DK0511221T3 - Fremgangsmåde til berigelse eller rensning af biomolekyler - Google Patents

Fremgangsmåde til berigelse eller rensning af biomolekyler

Info

Publication number
DK0511221T3
DK0511221T3 DK91900759.1T DK91900759T DK0511221T3 DK 0511221 T3 DK0511221 T3 DK 0511221T3 DK 91900759 T DK91900759 T DK 91900759T DK 0511221 T3 DK0511221 T3 DK 0511221T3
Authority
DK
Denmark
Prior art keywords
pct
concentration
date jul
sec
aqueous
Prior art date
Application number
DK91900759.1T
Other languages
English (en)
Inventor
Kurt Lang
Andreas Kreimeyer
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0511221T3 publication Critical patent/DK0511221T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6427—Chymotrypsins (3.4.21.1; 3.4.21.2); Trypsin (3.4.21.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
DK91900759.1T 1990-01-18 1990-12-20 Fremgangsmåde til berigelse eller rensning af biomolekyler DK0511221T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4001238A DE4001238A1 (de) 1990-01-18 1990-01-18 Verfahren zur anreicherung bzw. reinigung von biomolekuelen

Publications (1)

Publication Number Publication Date
DK0511221T3 true DK0511221T3 (da) 1994-10-17

Family

ID=6398254

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91900759.1T DK0511221T3 (da) 1990-01-18 1990-12-20 Fremgangsmåde til berigelse eller rensning af biomolekyler

Country Status (8)

Country Link
US (1) US5304310A (da)
EP (1) EP0511221B1 (da)
JP (1) JPH05503511A (da)
AT (1) ATE111481T1 (da)
CA (1) CA2067790A1 (da)
DE (2) DE4001238A1 (da)
DK (1) DK0511221T3 (da)
WO (1) WO1991010677A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0141651B1 (ko) * 1994-09-07 1998-06-15 강재헌 금속이온 친화성 크로마토그라피를 이용한 히루딘의 정제방법
DE69719497T2 (de) * 1996-03-15 2003-10-30 Novozymes As Verfahren zur proteinaufreinigung aus einer proteinhaltigen lösung
US6080844A (en) * 1998-04-23 2000-06-27 Abbott Laboratories Process for the recovery and purification of a recombinant protein from a cell
DE19855422A1 (de) 1998-12-01 2000-06-08 Basf Ag Hartstoff-Sinterformteil mit einem nickel- und kobaltfreien, stickstoffhaltigen Stahl als Binder der Hartstoffphase
AU778477B2 (en) * 1999-03-25 2004-12-09 Valtion Teknillinen Tutkimuskeskus Process for partitioning of proteins
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
SE0104462D0 (sv) * 2001-12-29 2001-12-29 Carlbiotech Ltd As Peptide purifcation (Peptidrening)
DE602005020258D1 (de) * 2004-02-27 2010-05-12 Dow Global Technologies Inc Verfahren zur extraktion eines intrazellulären proteins aus einer fermentationsbrühe
US7686786B2 (en) 2004-10-21 2010-03-30 Novo Nordiks A/S Dial-down mechanism for wind-up pen
US8088900B2 (en) 2006-03-30 2012-01-03 Novo Nordisk A/S Two-phase precipitation of proteins
EP2019701B1 (en) 2006-05-16 2010-02-24 Novo Nordisk A/S A gearing mechanism for an injection device
JP5253387B2 (ja) 2006-05-18 2013-07-31 ノボ・ノルデイスク・エー／エス モード固定手段を備えている注入装置
WO2011159537A2 (en) * 2010-06-15 2011-12-22 The Regents Of The University Of California Method and device for analyte detection
US9533106B2 (en) 2011-12-29 2017-01-03 Novo Nordisk A/S Torsion-spring based wind-up auto injector pen with dial-up/dial-down mechanism
US9867763B2 (en) 2013-05-10 2018-01-16 Noxell Corporation Modular emulsion-based product differentiation
CN112321703B (zh) * 2020-11-24 2023-03-28 山东沃华医药科技股份有限公司 一种乳状液膜法纯化水蛭素方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3300383A (en) * 1963-10-15 1967-01-24 Dresden Arzneimittel Hirudine from leeches and process for recovery thereof
US3432596A (en) * 1967-10-13 1969-03-11 Dresden Arzneimittel Method for producing highly pure hirudine
US3637462A (en) * 1969-04-21 1972-01-25 Wadley Res Inst & Blood Bank Purification of enzymes
US4390630A (en) * 1980-10-28 1983-06-28 The Regents Of The University Of California Hementin--a fibrinolytic agent
US4588587A (en) * 1983-03-01 1986-05-13 Pennsylvania Hospital Method of treatment to inhibit metastasis
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
CA1315228C (en) * 1986-04-28 1993-03-30 Chan W. Kim Liquid-liquid extraction with particulate polymeric adsorbent
US4832849A (en) * 1988-06-16 1989-05-23 Merrell Dow Pharmaceuticals Inc. Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii
IL86856A0 (en) * 1988-06-24 1988-11-30 Yissum Res Dev Co Bovine xa factor and pharmaceutical compositions containing the same
US4980065A (en) * 1989-10-18 1990-12-25 Lehigh University Separation of mixtures by aqueous two-phase systems
US5078886A (en) * 1989-10-18 1992-01-07 Lehigh University Separation of mixtures by two-phase systems

Also Published As

Publication number Publication date
EP0511221A1 (de) 1992-11-04
EP0511221B1 (de) 1994-09-14
CA2067790A1 (en) 1991-07-19
ATE111481T1 (de) 1994-09-15
WO1991010677A1 (de) 1991-07-25
DE4001238A1 (de) 1991-07-25
US5304310A (en) 1994-04-19
DE59007173D1 (de) 1994-10-20
JPH05503511A (ja) 1993-06-10

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