DE753154C - Process for the production of a dry preparation from blood or serum for therapeutic purposes - Google Patents

Process for the production of a dry preparation from blood or serum for therapeutic purposes

Info

Publication number
DE753154C
DE753154C DEM152012D DEM0152012D DE753154C DE 753154 C DE753154 C DE 753154C DE M152012 D DEM152012 D DE M152012D DE M0152012 D DEM0152012 D DE M0152012D DE 753154 C DE753154 C DE 753154C
Authority
DE
Germany
Prior art keywords
serum
blood
production
therapeutic purposes
dry preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DEM152012D
Other languages
German (de)
Inventor
Guenther Dr Med Albus
Alfred Dr Phil Kuhn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Madaus Holding GmbH
Original Assignee
Dr Madaus GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Madaus GmbH and Co filed Critical Dr Madaus GmbH and Co
Priority to DEM152012D priority Critical patent/DE753154C/en
Application granted granted Critical
Publication of DE753154C publication Critical patent/DE753154C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Description

Verfahren zur Herstellung eines Trockenpräparates aus Blut oder Serum für therapeutische Zwecke Es ist bekannt, daß Krankheiten verschiedenster Art im Blut Abwehnstoffe erzeugen, z. B. entstehen bei allergischen Erkrankungen im Blut Antikörper in analoger Weise wie bei Infektionskrankheiten, die meist sehr spezifisch auf das Allergen- bEzw. auf das Bakterien- und V,irustoxin,abgestimmt sind.Process for the production of a dry preparation from blood or serum for therapeutic purposes It is known that diseases of various kinds in the Produce blood rejects, e.g. B. arise in allergic diseases in the blood Antibodies in a manner analogous to infectious diseases, which are usually very specific on the allergen or to which bacterial and V, irustoxin, are coordinated.

Man kann auch im tierischen Blut durch aktive Immunisierung Antikörper erzeugen.Antibodies can also be found in animal blood through active immunization produce.

Es hat sich nun gezeigt, daß solches antikörperenthaltendes Blut oder dessen Serum sich vorteilhaft zur Behandlung von Allergien und mit hyperergischen Erscheinungen ein hergehenden Erkrankungen verwenden läßt, und zwar durch intranasale, intrapharyngeale, intralaryngeale, intraorale, perorale und intrarectale Anwendung bzw. durch Aufbringung auf infizierte Wunden in Form von Trockenpulvern des Blutes oder des Serums von Menschen oder Tieren.It has now been shown that such antibody-containing blood or whose serum is beneficial for the treatment of allergies and with hyperergic Phenomena related to diseases can be used, namely through intranasal, intrapharyngeal, intralaryngeal, intraoral, peroral and intrarectal use or by application to infected wounds in the form of dry powder of the blood or the serum of humans or animals.

Das Verfahren bezweckt die Herstellung eines derartigen Heilmittels aus Blut oder Serum in trockner Form. Es besteht darin, daß das Blut bzw. Serum mit löslicher Stärke bei Temperaturen unter dem Koagulationspunkt des Eiweißes eingetrocknet wird. The purpose of the method is to produce such a medicinal product from blood or serum in dry form. It consists in the blood or serum dried with soluble starch at temperatures below the coagulation point of the egg white will.

Die bisher bekannten Wege zur Trocknung von Serum, z. B. im Vakuum oder in strömelder Luft usw., haben sich bei der Herstellung von Präparaten für die obengenannten Zwecke nicht bewährt, insbesondere bereitet die Verarbelitung von wenigen Kubikzentimetern Serum bei der normalen direkten Eindickung große Schwierigkeiten. Die glasharten Massen setzen sich an dem Trocknungsgefäß an und lassen sich nur schwer entfernen. Bei Verwendung von Glas und Porzellan werden die Gefäße stark korrodiert. The previously known ways of drying serum, e.g. B. in a vacuum or in strömelder Air, etc., have been used in the production of Preparations for the above-mentioned purposes not proven, in particular the Processing of a few cubic centimeters of serum with normal direct thickening great difficulties. The glass-hard masses settle on the drying vessel and are difficult to remove. When using glass and porcelain be the vessels are badly corroded.

Die Verarbeitung solch kleiner Mengen ist aber dann erforderlich, wenn das Serum eines Individuums z. B. bei den sehr spezifischen Pollenallergien zur Anwendung gebracht werden muß.The processing of such small quantities is necessary, however, when the serum of an individual is e.g. B. with the very specific pollen allergies must be applied.

Als Verteilungsmittel eignen sich nun nicht ohne weiteres alle löslichen Stoffe. Salze sind als indifferente Verteilungsmittel im allgemeinen nicht verwertbar, da sie im Verlauf des Eintrocknens solche Konzentrationen erreichen, die zur Koagulation des Eiweißes und damit zu dessen Denaturierung fiihren. Not all soluble ones are readily suitable as distributing agents Fabrics. Salts are generally not usable as indifferent distribution agents, because in the course of drying they reach concentrations that lead to coagulation of the protein and thus lead to its denaturation.

Auch pflanzliche Quellstoffe eignen sich nicht, da sie zur Klumpenbildung neigen. Die lösliche Stärke dagegen läßt sich ohne weiteres homogen mit dem Blut oder Serum mischen und eintrocknen. Dazu kommt noch weiter, daß das unter Verwendung löslicher Stärke hergestellte Trockenerzeugnis in Wasser wieder glatt lösbar ist und bei weiterer Verwendung keinerlei Schwierigkeiten bereitet, im Gegensatz zu den aufsaugfähigen, aber nur quellfähigen Materialien.Plant-based swelling substances are also unsuitable, as they lead to the formation of lumps tend. The soluble starch, on the other hand, can easily be homogeneous with the blood or mix and dry the serum. In addition to that, the using Soluble starch produced dry product is easily soluble in water again and does not cause any difficulties with further use, in contrast to absorbent, but only swellable materials.

Wesentlich ist die Erkenntnis, daß gerade lösliche Stärke mit einem mittleren Molekulargewicht besonders geeignet für den genannten Zweck ist. Lösliche Salze haben den großen Nachteil, daß sie auf der Schleimhaut beim Lösen eine hohe Konzentration erreichen und damit osmotisch wirksam werden, d. h. sie entziehen der Schleimhaut Wasser bzw. eine seröse Flüssigkeit, was sich in der Nase als Schnupfen äußert, worüber z. B. die Heuschnupfenkranken schon sowieso klagen. What is essential is the knowledge that soluble starch with a average molecular weight is particularly suitable for the stated purpose. Soluble Salts have the major disadvantage that they have a high level of dissolving on the mucous membrane Achieve concentration and thus become osmotically effective, d. H. withdraw them The mucous membrane water or a serous fluid, what in the nose as a runny nose expresses what z. B. the hay fever sufferers complain anyway.

Werden Stoffe von sehr hohem Molekulargewicht verwendet, so können wieder Allergien erzeugt werden. Aus diesem Grunde ist die Stärke als löslicher Stoff mit einem mittieren Molekulargewicht, wodurch beim Auflösen nur geringe osmotische Konzentrationen entstehen, besonders geeignet.If substances of very high molecular weight are used, so can again allergies are generated. For this reason, the starch is considered to be more soluble Substance with a medium molecular weight, which results in only low osmotic dissolution Concentrations arise, particularly suitable.

Ausführungsbeispiel 8 ccm Blut läßt man gerinnen und zentrifugiert das überstehende Serum ab. Die durchschnittliche Ausbeute von 4 ccm Serum wird mit den gleichen Gewichtsteilen Amylum solubile vermischt und im Vakuum zur Trockne gebracht. Das Pulver haftet nicht an der Unterlage, läßt sich leicht entfernen und ohne Schwierigkeiten in ein unfühlhares Pulver zerreiben. Embodiment 8 cc of blood are allowed to clot and centrifuged the excess serum. The average yield of 4 cc of serum is with the same parts by weight of Amylum solubile mixed and in vacuo to dryness brought. The powder does not adhere to the base, is easy to remove and grind into an imperceptible powder without difficulty.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines Trokkenpräparates aus Blut oder Serum für therapeutische Zwecke durch Auftrocknen des Blutes oder Serums auf einen indifferenten Träger, dadurch gekennzeichnet, daß das Blut oder Serum in Mischung mit löslicher Stärke bei Temperaturen unter dem Koagulationspunkt des Eiweißes eingetrocknet wird Zur Abgrenzung des Erfindungsgegenstands vom Stand der Technik sind im Erteilungsverfahren folgende Druckschriften in Betracht gezogen worden: Deutsche Patentschriften Nr. 283 882, 461 772, 683 524 PATENT CLAIM: Process for the production of a dry preparation from blood or serum for therapeutic purposes by drying the blood or Serum on an indifferent carrier, characterized in that the blood or Serum mixed with soluble starch at temperatures below the coagulation point of the egg white is dried to distinguish the subject matter of the invention from the state technology, the following publications are taken into account in the granting procedure been: German Patent Nos. 283 882, 461 772, 683 524
DEM152012D 1941-09-30 1941-09-30 Process for the production of a dry preparation from blood or serum for therapeutic purposes Expired DE753154C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEM152012D DE753154C (en) 1941-09-30 1941-09-30 Process for the production of a dry preparation from blood or serum for therapeutic purposes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM152012D DE753154C (en) 1941-09-30 1941-09-30 Process for the production of a dry preparation from blood or serum for therapeutic purposes

Publications (1)

Publication Number Publication Date
DE753154C true DE753154C (en) 1951-08-02

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Family Applications (1)

Application Number Title Priority Date Filing Date
DEM152012D Expired DE753154C (en) 1941-09-30 1941-09-30 Process for the production of a dry preparation from blood or serum for therapeutic purposes

Country Status (1)

Country Link
DE (1) DE753154C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE974541C (en) * 1952-03-26 1961-02-02 Diamalt Ag Process for the production of dry enzymatic desizing agents from pancreatic pressures

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE283882C (en) *
DE461772C (en) * 1925-09-22 1928-06-27 I G Farbenindustrie Akt Ges Process for the production of dosed, ready-to-use dry tuberculin preparations
DE683524C (en) * 1934-07-08 1939-11-09 Max Winckel Dr Process for transferring solutions of chemically labile substances in dry form

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE283882C (en) *
DE461772C (en) * 1925-09-22 1928-06-27 I G Farbenindustrie Akt Ges Process for the production of dosed, ready-to-use dry tuberculin preparations
DE683524C (en) * 1934-07-08 1939-11-09 Max Winckel Dr Process for transferring solutions of chemically labile substances in dry form

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE974541C (en) * 1952-03-26 1961-02-02 Diamalt Ag Process for the production of dry enzymatic desizing agents from pancreatic pressures

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