DK0476066T3 - Antiviralt præparat indeholdende 3-azido-2,3-dideoxy-5-methylcytidin - Google Patents
Antiviralt præparat indeholdende 3-azido-2,3-dideoxy-5-methylcytidinInfo
- Publication number
- DK0476066T3 DK0476066T3 DK90911253.4T DK90911253T DK0476066T3 DK 0476066 T3 DK0476066 T3 DK 0476066T3 DK 90911253 T DK90911253 T DK 90911253T DK 0476066 T3 DK0476066 T3 DK 0476066T3
- Authority
- DK
- Denmark
- Prior art keywords
- methylcytidine
- dideoxy
- azido
- preparation containing
- antiviral preparation
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title abstract 2
- 239000003937 drug carrier Substances 0.000 abstract 2
- GZSDAHQGNUAEBC-XLPZGREQSA-N 4-amino-1-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidin-2-one Chemical compound O=C1N=C(N)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 GZSDAHQGNUAEBC-XLPZGREQSA-N 0.000 abstract 1
- 208000030507 AIDS Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000001177 diphosphate Substances 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000001226 triphosphate Substances 0.000 abstract 1
- 235000011178 triphosphate Nutrition 0.000 abstract 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/362,756 US5084445A (en) | 1986-05-01 | 1989-06-07 | 3'-azido-2',3'-dideoxy-5-methylcytidine |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0476066T3 true DK0476066T3 (da) | 1997-09-22 |
Family
ID=23427415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90911253.4T DK0476066T3 (da) | 1989-06-07 | 1990-06-06 | Antiviralt præparat indeholdende 3-azido-2,3-dideoxy-5-methylcytidin |
Country Status (9)
Country | Link |
---|---|
US (1) | US5084445A (ja) |
EP (1) | EP0476066B1 (ja) |
JP (1) | JP2941942B2 (ja) |
AT (1) | ATE157252T1 (ja) |
DE (1) | DE69031340T2 (ja) |
DK (1) | DK0476066T3 (ja) |
ES (1) | ES2108014T3 (ja) |
HK (1) | HK1014660A1 (ja) |
WO (1) | WO1990014831A2 (ja) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6911470B1 (en) | 1988-09-22 | 2005-06-28 | Raymond F. Schinazi | Polyoxometalate compounds as antiviral agents |
US5506349A (en) * | 1992-05-13 | 1996-04-09 | Ribozyme Pharmaceuticals, Inc. | Chemical synthesis of 2', 3'-dideoxycytidine |
JPH07508022A (ja) * | 1992-05-13 | 1995-09-07 | リボザイム・ファーマシューティカルズ・インコーポレイテッド | ヌクレオチドモノマー類の合成 |
US5407927A (en) * | 1993-04-16 | 1995-04-18 | The Regents Of The University Of California | Treatment of mild depression and restoration of IGF-I levels in aging by dehydroepiandrosterone |
US6432924B1 (en) | 1993-12-26 | 2002-08-13 | East Carolina University | Method of treating disorders characterized by overexpression of cytidine deaminase or deoxycytidine deaminase |
US5824706A (en) * | 1994-09-26 | 1998-10-20 | Schinazi; Raymond F. | Method, compositions, and apparatus for treating and preventing respiratory viral infections |
RU98113785A (ru) * | 1995-12-22 | 2000-06-10 | Ист Каролина Юниверсити (US) | Агент и способ лечения заболеваний, связанных с чрезмерной экспрессией цитидиндезаминазы или дезоксицитидинзаминазы |
CA2323849C (en) * | 1997-12-22 | 2002-06-11 | Schering Corporation | Orally administrable solid ribavirin dosage forms and process for making them |
BR9911457A (pt) * | 1998-06-24 | 2001-12-11 | Univ Emory | Uso de 3'-azida-2', 3'-dideoxiuridina em combinaçãocom drogas anti-hiv adicionais para a manufaturade um medicamento para o tratamento de hiv |
US6407077B1 (en) | 1998-11-05 | 2002-06-18 | Emory University | β-L nucleosides for the treatment of HIV infection |
AU774720B2 (en) | 1998-11-05 | 2004-07-08 | Centre National De La Recherche Scientifique | Nucleosides with anti-hepatitis B virus activity |
US20030083304A1 (en) * | 2001-10-09 | 2003-05-01 | Smart Robert C. | CCAAT/enhancer binding protein-beta (C/EBPbeta) is a molecular target for cancer treatment |
CA2729613C (en) | 2008-03-03 | 2017-02-07 | Tosk, Incorporated | Methotrexate adjuvants to reduce toxicity and methods for using the same |
GB201001088D0 (en) | 2010-01-23 | 2010-03-10 | Trillion Genomics Ltd | Detection |
CN114276359B (zh) * | 2022-01-05 | 2023-05-05 | 浙江大学 | 一种1,2,3,4-四氢苯并[4,5]呋喃[2,3-c]吡啶衍生物的制备方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3282921A (en) * | 1964-06-04 | 1966-11-01 | Syntex Corp | Halo-deoxynucleosides and processes for the preparation thereof |
US3755295A (en) * | 1969-10-24 | 1973-08-28 | Syntex Corp | 1-(2-amino-2-deoxy-{62 -d-ribofuranosyl) pyrimidines and derivatives thereof |
US3775397A (en) * | 1969-11-12 | 1973-11-27 | Akad Wissenschaften Ddr | Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides |
US3687931A (en) * | 1970-03-19 | 1972-08-29 | Syntex Corp | Halogenated purine and pyrimidine nucleosides and process therefor |
US3817982A (en) * | 1971-12-29 | 1974-06-18 | Syntex Inc | 2{40 ,3{40 -unsaturated nucleosides and method of making |
DE2627076A1 (de) * | 1976-06-16 | 1977-12-29 | Max Planck Gesellschaft | Mittel zur inhibierung des zellwachstums |
US4071680A (en) * | 1976-12-20 | 1978-01-31 | Hoffmann-La Roche Inc. | 5'-Deoxy-5-fluoropyrimidine nucleosides |
US4093716A (en) * | 1977-04-28 | 1978-06-06 | Research Corporation | Compositions containing 5-amino-5-deoxythymidine and pharmaceutically acceptable salts thereof |
US4093715A (en) * | 1977-04-28 | 1978-06-06 | Research Corporation | 5-Iodo-5'-amino-2',5'-dideoxycytidine and the pharmaceutically acceptable salts thereof |
US4128639A (en) * | 1977-12-14 | 1978-12-05 | Research Corporation | Nitrosourea analogs of thymidine |
US4210638A (en) * | 1978-03-17 | 1980-07-01 | Pcr, Inc. | Antiviral composition and method of treating virus diseases |
US4230689A (en) * | 1979-05-01 | 1980-10-28 | Sue Choy | Hair grooming composition of matter |
US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4604382A (en) * | 1983-01-17 | 1986-08-05 | Research Corporation | 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof |
US4540566A (en) * | 1984-04-02 | 1985-09-10 | Forest Laboratories, Inc. | Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose |
DD224490A1 (de) * | 1984-04-30 | 1985-07-10 | Adw Ddr | Verfahren zur herstellung eines virostatischen mittels |
EP0196185B1 (en) * | 1985-03-16 | 1989-07-12 | The Wellcome Foundation Limited | Antiviral nucleosides |
US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
GB2181128A (en) * | 1985-09-17 | 1987-04-15 | Wellcome Found | 3'-azidonucleosides |
US4916122A (en) * | 1987-01-28 | 1990-04-10 | University Of Georgia Research Foundation, Inc. | 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition |
US4710492A (en) * | 1986-06-23 | 1987-12-01 | Yale University | 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses |
US4788181A (en) * | 1986-09-29 | 1988-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | 5-substituted-2',3'-dideoxycytidine compounds with anti-HTLV-III activity |
EP0286825A3 (en) * | 1987-03-18 | 1989-04-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of 3'-fluro-3' deoxythymidine for the manufacture of a medicament for the treatment of virus infections |
CA1340645C (en) * | 1987-04-17 | 1999-07-13 | Victor E. Marquez | Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus |
-
1989
- 1989-06-07 US US07/362,756 patent/US5084445A/en not_active Expired - Fee Related
-
1990
- 1990-06-06 ES ES90911253T patent/ES2108014T3/es not_active Expired - Lifetime
- 1990-06-06 JP JP2510715A patent/JP2941942B2/ja not_active Expired - Fee Related
- 1990-06-06 AT AT90911253T patent/ATE157252T1/de not_active IP Right Cessation
- 1990-06-06 DE DE69031340T patent/DE69031340T2/de not_active Expired - Fee Related
- 1990-06-06 DK DK90911253.4T patent/DK0476066T3/da active
- 1990-06-06 EP EP90911253A patent/EP0476066B1/en not_active Expired - Lifetime
- 1990-06-06 WO PCT/US1990/003207 patent/WO1990014831A2/en active IP Right Grant
-
1998
- 1998-12-28 HK HK98116012A patent/HK1014660A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2108014T3 (es) | 1997-12-16 |
DE69031340D1 (de) | 1997-10-02 |
WO1990014831A3 (en) | 1991-01-24 |
HK1014660A1 (en) | 1999-09-30 |
ATE157252T1 (de) | 1997-09-15 |
DE69031340T2 (de) | 1998-01-15 |
JPH05504940A (ja) | 1993-07-29 |
WO1990014831A2 (en) | 1990-12-13 |
EP0476066B1 (en) | 1997-08-27 |
JP2941942B2 (ja) | 1999-08-30 |
EP0476066A1 (en) | 1992-03-25 |
US5084445A (en) | 1992-01-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0476066T3 (da) | Antiviralt præparat indeholdende 3-azido-2,3-dideoxy-5-methylcytidin | |
EA200100298A1 (ru) | ФАРМАЦЕВТИЧЕСКИЕ ПРЕПАРАТЫ С РЕГУЛИРУЕМЫМ ВЫСВОБОЖДЕНИЕМ, СОДЕРЖАЩИЕ ИНГИБИТОР cGMP-ФОСФОДИЭСТЕРАЗЫ-5 | |
HUT47217A (en) | Process for producing pharmaceutical compositions containing indol derivatives as active components | |
UA40589C2 (uk) | Спосіб лікування людини, що страждає від вірусної інфекції, фармацевтична композиція, комбінація речовин для отримання ліків та фармацевтична комбінація | |
LU90956I2 (fr) | Metvix principe actif méthylaminolevulinique sous forme d'un selde préférence l'hyhrochlorure méthylaminolevulinique | |
CA2340156A1 (en) | .beta.-l-2'-deoxy-nucleosides for the treatment of hepatitis b | |
GB8827152D0 (en) | Anti-atherosclerotic diaryl compounds | |
CA2003289A1 (en) | Use of trifluoromethylphenyl-tetrahydropyridines for the preparation of pharmaceutical compositions useful for the treatment of anxiety and anxio-depressive disorders | |
ES2001094A6 (es) | Un procedimiento para la preparacion de un derivado de guanina | |
MY124465A (en) | Reduction of infarct volume using citicoline | |
ES2111352T3 (es) | Uso de diester fosfato para el tratamiento de enfermedades retinianas. | |
GB9108629D0 (en) | Heterocyclic pharmaceutical compounds,preparation and use | |
FR2500303B1 (ja) | ||
NZ229422A (en) | Certain (2',5')-oligoadehylate derivatives and pharmaceutical use | |
DE10299023I1 (de) | Antineoplastisch wirkender und den Antineoplastischen effekt Verstaerkender Wirkstoff | |
IL93594A0 (en) | Pharmaceutical compositions containing an imidazopyrimidone derivative | |
ES8501764A1 (es) | Un metodo para preparar nuevos derivados de guanina | |
ZA935045B (en) | Pharmacologically active alfa-(tertiary-aminomethyl)-ben-zenemethanol derivatives | |
RU94045140A (ru) | Фармацевтическая композиция для профилактики или лечения вирусных заболеваний, способ ее получения и применение антагониста брадикинина или его физиологически переносимой соли в качестве средства для профилактики или лечения вирусных заболеваний | |
DE69311135D1 (de) | Zubereitungen, die acyclovir-ähnliche verbindungen und 2'-vinylsubstituierte nukleosidanaloge enthalten, zur behandlung viraler infektionen | |
RU2001115094A (ru) | Нуклеозиды, обладающие активностью против вируса гепатита в | |
MY110769A (en) | Controlled release oxycodone compositions. | |
TH25306A (th) | วิธีของการใช้สำหรับยับยั้งการสูญเสียกระดูกและการลดคอเลสเทอรอลในซีรัม |