DK0495982T3 - Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel - Google Patents
Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddelInfo
- Publication number
- DK0495982T3 DK0495982T3 DK90914955.1T DK90914955T DK0495982T3 DK 0495982 T3 DK0495982 T3 DK 0495982T3 DK 90914955 T DK90914955 T DK 90914955T DK 0495982 T3 DK0495982 T3 DK 0495982T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- pharmaceutical composition
- active ingredient
- pyrimidine derivative
- bicyclic pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26476389 | 1989-10-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0495982T3 true DK0495982T3 (da) | 1996-07-01 |
Family
ID=17407851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90914955.1T DK0495982T3 (da) | 1989-10-11 | 1990-10-11 | Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel |
Country Status (11)
Country | Link |
---|---|
US (1) | US5378700A (fr) |
EP (1) | EP0495982B1 (fr) |
JP (1) | JP2541702B2 (fr) |
KR (1) | KR0155955B1 (fr) |
AT (1) | ATE139232T1 (fr) |
AU (1) | AU645504B2 (fr) |
CA (1) | CA2067221C (fr) |
DE (1) | DE69027440T2 (fr) |
DK (1) | DK0495982T3 (fr) |
ES (1) | ES2087916T3 (fr) |
WO (1) | WO1991005784A1 (fr) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0514540B1 (fr) * | 1989-09-19 | 1996-07-17 | Teijin Limited | DERIVE DE PYRROLO 2,3-d]PYRIMIDINE, SON PROCEDE DE PREPARATION, ET PREPARATION PHARMACEUTIQUE COMPRENANT LE DERIVE COMME INGREDIENT ACTIF |
US5254716A (en) * | 1992-10-15 | 1993-10-19 | Eli Lilly And Company | Intermediates, and processes thereto, for the preparation of 5,6-dihydropyrrolo[2,3-d]pyrimidines |
FR2699176B1 (fr) * | 1992-12-11 | 1995-03-03 | Adir | Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant. |
WO1995033752A1 (fr) * | 1994-06-09 | 1995-12-14 | Smithkline Beecham Corporation | Antagonistes du recepteur de l'endotheline |
AU716993B2 (en) | 1995-05-12 | 2000-03-16 | Neurogen Corporation | Novel deazapurine derivatives; a new class of CRF1 specific ligands |
EP0831829B1 (fr) * | 1995-06-07 | 2003-08-20 | Pfizer Inc. | Derives de pyrimidine heterocycliques a noyaux condenses |
US6395733B1 (en) | 1995-06-07 | 2002-05-28 | Pfizer Inc | Heterocyclic ring-fused pyrimidine derivatives |
WO1998000426A1 (fr) * | 1996-06-28 | 1998-01-08 | The Trustees Of Princeton University | DERIVES DE 5,6,7,8-TETRAHYDROPYRIMIDO[4,5-b]AZEPINE |
US6339089B2 (en) | 1997-08-13 | 2002-01-15 | Fujirebio Inc. | Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same |
WO1999011643A1 (fr) * | 1997-09-02 | 1999-03-11 | Du Pont Pharmaceuticals Company | Pyridines a cycle fusionne et a substitution heterocyclyle, antagonistes du facteur de liberation de la cortitropine (crf), utiles dans le traitement des troubles lies au snc et au stress |
US6472402B1 (en) | 1998-04-02 | 2002-10-29 | Neurogen Corporation | Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives |
CA2326319A1 (fr) | 1998-04-02 | 1999-10-14 | Neurogen Corporation | Derives de 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole et de 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole a substitution aminoalkyl: des ligands specifiques du crf1 |
DE69907448T2 (de) | 1998-06-09 | 2004-03-18 | Neurogen Corp., Branford | Pyrido[2,3-b]indolizinderivate und aza analoge: crf1 spezifische liganden |
GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
US20070021429A1 (en) * | 2003-04-09 | 2007-01-25 | Yves St-Denis | Condensed n-heterocyclic compounds and their use as crf receptor antagonists |
EP2426129B1 (fr) | 2005-12-13 | 2016-11-02 | Incyte Holdings Corporation | Pyrrolo[2,3-b]pyridines et pyrrolo[2,3-b]pyrimidines à substitution hétéroaryle en tant qu'inhibiteurs de la janus kinase |
NZ575274A (en) | 2006-08-08 | 2010-11-26 | Chugai Pharmaceutical Co Ltd | Pyrimidine derivative as pi3k inhibitor and use thereof |
PT3070090T (pt) | 2007-06-13 | 2019-03-20 | Incyte Holdings Corp | Utilização de sais do inibidor da janus cinase (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo |
US20110282056A1 (en) * | 2008-01-22 | 2011-11-17 | Merck Patent Gmbh | Protein kinase inhibitors and use thereof |
TW200938201A (en) * | 2008-02-07 | 2009-09-16 | Chugai Pharmaceutical Co Ltd | Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof |
WO2009107767A1 (fr) * | 2008-02-29 | 2009-09-03 | 大日本住友製薬株式会社 | Nouveau dérivé de pyrimidine bicyclique qui présente une activité antagoniste sur le récepteur h4 |
RS59632B1 (sr) | 2009-05-22 | 2020-01-31 | Incyte Holdings Corp | 3-[4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]oktan- ili heptan-nitril kao jak inhibitori |
US9249145B2 (en) * | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
KR102354472B1 (ko) | 2010-03-10 | 2022-01-21 | 인사이트 홀딩스 코포레이션 | Jak1 저해제로서의 피페리딘4일 아제티딘 유도체 |
HUE029035T2 (en) | 2010-05-21 | 2017-01-30 | Incyte Holdings Corp | Topical formulation for use as JAK inhibitor |
CA2818545C (fr) | 2010-11-19 | 2019-04-16 | Incyte Corporation | Pyrrolopyridines et pyrrolopyrimidines a substitution heterocyclique utilisees en tant qu'inhibiteurs des jak |
TW201249845A (en) | 2010-11-19 | 2012-12-16 | Incyte Corp | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
US20120295911A1 (en) | 2010-11-29 | 2012-11-22 | Galleon Pharmaceuticals, Inc. | Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases |
KR20140049961A (ko) | 2010-11-29 | 2014-04-28 | 갈레온 파마슈티칼스, 인코포레이티드 | 호흡 조절 장애 또는 질병의 치료를 위한 호흡 자극제로서의 신규 화합물 |
AR086983A1 (es) | 2011-06-20 | 2014-02-05 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
AR091079A1 (es) | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
CN113384546A (zh) | 2012-11-15 | 2021-09-14 | 因赛特公司 | 鲁索利替尼的缓释剂型 |
EP3985008A1 (fr) | 2013-03-06 | 2022-04-20 | Incyte Holdings Corporation | Procédés et intermédiaires pour fabriquer un inhibiteur de jak |
RS60469B1 (sr) | 2013-08-07 | 2020-07-31 | Incyte Corp | Dozni oblici sa produženim oslobađanjem za jak1 inhibitor |
US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
JP2019527725A (ja) * | 2016-08-15 | 2019-10-03 | パデュー リサーチ ファウンデイション | 4位置換アミノイソキノリン誘導体 |
TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
CN112105608B (zh) | 2018-01-30 | 2023-07-14 | 因赛特公司 | 制备(1-(3-氟-2-(三氟甲基)异烟碱基)哌啶-4-酮)的方法 |
EP3773593B1 (fr) | 2018-03-30 | 2024-05-15 | Incyte Corporation | Traitement de l'hidradénite suppurée à l'aide d'inhibiteurs de jak |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3631045A (en) * | 1969-11-04 | 1971-12-28 | American Home Prod | 4 5-diamino-7h-pyrrolo(2 3-d)pyrimidine derivatives |
EP0514540B1 (fr) * | 1989-09-19 | 1996-07-17 | Teijin Limited | DERIVE DE PYRROLO 2,3-d]PYRIMIDINE, SON PROCEDE DE PREPARATION, ET PREPARATION PHARMACEUTIQUE COMPRENANT LE DERIVE COMME INGREDIENT ACTIF |
-
1990
- 1990-10-11 EP EP90914955A patent/EP0495982B1/fr not_active Expired - Lifetime
- 1990-10-11 KR KR1019920700846A patent/KR0155955B1/ko not_active IP Right Cessation
- 1990-10-11 JP JP2513974A patent/JP2541702B2/ja not_active Expired - Fee Related
- 1990-10-11 AU AU65220/90A patent/AU645504B2/en not_active Ceased
- 1990-10-11 DE DE69027440T patent/DE69027440T2/de not_active Expired - Fee Related
- 1990-10-11 CA CA002067221A patent/CA2067221C/fr not_active Expired - Fee Related
- 1990-10-11 US US07/839,769 patent/US5378700A/en not_active Expired - Fee Related
- 1990-10-11 AT AT90914955T patent/ATE139232T1/de not_active IP Right Cessation
- 1990-10-11 WO PCT/JP1990/001313 patent/WO1991005784A1/fr active IP Right Grant
- 1990-10-11 ES ES90914955T patent/ES2087916T3/es not_active Expired - Lifetime
- 1990-10-11 DK DK90914955.1T patent/DK0495982T3/da active
Also Published As
Publication number | Publication date |
---|---|
JP2541702B2 (ja) | 1996-10-09 |
ES2087916T3 (es) | 1996-08-01 |
EP0495982A1 (fr) | 1992-07-29 |
EP0495982A4 (en) | 1994-07-20 |
AU645504B2 (en) | 1994-01-20 |
EP0495982B1 (fr) | 1996-06-12 |
CA2067221C (fr) | 1997-04-15 |
ATE139232T1 (de) | 1996-06-15 |
AU6522090A (en) | 1991-05-16 |
WO1991005784A1 (fr) | 1991-05-02 |
KR0155955B1 (ko) | 1998-11-16 |
CA2067221A1 (fr) | 1991-04-12 |
DE69027440T2 (de) | 1997-02-06 |
US5378700A (en) | 1995-01-03 |
DE69027440D1 (de) | 1996-07-18 |
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