DK0495982T3 - Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel - Google Patents

Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel

Info

Publication number
DK0495982T3
DK0495982T3 DK90914955.1T DK90914955T DK0495982T3 DK 0495982 T3 DK0495982 T3 DK 0495982T3 DK 90914955 T DK90914955 T DK 90914955T DK 0495982 T3 DK0495982 T3 DK 0495982T3
Authority
DK
Denmark
Prior art keywords
preparation
pharmaceutical composition
active ingredient
pyrimidine derivative
bicyclic pyrimidine
Prior art date
Application number
DK90914955.1T
Other languages
Danish (da)
English (en)
Inventor
Yasuji Sakuma
Masaichi Hasegawa
Kenichiro Kataoka
Kenji Hoshina
Noboru Yamazaki
Takashi Kadota
Hisao Yamaguchi
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DK0495982T3 publication Critical patent/DK0495982T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK90914955.1T 1989-10-11 1990-10-11 Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel DK0495982T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26476389 1989-10-11

Publications (1)

Publication Number Publication Date
DK0495982T3 true DK0495982T3 (da) 1996-07-01

Family

ID=17407851

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90914955.1T DK0495982T3 (da) 1989-10-11 1990-10-11 Bicyklisk pyrimidinderivat, fremgangsmåde til fremstilling deraf og farmaceutisk præparat omfattende dette som en aktiv bestanddel

Country Status (11)

Country Link
US (1) US5378700A (fr)
EP (1) EP0495982B1 (fr)
JP (1) JP2541702B2 (fr)
KR (1) KR0155955B1 (fr)
AT (1) ATE139232T1 (fr)
AU (1) AU645504B2 (fr)
CA (1) CA2067221C (fr)
DE (1) DE69027440T2 (fr)
DK (1) DK0495982T3 (fr)
ES (1) ES2087916T3 (fr)
WO (1) WO1991005784A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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EP0514540B1 (fr) * 1989-09-19 1996-07-17 Teijin Limited DERIVE DE PYRROLO 2,3-d]PYRIMIDINE, SON PROCEDE DE PREPARATION, ET PREPARATION PHARMACEUTIQUE COMPRENANT LE DERIVE COMME INGREDIENT ACTIF
US5254716A (en) * 1992-10-15 1993-10-19 Eli Lilly And Company Intermediates, and processes thereto, for the preparation of 5,6-dihydropyrrolo[2,3-d]pyrimidines
FR2699176B1 (fr) * 1992-12-11 1995-03-03 Adir Nouveaux composés bicycliques de pyrimidine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
WO1995033752A1 (fr) * 1994-06-09 1995-12-14 Smithkline Beecham Corporation Antagonistes du recepteur de l'endotheline
AU716993B2 (en) 1995-05-12 2000-03-16 Neurogen Corporation Novel deazapurine derivatives; a new class of CRF1 specific ligands
EP0831829B1 (fr) * 1995-06-07 2003-08-20 Pfizer Inc. Derives de pyrimidine heterocycliques a noyaux condenses
US6395733B1 (en) 1995-06-07 2002-05-28 Pfizer Inc Heterocyclic ring-fused pyrimidine derivatives
WO1998000426A1 (fr) * 1996-06-28 1998-01-08 The Trustees Of Princeton University DERIVES DE 5,6,7,8-TETRAHYDROPYRIMIDO[4,5-b]AZEPINE
US6339089B2 (en) 1997-08-13 2002-01-15 Fujirebio Inc. Pyrimidine nucleus-containing compound and a medicament containing the same for a blood oxygen partial pressure amelioration, and a method for preparing the same
WO1999011643A1 (fr) * 1997-09-02 1999-03-11 Du Pont Pharmaceuticals Company Pyridines a cycle fusionne et a substitution heterocyclyle, antagonistes du facteur de liberation de la cortitropine (crf), utiles dans le traitement des troubles lies au snc et au stress
US6472402B1 (en) 1998-04-02 2002-10-29 Neurogen Corporation Aminoalkyl substituted 5,6,7,8-Tetrahydro-9H-Pyridino [2,3-B]indole derivatives
CA2326319A1 (fr) 1998-04-02 1999-10-14 Neurogen Corporation Derives de 5,6,7,8-tetrahydro-9h pyrimidino[2,3-b]indole et de 5,6,7,8-tetrahydro-9h-pyrimidino[4,5-b]indole a substitution aminoalkyl: des ligands specifiques du crf1
DE69907448T2 (de) 1998-06-09 2004-03-18 Neurogen Corp., Branford Pyrido[2,3-b]indolizinderivate und aza analoge: crf1 spezifische liganden
GB0117396D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
US20070021429A1 (en) * 2003-04-09 2007-01-25 Yves St-Denis Condensed n-heterocyclic compounds and their use as crf receptor antagonists
EP2426129B1 (fr) 2005-12-13 2016-11-02 Incyte Holdings Corporation Pyrrolo[2,3-b]pyridines et pyrrolo[2,3-b]pyrimidines à substitution hétéroaryle en tant qu'inhibiteurs de la janus kinase
NZ575274A (en) 2006-08-08 2010-11-26 Chugai Pharmaceutical Co Ltd Pyrimidine derivative as pi3k inhibitor and use thereof
PT3070090T (pt) 2007-06-13 2019-03-20 Incyte Holdings Corp Utilização de sais do inibidor da janus cinase (r)-3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanonitrilo
US20110282056A1 (en) * 2008-01-22 2011-11-17 Merck Patent Gmbh Protein kinase inhibitors and use thereof
TW200938201A (en) * 2008-02-07 2009-09-16 Chugai Pharmaceutical Co Ltd Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof
WO2009107767A1 (fr) * 2008-02-29 2009-09-03 大日本住友製薬株式会社 Nouveau dérivé de pyrimidine bicyclique qui présente une activité antagoniste sur le récepteur h4
RS59632B1 (sr) 2009-05-22 2020-01-31 Incyte Holdings Corp 3-[4-(7h-pirolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]oktan- ili heptan-nitril kao jak inhibitori
US9249145B2 (en) * 2009-09-01 2016-02-02 Incyte Holdings Corporation Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
KR102354472B1 (ko) 2010-03-10 2022-01-21 인사이트 홀딩스 코포레이션 Ｊａｋ１ 저해제로서의 피페리딘­４­일 아제티딘 유도체
HUE029035T2 (en) 2010-05-21 2017-01-30 Incyte Holdings Corp Topical formulation for use as JAK inhibitor
CA2818545C (fr) 2010-11-19 2019-04-16 Incyte Corporation Pyrrolopyridines et pyrrolopyrimidines a substitution heterocyclique utilisees en tant qu'inhibiteurs des jak
TW201249845A (en) 2010-11-19 2012-12-16 Incyte Corp Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
US20120295911A1 (en) 2010-11-29 2012-11-22 Galleon Pharmaceuticals, Inc. Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases
KR20140049961A (ko) 2010-11-29 2014-04-28 갈레온 파마슈티칼스, 인코포레이티드 호흡 조절 장애 또는 질병의 치료를 위한 호흡 자극제로서의 신규 화합물
AR086983A1 (es) 2011-06-20 2014-02-05 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
AR091079A1 (es) 2012-05-18 2014-12-30 Incyte Corp Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak
CN113384546A (zh) 2012-11-15 2021-09-14 因赛特公司 鲁索利替尼的缓释剂型
EP3985008A1 (fr) 2013-03-06 2022-04-20 Incyte Holdings Corporation Procédés et intermédiaires pour fabriquer un inhibiteur de jak
RS60469B1 (sr) 2013-08-07 2020-07-31 Incyte Corp Dozni oblici sa produženim oslobađanjem za jak1 inhibitor
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
JP2019527725A (ja) * 2016-08-15 2019-10-03 パデュー リサーチ ファウンデイション ４位置換アミノイソキノリン誘導体
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
CN112105608B (zh) 2018-01-30 2023-07-14 因赛特公司 制备(1-(3-氟-2-(三氟甲基)异烟碱基)哌啶-4-酮)的方法
EP3773593B1 (fr) 2018-03-30 2024-05-15 Incyte Corporation Traitement de l'hidradénite suppurée à l'aide d'inhibiteurs de jak
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3631045A (en) * 1969-11-04 1971-12-28 American Home Prod 4 5-diamino-7h-pyrrolo(2 3-d)pyrimidine derivatives
EP0514540B1 (fr) * 1989-09-19 1996-07-17 Teijin Limited DERIVE DE PYRROLO 2,3-d]PYRIMIDINE, SON PROCEDE DE PREPARATION, ET PREPARATION PHARMACEUTIQUE COMPRENANT LE DERIVE COMME INGREDIENT ACTIF

Also Published As

Publication number Publication date
JP2541702B2 (ja) 1996-10-09
ES2087916T3 (es) 1996-08-01
EP0495982A1 (fr) 1992-07-29
EP0495982A4 (en) 1994-07-20
AU645504B2 (en) 1994-01-20
EP0495982B1 (fr) 1996-06-12
CA2067221C (fr) 1997-04-15
ATE139232T1 (de) 1996-06-15
AU6522090A (en) 1991-05-16
WO1991005784A1 (fr) 1991-05-02
KR0155955B1 (ko) 1998-11-16
CA2067221A1 (fr) 1991-04-12
DE69027440T2 (de) 1997-02-06
US5378700A (en) 1995-01-03
DE69027440D1 (de) 1996-07-18

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