DE972443C - Skin care products - Google Patents

Description

ISSUED OCTOBER 15, 1959

C 8373 IVa / 30 h

Skin care products

The invention relates to a new cosmetic agent for treating and caring for the skin. Its special feature consists in a content of pregnenolone (/ i ⁵ · ⁶ -3-oxy-2o-oxo-pregnen) and / or one of its esters or ethers.

It is known to add hormones, especially gender-specific hormones, to skin care products (H. Janistyn, "Fragrances, Soaps, Cosmetics", Vol. II, p. 387 [1950]).

to it was added ¹ now been found that pregnenolone and Seine derivatives stimulate the growth of the epidermis, leading to an increase in the Epidermiszellagen and to cell proliferation with enlargement of the nuclei and the cytoplasm and can thus be found in an advantageous manner as a skin care product use. So they cause z. B. on aging skin a rejuvenated, firm appearance and a removal of wrinkles.

To produce the new skin care products, the usual ingredients of skin care products are ao mixed with pregnenolone and / or with one of its esters or ethers. They can be used as creamy or liquid emulsions are used. It has been shown that it is particularly advantageous add one or more of the following substances: Aliphatic hydrocarbons, such as yellow or white petroleum jelly, triglycerides, such as B. pork fat, cocoa butter, almond oil, saturated or unsaturated

909 621/8

higher fatty acids such as myristic acid, undecylenic acid, oleic acid and its esters, balsam of Peru, Chlorophyll and especially esters and ethers of benzyl alcohol, such as lauric acid, oleic acid or Cinnamon acid benzyl ester, dibenzyl or pregnenolone benzyl ether, primarily benzoic acid or Benzyl α-naphthoate. This addition increases the effectiveness of the pregnenolone and its Derivatives strengthened, d. H. to have the same effect

ίο has to be a much smaller amount to be used on pregnenolone and its esters and ethers. It is also advantageous to use substances to add, which stimulate the blood circulation in the skin, such as nicotinic acid amide, its addition to Skin care products already z. B. from Swiss patent 258,982 is known.

The patent protection does not extend to the manufacture and use of the agent for therapeutic purposes Purposes.

The invention is described in the following examples. Between part by weight and part by volume exists the same relationship as between grams and cubic centimeters. The temperatures are given in degrees Celsius.

B e i s ρ i e 1 ι

One melts on the water bath 0.5 part by weight of pregnenolone, pure, 20.0 - stearic acid,

2.5 - almond oil, preserved,

0.8 - cetyl alcohol as well

0.2 - methyl p-oxybenzoate

and heated until the melt has become clear and has reached 80 °.
Likewise, 1.8 parts by weight of triethanolamine are mixed,

5.0 - glycerin and 69.2 - distilled water

and heated to 80 °. The 80 ° warm colized melt is emulsified in the usual way with the filtered aqueous solution, heated to 80 °, and stirred while cold. At 40 ⁰ , the required perfume oil mixture is added. The mixture to 25 ⁰ is then further mixed until to cool down. A matt skin cream is obtained in this way.

Example 2

0.1 part by weight of pregnenolone, pure, 10.0 parts by weight of stearic acid is melted on a water bath.
10.0 - myristic acid,

2,5 - benzyl benzoate,

0.8 - cetyl alcohol as well

0.2 - methyl p-oxybenzoate

and heated until the melt has become clear and has reached 80 °.

Likewise, 1.8 parts by weight of triethanolamine are mixed, 5.0 - glycerin,

69.6 - distilled water

and heated to 80 °. The 80 ° warm colized melt is emulsified in the usual way with the filtered aqueous solution heated to 80 ° and stirred while cold. At 40 ⁰ , the required perfume oil mixture is added. Mixing is then continued until the mixture has cooled to 25 °. This gives a preparation which can be used as a matt skin cream.

Example 3

You melt on that. water bath

0.2 parts by weight of pregnenolone, pure,

10.0 - beeswax, bleached,

10.0 - peanut oil, hydrogenated,

5.0 - benzyl laurate,

5.0 - Whale Rat,

35.0 - Almond oil, preserved,

2.5 - lanolin,

1,7 - sorbitan sesquioleate as well

0.8 - cholesterol

and heated until the melt has become clear and has reached 80 °.

Likewise are mixed

3.0 parts by weight of glycerine,
_ 0.2 - magnesium sulfate,

0.6 - borax and

26.0 - distilled water

and heated to 80 °. The 80 ° warm colized melt is emulsified in the usual way with the filtered aqueous solution, heated to 80 °, and stirred while cold. At 40 ⁰ , the is added. required perfume oil mixture. Mixing is then continued until the mixture has cooled to 25 °. A greasy skin cream is obtained in this way.

Example 4

One melts on the water bath

0.2 parts by weight of pregnenolone, pure,

6.0 - stearic acid,

2,0 - a-naphthoic acid benzyl ester,

0.3 - ceryl alcohol,

0.3 - sorbitan monooleate,

1,5 - polyalkylene oxide sorbitan

monostearate and 0.2 p-oxybenzoic acid methyl ester

and heated until the melt has become clear and has reached 80 °.

Be the same

2.3 parts by weight of triethanolamine oleate, 3.0 - glycerol and

84.2 - distilled water

mixed and heated to 90 ° and filtered by "(88 °) with the tumbled melt (8o °) emulsified in a conventional manner and brought to 40 ⁰ with vigorous mixing. addition of the necessary

Amount of perfume oil mixture and, with further thorough mixing, cool down to 25 ^° . A facial milk of medium viscosity is obtained in this way.

Example 5
One melts on the water bath

0.5 part by weight of pregnenolone benzyl ether,
2o, o - stearic acid,

2.5 - sesame oil, preserved,

0.8 - ceryl alcohol as well

0.2 - methyl p-oxybenzoate

and heated until the melt has become clear and has reached 80 °.

Likewise are mixed

1.8 parts by weight of trietbanolamine,

5.0 - glycerin and

69.2 - distilled water

and heated to 80 °. The 80 ° warm colized melt is emulsified in the usual way with the filtered aqueous solution, heated to 80 °, and stirred while cold. At 40 ⁰ , the required perfume oil mixture is added. Mixing is then continued until the mixture has cooled to 25 °. A matt skin cream is obtained in this way.

Example 6
You melt on the water bath

0.5 part by weight of pregnenolone acetate,

10.0 - beeswax, bleached,

10.0 - peanut oil, hydrogenated,

5.0 - Whale Rat,

40.0 - Almond oil, preserved,

2.5 - lanolin,

1,7 - sorbitan sesquioleate,

0.8 - cholesterol

and heated until the melt has become clear and has reached 80 °.

Likewise are mixed

3.0 parts by weight of glycerine,
0.2 - magnesium sulfate and

0.6 - borax as well

25.7 - - distilled water

and heated to 80 °. The 80 ° warm colized melt is emulsified in the usual way with the filtered aqueous solution, heated to 80 °, and stirred while cold. At 40 ⁰ , the required perfume oil mixture is added. Mixing is then continued until the mixture has cooled to 25 °. A greasy skin cream is obtained in this way.

Example 7 One melts on the water bath

0.5 part by weight of pregnenolone, pure,

10.0 - beeswax, bleached,

10.0 - peanut oil, hydrogenated,

5.0 - Whale Rat,

40.0 - Almond oil, preserved,

2,5 - lanolin,,

1,7 - sorbitan sesquioleate,

0.8 - cholesterol

and heated until the melt has become clear and has reached 80 °. Likewise are mixed

3.0 parts by weight of glycerine,

0.2 - magnesium sulfate,

0.6 - borax,

1.0% nicotinic acid amide solution

in WaS ¹ SeT and 24.7 - distilled water

and heated to 80 °. The 80 ° warm colized melt is emulsified in the usual way with the filtered aqueous solution, heated to 80 °, and stirred while cold. At 40 ⁰ , the required perfume oil mixture is added. Mixing is then continued until the mixture has cooled to 25 °. A greasy skin cream is obtained in this way.

Claims (6)

PATENT CLAIMS: 1. Skin care products, characterized by a content of pregnenolone and / or one of its esters or ethers. 2. skin care agent according to claim 1, characterized by a content of pregnenolone and / or one of its esters or ethers and an addition of an ester or Benzyl alcohol ether s. 3. Skin care products according to claims 1 and 2, characterized by the addition of nicotinic acid amide. 4. Skin care products according to claims 1 to 3, characterized by a content of pregnenolone and nicotinic acid amide. 5. Skin care products according to Claims 1 to 4, characterized by a content of Pregnenolone and benzyl benzoate. 6. skin care agent according to claims 1 to 4, characterized by a content of Pregnenolone and benzyl α-naphthoate. Considered publications: H. J a η i s t y η, »Fragrances, Soaps, Cosmetics«, 1950, Vol. II, p. 387; Swiss patent specification No. 258 982. © 509 698/442 3. (909 621/5 10.59)