DK0496160T3 - Syntetisk omdannelse af Bryostatin 2 til Bryostatin 1 - Google Patents
Syntetisk omdannelse af Bryostatin 2 til Bryostatin 1Info
- Publication number
- DK0496160T3 DK0496160T3 DK91311568.9T DK91311568T DK0496160T3 DK 0496160 T3 DK0496160 T3 DK 0496160T3 DK 91311568 T DK91311568 T DK 91311568T DK 0496160 T3 DK0496160 T3 DK 0496160T3
- Authority
- DK
- Denmark
- Prior art keywords
- bryostatin
- synthetic conversion
- synthetic
- conversion
- converted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Auxiliary Devices For Music (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/636,212 US5072004A (en) | 1990-12-31 | 1990-12-31 | Synthetic conversion of bryostatin 2 into bryostatin 1 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0496160T3 true DK0496160T3 (da) | 1997-07-28 |
Family
ID=24550938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91311568.9T DK0496160T3 (da) | 1990-12-31 | 1991-12-12 | Syntetisk omdannelse af Bryostatin 2 til Bryostatin 1 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5072004A (es) |
EP (1) | EP0496160B1 (es) |
JP (1) | JP3225318B2 (es) |
AT (1) | ATE152724T1 (es) |
CA (1) | CA2057441C (es) |
DE (1) | DE69126011T2 (es) |
DK (1) | DK0496160T3 (es) |
ES (1) | ES2103788T3 (es) |
GR (1) | GR3023990T3 (es) |
MX (1) | MX9102830A (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7256286B2 (en) * | 1999-11-30 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
WO2002087423A2 (en) * | 2001-05-02 | 2002-11-07 | Blanchette Rockefeller Neurosciences Institute | Carbonic anhydrase activators for enhancing learning and memory |
US6825229B2 (en) | 2002-03-07 | 2004-11-30 | Blanchette Rockefeller Neurosciences Institute | Methods for Alzheimer's Disease treatment and cognitive enhancement |
US20050065205A1 (en) * | 2002-03-07 | 2005-03-24 | Daniel Alkon | Methods for Alzheimer's disease treatment and cognitive enhance |
US20080004332A1 (en) * | 2002-03-07 | 2008-01-03 | Alkon Daniel L | Methods for alzheimer's disease treatment and cognitive enhancement |
TW201207390A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
WO2007016202A1 (en) * | 2005-07-29 | 2007-02-08 | Blanchette Rockefeller Neurosciences Institute | Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory |
US7754465B2 (en) * | 2006-04-27 | 2010-07-13 | James A Papp | Decontamination of biological agents |
US20080025961A1 (en) | 2006-07-28 | 2008-01-31 | Alkon Daniel L | Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory |
CA2864550C (en) | 2007-02-09 | 2018-07-10 | Blanchette Rockefeller Neurosciences Institute | Therapeutic effects of bryostatins, bryologs, and other related substances on ischemia/stroke-induced memory impairment and brain injury |
CN101848726A (zh) | 2007-02-09 | 2010-09-29 | 布朗歇特洛克菲勒神经科学研究所 | 苔藓抑素、苔藓抑素类似物和其它相关物质对头部创伤引起的记忆缺陷和脑损伤的疗效 |
WO2012006516A2 (en) | 2010-07-08 | 2012-01-12 | Alkon Daniel L | Dag-type and indirect protein kinase c activators and anticoagulant for the treatment of stroke |
CA2808660A1 (en) | 2010-08-19 | 2012-02-23 | Blanchette Rockefeller Neurosciences Institute | Treatment of cognitive disorders associated with abnormal dendritic spines using pkc activators |
EP3967299A1 (en) | 2011-11-13 | 2022-03-16 | Cognitive Research Enterprises, Inc. | Pkc activators and combinations thereof |
WO2016130969A1 (en) | 2015-02-13 | 2016-08-18 | George Robert Pettit | Silstatin compounds |
US20180217163A1 (en) | 2015-05-11 | 2018-08-02 | Daniel L. Alkon | Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele |
WO2019094709A1 (en) | 2017-11-09 | 2019-05-16 | Pettit George R | Betulastatin compounds |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4560774A (en) * | 1982-11-17 | 1985-12-24 | Arizona State University | Macrocyclic lactones |
US4611066A (en) * | 1984-08-10 | 1986-09-09 | Arizona State University | Bryostatins 4 to 8 |
US4833257A (en) * | 1986-07-28 | 1989-05-23 | Arizona Board Of Regents | Compositions of matter and methods of using same |
-
1990
- 1990-12-31 US US07/636,212 patent/US5072004A/en not_active Expired - Lifetime
-
1991
- 1991-12-11 CA CA002057441A patent/CA2057441C/en not_active Expired - Fee Related
- 1991-12-12 AT AT91311568T patent/ATE152724T1/de not_active IP Right Cessation
- 1991-12-12 DK DK91311568.9T patent/DK0496160T3/da active
- 1991-12-12 ES ES91311568T patent/ES2103788T3/es not_active Expired - Lifetime
- 1991-12-12 DE DE69126011T patent/DE69126011T2/de not_active Expired - Fee Related
- 1991-12-12 EP EP91311568A patent/EP0496160B1/en not_active Expired - Lifetime
- 1991-12-27 MX MX9102830A patent/MX9102830A/es not_active IP Right Cessation
- 1991-12-27 JP JP36135791A patent/JP3225318B2/ja not_active Expired - Fee Related
-
1997
- 1997-07-02 GR GR970401645T patent/GR3023990T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP3225318B2 (ja) | 2001-11-05 |
GR3023990T3 (en) | 1997-10-31 |
MX9102830A (es) | 1992-06-01 |
CA2057441A1 (en) | 1992-07-01 |
CA2057441C (en) | 2002-06-11 |
DE69126011T2 (de) | 1997-09-25 |
ATE152724T1 (de) | 1997-05-15 |
ES2103788T3 (es) | 1997-10-01 |
US5072004A (en) | 1991-12-10 |
EP0496160A1 (en) | 1992-07-29 |
EP0496160B1 (en) | 1997-05-07 |
DE69126011D1 (de) | 1997-06-12 |
JPH0867683A (ja) | 1996-03-12 |
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