DK0452712T3 - Nye 4-quinolyl-dihydropyridiner, fremgangsmåde til deres fremstilling og deres anvendelse i lægemidl er - Google Patents
Nye 4-quinolyl-dihydropyridiner, fremgangsmåde til deres fremstilling og deres anvendelse i lægemidl erInfo
- Publication number
- DK0452712T3 DK0452712T3 DK91104723.1T DK91104723T DK0452712T3 DK 0452712 T3 DK0452712 T3 DK 0452712T3 DK 91104723 T DK91104723 T DK 91104723T DK 0452712 T3 DK0452712 T3 DK 0452712T3
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atoms
- chain
- straight
- halogen
- branched alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4011105A DE4011105A1 (de) | 1990-04-06 | 1990-04-06 | Neue 4-chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0452712T3 true DK0452712T3 (da) | 1995-08-28 |
Family
ID=6403870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91104723.1T DK0452712T3 (da) | 1990-04-06 | 1991-03-26 | Nye 4-quinolyl-dihydropyridiner, fremgangsmåde til deres fremstilling og deres anvendelse i lægemidl er |
Country Status (18)
Country | Link |
---|---|
US (1) | US5100900A (da) |
EP (1) | EP0452712B1 (da) |
JP (1) | JPH04234873A (da) |
KR (1) | KR910018385A (da) |
AT (1) | ATE121398T1 (da) |
AU (1) | AU640217B2 (da) |
CA (1) | CA2039684A1 (da) |
DE (2) | DE4011105A1 (da) |
DK (1) | DK0452712T3 (da) |
ES (1) | ES2072471T3 (da) |
FI (1) | FI911615A (da) |
GR (1) | GR3015904T3 (da) |
HU (1) | HU208006B (da) |
IE (1) | IE66685B1 (da) |
IL (3) | IL110792A (da) |
NZ (1) | NZ237656A (da) |
PT (1) | PT97252B (da) |
ZA (1) | ZA912531B (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4117750A1 (de) * | 1991-05-30 | 1992-12-24 | Bayer Ag | Neue 2-amino-5-cyano-1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4118707A1 (de) * | 1991-06-07 | 1992-12-10 | Bayer Ag | Pharmazeutische verwendung von 3-formyl-1,4-dihydropyridinen, neue verbindungen und verfahren zu ihrer herstellung |
DE4134760A1 (de) * | 1991-10-22 | 1993-07-08 | Bayer Ag | Aryl-chinolyl-substituierte 1,4-dihydropyridin-dicarbonsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4202526A1 (de) * | 1992-01-30 | 1993-08-05 | Bayer Ag | Neue 4-cinnolinyl- und 4-naphthyridinyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE4233601A1 (de) * | 1992-10-06 | 1994-04-07 | Bayer Ag | 3-substituierte Chinolin-5-carbonsäuren |
DE4313693A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2-Amino-4-chinolin-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung |
DE4313692A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 3-Chinolyl substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313697A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Chinolyl-dihydropyridinester, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4313691A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | 2,6-Disubstituierte 4-Chinolyl-dihydropyridine |
DE4313690A1 (de) * | 1993-04-27 | 1994-11-03 | Bayer Ag | Kondensierte Chinolyl-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
DE4321030A1 (de) * | 1993-06-24 | 1995-01-05 | Bayer Ag | 4-bicyclisch substituierte Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimittel |
DE4426374A1 (de) * | 1994-07-26 | 1996-02-01 | Bayer Ag | 4-Amino-3-hydroxy-phthalimidin, sowie ein Verfahren zu seiner Herstellung |
DE4426373A1 (de) * | 1994-07-26 | 1996-02-01 | Bayer Ag | 3-Substituierte Chinolin-5-carbonsäurederivate und Verfahren zu ihrer Herstellung |
AU2004272078A1 (en) * | 2003-09-10 | 2005-03-24 | Synta Pharmaceuticals Corp. | Dihydropyridine compounds for treating or preventing metabolic disorders |
AU2009289316A1 (en) * | 2008-09-02 | 2010-03-11 | Novartis Ag | Bicyclic kinase inhibitors |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2359329A (en) * | 1943-06-18 | 1944-10-03 | Burroughs Wellcome Co | Quinoline substituted dihydropyridines |
US2400500A (en) * | 1944-02-04 | 1946-05-21 | Goodrich Co B F | Dihydroquinoline condensation product |
GB582254A (en) * | 1944-05-15 | 1946-11-11 | Burroughs Wellcome Co | Quinoline substituted dihydropyridines |
DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
US4049662A (en) * | 1972-03-06 | 1977-09-20 | Bayer Aktiengesellschaft | 4-Quinoline and isoquinoline substituted 2,6-diamino-1,4-dihydropyridine derivatives |
DE2210667A1 (de) * | 1972-03-06 | 1973-09-20 | Bayer Ag | Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US3943140A (en) * | 1972-09-30 | 1976-03-09 | Bayer Aktiengesellschaft | 2,3,5,6-Tetracarboxy-1,4-dihydropyridine derivatives |
DE2658804A1 (de) * | 1976-12-24 | 1978-07-06 | Bayer Ag | Kreislaufbeeinflussende mittel |
DE2752820A1 (de) * | 1977-11-26 | 1979-05-31 | Bayer Ag | Neue nitrosubstituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
US4483985A (en) * | 1978-10-31 | 1984-11-20 | Bayer Aktiengesellschaft | Production of 1,4-dihydropyridinecarboxylic acids |
DE3311005A1 (de) * | 1983-03-25 | 1984-09-27 | Bayer Ag, 5090 Leverkusen | Chromon- und thiochromonsubstituierte 1,4-dihydropyridinderivate, mehrere verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
DE3311003A1 (de) * | 1983-03-25 | 1984-09-27 | Bayer Ag, 5090 Leverkusen | Chromon- und thiochromonsubstituierte 1,4-dihydropyridinlactone, mehrere verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE3447169A1 (de) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
-
1990
- 1990-04-06 DE DE4011105A patent/DE4011105A1/de not_active Withdrawn
-
1991
- 1991-03-26 EP EP91104723A patent/EP0452712B1/de not_active Expired - Lifetime
- 1991-03-26 ES ES91104723T patent/ES2072471T3/es not_active Expired - Lifetime
- 1991-03-26 DE DE59105219T patent/DE59105219D1/de not_active Expired - Fee Related
- 1991-03-26 AT AT91104723T patent/ATE121398T1/de not_active IP Right Cessation
- 1991-03-26 DK DK91104723.1T patent/DK0452712T3/da active
- 1991-03-29 US US07/677,718 patent/US5100900A/en not_active Expired - Fee Related
- 1991-04-02 JP JP3094995A patent/JPH04234873A/ja active Pending
- 1991-04-03 IL IL11079291A patent/IL110792A/en not_active IP Right Cessation
- 1991-04-03 CA CA002039684A patent/CA2039684A1/en not_active Abandoned
- 1991-04-03 IL IL9775391A patent/IL97753A/en not_active IP Right Cessation
- 1991-04-03 NZ NZ237656A patent/NZ237656A/xx unknown
- 1991-04-04 FI FI911615A patent/FI911615A/fi unknown
- 1991-04-04 PT PT97252A patent/PT97252B/pt not_active IP Right Cessation
- 1991-04-04 KR KR1019910005461A patent/KR910018385A/ko not_active Application Discontinuation
- 1991-04-05 ZA ZA912531A patent/ZA912531B/xx unknown
- 1991-04-05 AU AU74145/91A patent/AU640217B2/en not_active Ceased
- 1991-04-05 HU HU911121A patent/HU208006B/hu not_active IP Right Cessation
- 1991-04-05 IE IE114391A patent/IE66685B1/en not_active IP Right Cessation
-
1994
- 1994-08-26 IL IL11079294A patent/IL110792A0/xx unknown
-
1995
- 1995-04-20 GR GR950400859T patent/GR3015904T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI911615A (fi) | 1991-10-07 |
FI911615A0 (fi) | 1991-04-04 |
IL110792A0 (en) | 1994-11-11 |
IL97753A (en) | 1995-01-24 |
ATE121398T1 (de) | 1995-05-15 |
IL97753A0 (en) | 1992-06-21 |
DE59105219D1 (de) | 1995-05-24 |
HU208006B (en) | 1993-07-28 |
ES2072471T3 (es) | 1995-07-16 |
EP0452712B1 (de) | 1995-04-19 |
PT97252A (pt) | 1992-01-31 |
JPH04234873A (ja) | 1992-08-24 |
ZA912531B (en) | 1992-01-29 |
CA2039684A1 (en) | 1991-10-07 |
AU640217B2 (en) | 1993-08-19 |
IL110792A (en) | 1995-06-29 |
GR3015904T3 (en) | 1995-07-31 |
HUT58312A (en) | 1992-02-28 |
EP0452712A1 (de) | 1991-10-23 |
DE4011105A1 (de) | 1991-10-10 |
NZ237656A (en) | 1993-08-26 |
US5100900A (en) | 1992-03-31 |
IE911143A1 (en) | 1991-10-09 |
HU911121D0 (en) | 1991-10-28 |
AU7414591A (en) | 1991-10-10 |
KR910018385A (ko) | 1991-11-30 |
IE66685B1 (en) | 1996-01-24 |
PT97252B (pt) | 1998-07-31 |
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