DE915853C - Process for the manufacture of vaccines - Google Patents

Process for the manufacture of vaccines

Info

Publication number
DE915853C
DE915853C DES11800D DES0011800D DE915853C DE 915853 C DE915853 C DE 915853C DE S11800 D DES11800 D DE S11800D DE S0011800 D DES0011800 D DE S0011800D DE 915853 C DE915853 C DE 915853C
Authority
DE
Germany
Prior art keywords
vaccines
virus
immunization
manufacture
sound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DES11800D
Other languages
German (de)
Inventor
Dr Med Helmut Ruska
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens AG
Original Assignee
Siemens AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens AG filed Critical Siemens AG
Priority to DES11800D priority Critical patent/DE915853C/en
Application granted granted Critical
Publication of DE915853C publication Critical patent/DE915853C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
    • A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/00051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

Verfahren zur Herstellung von Impfstoffen Die Erfindung betrifft ein Verfahren zur Herstellung von Impfstoffen zur aktiven Immunisierung, insbesondere gegen Viruskrankheiten. Erfindungsgemäß werden die Bakterien, insbesondere Virus, der krank machenden Wirkung durch Schall, insbesondere Ultraschall, beraubt. Dabei wird die Beschallung so gesteuert, daß die Vermehrungsfähigkeit des Krankheitserregers zerstört wird, daß aber die den Immunisierungsvorgang bedingenden chemischen Gruppen erhalten bleiben.Process for making vaccines The invention relates to a Process for the preparation of vaccines for active immunization, in particular against viral diseases. According to the invention, the bacteria, in particular virus, deprived of the pathogenic effects of sound, especially ultrasound. Included the sound is controlled so that the ability of the pathogen to multiply is destroyed, but that the chemical groups causing the immunization process remain.

Man kann das Verfahren nach der Erfindung zur Herstellung von Impfstoffen für die Impfung von Mensch und Tier bei Infektionskrankheiten, die eine natürliche Immunität hinterlassen, anwenden. Bei Versuchen mit Tabakmosaikvirus wurde festgestellt, daß Ultraschall die krank machende Wirkung des Virusproteins aufhebt.Die elektronenmikroskopische Untersuchung beschallter Viruslösungen zeigte, daß die Virusmoleküle zerschlagen sind. Wahrscheinlich ist diese Zerschlagung für den Verlust der Vermehrungsfähigkeit des Virus verantwortlich. Die Virusbruchstücke können erfindungsgemäß zur Immunisierung verwendet werden. Auf diesem Gedanken aufbauend, können bei Anwendung der Erfindung u. a. Impfstoffe für Maul- und Klauenseuche hergestellt werden. One can use the method of the invention for the preparation of vaccines for vaccination of humans and animals in infectious diseases that are a natural Leave immunity, apply. Tests with tobacco mosaic virus found that ultrasound cancels the disease-causing effect of the virus protein Examination of sonicated virus solutions showed that the virus molecules disintegrated are. Probably this breaking up is for the loss of the ability to reproduce of the virus. According to the invention, the virus fragments can be used for immunization be used. Building on this idea, when applying the invention i.a. Vaccines for foot and mouth disease are made.

Das neue Verfahren vermeidet jeden Zusatz von Fremdstoffen (Phenol, Adsorbentien u. dgl.) und erhöht durch Verritigerung des zur I mpfung erforderlichen Impfstoffvolumens die Leistungsfähigkeit der Impfstoffproduktionsstellen. The new process avoids any addition of foreign substances (phenol, Adsorbents and the like) and increased by denial of the vaccination the vaccine production facilities.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von Impfstoffen zur aktiven Immunisierung insbesondere gegen Viruskrankheiten, dadurch gekennzeichnet, daß die Bakterien, insbesondere Virus, der krank machenden Wirkung durch Schall, insbesondere Ultraschall, beraubt werden, wobei die Beschallung so gesteuert wird, daß die Vermehrungsfähigkeit des Krankheitserregers zerstört wird, daß aber die den Immunisierungsvorgang bedingenden chemischen Gruppen erhalten bleiben. PATENT CLAIM: Process for the production of vaccines for active Immunization in particular against viral diseases, characterized in that the Bacteria, particularly viruses, of the disease-causing effects of sound, in particular Ultrasound, whereby the sonication is controlled in such a way that the ability to reproduce of the pathogen is destroyed, but that which causes the immunization process chemical groups are retained.
DES11800D 1945-02-01 1945-02-01 Process for the manufacture of vaccines Expired DE915853C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DES11800D DE915853C (en) 1945-02-01 1945-02-01 Process for the manufacture of vaccines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DES11800D DE915853C (en) 1945-02-01 1945-02-01 Process for the manufacture of vaccines

Publications (1)

Publication Number Publication Date
DE915853C true DE915853C (en) 1954-07-29

Family

ID=7473769

Family Applications (1)

Application Number Title Priority Date Filing Date
DES11800D Expired DE915853C (en) 1945-02-01 1945-02-01 Process for the manufacture of vaccines

Country Status (1)

Country Link
DE (1) DE915853C (en)

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