DE1072360B - - Google Patents

Description

The cosmetic skin care is aimed at normal Preserve the texture of the skin. A wide variety of means have been used for this purpose been. They generally consist of a vehicle, e.g. B. an ointment or milk base, and an effective ingredient, e.g. B. vitamins and the like, and are usually as semi-fat or liquid Emulsions applied.

There is already an anti-rheumatic cream known which, as an active ingredient, cortisone, adrenaline or contains other derivatives of catechol which have an anti-rheumatic effect.

It is also known to use pregnenolone or its derivatives, e.g. B. the esters and ethers, as constituents of skin care products to use.

Finally, skin care products are also included. a content of various physiologically inactive steroid compounds, \ vie z. B. 17a-Ethy1-.d ⁴ -androstcn-17 ^ -01-3-011, known.

It has now been found that the adrenal cortex steroids, i.e. H. the corticosteroids that were previously used not yet used in skin care products when applied to human skin have the following effects:

They promote the build-up of glycogen in the subcutaneous tissue and regulate the water and mineral balance; they help to maintain the tone of the capillary vessels and control the temperature regulation the skin, and therefore its appearance despite fluctuations in temperature and humidity; they also protect against ultraviolet radiation, promote even blood circulation and cause a general increase in resistance by increasing the immune system of healthy skin.

The subject matter of the invention is therefore a skin care product which contains corticosteroids of natural or synthetic origin.

Although all corticosteroids and their derivatives and compounds can be used in the context of the invention, hydrocortisone is preferred because of its particularly good effectiveness. Also the synthetically obtained corticosteroids, such as prednisone (zl ^ -Pregnadien-na ^ l-diol-S.ll ^ O-trion) and prednisolone (zi ¹ ' ⁴ -Pregnadien-ll ^, 17a-21-triol-3.20 -dion) (cf. J. am. Chem. Soc, 77, 4781 to 4784 119551 and Ulimanns Encyklopadie der technischen Chemie, Vol. 8, 1957, pp. 667 and 685 to 687) have a corresponding effectiveness.

The skin care products according to the invention advantageously contain the corticosteroids in an amount of about 1 to 3 ^fl / o, in particular about 2%.

As a basis for the skin care products according to the invention any medium can serve, the skin care product

Applicant:

Dr. med. Gerhard Willich, Tehran (Iran)

Representative: Dr.-Ing. W. Abitz, patent attorney, Munich 27, Gaußstr. 6th

Dr. med. Gerhard Willich, Tehran (Iran), has been named as the inventor

is compatible with the corticosteroids, e.g. B. one of the usual bases for facial lotions, head aremes, emulsions and water or media of a more solid consistency, e.g. B. Vaseline, the well-known cream base and beauty milk.

In the following, the production of some skin care products is described by way of example to explain the invention described.

example 1

M to heated g in a very large vessel on the water bath 150 ¹ stearin (Glycerinester of palmitic and stearic acid), 30 g vaseline, 5gCacaobutter, 10 g of white wax and 20 g of white petrolatum until melted. A solution of 15 g of potash in 50 g of water and a solution of 8 g of borax in 850 g of water are prepared separately. As soon as the stearin and the other fats have melted, the concentrated potash solution is first heated to the boil and gradually, but fairly quickly, added to the molten fat while stirring. The mass is constantly stirred; as soon as it no longer rises, the borax solution, which has been heated to the boil, is added quickly while stirring and then heated to the boil. Continue the gentle simmering of the mass with stirring for about an hour, then remove it from the fire, compensate for any losses of water and cool with constant further stirring until the mass becomes thick. When solidification begins, 3% hydrocortisone is incorporated.

A smooth, grain-free cream is obtained which is excellently suited as a skin care product.

H e i s ρ i e. 1 2

lune fattere 1 Iautpflegecrcme is made by one 40 g of cetyl alcohol, 145 g of paraffin, 240 g of La-

909 707/316

Claims (1)

nolki anhydr. and 175 g of white vaseline oil melts, B e i s ρ i e 1 4 in the melt 600 g of water at one temperature. 4 g of boric acid and 3 g of hydrocortisone are dissolved in Stir in from 60 to 70 ° C and continue stirring, ^{add 50 cm 3 of} alcohol and 50 cm ^{3 of} water. Man until the emulsion has become homogeneous and thick. receives a skin care product suitable as a facial tonic In this creme granular layer one works in the medium. borrowed way 2% hydrocortisone. The patent protection does not extend to the animal-awarded, smooth, homogeneous skin care fatty acid category. position and use of the agent for therapeutic ^; _π . . , “Table purposes.
Example 3 , r,, ·, -,, ·, claims: It is made up of the following components: io peeled almonds. 50 g * · skin care product, marked with a Rose water 600 g corticosteroid content. !! natural or syn- Glycerin ^ .......................... 50 g of thetic origin. Borax 5 ir ^ " skin care product according to claim 1, characterized I benzoin tincture ...................... 10 ° - ^X 5 marked that the corticosteroids therein are in l ' ^ta an amount of 1 to 3%, in particular 2%, First make a stiff paste by holding the almonds. pounded with a little rose water, separately a solution 3. Skin care products ηaah claims 1 and 2, there- of the borax in the remaining rose water and characterized by that it is called Corticoste.roid into the benzoin tincture. The emulsion obtained contains ao hydrocortisone. is now gradually being used along with 2.5% prednisolone incorporated into the paste with constant rubbing, resulting in a rather thick milk. Considered publications are allowed:
Sit for 8 days, pour through a close-meshed sieve German Patent No. 950 960;
away. and optionally adds perfumes. 25 Belgian patents Nos. 524 132, 531 437; This gives an H. Janistyn that can be used as facial milk: "Fragrances, soaps, cosmetics", Skin care products. 1950, Vol. II, pp. 384 to 389. 1 909 707/316 12.59