DK0617027T3 - N-benzylpiperazinforbindelser, fremgangsmåde til fremstilling heraf og sammensætninger indeholdende forbindelserne - Google Patents

N-benzylpiperazinforbindelser, fremgangsmåde til fremstilling heraf og sammensætninger indeholdende forbindelserne

Info

Publication number
DK0617027T3
DK0617027T3 DK94400609T DK94400609T DK0617027T3 DK 0617027 T3 DK0617027 T3 DK 0617027T3 DK 94400609 T DK94400609 T DK 94400609T DK 94400609 T DK94400609 T DK 94400609T DK 0617027 T3 DK0617027 T3 DK 0617027T3
Authority
DK
Denmark
Prior art keywords
compounds
benzylpiperazine
preparation
methods
compositions containing
Prior art date
Application number
DK94400609T
Other languages
Danish (da)
English (en)
Inventor
Yves Rolland
Jean-Paul Tillement
Jean Lepagnol
Michel Wierzbicki
Bernard Testa
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Application granted granted Critical
Publication of DK0617027T3 publication Critical patent/DK0617027T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK94400609T 1993-03-24 1994-03-22 N-benzylpiperazinforbindelser, fremgangsmåde til fremstilling heraf og sammensætninger indeholdende forbindelserne DK0617027T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9303364A FR2703048B1 (fr) 1993-03-24 1993-03-24 Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.

Publications (1)

Publication Number Publication Date
DK0617027T3 true DK0617027T3 (da) 2000-10-09

Family

ID=9445280

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94400609T DK0617027T3 (da) 1993-03-24 1994-03-22 N-benzylpiperazinforbindelser, fremgangsmåde til fremstilling heraf og sammensætninger indeholdende forbindelserne

Country Status (13)

Country Link
US (1) US5492913A (ja)
EP (1) EP0617027B1 (ja)
JP (1) JP3074109B2 (ja)
AT (1) ATE193703T1 (ja)
AU (1) AU675487B2 (ja)
CA (1) CA2119661C (ja)
DE (1) DE69424816T2 (ja)
DK (1) DK0617027T3 (ja)
ES (1) ES2149247T3 (ja)
FR (1) FR2703048B1 (ja)
GR (1) GR3033993T3 (ja)
NZ (1) NZ260158A (ja)
PT (1) PT617027E (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688797A (en) * 1996-04-26 1997-11-18 Thomas Jefferson University Treatment of acute central nervous system injury with piperazine derivatives
FR2757164B1 (fr) * 1996-12-16 1999-01-22 Adir Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP3476203B2 (ja) 1997-02-24 2003-12-10 ザイモジュネティックス インコーポレイテッド カルシトニン擬似体
US6268367B1 (en) 1998-02-23 2001-07-31 Zymogenetics, Inc. Piperazine derivatives for treating bone deficit conditions
US6063295A (en) * 1998-07-23 2000-05-16 Williams; Russell L. Apparatus and method to increase oxygen levels in livestock drinking water
FR2827284B1 (fr) * 2001-07-16 2003-10-31 Servier Lab Nouveaux derives de n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR805M (ja) * 1960-06-30 1961-09-01
FR1302958A (fr) * 1961-03-21 1962-09-07 Science Union & Cie Préparations des dérivés trialcoxylés de la benzyl-1 pipérazine
FR2493316A1 (fr) * 1980-11-06 1982-05-07 Science Union & Cie Nouveau procede de preparation des (trialcoxy benzyl)-1 piperazines et notamment de la (trimethoxy-2', 3', 4' benzyl)-1 piperazine
KR890011868A (ko) * 1988-01-26 1989-08-23 원본미기재 간질환 치료제 및 피페라진 유도체
FR2661176B1 (fr) * 1990-04-20 1992-06-12 Adir Nouveau procede de preparation de la 1-(2,3,4-trimethoxybenzyl) piperazine en amination reductive.
AU646926B2 (en) * 1991-03-20 1994-03-10 Duphar International Research B.V. Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory enhancing and anti-convulsive activity
FR2681324B1 (fr) * 1991-09-18 1993-10-29 Adir Cie Nouveaux derives de la trimetazidine, leur procede de preparation et les compositions pharmaceutiques les contenant.
JP3298305B2 (ja) * 1994-06-10 2002-07-02 ダイキン工業株式会社 クロスフィン熱交換器

Also Published As

Publication number Publication date
GR3033993T3 (en) 2000-11-30
DE69424816T2 (de) 2001-01-04
AU5795594A (en) 1994-09-29
NZ260158A (en) 1994-12-22
PT617027E (pt) 2000-09-29
FR2703048B1 (fr) 1996-01-05
JPH072814A (ja) 1995-01-06
EP0617027A1 (fr) 1994-09-28
FR2703048A1 (fr) 1994-09-30
ATE193703T1 (de) 2000-06-15
ES2149247T3 (es) 2000-11-01
JP3074109B2 (ja) 2000-08-07
CA2119661A1 (fr) 1994-09-25
AU675487B2 (en) 1997-02-06
US5492913A (en) 1996-02-20
DE69424816D1 (de) 2000-07-13
EP0617027B1 (fr) 2000-06-07
CA2119661C (fr) 2001-04-10

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