DK0612350T3 - Ubiquitin-specifikke proteaser - Google Patents

Ubiquitin-specifikke proteaser

Info

Publication number
DK0612350T3
DK0612350T3 DK92924325T DK92924325T DK0612350T3 DK 0612350 T3 DK0612350 T3 DK 0612350T3 DK 92924325 T DK92924325 T DK 92924325T DK 92924325 T DK92924325 T DK 92924325T DK 0612350 T3 DK0612350 T3 DK 0612350T3
Authority
DK
Denmark
Prior art keywords
ubiquitin
specific proteases
class
proteases
fusion protein
Prior art date
Application number
DK92924325T
Other languages
English (en)
Inventor
Rohan T Baker
John W Tobias
Alexander Varshavsky
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK0612350T3 publication Critical patent/DK0612350T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK92924325T 1991-11-08 1992-11-06 Ubiquitin-specifikke proteaser DK0612350T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/789,915 US5212058A (en) 1990-05-09 1991-11-08 Nucleic acid encoding ubiquitin-specific proteases
PCT/US1992/009562 WO1993009235A2 (en) 1991-11-08 1992-11-06 Ubiquitin-specific proteases

Publications (1)

Publication Number Publication Date
DK0612350T3 true DK0612350T3 (da) 2000-08-07

Family

ID=25149095

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92924325T DK0612350T3 (da) 1991-11-08 1992-11-06 Ubiquitin-specifikke proteaser

Country Status (10)

Country Link
US (3) US5212058A (da)
EP (1) EP0612350B1 (da)
JP (2) JP3592326B2 (da)
AT (1) ATE192496T1 (da)
CA (1) CA2123107C (da)
DE (1) DE69231001T2 (da)
DK (1) DK0612350T3 (da)
ES (1) ES2145015T3 (da)
GR (1) GR3034052T3 (da)
WO (1) WO1993009235A2 (da)

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US20020146764A1 (en) * 1985-03-28 2002-10-10 Chiron Corporation Expression using fused genes providing for protein product
US5212058A (en) * 1990-05-09 1993-05-18 Massachusetts Institute Of Technology Nucleic acid encoding ubiquitin-specific proteases
US6277609B1 (en) * 1993-01-06 2001-08-21 Basf Aktiengesellschaft Method to produce biotin
US5565352A (en) * 1993-11-24 1996-10-15 Arch Development Corporation Deubiquitinating enzyme: compositions and methods
US5744343A (en) * 1994-01-04 1998-04-28 Mitotix, Inc. Ubiquitin conjugating enzymes
WO1995018974A2 (en) * 1994-01-04 1995-07-13 Mitotix, Inc. Ubiquitin conjugating enzymes
US5981699A (en) * 1994-01-04 1999-11-09 Mitotix, Inc. Human ubiquitin conjugating enzyme
US5763212A (en) * 1994-02-04 1998-06-09 California Institute Of Technology Inhibiting degradation of a degron-bearing protein
US5538862A (en) * 1994-02-04 1996-07-23 California Institute Of Technology Heat-inducible N-degron module
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
WO1997006247A2 (en) 1995-08-09 1997-02-20 Dana Farber Cancer Institute Deubiquitinating enzymes that regulate cell growth
US5770720A (en) * 1995-08-30 1998-06-23 Barnes-Jewish Hospital Ubiquitin conjugating enzymes having transcriptional repressor activity
US6001619A (en) * 1995-10-04 1999-12-14 Cold Spring Harbor Laboratory Ubiquitin ligases, and uses related thereto
US6960656B1 (en) * 1996-10-25 2005-11-01 Cedars Sinai Medical Center Nucleic acid encoding DS-CAM proteins and products related thereto
US6747128B2 (en) 1997-08-20 2004-06-08 Gpc Biotech, Inc. Components of ubiquitin ligase complexes, and uses related thereto
US20030215421A1 (en) * 1999-07-21 2003-11-20 Mcdonald John R. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US7157418B1 (en) 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US7960540B2 (en) * 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318890A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20080318889A1 (en) * 1999-04-08 2008-12-25 Antisoma Research Limited Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
EP1181304B1 (en) * 1999-04-08 2007-10-10 Antisoma Research Limited Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) * 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US6709839B1 (en) * 1999-09-24 2004-03-23 Rigel Pharmaceuticals, Inc. SYK-UBP proteins, compositions and methods of use
CN1300818A (zh) * 1999-12-21 2001-06-27 复旦大学 一种新的多肽－蛋白内切酶Clp12和编码这种多肽的多核苷酸
WO2001066763A2 (en) * 2000-03-07 2001-09-13 Millennium Pharmaceuticals, Inc. 23436, a human ubiquitin protease family member and uses thereof
US7070947B2 (en) * 2000-02-29 2006-07-04 Millennium Pharmaceuticals, Inc. Human protein kinase, phosphatase, and protease family members and uses thereof
CZ20024085A3 (cs) 2000-06-15 2003-05-14 Smithkline Beecham Corporation Způsob přípravy fyziologicky aktivního IL-18 polypeptidu
KR100927261B1 (ko) 2001-01-17 2009-11-18 트루비온 파마슈티칼스, 인코포레이티드 결합 도메인-면역글로불린 융합 단백질
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7122332B2 (en) * 2001-03-29 2006-10-17 Rigel Pharmaceuticals, Inc. Modulators of leukocyte activation, compositions and methods of use
AU2002322544A1 (en) * 2001-07-18 2003-03-03 Expressive Constructs, Inc. A vector containing an enhanced p15a origin of replication
WO2005003305A2 (en) * 2003-06-19 2005-01-13 Exelixis, Inc. Usps as modifiers of the beta catenin pathway and methods of use
PL213561B1 (pl) * 2004-01-09 2013-03-29 Inst Biotechnologii I Antybiotykow Sposób otrzymywania plazmidu, plazmid oraz zastosowania
EP1713930B1 (en) 2004-01-17 2010-11-03 Korea Research Institute of Bioscience and Biotechnology Rapid screening method of translational fusion partners for producing recombinant proteins and translational fusion partners screened therefrom
PL1841862T3 (pl) 2005-01-10 2013-10-31 Inst Biotechnologii I Antybiotykow Mutant proteazy UBP1 i jego sekwencja kodująca, ich zastosowania oraz system ekspresji białka heterologicznego
AU2006284922B2 (en) 2005-08-30 2012-01-19 University Of Miami Immunomodulating tumor necrosis factor receptor 25 (TNFR25) agonists, antagonists and immunotoxins
US8173792B2 (en) 2007-02-09 2012-05-08 The Board Of Trustees Of The Leland Stanford Junior University Method for regulating protein function in cells using synthetic small molecules
US20090131351A1 (en) * 2007-11-16 2009-05-21 Antisoma Research Limited Methods, compositions, and kits for modulating tumor cell proliferation
US8530636B2 (en) * 2008-05-07 2013-09-10 The Board Of Trustees Of The Leland Stanford Junior University Method for regulating protein function in cells in vivo using synthetic small molecules
CN102203618B (zh) 2008-10-30 2014-10-15 郭培宣 用于dna测序和其他用途的膜集成病毒dna包装马达蛋白连接器生物传感器
CN102239183B (zh) * 2008-12-04 2017-06-30 韩国生命工学研究院 大量分泌的蛋白的筛选和它们作为融合配偶体在重组蛋白制备中应用
DK2462165T3 (da) 2009-08-03 2016-08-29 Univ Miami Fremgangsmåde til in-vivo proliferation af regulatoriske T-celler
WO2012060666A2 (ko) 2010-11-04 2012-05-10 한국생명공학연구원 효모에서 인체 상피세포 성장인자를 대량 생산하는 방법
EP2943253B1 (en) 2013-01-09 2021-10-20 University Of Miami Compositions and methods for the regulation of t regulatory cells using tl1a-ig fusion protein and il-2
US11446398B2 (en) 2016-04-11 2022-09-20 Obsidian Therapeutics, Inc. Regulated biocircuit systems
CN112292142A (zh) * 2018-03-06 2021-01-29 Pepvax公司 核酸分子及其使用方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2612874B2 (ja) * 1986-10-02 1997-05-21 マサチユセツツ・インスチチユート・オブ・テクノロジー タンパク質の代謝的安定性を調節する方法
US5132213A (en) * 1986-10-02 1992-07-21 Massachusetts Institute Of Technology Method for producing proteins and polypeptides using ubiquitin fusions
US5156968A (en) * 1988-06-24 1992-10-20 Genentech, Inc. Purified yeast ubiquitin hydrolase
US5108919A (en) * 1988-06-24 1992-04-28 Genentech, Inc. Dna sequences encoding yeast ubiquitin hydrolase
ATE121454T1 (de) * 1990-05-09 1995-05-15 Massachusetts Inst Technology Ubiquitinspezifische protease.
US5212058A (en) * 1990-05-09 1993-05-18 Massachusetts Institute Of Technology Nucleic acid encoding ubiquitin-specific proteases

Also Published As

Publication number Publication date
US5494818A (en) 1996-02-27
WO1993009235A2 (en) 1993-05-13
US5683904A (en) 1997-11-04
US5212058A (en) 1993-05-18
JPH07502647A (ja) 1995-03-23
DE69231001T2 (de) 2000-09-28
DE69231001D1 (de) 2000-06-08
CA2123107C (en) 2001-03-27
WO1993009235A3 (en) 1993-07-22
JP3592326B2 (ja) 2004-11-24
JP2003125790A (ja) 2003-05-07
ES2145015T3 (es) 2000-07-01
EP0612350A1 (en) 1994-08-31
ATE192496T1 (de) 2000-05-15
EP0612350B1 (en) 2000-05-03
GR3034052T3 (en) 2000-11-30
CA2123107A1 (en) 1993-05-13

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