso, composição farmacêutica e processo para a sua preparação, processo para a desintoxicação de um lps de bactérias gram-negativas e processo para a preparação de um dìmero de peptìdeo paralelo e antiparalelo saep ii
US8030034B2 (en) 2005-12-09 2011-10-04 Promega Corporation Nucleic acid purification with a binding matrix
JP5275982B2 (ja) 2006-06-12 2013-08-28 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ワクチン
ES2350430B1 (es) * 2009-05-28 2011-11-18 Fundacion De La Comunidad Valenciana Centro De Investigacion Principe Felipe,95%. Conjugado polimerico para el tratamiento de infecciones bacterianas
TWI548746B (zh) * 2009-08-06 2016-09-11 英特威特國際股份有限公司 防備豬胸膜肺炎之疫苗及製備該疫苗之方法
US8039613B2 (en) 2009-08-28 2011-10-18 Promega Corporation Methods of purifying a nucleic acid and formulation and kit for use in performing such methods
US8222397B2 (en) 2009-08-28 2012-07-17 Promega Corporation Methods of optimal purification of nucleic acids and kit for use in performing such methods
CN103002910A (zh) 2010-03-10 2013-03-27 葛兰素史密丝克莱恩生物有限公司 疫苗组合物
KR101858840B1 (ko) * 2016-01-15 2018-05-16 단국대학교 천안캠퍼스 산학협력단 집먼지진드기 유래 알레르겐에 의한 과민반응 면역조절제

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340012C (en) * 1987-08-17 1998-08-25 Trustees Of Leland Stanford Jr. University Peptide determinant associated with immunity
US5593966A (en) * 1989-03-31 1997-01-14 The United States Of America As Represented By The Department Of Health And Human Services Peptide derivatives of cytochrome b558 and their use as medicaments
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
US5371186A (en) * 1991-02-11 1994-12-06 Biosynth S.R.L. Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock
ZA92943B (en) * 1991-02-11 1992-11-25 Porro Massimo Synthetic peptides for detoxification of bacterial endotoxins and for the prevention and treatment of septic shock

Also Published As

Publication number Publication date
EP0623144A1 (en) 1994-11-09
IL100811A0 (en) 1992-09-06
WO1993014115A1 (en) 1993-07-22
DE69232378T2 (de) 2002-10-31
IL100811A (en) 1999-07-14
US5589459A (en) 1996-12-31
NZ241446A (en) 1995-03-28
TW215441B (da) 1993-11-01
ATE212355T1 (de) 2002-02-15
ES2172506T3 (es) 2002-10-01
AU665945B2 (en) 1996-01-25
HU9401970D0 (en) 1994-09-28
AU1691492A (en) 1993-08-03
HUT69707A (en) 1995-09-28
IE920437A1 (en) 1992-08-12
US5371186A (en) 1994-12-06
DE69232378D1 (de) 2002-03-14
CA2123576A1 (en) 1993-07-22
JPH07505606A (ja) 1995-06-22
EP0623144B1 (en) 2002-01-23
FI943396A0 (fi) 1994-07-15
FI943396A (fi) 1994-07-15

Similar Documents

Publication Publication Date Title
DK0623144T3 (da) Syntetiske peptider til detoksificering af bakterielle endotoksiner og behandling af septisk shock
DK0750506T3 (da) Bredspektrede, antimikrobielle forbindelser og fremgangsmåder til anvendelse af disse
EP0301570A3 (en) Oligopeptides useful for treating aids
MY131388A (en) Inhibitors of hiv protease useful for the treatment of aids.
AU9315398A (en) Chemokine peptides, variants, derivatives and analogs. their use in methods to inhibit or augment an inflammatory response
ATE132164T1 (de) Verfahren zur steigerung und zur hemmung der wirkung eines insulinähnlichen wachstumfaktors
ES2000852A6 (es) Un nuevo procedimiento para preparar intermediarios con residuos de acido 5-amino-2,5-disustituido -4- hidroxipentanoico,utiles en la sintesis de polipeptidos inhibidores de renina.
DK0463969T3 (da) Hidtil ukendte 4-aminosmørsyreforbindelser, fremgangsmåde til fremstilling heraf og farmaceutiske præparater, som indeholder dem
IL114809A0 (en) Mutant br96 antibodies
DK539483D0 (da) Fremgangsmade til fremstilling af peptider
DK0896615T3 (da) Peptid fra opløselig form af acetylcholinesterase, der er aktivt som calcium-kanal-modulator
PT983079E (pt) Metodo para tratamento de doencas diareicas e eliminacao de determinadas populacoes bacterianas do colon
EP0498784A3 (en) Inhibitors of retroviral protease
ES2002469A6 (es) Un procedimiento para la preparacion de nuevos di -.tri -. y tetrapeptidos inhibidores de renina.
DK0598899T3 (da) Væskefasesyntese af peptider og peptidderivater
WO1988003927A3 (en) Renin inhibitors
DK1117682T3 (da) Chi-conotoksin-peptider som inhibitorer af neuronale amintransportere
DE69526087T2 (de) Or-1, ein wais-rezeptor der nuklearen rezeptoren familie
ATE45165T1 (de) Reduzierte peptide, hemmungsstoffe gastrischer ausscheidung, verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
EP0156318A3 (en) C-terminal amide cyclic renin inhibitors containing peptide isosteres
KR970701732A (ko) 펩신 방출을 억제하기 위한 펩티드(Peptides Inhibiting the Release of Pepsin)
NO962204L (no) Dobbeltkjedede hemoregulatoriske peptider
FR2712728B1 (fr) Système de maintien des isolateurs en porcelaine pour la haute tension pendant la cuisson.