DK0385423T3 - Fremgangsmåde til fremstilling af de optiske isomerer af 1,4-dihydro-5-isopropoxy-2-methyl-4-(2- trifluormethylphenyl)-1,6-naphthyridin-3-carboxylsyre-ethylester og 1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluormethylphenyl)-1,6-naphthyridin-3-carboxylsyre-(2-(N-methyl-N-phenylmethylamino)-ethyl)ester - Google Patents

Fremgangsmåde til fremstilling af de optiske isomerer af 1,4-dihydro-5-isopropoxy-2-methyl-4-(2- trifluormethylphenyl)-1,6-naphthyridin-3-carboxylsyre-ethylester og 1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluormethylphenyl)-1,6-naphthyridin-3-carboxylsyre-(2-(N-methyl-N-phenylmethylamino)-ethyl)ester

Info

Publication number
DK0385423T3
DK0385423T3 DK90103870.3T DK90103870T DK0385423T3 DK 0385423 T3 DK0385423 T3 DK 0385423T3 DK 90103870 T DK90103870 T DK 90103870T DK 0385423 T3 DK0385423 T3 DK 0385423T3
Authority
DK
Denmark
Prior art keywords
methyl
naphthyridine
trifluoromethylphenyl
isopropoxy
dihydro
Prior art date
Application number
DK90103870.3T
Other languages
Danish (da)
English (en)
Inventor
Wolfgang Dr Herrmann
Klaus Dr Steiner
Juergen Dr Kleinschroth
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Ag filed Critical Goedecke Ag
Application granted granted Critical
Publication of DK0385423T3 publication Critical patent/DK0385423T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK90103870.3T 1989-03-01 1990-02-28 Fremgangsmåde til fremstilling af de optiske isomerer af 1,4-dihydro-5-isopropoxy-2-methyl-4-(2- trifluormethylphenyl)-1,6-naphthyridin-3-carboxylsyre-ethylester og 1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluormethylphenyl)-1,6-naphthyridin-3-carboxylsyre-(2-(N-methyl-N-phenylmethylamino)-ethyl)ester DK0385423T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3906460A DE3906460C1 (es) 1989-03-01 1989-03-01

Publications (1)

Publication Number Publication Date
DK0385423T3 true DK0385423T3 (da) 1995-06-12

Family

ID=6375232

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90103870.3T DK0385423T3 (da) 1989-03-01 1990-02-28 Fremgangsmåde til fremstilling af de optiske isomerer af 1,4-dihydro-5-isopropoxy-2-methyl-4-(2- trifluormethylphenyl)-1,6-naphthyridin-3-carboxylsyre-ethylester og 1,4-dihydro-5-isopropoxy-2-methyl-4-(2-trifluormethylphenyl)-1,6-naphthyridin-3-carboxylsyre-(2-(N-methyl-N-phenylmethylamino)-ethyl)ester

Country Status (8)

Country Link
US (1) US5037987A (es)
EP (1) EP0385423B1 (es)
JP (1) JPH02275879A (es)
AT (1) ATE118205T1 (es)
DE (2) DE3906460C1 (es)
DK (1) DK0385423T3 (es)
ES (1) ES2067577T3 (es)
GR (1) GR3015659T3 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9405833D0 (en) * 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine
EP3560922A1 (de) * 2018-04-24 2019-10-30 Bayer Aktiengesellschaft Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3832388A (en) * 1972-09-07 1974-08-27 R Lorenz Resolution of 2-(p-hydroxy)phenylglycine
PL221188A1 (es) * 1979-01-05 1980-12-01 Ciba Geigy Ag
US4760081A (en) * 1984-08-25 1988-07-26 Goedecke Aktiengesellschaft 1,6-naphthyridine derivatives useful for treating diseases of the blood vessels
DE3602655A1 (de) * 1985-01-29 1987-07-30 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
IL75987A (en) * 1984-08-25 1991-07-18 Goedecke Ag Tri-and tetrasubstituted-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung

Also Published As

Publication number Publication date
EP0385423A3 (de) 1991-08-14
JPH02275879A (ja) 1990-11-09
ATE118205T1 (de) 1995-02-15
EP0385423A2 (de) 1990-09-05
DE3906460C1 (es) 1990-11-15
GR3015659T3 (en) 1995-07-31
ES2067577T3 (es) 1995-04-01
EP0385423B1 (de) 1995-02-08
US5037987A (en) 1991-08-06
DE59008426D1 (de) 1995-03-23

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