CH399655A - Skin care products - Google Patents

Skin care products

Info

Publication number
CH399655A
CH399655A CH798161A CH798161A CH399655A CH 399655 A CH399655 A CH 399655A CH 798161 A CH798161 A CH 798161A CH 798161 A CH798161 A CH 798161A CH 399655 A CH399655 A CH 399655A
Authority
CH
Switzerland
Prior art keywords
skin care
sphingolipoids
care products
skin
wrinkles
Prior art date
Application number
CH798161A
Other languages
German (de)
Inventor
Gustav Dr Erlemann
Joseph Dr Kiss
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Priority to CH798161A priority Critical patent/CH399655A/en
Publication of CH399655A publication Critical patent/CH399655A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • A61K8/345Alcohols containing more than one hydroxy group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)

Description

  

  
 



     Hautpflegeniittei   
Beim Altern der Haut tritt ein Elastizitätsverlust und eine Verminderung des Turgors ein, als deren Folge sich Runzel- und Faltenbildung einstellen. Es ist bisher nicht gelungen, diesen Alterserscheinungen auf kosmetischer Basis in befriedigender Weise entgegenzuwirken.



   Es wurde nun gefunden, dass Sphingolipoide einen günstigen Einfluss in dieser Richtung ausüben. Unter dem Begriff Sphingolipoide versteht man Lipoide, welche als Base Sphingosin oder Dihydrosphingosin enthalten und vorzugsweise in den Nervengeweben auftreten. Man unterscheidet dabei Sphingamidylphosphocholine oder Sphingomyeline, die sich aus einer Fettsäure, Phosphorsäure, Cholin und Sphingosin bzw. Dihydrosphingosin zusammensetzen, und Cerebroside oder Glykosidosphingoside, die ausser Spingosin bzw. Dihydrosphingosin Fettsäure und einen Zucker in Glykosidbindung, jedoch keine Phosphorsäure enthalten. Sphingolipoide können z. B. aus Ochsenhirn gewonnen werden [J. Biol. Chem.



  169, 77 (1947)].



   Die genannten Sphingolipoide erhöhen den Turgor der Haut und verleihen ihr schon nach kurzer Anwendung ein samtartiges, angenehmes Gefühl. Während die Sphingolipoide bei alter Haut der Falten- und Runzelbildung entgegenwirken, verleihen sie der jugendlichen Haut ein Gefühl der Frische. Auch in höheren Konzentrationen lösen sie keine Reizerscheinungen aus.



   Die Erfindung betrifft demnach ein Hautpflegemittel, welches als Komponente ein oder mehrere Sphingolipoide enthält. Zweckmässigerweise werden die Sphingolipoide in Konzentrationen von 0,1-25    /o    verwendet. Als Träger eignen sich alle in kosmetischen Zubereitungsformen, wie Salben, Cremen, Lotionen, usw., üblichen Stoffe, z. B. Wollfett, höhere Fettalkohole, Wachse, pflanzliche Öle, Vaseline.



   Beispiel 1
Gesichts- und Handlotion
1,00 g Isopropylpalmitat,
0,50 g   1, 2, 3-Trihydroxy-3, 7, 11, 1 5-tetramethyl-    hexadecan (hergestellt durch Behandlung von
Isophytol mit Perameisensäure und Ver seifung des Reaktionsproduktes mit Natron lauge),
0,60 g Oxäthylierter Fettalkohol,
0,25 g Cetylalkohol,
0,50 g Panthenol,
0,25 g Acetostearat und    0, 50 g    Isophytol werden auf   70"    erwärmt. Unter
Rühren wird eine Suspension von
1,00 g   Sphingolipoiden    in 20,00 g einer   10/obigen    wässrigen Polyacrylsäurelösung mit der Fettphase emulgiert. In die Emul sion wird eine Lösung, die
5,00 g Glyzerin und 70,00 g Wasser enthält, bei 500 C eingearbeitet. Die gewünschte Viskosität wird durch Zugabe von Arginin eingestellt.

   Die Lotion kann nach Wunsch   parfümiert    und gefärbt wer den.



   Beispiel 2    Fettcreme    10,00 g Stearin,
2,00 g Cetylalkohol,
2,00 g Wollfett,
4,00 g Bienenwachs, 10,00 g Mandelöl,
5,00 g   1, 2, 3-Trihydroxy-3, 7, 1 1, 15-tetramethyl-    hexadecan,  
5,00 g Oxäthylierter Fettalkohol, 10,00 g Perhydrosqualen und
5,00 g Glyzerinmonostearat werden auf 700 C er wärmt. In die Schmelze wird unter Rühren eine wässrige Suspension von
3,00 g Sphingolipoiden,
2,00 g oxäthylierter Fettalkohol und 42,00 g Wasser bei 600 C eingearbeitet.



   Die Creme kann nach Wunsch parfümiert werden.



   Beispiel 3
Gel zur Behandlung von fetter Haut
3,00 g Sphingolipoide werden mit 97,00 g einer 20/oigen Polyacrylsäurelösung bei 500 C vermischt. Anschliessend wird mit einer ba sischen Aminosäure, z. B. Arginin, die ge wünschte Konsistenz eingestellt.   



  
 



     Skin care products
As the skin ages, there is a loss of elasticity and a reduction in turgor, as a result of which wrinkles and wrinkles appear. So far it has not been possible to counteract these signs of aging on a cosmetic basis in a satisfactory manner.



   It has now been found that sphingolipoids have a beneficial influence in this direction. The term sphingolipoids is understood as meaning lipoids which contain sphingosine or dihydrosphingosine as a base and which preferably occur in the nerve tissues. A distinction is made between sphingamidylphosphocholines or sphingomyelins, which are made up of a fatty acid, phosphoric acid, choline and sphingosine or dihydrosphingosine, and cerebrosides or glycosidosphingosides, which apart from spingosine or dihydrosphingosine contain fatty acid and a sugar in a glycoside bond, but no phosphoric acid. Sphingolipoids can e.g. B. obtained from ox brain [J. Biol. Chem.



  169, 77 (1947)].



   The mentioned sphingolipoids increase the turgor of the skin and give it a velvety, pleasant feeling after just a short application. While the sphingolipoids counteract the formation of wrinkles and wrinkles in old skin, they give young skin a feeling of freshness. Even in higher concentrations, they do not cause any irritation.



   The invention accordingly relates to a skin care product which contains one or more sphingolipoids as a component. The sphingolipoids are expediently used in concentrations of 0.1-25 / o. Suitable carriers are all substances customary in cosmetic preparation forms, such as ointments, creams, lotions, etc., e.g. B. wool fat, higher fatty alcohols, waxes, vegetable oils, petroleum jelly.



   example 1
Face and hand lotion
1.00 g isopropyl palmitate,
0.50 g of 1, 2, 3-trihydroxy-3, 7, 11, 1 5-tetramethylhexadecane (produced by treating
Isophytol with performic acid and saponification of the reaction product with caustic soda),
0.60 g of oxethylated fatty alcohol,
0.25 g of cetyl alcohol,
0.50 g panthenol,
0.25 g acetostearate and 0.50 g isophytol are heated to 70 ". Under
Stir a suspension of
1.00 g of sphingolipoids in 20.00 g of a 10 / above aqueous polyacrylic acid solution emulsified with the fatty phase. In the emulsion is a solution that
Contains 5.00 g glycerine and 70.00 g water, incorporated at 500 C. The desired viscosity is set by adding arginine.

   The lotion can be perfumed and colored as desired.



   Example 2 fat cream 10.00 g stearin,
2.00 g of cetyl alcohol,
2.00 g wool fat,
4.00 g beeswax, 10.00 g almond oil,
5.00 g 1, 2, 3-trihydroxy-3, 7, 1 1, 15-tetramethylhexadecane,
5.00 g of oxethylated fatty alcohol, 10.00 g of perhydrosqualene and
5.00 g of glycerol monostearate are heated to 700 C. An aqueous suspension of is in the melt with stirring
3.00 g sphingolipids,
2.00 g of oxyethylated fatty alcohol and 42.00 g of water are incorporated at 600.degree.



   The cream can be perfumed as desired.



   Example 3
Gel for the treatment of oily skin
3.00 g of sphingolipids are mixed with 97.00 g of a 20% polyacrylic acid solution at 500.degree. Then with a basic amino acid, z. B. arginine, the ge desired consistency set.

 

Claims (1)

PATENTANSPRUCH Hautpflegemittel, welches als Komponente ein oder mehrere Sphingolipoide enthält. PATENT CLAIM Skin care product which contains one or more sphingolipoids as a component. UNTERANSPRUCH Mittel nach Patentanspruch, dadurch gekennzeichnet, dass es die Sphingolipoide in Konzentrationen von 0,1 bis 25 O/o enthält. UNDER CLAIM Agent according to patent claim, characterized in that it contains the sphingolipoids in concentrations of 0.1 to 25%.
CH798161A 1961-07-07 1961-07-07 Skin care products CH399655A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CH798161A CH399655A (en) 1961-07-07 1961-07-07 Skin care products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH798161A CH399655A (en) 1961-07-07 1961-07-07 Skin care products

Publications (1)

Publication Number Publication Date
CH399655A true CH399655A (en) 1965-09-30

Family

ID=4333320

Family Applications (1)

Application Number Title Priority Date Filing Date
CH798161A CH399655A (en) 1961-07-07 1961-07-07 Skin care products

Country Status (1)

Country Link
CH (1) CH399655A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60163806A (en) * 1984-02-03 1985-08-26 Pola Chem Ind Inc Skin pharmaceutical for external use
WO1986000015A1 (en) * 1984-06-15 1986-01-03 Pentapharm A. G. Cosmetic product for the treatment of the skin
JPS6229508A (en) * 1985-07-31 1987-02-07 Kao Corp Cosmetic
JPS62120308A (en) * 1985-11-20 1987-06-01 Kao Corp Cosmetic
WO2013017361A1 (en) * 2011-08-03 2013-02-07 Evonik Goldschmidt Gmbh Use of sphinganine to improve the visual appearance of skin and hair
WO2015014558A3 (en) * 2013-07-29 2015-04-23 Evonik Industries Ag Formulations containing sphinganine

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60163806A (en) * 1984-02-03 1985-08-26 Pola Chem Ind Inc Skin pharmaceutical for external use
JPH0457641B2 (en) * 1984-02-03 1992-09-14 Pola Kasei Kogyo Kk
WO1986000015A1 (en) * 1984-06-15 1986-01-03 Pentapharm A. G. Cosmetic product for the treatment of the skin
JPS6229508A (en) * 1985-07-31 1987-02-07 Kao Corp Cosmetic
JPS62120308A (en) * 1985-11-20 1987-06-01 Kao Corp Cosmetic
WO2013017361A1 (en) * 2011-08-03 2013-02-07 Evonik Goldschmidt Gmbh Use of sphinganine to improve the visual appearance of skin and hair
CN103764108A (en) * 2011-08-03 2014-04-30 赢创德固赛有限公司 Use of sphinganine to improve the visual appearance of skin and hair
US9610232B2 (en) 2011-08-03 2017-04-04 Evonik Degussa Gmbh Use of sphinganine to improve the visual appearance of skin and hair
WO2015014558A3 (en) * 2013-07-29 2015-04-23 Evonik Industries Ag Formulations containing sphinganine

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